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Hollismason posted:What's the efficacy of Moderna after 2nd dose 1 week? I really wanna eat out at a resteraunt. Just wait another week or two. You're literally one step from the finish line, don't stop now.
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Mar 19, 2021 17:38
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Rolo posted:Anyone on the vax develop mild tinnitus? Yep, several people in CSPAM got ringing in their ears
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Mar 19, 2021 17:39
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Antigravitas posted:The confidence interval for >65 was -1405% to 94%. Not a typo. Yeah looking at the data they recruited people 18-55 for the majority of their studies and only threw in a handful of people older at the end. Like out of 24k participants only something like 660 were 65+ and since there were only two cases of COVID in that cohort the result was "who the gently caress knows". Zero of those 65+ participants were in the group where they discovered the altered dosing schedule was more effective. What the gently caress Oxford lol. Like there seems to be enough real world data now showing it works in 65+ people but how do you bungle that poo poo so badly in a vaccine for a disease that is especially lethal to old people. For comparison 42% of Pfizer's participants were over 55. Mr Luxury Yacht fucked around with this message at 17:51 on Mar 19, 2021 |
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Mar 19, 2021 17:40
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Has there been any word on J and J supply line are they still on target for delivering 20 million doses in March?
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Mar 19, 2021 17:41
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Snowglobe of Doom posted:Yep, several people in CSPAM got ringing in their ears Phew ok. It feels more mild than yesterday when my symptoms peaked but I’m also majorly afraid of tinnitus after working around airplanes most of my life.
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Mar 19, 2021 18:02
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Hollismason posted:What's the efficacy of Moderna after 2nd dose 1 week? I really wanna eat out at a resteraunt. Going out for a 7 course meal of soup and jello?
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Mar 19, 2021 18:06
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21 hours in and I can hardly even feel the microchip
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Mar 19, 2021 18:11
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Rolo posted:Anyone on the vax develop mild tinnitus? Yep. About 5 minutes after receiving Pfizer, I had tinnitus for a very brief amount of time (like a minute or two). It's apparently a known side effect: https://www.drugdiscoverytrends.com/tinnitus-reports-grow-amid-covid-19-vaccinations/
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Mar 19, 2021 21:18
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So now that everyone in my house including me is fully vaccinated, is it safe for me to do my food delivery gig job again? y’know until I get a real job or while working a real job
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Mar 19, 2021 21:29
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Got dose 1 of pfizer today, zero effects and I didn't even feel the needle, did I get pranked Free band-aid though!
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Mar 19, 2021 21:32
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Well, I’ve already got tinnitus (15 years) and various things basically hurt all the time (5+ years), I may not even notice vaccine effects whenever I eventually get it. Yay I guess. Would be nice not to be worried all the time though.
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Mar 19, 2021 21:34
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redgubbinz posted:Got dose 1 of pfizer today, zero effects and I didn't even feel the needle, did I get pranked Same thing happened to me, I barely felt anything on the injection site the next day and had pretty much no effects. I thought maybe I had some brain fog or fatigue but I'm pretty much always in some level of fatigue so hard to say if it was related to the shot or not. Hopefully the next one is just as easy.
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Mar 19, 2021 21:34
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redgubbinz posted:Got dose 1 of pfizer today, zero effects and I didn't even feel the needle, did I get pranked My worst symptoms hit about 18 hours in. I did have the same experience where the shot itself barely hurt at all. One of the easiest ones I’ve ever had and I don’t like shots.
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Mar 19, 2021 21:34
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There should be a reality TV Show called COVID Island, and its a pure island, no COVID and 12 people land there and have to find the one of them who has it, and they cant leave until they do,
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Mar 19, 2021 21:37
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Shot number 2 had the same weird thing ~48 hours in where my aches/hot-cold switches got not as bad but all the sudden I got really nauseous. Fun.
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Mar 19, 2021 21:42
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explosivo posted:I'm pretty much always in some level of fatigue same I’m finally seeing a doctor about it next week
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Mar 19, 2021 21:47
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redgubbinz posted:Got dose 1 of pfizer today, zero effects and I didn't even feel the needle, did I get pranked No lollipop? You definitely got pranked.
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Mar 19, 2021 21:52
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I. M. Gei posted:So now that everyone in my house including me is fully vaccinated, is it safe for me to do my food delivery gig job again? 'Safe' is a relative concept here. Even if you've waited the recommended amount of time after the final shot (2 weeks after the 2nd shot, etc) when the vaccine should be at full efficacy it's not 100% protection, there's still a small chance you could catch it. If you did it would almost certainly be a very mild case and it's very very unlikely that you'd end up in hospital and so far it seems unlikely that you'd get any longterm effects, and it's also unlikely that you'd pass it along to anyone else in your house but not 100% certain. There's already been several reported cases of people catching the virus after their 2nd jab, the odds are super super low but it's still a possibility. If you did catch it there'd be a chance that you might pass it on to someone outside your household so you should keep wearing masks. If those odds are acceptable to you then you could consider it 'safe'
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Mar 19, 2021 21:53
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We also have essentially zero real world data on how the mRNA vaccines perform against the escape mutants most prevalent in SA and Brazil but which are definitely present in the US. Almost certainly better than the vaccinee serum experiments suggest, but how they compare to JnJ under those circumstances (~59% reduction of severe illness and likely much more reduction of critical illness/hospitalization/death, but small studies) is still a mystery.
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Mar 19, 2021 21:57
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The gift that keeps on giving...quote:A cohort of scientists from across the world believe that there is a growing body of evidence that Covid-19 can cause diabetes in some patients. https://www.theguardian.com/world/2021/mar/19/doctors-suggest-link-between-covid-19-and-diabetes quote:Twelve months of Covid-19 has reversed 12 years of global progress against tuberculosis, worse than previously estimated. https://www.theguardian.com/global-development/2021/mar/19/fight-against-tuberculosis-set-back-12-years-by-covid-pandemic-report-finds
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Mar 19, 2021 22:10
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Snowglobe of Doom posted:Yep, several people in CSPAM got ringing in their ears Yeah but I don't think this has anything to do with the vaccine
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Mar 19, 2021 22:16
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SchnorkIes posted:We also have essentially zero real world data on how the mRNA vaccines perform against the escape mutants most prevalent in SA and Brazil but which are definitely present in the US. Almost certainly better than the vaccinee serum experiments suggest, but how they compare to JnJ under those circumstances (~59% reduction of severe illness and likely much more reduction of critical illness/hospitalization/death, but small studies) is still a mystery. The vaccine sera experiments vary widely, too. Feingl‐ding and others are panicking over this paper that shows reduction of twenty to forty fold, but this paper shows less than eight fold.   The first chart has slick graphic design, but the second study is really interesting. It looks at which particular antibodies are generated, which areas of the spike they bind to, and how the mutations prevent binding.   Note that AstraZeneca in this chart is their monoclonal antibody cocktail, not vaccine serum.
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Mar 19, 2021 22:19
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Platystemon posted:The vaccine sera experiments vary widely, too. There seem to be a lot of immunologists who think the non-antibody immune responses (T cells, B cells, etc) are pretty important as well. I don't think they are considered in this kind of study because they're much more difficult to deal with than antibodies. The second one at least mentions them: quote:How previously infected or vaccinated individuals respond to these new variant vaccines will be the subject of intense study over the coming months, as there is a general reckoning that the current problem is not over. However, even if antibody responses to the new variants are not able to prevent infection, they may moderate severity. In addition, T cell responses to spike may not be disrupted by the mutational changes and be able to limit spread to the lower respiratory tract and prevent severe disease.
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Mar 19, 2021 22:27
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7of7 posted:There seem to be a lot of immunologists who think the non-antibody immune responses (T cells, B cells, etc) are pretty important as well. T and B cells are a big part of why SARS and MERS patients still have immunity. E: I think but I’m not sure that it has also translated to resistance to SARS2: The SARSening but I can’t find that article right now.
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Mar 19, 2021 22:29
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7of7 posted:There seem to be a lot of immunologists who think the non-antibody immune responses (T cells, B cells, etc) are pretty important as well. Yeah they seem to be crucial which is why I'm getting tired of seeing breathless tweets about serum studies lol, not the hunt serum studies aren't interesting and important
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Mar 19, 2021 22:44
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Hey buster, the rule says covid can't travel farther than three feet. It's a virus so it doesn't know how to break the rules. Those kids are totally safe.
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Mar 19, 2021 23:00
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SchnorkIes posted:Yeah they seem to be crucial which is why I'm getting tired of seeing breathless tweets about serum studies lol, not the hunt serum studies aren't interesting and important I really, really want to see Janssen sera studied. The original trials had the intriguing result that quote:neutralizing activity against this variant of the B.1.1.7 lineage was approximately 9-fold lower at 28 days and 3.3-fold lower at 70 days compared to the neutralization of the reference SARS-CoV-2 Victoria 1/2020 strain. Between 28 and 70 days after vaccination the neutralizing activity against the reference strain also increases. Thus, not only do Ad26.COV2.S elicited antibody titers increase over time, these data also imply maturation of the immune response with improved variant coverage That’s from their briefing to the FDA’s VRBPA committee, page thirty‐nine.
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Mar 19, 2021 23:03
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dwarf74 posted:21 hours in and I can hardly even feel the microchip It takes a while to download the update unless you're in an area with 5G
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Mar 19, 2021 23:23
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The ringing in the ears is the 5G frequency tuning process.
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Mar 19, 2021 23:42
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redgubbinz posted:Got dose 1 of pfizer today, zero effects and I didn't even feel the needle, did I get pranked I got my first dose of Pfizer on Tuesday. I did not feel the needle, and didn't have not really had any noticeable side effects a few days later. My arm was sore the second day, but that's pretty cleared up as of today.
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Mar 19, 2021 23:58
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Antigravitas posted:The confidence interval for >65 was -1405% to 94%. Not a typo. I've only had one course in research statistics but I'm pretty sure if your confidence interval includes "0" that means the result isn't statistically significant at whatever confidence level you chose.
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Mar 20, 2021 00:04
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Rolo posted:Anyone on the vax develop mild tinnitus? In case you weren’t given this info when you got your shot (I wasn’t) there is a side effect tracker at http://vsafe.cdc.gov
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Mar 20, 2021 00:17
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U.K. has a site that they are asking people to report side effects to - don’t think it matters you are in another country because they are only really interested in the batch numbers and what happened. https://coronavirus-yellowcard.mhra.gov.uk/
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Mar 20, 2021 00:36
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Fallom posted:I've only had one course in research statistics but I'm pretty sure if your confidence interval includes "0" that means the result isn't statistically significant at whatever confidence level you chose. It’s not great, but in practice it’s probably an artifact from clamping the maximum efficacy to 100% while allowing for an unbounded negative efficacy (ie in theory a vaccine could increase infection/hospitalization rates by many orders of magnitude). A confidence interval is just a standard way to express the variance of the probability curve, 95% tends to be standard for research, but you could just as easily use some other metric or interval. I would be more interested in something like P(<25%) vs P(25-75%) before discarding the results offhand.
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Mar 20, 2021 01:26
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Something I've been curious about and can't find any conclusive science on is how the efficacy of a vaccine as measured in a population translates to efficacy on an individual level. When people discuss how effective the vaccines are, it seems like the assumption is that a vaccine that is 90% effective means that any single person who is vaccinated has a 10% chance of still catching the disease. Is that actually an accurate assessment of how immunity works, or is it the case that 90% of the people who get the vaccine are fully immune, and 10% of people who get the vaccine end up with no protection? The numbers play out the same on the population level of course, but I still find the question interesting. Anyone have any insight?
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Mar 20, 2021 03:19
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95% of cats infected with Feline Coronavirus just get a kitty cold, the remaining 5% develop a pneumonia-like condition that is fatal in 90% of the cases it occurs in. I knew someone who adopted a kitten who died a couple months after of just that. Improbable things happen, sometimes you just win the anti-lottery.
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Mar 20, 2021 03:48
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finally got my appointment for the first dose next week, can't wait to see twitch chat emotes IRL with the microchip upgrade
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Mar 20, 2021 04:06
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 spouse is on a plane and totally unvaccinated and says it's assholes to elbows in there
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Mar 20, 2021 04:09
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Got moderna yesterday, girlfriend got pfizer. Both of us have been kinda loopy today and I feel like I'm having serious hay fever, and my injection site is sore as gently caress. Sounds a lot like a mild case my coworker had a few weeks ago. Kinda lovely but COVID took my maternal grandparents from independent living to a nursing home in November, so gently caress that poo poo. Edit: oh yeah, they tried to deny me my shot because the health insurance company I've been with since 2019 transposed my birthdate as x/xx/2019 vs. x/xx/1986, and I had to lie about not having health insurance as a result. I bitched everyone out, got my shot, and my insurance company apologized to me when they fixed it 4 hours later. It's nice to know I was throwing money in a loving hole, you know. MrQwerty fucked around with this message at 08:11 on Mar 20, 2021 |
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Mar 20, 2021 04:19
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Lolie posted:The gift that keeps on giving... Jokes on them. I already got the beetus. Saw this in a gun store a few weeks ago. emailed and they sent me a picture of it. I thought it was amusing. 
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