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Kirios posted:Ugh, guess I have to wait until the middle of December to get my booster. I was hoping it would be closer to six months from second dose as December / January will likely be the peak of the virus this year. I will be eligible for my booster on my 40th birthday. Seeing as I plan on spending that day curled up in a ball crying, it's probably the perfect day to get it done!
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Aug 18, 2021 22:39
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I’m an older millenial (‘84) and I only use voice calls ans voicemail to interact with my dad, who has a flip phone and home phone. With my mom it’s facetime.
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Aug 18, 2021 23:07
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Riven posted:I’m an older millenial (‘84) and I only use voice calls ans voicemail to interact with my dad, who has a flip phone and home phone. With my mom it’s facetime. Also born in '84 and I'm the same . With your mom I mean
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Aug 18, 2021 23:27
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Lot of people in this thread either not looking for a job or regularly being interviewed for welfare. Retry much have to answer the phone if the area code seems regionally close.
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Aug 18, 2021 23:28
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Born in 89, I use the phone for interactions where I need to talk to someone right now. SMS/DMs/etc. have their place, but they're too easy to ignore, so for work stuff if I have to get a response, I will phone. Usually after first trying a text, depending on the circumstance. Other people mostly do the same, the phone is like the signal that "hey this poo poo is important and time-sensitive!"
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Aug 18, 2021 23:30
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blackmet posted:I will be eligible for my booster on my 40th birthday. I was planning to be killing myself in a 60 mile mountain bike race on my 40th birthday, but I think Delta might be putting an end to that plan! Unless cases drop off real far and real fast I'm not feeling a mass start of hundreds of people even if it's outdoors
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Aug 18, 2021 23:35
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2 of my teenagers went back to high school last Thursday, so they've been in school 5 days now. I've received a positive COVID test notification email from the principal for the past 4 straight days. Things going to go real well.
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Aug 18, 2021 23:36
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https://twitter.com/PeterHotez/status/1428100925982445568?s=20
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Aug 19, 2021 00:36
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That's wonderful and all but why do I have to wait eight months then?!
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Aug 19, 2021 00:50
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stolen from GBS Schadenfreude thread. https://twitter.com/Gizmodo/status/1427739399182110722 is this the first notable hammer dropped on faking vac stuff. i hope the fed and local gov. make a good public show of fuckfaces.
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Aug 19, 2021 00:53
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e wrong thread again, sorry folks!
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Aug 19, 2021 00:53
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Has anyone anywhere reported the prevalence of breakthrough infections on people who have been vaccinated and who had covid prior to vaccination?
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Aug 19, 2021 01:21
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Riptor posted:Has anyone anywhere reported the prevalence of breakthrough infections on people who have been vaccinated and who had covid prior to vaccination? There are recorded cases, but I don't know if anyone has numbers.
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Aug 19, 2021 01:31
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Kirios posted:That's wonderful and all but why do I have to wait eight months then?! Bit mysterious as current indications are that it's best at 5-6 months
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Aug 19, 2021 01:33
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A bit offtopic, but vaccine chat and trials are a popular topic here so I'll just mention it: I got an email from my local big university about a vaccine trial for... yellow fever. Given the track record in that space, I don't think I'm brave enough to volunteer.
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Aug 19, 2021 01:34
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Koumpounophilia posted:A bit offtopic, but vaccine chat and trials are a popular topic here so I'll just mention it: I got an email from my local big university about a vaccine trial for... yellow fever. Given the track record in that space, I don't think I'm brave enough to volunteer. What, that there's a working and highly effective vaccine against it? Honestly, I'd take it. I got the currently approved one, and frankly if they think it's worth developing another one, they must have some sort of reason for doing so.
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Aug 19, 2021 02:02
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Interesting statistical “paradox” in vaccine effectiveness estimates (click thru for the thread): https://twitter.com/CT_Bergstrom/status/1427767356600688646?s=20
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Aug 19, 2021 02:57
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Yeah this always bound to happen when people just quote raw numbers out of context.
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Aug 19, 2021 03:36
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Kirios posted:That's wonderful and all but why do I have to wait eight months then?! It's been eight months since the first post-EUA vaccinations, so that's the number that number that won't get people asking why they shot down the booster data the first time is was presented  Sharks Eat Bear posted:Interesting statistical “paradox” in vaccine effectiveness estimates (click thru for the thread): Knowing about confounding and Simpson's paradox is useful and this is a nice example, but the VE estimates suggesting declining protection over time that were released by Israel's Ministry of Health were adjusted for age and I think a few other demographic features like immunocompromised status. There have been a lot of terrible statistics over the course of the pandemic, but a national health department failing to adjust for something as obvious as age in a VE estimate from observational data would be an unbelievable level of incompetence (or malice)! Age confounding explains this raw number, but it doesn't explain Israel's analysis. That might still be affected by unaccounted-for factors or just random chance, but it's not as simple as Bergstrom's explanation. E: I'll have to see if I can find the released numbers again. I don't think the full analysis was ever released, but they at least described some of the methodology. Stickman fucked around with this message at 03:51 on Aug 19, 2021 |
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Aug 19, 2021 03:49
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The main problem is that Israel hasn't provided a detailed study or analysis like (for example) REACT in the UK which means people have to sift through the data themselves. Even if there is significant efficacy waning it's difficult to know with what we have.
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Aug 19, 2021 03:56
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buglord posted:Called mom today and told her that she'd be eligible for a third dose in a month since she got her poke in late Jan. Shes open to it, but wants to wait and see how other people react first, which kind of made me wonder how i'll feel on the third round. Both her and I got Moderna, and both her and I got absolutely flattened by dose #2. Anyone ITT get their third (or know of a "friend") and had any reaction? I'll still happily take my booster when my turn is up, but i'd schedule it strategically this time. Broadly, the side effects were less bad after each of the three shots. AZ kicked in about 10-12 hours after the shot: Soreness, fever, and chills, I stayed in bed for a couple of days. Pfizer 1 was similar but it hit me faster and only lasted about a day. Pfizer 2 was pretty light by comparison, I could have worked from home if I had to, but I was dealing with some emotional stuff around that time anyway so I just lazed it out on the couch. I took Tylenol to control symptoms after each shot and I think it helped quite a bit.
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Aug 19, 2021 04:34
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This graph is suggesting the immune response goes back to 0 after 8 months, which I’m guessing is wildly wrong.
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Aug 19, 2021 04:48
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Henrik Zetterberg posted:This graph is suggesting the immune response goes back to 0 after 8 months, which I’m guessing is wildly wrong. Worth reading the full thread: https://twitter.com/PeterHotez/status/1428104820695740435
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Aug 19, 2021 05:07
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Sir John Falstaff posted:Worth reading the full thread:
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Aug 19, 2021 06:26
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Riptor posted:Has anyone anywhere reported the prevalence of breakthrough infections on people who have been vaccinated and who had covid prior to vaccination? 
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Aug 19, 2021 10:36
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Why is the margin of uncertainly comparatively small for the AZ vaccine with prior infection?
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Aug 19, 2021 10:43
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Could be a sample size thing.
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Aug 19, 2021 10:54
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Charles 2 of Spain posted:From the UK a few hours ago: Thank you!
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Aug 19, 2021 11:37
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So is the "8 Months until eligible for a booster" thing in the US, like, official-official? Or is it still being worked out? I guess I'm just wondering when the official guidance related to boosters is going to be communicated and everyone is going to be looking for them.
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Aug 19, 2021 14:05
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Platystemon posted:Why is the margin of uncertainly comparatively small for the AZ vaccine with prior infection? Uncertainty is basically a function of sample size.
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Aug 19, 2021 14:21
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O.K. but the why is the “AZ prior inf” group so large? On the uninfected side, there appear to be more Pfizer recipients. Just going off the graph and my vague recollection of nine-month-old events, is the dataset exlcusively healthcare workers? Were they overwhelmingly likely to have fought off an infection in the months before a vaccine was available and then further overwhelmingly likely to get the AstraZeneca vaccine because at the time Pfizer shipments were a trickle? And I suppose that second-line staff would be less likely to have ever been, infected, vaccinated later, and therefore with Pfizer.
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Aug 19, 2021 14:33
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It's probably better if you read the paper: https://www.ndm.ox.ac.uk/covid-19/covid-19-infection-survey/results/new-studies 300,000+ randomly selected people, predetermined testing schedule, covers both Alpha and Delta periods. It's probably the most comprehensive study we've got for vaccine efficacy at the moment.
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Aug 19, 2021 14:55
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https://twitter.com/WLimestall/status/1428355243490742286?s=20
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Aug 19, 2021 15:01
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Charles 2 of Spain posted:It's probably better if you read the paper: That doesn’t explain the tight confidence interval I was wondering about. Page thirty-six shows that the no-prior-infection AZ group is ten times the size. Ten times the sample size, yet wider confidence intervals.
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Aug 19, 2021 15:11
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Someone better at stats can comment, but it seems like they're doing model estimation there, so if the standard errors in that model are small then the CIs will be too. Might not be an issue of sample size. Alternatively this is just a preprint so the figure might be incorrect.
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Aug 19, 2021 15:39
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https://twitter.com/profvrr/status/1428353084170792964?s=20 Trolling from a position of technical correctness is an art.
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Aug 19, 2021 16:31
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He’a not even technically correct. Go look at the primary outcome measures for the clinical trials. Moderna’s is this:
Prevention of severe disease is nice and all, but it was literally and explicitly a secondary objective. https://clinicaltrials.gov/ct2/show/NCT04470427
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Aug 19, 2021 16:42
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I suspect a Doctor of Microbiology, who literally writes textbooks on Virology, might be aware of what he's saying. https://microbiology.columbia.edu/faculty-vincent-racaniello CommieGIR fucked around with this message at 17:07 on Aug 19, 2021 |
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Aug 19, 2021 17:02
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Platystemon posted:
Yeah, but that's what you settle for when 1/3rd of the country is cultists who won't get inoculated.
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Aug 19, 2021 17:09
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CommieGIR posted:I suspect a Doctor of Microbiology, who literally writes textbooks on Virology, might be aware of what he's saying. Yeah that's the best part. He definitely knows what he's talking about but implicit in his argument is that mild infections are no big deal, which is something that I think could be argued against. He also doesn't believe that vaccinated people who are infected have been shown to be transmitting, which I think is the other part of the rationale for a booster. Anyway he's not the only one thinking boosters aren't needed yet. https://twitter.com/statnews/status/1428366836966457354?s=20 The Biden admin is in a tough position because it's stuck between two misconceptions, on one hand that vaccines aren't working if vaccinated people are getting infected and on the other that 'mild' infections are no big deal. There's also very little good data out there.
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Aug 19, 2021 17:18
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