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atomicthumbs posted:I have discovered that there is a brand of woo involving breathing singlet oxygen to supposedly increase fitness performance Oh no it's fine I'll have a kale-beetroot-berry shake to store up my antioxidants. .....riiiiiiight after my bleach enema Rigged Death Trap has a new favorite as of 20:57 on Jan 13, 2016 |
# ? Jan 13, 2016 20:47 |
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# ? Jun 2, 2024 02:53 |
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Suitaru posted:A methyl group is a carbon with three hydrogens on it, with the fourth available bond on the carbon sticking to whatever's been methylated. Methyl groups are sizable compared to their mass and nonpolar. If cell walls get methylated, the lipids don't fit together very well and the membrane starts leaking; if DNA gets methylated when it shouldn't be (DNA methylation is a common reaction in many forms of life, but only at specific spots on the genome), the various proteins that read it and do things to it bump into the methyl group and can't go any further; anything that relies on being polar to participate in enzymatic reactions will stop working if the ligand or enzyme gets methylated. It's kind of hard to nail down exactly what goes wrong with methylation because A. it's like dumping ball bearings covered in glue into a car engine, something's gonna get weird but who the hell knows what, and B. usually the methyl group itself is not nearly as dangerous as what it's attached to, because methyl groups being nonpolar/not very dense/relatively small mean they happily float through lipid membranes and anything else nonpolar. As people have mentioned, this is basically a VIP ticket for whatever's attached to go hang out and party inside the nearest available cell. For example, you might have seen pictures of people sitting on liquid mercury and being fine, but dimethylmercury is one of the most powerful neurotoxins known to science. The famous case of Karen Wetterhahn is the classic example - she spilled a couple drops of dimethylmercury onto her latex-gloved hand, cleaned it off after maybe a minute, and spent the remaining year of her life in a vegetative state. The methyl groups helped the mercury diffuse through the glove, through her skin, and into her body in the space of twenty seconds tops, and from that point on she was doomed.
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# ? Jan 13, 2016 21:37 |
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Rigged Death Trap posted:Oh no it's fine I'll have a kale-beetroot-berry shake to store up my antioxidants. Boy, this is the FOOF thread. The only acceptable enema in this thread is a self-administered hydrofluoric acid enema.
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# ? Jan 13, 2016 21:42 |
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darthbob88 posted:All righty. Thanks for the horrifying explanation. It's not all bad. A common solvent in many applications is dimethyl sulfoxide. Though it is a polar molecule (due to the sulfur and double-bonded oxygen loving the poo poo out of electrons, too strong for the methyl groups to hold on to them), the methyl groups give it the same property of quickly diffusing through nonpolar things like lipid membranes (well, it diffuses through almost anything, but that's beside the point). But it's not very toxic - I mean, you could certainly kill yourself with some, but in the same way you could kill yourself with a cabinet full of Everclear or something - and odorless, which is unusual for a sulfur-containing compound. For this reason it is used for topical painkillers and stuff - put a bit of a medicine in DMSO, apply the solution to the skin, and the DMSO quickly diffuses through the skin into the body, carrying the medicine with it. You just have to be careful not to put anything bad into the mix, because it'll carry the bad poo poo with it just as readily. My favorite property of DMSO is that it tastes like garlic, and if it's placed anywhere on the skin, after less than a minute most people taste garlic. It goes right through your skin so quickly that it hits the bloodstream almost right away, and when it gets to the mouth, some will diffuse right back out and land on the tongue, causing the taste. It's thought that excessive DMSO use was the cause of the "toxic lady"; the theory is that doctors' use of oxygen and defibrillation in an attempt to stabilize a woman suffering from cervical cancer caused the DMSO in her system - built up to incredibly high levels due to kidney problems preventing its elimination from her body - to undergo a series of chemical reactions, eventually creating small amounts of the extremely toxic dimethyl sulfate.
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# ? Jan 13, 2016 22:15 |
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`Nemesis posted:https://fat.gfycat.com/EarnestEqualAlpinegoat.webm Norwegian state broadcasting is awesome. The show is called "Don't try this at home" and they mean it. Here they make 32 grams of Triacetone Triperoxide (TATP) out of badly concealed household chemicals and blow up a pillow.
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# ? Jan 13, 2016 22:22 |
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Thomas Midgley, who postumously has the distinction of both being the father of high octane fuels and being humanities greatest poisoner. In one specific instance, Midgley, in order to demonstrate the apparent safety of leaded gasoline: quote:poured [Tetraethyllead-infused gasoline] over his hands, then placed a bottle of the chemical under his nose and inhaled its vapor for sixty seconds, declaring that he could do this every day without succumbing to any problems whatsoever After this demonstration of how safe leaded gasoline truly is, he ended up undergoing chellation therapy in Europe for almost two years Gobbeldygook posted:Boy, this is the FOOF thread. The only acceptable enema in this thread is a self-administered hydrofluoric acid enema. What the gently caress, why would you quote:while intoxicated from intranasal cocaine administration. Oh. A Festivus Miracle has a new favorite as of 22:37 on Jan 13, 2016 |
# ? Jan 13, 2016 22:34 |
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Suitaru posted:
You can also dissolve toxins in DMSO. Then you can kill people by just spraying some of that solution on their skin.
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# ? Jan 13, 2016 22:46 |
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Caconym posted:Norwegian state broadcasting is awesome.
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# ? Jan 13, 2016 22:57 |
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zedprime posted:Asbestos did nothing wrong. Asbestos is usually fine, until you find it in it's raw form in the base of a metasomatised zinc-lead deposit and then lose 6 weeks of mine production while you find qualified hazardous waste removalists who are also qualified to work underground to get rid of it for you. Good things it's rare in that environment. Stupid asbestos.
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# ? Jan 13, 2016 23:07 |
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A White Guy posted:
quote:I'm not even making this up. the two best quotes about him are that he "had more impact on the atmosphere than any other single organism in Earth's history" (J. R. McNeill) and that he had "an instinct for the regrettable that was almost uncanny" (Bill Bryson).
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# ? Jan 13, 2016 23:11 |
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Memento posted:Asbestos is usually fine, until you find it in it's raw form in the base of a metasomatised zinc-lead deposit and then lose 6 weeks of mine production while you find qualified hazardous waste removalists who are also qualified to work underground to get rid of it for you. Good things it's rare in that environment. Then they want twice the going rate and there's a slipstrike fault in the overburden... Oh, and it's loving Crocidolite.
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# ? Jan 14, 2016 02:43 |
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Carbon dioxide posted:You can also dissolve toxins in DMSO. Then you can kill people by just spraying some of that solution on their skin. Skip the middleman and use pure dimethyl mercury.
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# ? Jan 14, 2016 16:44 |
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Ignimbrite posted:Oh, and it's loving Crocidolite. that article posted:Bolivian crocidolite was used in Kent Micronite cigarette filters in the 1950s. "Kent Micronite: No, seriously. Cancer."
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# ? Jan 14, 2016 19:45 |
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More info about the Kent Micronite filters and the resulting lawsuits here: http://www.fairwarning.org/2013/10/legal-battles-smolder-six-decades-after-the-greatest-health-protection-in-cigarette-history/
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# ? Jan 14, 2016 19:56 |
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quote:DMSO
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# ? Jan 14, 2016 20:15 |
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Hypofluorous acid is a fun little chemical. Made from fluorine gas (uh-oh), it spontaneously explodes at 0°C and turns into hydrofluoric acid and oxygen gas, all agitated and mobilized and ready to eat your bones and set your lab on fire.
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# ? Jan 15, 2016 01:00 |
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Recently I've been asked to work with a series of nerve agent simulants, mainly ones similar to sarin in IR Sarin for reference: here's the primary simulant most people use PI says "Can we get something more similar to sarin?" And I mean, technically the answer is yes. Most simulants say "harmful if ingested" or "harmful on contact" Ethyl methylphosphonofluoridate? "deadly on contact, deadly if ingested, deadly if inhaled" and also "If you plan on using this contact your local hospital so they can order the antidote." At this point it's like why not just order sarin. I'm probably dead either way. Someone in my lab got decently permanently blinded after opening a chemical fridge too quickly and spilled chemicals down their forehead past their goggles into their eyes. This will probably be my last post depending on if I eat nerve agents or not
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# ? Jan 15, 2016 04:25 |
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Mortimer posted:Recently I've been asked to work with a series of nerve agent simulants, mainly ones similar to sarin in IR Jesus Christ, simply saying that thing's name out loud might as well be a crime.
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# ? Jan 15, 2016 04:49 |
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Wrong thread.
OMFG PTSD LOL PBUH has a new favorite as of 05:35 on Jan 15, 2016 |
# ? Jan 15, 2016 05:29 |
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Mortimer posted:Recently I've been asked to work with a series of nerve agent simulants, mainly ones similar to sarin in IR Find another employer.
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# ? Jan 15, 2016 05:35 |
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Get a new job.
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# ? Jan 15, 2016 05:36 |
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Do you have skulls on your work uniform?
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# ? Jan 15, 2016 05:38 |
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Mortimer posted:Recently I've been asked to work with a series of nerve agent simulants, mainly ones similar to sarin in IR I appreciate and sympathize with you guys while simultaneously deciding to go to no-science teaching was the best choice I made. No wonder the life expectancy for chemists is so low. Literally staring death in the face as needed.
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# ? Jan 15, 2016 05:55 |
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Mortimer posted:This will probably be my last post depending on if I eat nerve agents or not Thanks for making me feel better about having kind of a lovely week in grad school.
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# ? Jan 15, 2016 06:09 |
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Mortimer posted:Recently I've been asked to work with a series of nerve agent simulants, mainly ones similar to sarin in IR What do you do? Work for Cobra Commander?
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# ? Jan 15, 2016 06:28 |
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Mortimer posted:Recently I've been asked to work with a series of nerve agent simulants, mainly ones similar to sarin in IR quote:This will probably be my last post depending on if I eat nerve agents or not
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# ? Jan 15, 2016 06:35 |
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Mortimer posted:Recently I've been asked to work with a series of nerve agent simulants, mainly ones similar to sarin in IR Thank you for your dedication and willingness to donate your body to science
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# ? Jan 15, 2016 07:56 |
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SynthOrange posted:Do you have skulls on your work uniform? Pertinent question.
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# ? Jan 15, 2016 11:01 |
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Mortimer posted:Recently I've been asked to work with a series of nerve agent simulants, mainly ones similar to sarin in IR Let's break this down. Ethyl? Nope. Methyl-? Nope. Phosphono-? Nope. -Fluoridate? Nope. There is no part of that entire compound anyone wants to be around. It's the all-star team of "Will kill you in new and horrifying ways." It's the sort of thing loving Doctor Doom would create. Might as well bolt some loving chlorine in there too, just to shine it up nice. Gyro Zeppeli has a new favorite as of 11:34 on Jan 15, 2016 |
# ? Jan 15, 2016 11:31 |
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What color jumpsuit do you wear? Is the commute to the volcano base terrible, or do you just live on site?
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# ? Jan 15, 2016 11:33 |
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Please, speed suit
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# ? Jan 15, 2016 11:56 |
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Hijo Del Helmsley posted:Let's break this down. I'm coming back to what I said before about Organometallic compunds: It's the whole, not the parts on their lonesome. Though what makes Sarin do what sarin does is that methylphosphonofluoridate core, everything else added on increases or decreases it's efficiency. fake e: Was gonna write some things about chirality and stereoisomers but decided against it.
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# ? Jan 15, 2016 13:28 |
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Hijo Del Helmsley posted:Let's break this down.
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# ? Jan 15, 2016 13:32 |
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Hijo Del Helmsley posted:Let's break this down. It's real-life "ethylmethylbadstuff" Our HAZMAT/EOD instructor liked to throw out to make us laugh at some of the horrific training pictures/videos we got to see. Also, sever.
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# ? Jan 15, 2016 15:14 |
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sharing in the terrorRigged Death Trap posted:fake e:
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# ? Jan 15, 2016 15:18 |
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Rigged Death Trap posted:I'm coming back to what I said before about Organometallic compunds: This is very true. Ethanol, the thing I want to consume after looking at death the molecule, contains an ethyl group. The short chain organics just do so much for bioavailability.
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# ? Jan 15, 2016 15:24 |
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The safety department did the first cool thing they've ever done. I send in my request to get this stuff and of course they call me to confirm I want to do this dumb thing and ask if I have proper safety equipment. Aha, I've found an out. I say uhh no we don't sorry, I'll let you know when we do. I told the PI safety was jerking me around and it'll get ordered when they approve it. That's not true of course, but if I told him "I don't think this is safe" or "I want to live to see 30" he would be very mad with me. I work in a civilian military lab, so funded by and run by the military/usgov but staffed by mostly ex-NIST people. My other area of work is in explosives detection, nothing gets your blood flowing than mixing #2 fuel oil into ammonium nitrate crystals. It turns into this weird explosive paste. Nothing I do is as dangerous as like...Jimmie Oxleys group at URI. One of the people I work with from there taught me to make small batches of C4 which didn't even phase him because he was used to making it by the kilo
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# ? Jan 15, 2016 16:39 |
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I don't know if I should be the one to ask because I'd probably just lurk a hypothetical A/T thread, but have you considered making an A/T thread? Unless the military connection means you can't say much. This all sounds incredibly .
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# ? Jan 15, 2016 16:59 |
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Mortimer posted:The safety department did the first cool thing they've ever done. All you guys need is a biochem department. Jesus how much are they paying you. I know it's not (as) much (as it should be), Chemist job market It's why I bailed off my course. Suitaru posted:sharing in the terror I didn't because it's supremely boring and I hate to explain it but usually it ends up as something like: Because this molecule is rotated around this point in this certain way, it does not work! But if it was rotated this way you're dead! Example: LSD has 4 stereoisomers, only one is active, the rest do absolutely gently caress all even if you ate a gram. (I absolutely hate explaining chirality/steroisomerism so please no) Rigged Death Trap has a new favorite as of 17:14 on Jan 15, 2016 |
# ? Jan 15, 2016 17:02 |
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AlphaKretin posted:I don't know if I should be the one to ask because I'd probably just lurk a hypothetical A/T thread, but have you considered making an A/T thread? Unless the military connection means you can't say much. This all sounds incredibly . I've considered it but the same parts that are the most interesting are also the things I can't talk about. Rigged Death Trap posted:All you guys need is a biochem department. I'm actually a biochemist who did a lot of analytical chemistry and most employers just ask "Can you use a GCMS and FTIR? We don't care what else you did." I used to work on kidney cancer early diagnosis Confirmed for not paid a lot though
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# ? Jan 15, 2016 17:16 |