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tfw your life sucks because youre not actually jesus and cant turn water into beer
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Jul 22, 2017 05:56
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Poopernickel posted:the ultimate hipster drink is vermouth on the rocks that's some bill Murray poo poo right there https://youtu.be/jHklKfiyKx0
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Jul 22, 2017 05:57
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nice
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Jul 22, 2017 07:25
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so pharmacologically.. ethanol.. it's a little bit hard to study compared to other drugs because while it does bind to a lot of receptors its purely through flinging poo poo at a wall first of all lets look at how non potent it is. potency is the measure of a drug to have an effect based on the amount given. LSD and fentanyl are extremely potent (active in the 10-100s microgram ranges). acetiminophen/paracetamol is probably the least potent drug most people know, with doses of 4g in a day.. alcohol? one standard drink itself is already 10g.. and so half a doz beers? looking at 60-70grams of drugs??? that is an INSANE volume of drug for your body to work through this is why alcohol doesnt have a half life as such.. well technically it does but you exceed half life of ethanol very early on, youve saturated the enzymes so they are always working at 100% and in an average person can chew through maybe 10g an hour? these are liver enzymes which is why its so hard on the liver. it gets converted to energy amongst other things which contribues to fatty liver.. enzyme induction means those that drink a lot will have more of the enzymes that metabolise alcohol so theyll siober up faster and be less hungover absorption - most drugs rely on some form of transport across the cell walls. as far as I know alcohol isnt transported over the cell wall but moves directly through it due to it being lipid soluble. this means alcohol is absorbed everywhere, rather than having to wait to get into the intestine.. yes alcohol is absorbed through the stomach lining and hence can start to enter the bloodstream within like 7 minutes after druinking? thats insane receptor wise what does it bind to? well, like I mentioned before you are putting such huge volumes that are in the bloodstream it tends to bind to everything.. ugh.. largely the depressive parts of the CNS. its also a solvent so its posited that it actually also disrupts neurological signalling through interfering with neuronal cell walls but because of its very nature its a bit harder to study with the models we use to study otehr drugs and as far as receptor affinities etc and ethanol is generally what we think of when we think alcohol but something to be aware of I guess is that the microbes that turn whatever into alcohol dont make 100% ethanol but also methanol as the msot significant secondary alcohol but also a whole host of short chained alcohols.. ugh.. and most of these chemicals will have similar pharmacological effects but their metabolites will be significantly differently (this is how methanol is bad) and will lead to tragic hangovers i saw a sign at a bar that said that intoxicated people will be served food to reduce the effect of alcohol but there is no basis as far as I can tell for food being able to "soak up" alcohol, and in fact fatty food probably "ties up" the liver a bit and I suspect it would make you metabolise alcohol slower.. the only positive effect food will have on drinking is that youre likely to drink slower when youre full. there is no interaction between food and alcohol or even a significant effect on alcohol absorption that would imply eating "helps" studies have been done to see if there is any way to reduce hangovers.. the evidence points to there being only one method that works - drink less. and ill add to that and say drink higher quality too, due to what I mentioned about alcohols other than ethanol. water helps maybe? but rehyudrating is easy and hangovers are barely just dehydration ethanol metabolism forces paracetamol/acetimonphen metabolism down a pathway which creates a hepatoxic metabolite so this is why we say dont take it when drinking or after to kill pain.. itll murder ya liver. just take ibuprofen and the risk there is if youre dehydrated just a fact or two lmao - 
echinopsis fucked around with this message at 07:59 on Jul 22, 2017 |
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Jul 22, 2017 07:55
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drink instead of having dinner. thats my primary advice. because being drunk might be unattractive but being fat and drunk?? img spew on self goon dot jay peg can someone please post that
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Jul 22, 2017 07:59
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echinopsis posted:so pharmacologically.. ethanol.. it's a little bit hard to study compared to other drugs because while it does bind to a lot of receptors its purely through flinging poo poo at a wall please continue to post like this whenever baby-shaggar up there accuses you of not knowing how drugs work. lmao
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Jul 22, 2017 08:07
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Nikka Coffey Grain Whisky (had to choose whiskey as there was no whisky option) also gotta second the suggestion of Lagavulin 16 also Springbank 15 and Hazelburn 12 are both quite good and lol if you don't have the Glenmorangie trinity in your cabinet: La Santa, Quinta Ruban, and Nectar D'Or
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Jul 22, 2017 09:45
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echinopsis posted:what's it called when you really want a drink tonight but you don't have one Responsible driving?
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Jul 22, 2017 12:13
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I have to say that was a good echi post Also I have never drank a glenmorangie anything
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Jul 22, 2017 16:13
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eschaton posted:Nikka Coffey Grain Whisky lol @ liquor hoarders who have more than 2 kinds of scotch (expensive and cheap) just drink it, there's more at the store m8 
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Jul 22, 2017 16:14
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Poopernickel posted:lol @ liquor hoarders who have more than 2 kinds of scotch (expensive and cheap)
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Jul 22, 2017 16:23
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echinopsis posted:drink instead of having dinner. thats my primary advice. because being drunk might be unattractive but being fat and drunk?? i do this every now and then and i can tell u you its not gr8, u end up more hungover usually always fucken eat when ur drinkin fwiw im very thin
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Jul 22, 2017 17:13
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qhat posted:Drug seeking behaviour Captain Foo posted:you're an alcoholic m8 no alcoholic shaming itt unless ur drinking like, 1L of spirits a day in which case ok thats bad
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Jul 22, 2017 17:15
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i have over 200 bottles of rare beer in my basement that will most likely to to waste because my beer club stopped meeting and there is no way i am drinking all these 10%+ beers by myself.
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Jul 22, 2017 17:18
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Poopernickel posted:what is good to drink: alcohol Poopernickel posted:let's play a drinking game
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Jul 22, 2017 17:24
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Lyon posted:i have over 200 bottles of rare beer in my basement that will most likely to to waste because my beer club stopped meeting and there is no way i am drinking all these 10%+ beers by myself. weakling
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Jul 22, 2017 17:26
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just give them away to your friends/family
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Jul 22, 2017 17:29
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Sham bam bamina! posted:just give them away to me
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Jul 22, 2017 17:34
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also they are mostly bourbon barrel aged stouts and it is hot as gently caress out right now, i will probably drink them in the fall/winter
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Jul 22, 2017 18:01
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Lyon posted:also they are mostly bourbon barrel aged stouts and it is hot as gently caress out right now, i will probably drink them in the fall/winter ok that's legit
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Jul 22, 2017 19:06
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Mr SuperAwesome posted:i do this every now and then and i can tell u you its not gr8, u end up more hungover usually analyse the drinking and tell me if the difference is only the presence of food or if you drink more/quicker when you don't eat?
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Jul 22, 2017 19:55
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i've noticed that i do feel more messed up when i drink without having eaten in a while, but i always assumed it was just compounding the effects of the booze and low blood sugar
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Jul 22, 2017 20:02
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i guess that's possible.. the biggest risk when children and infants drink is hypoglycaemia, gluconeogenesis, the process where the liver creates glucose to maintain blood glucose levels stops or slows down in the presence of alcohol metabolism it's interesting for me as a diabetic because when i drink my blood sugars don't go up despite all the glucose in the beer i drink
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Jul 22, 2017 20:16
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I have some kracken rum that i should probably drink before i move in a few days but the only mixer in the house is some flat coke. can you drink just rum and ice? i have some limes too
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Jul 22, 2017 20:27
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echinopsis posted:i guess that's possible.. the biggest risk when children and infants drink is hypoglycaemia, gluconeogenesis, the process where the liver creates glucose to maintain blood glucose levels stops or slows down in the presence of alcohol metabolism i thought you were going to fast until your pancreas was reset?
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Jul 22, 2017 20:42
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a very small horse posted:I have some kracken rum that i should probably drink before i move in a few days but the only mixer in the house is some flat coke. can you drink just rum and ice? i have some limes too pour yourself a rum and rum
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Jul 22, 2017 20:57
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Poopernickel posted:pour yourself a rum and rum This is very dangerous and the mixture could be flammable!
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Jul 22, 2017 21:01
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a very small horse posted:I have some kracken rum that i should probably drink before i move in a few days but the only mixer in the house is some flat coke. can you drink just rum and ice? i have some limes too Freeze the rum into tiny ice cubes and swallow them whole.
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Jul 22, 2017 21:03
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a very small horse posted:I have some kracken rum that i should probably drink before i move in a few days but the only mixer in the house is some flat coke. can you drink just rum and ice? i have some limes too make limeade with some sugar and mix with that I guess
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Jul 22, 2017 21:07
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back in my day, when men were men,
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Jul 22, 2017 21:08
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Salt Fish posted:Freeze the rum into tiny ice cubes and swallow them whole. ethanol freezes at -114C so you might wanna put 911 on speed-dial
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Jul 22, 2017 21:15
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angry_keebler posted:i thought you were going to fast until your pancreas was reset? that was a good idea
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Jul 22, 2017 21:37
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 l'chaim, saturday nite drinks thread
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Jul 22, 2017 22:10
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i drank half a doz and fell asleep in front of the fire and now i'm cooking oats for the kids god bless drinking
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Jul 22, 2017 22:11
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echinopsis posted:i drank half a doz and fell asleep in front of the fire and now i'm cooking oats for the kids
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Jul 22, 2017 22:13
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I got 2 bottles of this red wine I like for €6 total today, god bless buy one get free offers
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Jul 22, 2017 22:16
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Kenny Logins posted:you sound like the fuckup dad from little house on the prairie 
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Jul 22, 2017 22:48
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about to see jurassic park with the philadelphia orchestra playing the score and brought a sixer of blood orange gose and a sixer of a session ipa. going to get rowdy with the dinosaurs.
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Jul 22, 2017 23:00
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i'm going to a party tongiht, gonna drink a buncha beers but i haven't decided what yet
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Jul 22, 2017 23:54
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| # ? May 20, 2024 02:48 |
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you've decided that you are going to and that's all that matters
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Jul 23, 2017 00:06
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