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https://www.youtube.com/watch?v=VBv_jNG9ck0
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Apr 13, 2018 00:36
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spog posted:I hope she got an F from you. he can't fail all his students
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Apr 13, 2018 00:39
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ekuNNN posted:That can't be right? Only thing left for this guy to do, is to do it on a hoverboard, like that lazy assed Catholic priest.
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Apr 13, 2018 00:44
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hobbesmaster posted:he can't fail all his students I've had professors that'd disagree with that.
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Apr 13, 2018 00:52
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Charles posted:Ouch... I hope everybody's okay. An even more pants making GBS threads view from the place next door to it: https://www.youtube.com/watch?v=9WLmCJfO5gE The building it hit was a two century old building. RIP.
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Apr 13, 2018 00:52
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duz posted:I've had professors that'd disagree with that. Professors actually get in a lot of trouble if they go through with it.
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Apr 13, 2018 01:44
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Synthbuttrange posted:An even more pants making GBS threads view from the place next door to it: "I'm sorry sir, you still need a reservation to sit on the patio, I'll have to ask you to leave"
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Apr 13, 2018 02:33
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cakesmith handyman posted:Please specify these toxins and how a reduced heart rate prevents your liver and kidneys from effectively dealing with them. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650477/ The early mechanisms likely involve a reduction in nitric oxide (NO) synthesis and bioavailability that is largely the result of oxidative stress and endogenous inhibition of endothelial NO synthase (eNOS) (21). (Oxidative stress is a result of free radicals from metabolic byproducts) Pathological levels of the free radical superoxide (O2−) are capable of rapidly reacting with NO to form the secondary radical peroxynitrite (ONOO−), reducing the overall bioavailability of NO available for vasodilation. This mechanism appears to contribute to the oxidative stress mediated suppression of endothelial function in CKD (Superoxide is a mitochondrial metabolic byproduct)
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Apr 13, 2018 02:47
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ekuNNN posted:That can't be right? CHEM-LAWN! COMING THROUGH!
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Apr 13, 2018 03:05
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theflyingexecutive posted:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650477/ Note that nitric oxide is itself a free radical. Phanatic posted:"Antioxidant," like "free radical," is just a broad classification that tells you little. Antioxidants that eat a free radical that was going to damage your DNA are good, but those same antioxidants could also eat up the nitric oxide molecules that themselves protect your cells from damage and oxidative stress, and wind up causing cancer. That paper says that if you've got CKD, then you're getting some endothelial dysfunction, which increases your risk for CVD. Nitric oxide is a potent vasodilator, and if you're producing less of it you're more likely to get CVD. The paper further says that aerobic exercise can restore some of that lost endothelial dysfunction. This paper does does not say that endothelial dysfunction or CKD are caused by poor circulation that results from assal horizontology meaning you don't filter toxins from your blood. It's the CKD that's causing the elevation in ROS, not the other way around: "Oxidative stress is characterized by a disproportionate increase in cellular reactive oxygen species (ROS) relative to endogenous antioxidant defenses, and is a key mechanism in the early pathogenesis of endothelial dysfunction in patients with mild-to-moderate CKD."
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Apr 13, 2018 03:07
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When I was playing hockey and super fit I had a resting heart rate of something like 50 bpm. My blood was basically just sitting still! Being fat and out of shape is much better for keeping the blood moving along.
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Apr 13, 2018 03:21
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theflyingexecutive posted:No that’s basically how it works. Reduced aerobic activity leads to reduced endothelial muscle tone leads to reduced renal clearance. Your blood gets “stale” and full of toxins What, exactly, is “endothelial muscle”?
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Apr 13, 2018 03:31
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drgitlin posted:What, exactly, is “endothelial muscle”? The smooth muscle in your arteries, arterioles, and capillaries that mediates blood flow And yes I was definitely talking about a low resting bpm
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Apr 13, 2018 03:36
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theflyingexecutive posted:The smooth muscle in your arteries, arterioles, and capillaries that mediates blood flow Take it from someone who’s PhD was on crosstalk between vasodilator pathways, and who then spent six years in cardiovascular research: this is factually incorrect. You have endothelial cells, which are the ones that line blood vessels, and you have smooth muscle cells, which are the ones directly below the endothelium. But there is absolutely no such thing as an “endothelial muscle.”
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Apr 13, 2018 03:42
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glynnenstein posted:When I was playing hockey and super fit I had a resting heart rate of something like 50 bpm. My blood was basically just sitting still! Being fat and out of shape is much better for keeping the blood moving along. This is the new Presidential Physical Fitness standard. 
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Apr 13, 2018 04:01
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Platystemon posted:This is the new Presidential Physical Fitness standard. why does it have an unread discord notification on it
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Apr 13, 2018 04:07
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Here's an OSHA-adjacent photo from a friend. The cable internet installer basically went "yep, that's done. Conduit? Never heard of him."
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Apr 13, 2018 04:33
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Memento posted:Here's an OSHA-adjacent photo from a friend. Not for nothing, but an uninterrupted line of coaxial cable is as weatherproof as it can get, it's the splices and terminations that need protecting. Hard to tell what applies based on one picture, though. drgitlin posted:But there is absolutely no such thing as an "endothelial muscle." Could it simply be a referral to the entirety of the disparate endothelial aspects without being overly technical?
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Apr 13, 2018 05:07
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Mistle posted:Not for nothing, but an uninterrupted line of coaxial cable is as weatherproof as it can get, it's the splices and terminations that need protecting. Weatherproof is one thing, but that's just hanging from its brackets in a common area, accessible to anyone. It's a high turnover area with lots of students - some drunk business major is going to come along one night and see how far they can pull it out from the wall before it breaks.
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Apr 13, 2018 05:13
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Ursine Catastrophe posted:why does it have an unread discord notification on it sometimes the client just bugs out and you cant clear the notif, it drives me up the wall
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Apr 13, 2018 05:40
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drgitlin posted:Take it from someone who’s PhD was on crosstalk between vasodilator pathways, and who then spent six years in cardiovascular research: this is factually incorrect. You have endothelial cells, which are the ones that line blood vessels, and you have smooth muscle cells, which are the ones directly below the endothelium. But there is absolutely no such thing as an “endothelial muscle.” Now do "toxins" in the blood.
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Apr 13, 2018 06:00
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drgitlin posted:Take it from someone who’s PhD was on crosstalk between vasodilator pathways, and who then spent six years in cardiovascular research: this is factually incorrect. You have endothelial cells, which are the ones that line blood vessels, and you have smooth muscle cells, which are the ones directly below the endothelium. But there is absolutely no such thing as an “endothelial muscle.” Ah, the intima. You must have loved the St. Jude Symmetry product, and more particularly its applicator. Those things were OSHA in their own right, and if I can find what I'm looking for I will 
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Apr 13, 2018 06:35
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ekuNNN posted:That can't be right? Miracle-Gro! 
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Apr 13, 2018 11:43
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drgitlin posted:Take it from someone who’s PhD was on crosstalk between vasodilator pathways, and who then spent six years in cardiovascular research: this is factually incorrect. You have endothelial cells, which are the ones that line blood vessels, and you have smooth muscle cells, which are the ones directly below the endothelium. But there is absolutely no such thing as an “endothelial muscle.” yes I know this, I wrote “endothelial muscle” as shorthand for “smooth muscle colocated with endothelial tissue”. I studied neural vasculature at the school where NO was discovered 
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Apr 13, 2018 12:11
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I have a heart, so there.
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Apr 13, 2018 12:19
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https://www.youtube.com/watch?v=9-_QxNc__MA I'm pretty sure no-one died. vvv: the thing that the guy walks up to and inspects appears to be a bit of blasted off tanker. Well, he could be a psychopath, I guess. IPCRESS fucked around with this message at 14:48 on Apr 13, 2018 |
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Apr 13, 2018 14:13
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IPCRESS posted:https://www.youtube.com/watch?v=9-_QxNc__MA Then why aren't they moving?
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Apr 13, 2018 14:15
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Mistle posted:Not for nothing, but an uninterrupted line of coaxial cable is as weatherproof as it can get, it's the splices and terminations that need protecting. No. Since this is the OSHA thread, it would be like someone saying “chainsaw nails”. The words he was looking for were “blood vessels”. Endothelial cells are one thing, smooth muscle cells are a completely different thing.
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Apr 13, 2018 14:47
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theflyingexecutive posted:yes I know this, I wrote “endothelial muscle” as shorthand for “smooth muscle colocated with endothelial tissue”. I studied neural vasculature at the school where NO was discovered Then you ought to know better.  FYI my PhD supervisor was one of John Vane’s students, did a postdoc in Murad’s lab, worked a lot with Moncada, and is one of the leading experts on NO.I might be one of the last people trained to do classical bioassays with cascades of perfused tissues like in the old days. Those were fiddly buggers to set up. Edit: this might have come across as ruder than I intended. For that I apologize. drgitlin fucked around with this message at 15:04 on Apr 13, 2018 |
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Apr 13, 2018 14:51
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5er posted:Only thing left for this guy to do, is to do it on a hoverboard, like that lazy assed Catholic priest. just get a sprinkler system and bless that if you're going to be lazy don't halfass it
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Apr 13, 2018 15:11
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From the Crappy Construction thread in DIY:kid sinister posted:Crappy construction in progress!
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Apr 13, 2018 16:20
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"chainsaw nails" sounds like it's own kind of OSHA.
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Apr 13, 2018 16:37
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The best band names always do
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Apr 13, 2018 16:51
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Dagen H posted:From the Crappy Construction thread in DIY: Can't squint your ears.
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Apr 13, 2018 17:03
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IPCRESS posted:https://www.youtube.com/watch?v=9-_QxNc__MA "You guys get the valve open yet? Ah, yep, looks, like it, good job." chitoryu12 posted:Then why aren't they moving? Shoes still on as far as I can tell.
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Apr 13, 2018 20:36
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https://i.imgur.com/xEVi4Do.mp4 This sawdust cannon is a nice reminder of how incredibly dangerous particle explosions are.
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Apr 13, 2018 20:52
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More fire stuff. I just found out about this. https://en.wikipedia.org/wiki/Darvaza_gas_crater I knew about the Centralia mine fire and other coal fires, but it never clicked in my head that other hydrocarbon sites could catch fire and burn forever.*
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Apr 13, 2018 22:16
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PhazonLink posted:More fire stuff. I just found out about this. Australia's got Burning Mountain, a coal seam fire like Centralia that they estimate has been going for 6,000 years. I think there's one in Germany that's been going since the 1500s or something, too.
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Apr 13, 2018 23:07
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Venture county has three underground tar/oil fires. Speaking of underground fires... Burning underground coal may have the worst mass extinction on earth. https://www.theguardian.com/environment/climate-consensus-97-per-cent/2018/mar/12/burning-coal-may-have-caused-earths-worst-mass-extinction
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Apr 13, 2018 23:22
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https://i.imgur.com/qwUnjR3.mp4
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Apr 13, 2018 23:48
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