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MadJackal posted:The Pope’s Gun sounds like a fuckin’ sick legendary drop. Illuminates user when equipped Sets Heathen enemies on fire 10% chance to deal +500% Holy Damage Gun smoke turns from black to white when last round in the magazine is fired
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Jan 12, 2021 16:05
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dawnbreaker except it’s a gun
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Jan 12, 2021 16:06
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https://twitter.com/lachlan/status/1348995991496699905
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Jan 12, 2021 16:07
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Owlofcreamcheese posted:How old is the pope's doctor? Why would anyone expect he would die by default and it requires some sort of special explanation about secret rich people drugs? Most people do not die of covid. Even if you are 100+ the most likely outcome is survival. It's a bad disease across populations but no one specific guy is specifically that likely to die. If it makes you feel better, the mutations cropping up are going to make the rich people's drugs useless first.
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Jan 12, 2021 16:09
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fosborb posted:welp theres another one i guess this will be an interesting test, to see how many got it there. congress only had their first dose, right? and that's 2 now that got pozzed but maybe not the others
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Jan 12, 2021 16:09
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mastershakeman posted:i guess this will be an interesting test, to see how many got it there. congress only had their first dose, right? and that's 2 now that got pozzed but maybe not the others The vaccine isn't sterilizing, so you can still get COVID and test positive, but not have any symptoms If congress members start falling ill/need hospitalization, then that's a neat proof of concept that a single dose of Pfizer isn't enough to prevent illness
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Jan 12, 2021 16:12
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Have there been any discussions about whether the monoclonal antibody therapies will be effective with these new strains? Particularly the Japan-Brazil one; it seems like that's the main safeguard that's available to the rich that the poor won't have access to.
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Jan 12, 2021 16:13
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mastershakeman posted:i guess this will be an interesting test, to see how many got it there. congress only had their first dose, right? and that's 2 now that got pozzed but maybe not the others Half dose is still like 70%+ effective at preventing the rona. If they dont develop symptoms I'd say its a big success.
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Jan 12, 2021 16:13
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https://twitter.com/JordanUhl/status/1348870843368153091?s=19
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Jan 12, 2021 16:16
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This mrna stuff is really cool, it really is just like casting a new key for a specific lock out of a protein. I imagine this is going to have a lot of applications targeting all sorts of diseases in the next few years right?
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Jan 12, 2021 16:19
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Pryor on Fire posted:This mrna stuff is really cool, it really is just like casting a new key for a specific lock out of a protein. I imagine this is going to have a lot of applications targeting all sorts of diseases in the next few years right? yeah. cancer treatment in particular will benefit from mRNA vaccines since it'll let clinicians target very specific proteins that some cancer cells have on their surface. it's not a cure all and cancer cells are tricky, but it will save a lot of lives.
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Jan 12, 2021 16:22
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https://twitter.com/dreamspace2/status/1348867448418820098?s=21
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Jan 12, 2021 16:23
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Pryor on Fire posted:This mrna stuff is really cool, it really is just like casting a new key for a specific lock out of a protein. I imagine this is going to have a lot of applications targeting all sorts of diseases in the next few years right? That's the main reason why they decided to go all-in on mRNA vaccines for covid. It will push the technology into mainstream use.
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Jan 12, 2021 16:24
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Nothus posted:Yes, it's your immune system doing it's thing. Thanks - I appreciate the genuine response. I'm just going to stop it all together. Although maybe I'll pick it up again down the road as I run nearly every day and my knees were both uncharacteristically sore yesterday evening lol Is the bolded advice intended to maximize the immune response? I got the shot Friday morning and took the supplement for the final time on Sunday.
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Jan 12, 2021 16:27
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Admiral Ray posted:yeah. cancer treatment in particular will benefit from mRNA vaccines since it'll let clinicians target very specific proteins that some cancer cells have on their surface. it's not a cure all and cancer cells are tricky, but it will save a lot of lives. and this is the "killer application" that both Moderna and Pfizer are gunning for. in a lot of ways the Covid vaccine is just PR for mRNA technology and they likely aren't making bank off of it. the end goal is for them to get a cancer biopsy, run it through a proprietary program to analyze it for unique markers which could be immune targets, and print up a new custom "vaccine" for that person which they will then charge $500k for.
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Jan 12, 2021 16:27
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Gio posted:i just got pozzed with bill gates pfizer microchip. county health department said they were only doing frontline workers, i took a gamble and assumed they wouldnt turn me down. wow, you know, maybe epstein did kill himself...
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Jan 12, 2021 16:28
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Nothus posted:That's the main reason why they decided to go all-in on mRNA vaccines for covid. It will push the technology into mainstream use. It's way more like all the first vaccines are mRNA because once you have the platform set up changing out the specific RNA is like an hour or two of design a new one. If a new virus appeared you could probably make a "you shouldn't take this but eh, it's probably right" mRNA vaccine in the same day once you have the general process.
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Jan 12, 2021 16:32
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chairface posted:9 out of 10. Galveston Hurricane is now the only single day/cause mass casualty event that's not "a day in the last month" fwiw these lists comparing covid deaths to battles and hurricanes are bullshit because they don't include things like the spanish flu, which definitely killed far more people in a single day than covid has (so far)
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Jan 12, 2021 16:38
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Jan 12, 2021 16:38
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Cao Ni Ma posted:Half dose is still like 70%+ effective at preventing the rona. If they dont develop symptoms I'd say its a big success. for Pfizer it's 54%. :X
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Jan 12, 2021 16:40
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Fireside Nut posted:Thanks - I appreciate the genuine response. I'm just going to stop it all together. Although maybe I'll pick it up again down the road as I run nearly every day and my knees were both uncharacteristically sore yesterday evening lol Yes, it's erring on the side of caution. I don't know how anti-inflammatory turmeric supplements really are or if they can actually affect an on-going immune response, but it seems like common sense to back off of them if you're trying to encourage an immune response.
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Jan 12, 2021 16:44
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Shifty Pony posted:and this is the "killer application" that both Moderna and Pfizer are gunning for. in a lot of ways the Covid vaccine is just PR for mRNA technology and they likely aren't making bank off of it. the end goal is for them to get a cancer biopsy, run it through a proprietary program to analyze it for unique markers which could be immune targets, and print up a new custom "vaccine" for that person which they will then charge $500k for. regular patients can't pay that kind of money. it would be better for them to develop vaccine production systems small enough to fit in a single room or two and then charge a hospital or other entity a subscription or licensing fee or something, imo. if they model it after radioisotope production they'd actually be able to make stupid amounts of money without haggling much with insurers.
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Jan 12, 2021 16:45
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Admiral Ray posted:regular patients can't pay that kind of money. it would be better for them to develop vaccine production systems small enough to fit in a single room or two and then charge a hospital or other entity a subscription or licensing fee or something, imo. if they model it after radioisotope production they'd actually be able to make stupid amounts of money without haggling much with insurers. DRMA
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Jan 12, 2021 16:48
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Fireside Nut posted:can soreness in the arm be indicative of an immune reaction or is that more likely due tot he trauma of the injection itself? Carl Zimmer did a nice infographic on the NYT. Here is the relevant image. They left out the part (to not scare people) that the immune system recognizes the muscle cell as foreign and destroys it. That's what the soreness is from: the immune system cleaning up and recognizing antigens from the lysed muscle cells.  https://www.nytimes.com/interactive/2020/health/moderna-covid-19-vaccine.html
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Jan 12, 2021 16:58
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brugroffil posted:Don't trials usually take longer to determine both safety and efficacy because they're much smaller and there isn't an insanely infectious uncontrolled virus raging through most of the world? We know that Pfizer and Moderna reached their endpoints more quickly than originally anticipated because infections were spiking in October. https://www.ema.europa.eu/en/documents/other/ema-considerations-covid-19-vaccine-approval_en.pdf posted:Post-approval follow-up for safety and efficacy However as things stand the choices are getting the vaccine or getting COVID. So everybody (that can) should get the vaccine. brugroffil posted:Are that public health/virologist/vaccinologist or other relevant experts expressing concerns over the safety of these vaccines?
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Jan 12, 2021 16:58
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Shifty Pony posted:Illuminates user when equipped Buriza Do Canon Law
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Jan 12, 2021 17:00
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man, listening to a vaccine oversight committee in NYC and we are all so hosed. they open by saying our target is to utilize 1,000,000 doses by the end of the month, while also touting how exciting it is that theyre going to open 2 more 24 hour sites by the 17th which will add 4,000 new vaccination slots per week! to date theyve given out ~215k doses, 100k of which have happened since January 1st.
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Jan 12, 2021 17:07
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also when asked why the health&hospital system built 3 entirely new patient portals, all of which require redundant info when h&h already built out a systemwide patient portal over the past few years that already has all the same info (which you needed to provide to get covid tested, so it already has all the info ready to go!), their answer is basically "dunno". lol
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Jan 12, 2021 17:09
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OWS’s goal was 20 million vaccinations by the end of 2020. we didn’t even hit 5 million. consequently I take all of these goals they make and cut them down by 75% because it’s probably more in the realm of reality.
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Jan 12, 2021 17:09
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Cao Ni Ma posted:Half dose is still like 70%+ effective at preventing the rona. If they dont develop symptoms I'd say its a big success. what vaccine are you talking about? Pfizer didn't do a secondary end point 1 dose study, and moderna's secondary end point one dose study had little data (only 46 cases out of 1100 people) giving a .95 confidence interval of 52% - 94%. Both vaccine companies and the FDA have refuted the safety and efficacy of recommending skipping, or delaying the second dose. If you don't believe me just ask bowser. https://www.youtube.com/watch?v=OPAQA_P_RQY
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Jan 12, 2021 17:09
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Given their recent track record, at this point I'm assuming my local public health authorities will gently caress things up so badly I won't get a covid vaccine until 2022, but it's nice that all the rich people will have custom tailored cancer vaccines and whatnot before Easter.
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Jan 12, 2021 17:11
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I think it's a moral imperative to get the vaccine ASAP by whatever means necessary Imagine vaccine distribution during a Civil War where the opposing side hates science - we're possibly a week away from that
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Jan 12, 2021 17:11
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Nothus posted:Yes, it's erring on the side of caution. I don't know how anti-inflammatory turmeric supplements really are or if they can actually affect an on-going immune response, but it seems like common sense to back off of them if you're trying to encourage an immune response. Awesome - thanks again Rauros posted:Carl Zimmer did a nice infographic on the NYT. Here is the relevant image. They left out the part (to not scare people) that the immune system recognizes the muscle cell as foreign and destroys it. That's what the soreness is from: the immune system cleaning up and recognizing antigens from the lysed muscle cells. that's pretty rad. thank you. my arm was sore enough it woke me up once or twice the first night and was sore for a few days after. good stuff
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Jan 12, 2021 17:15
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facetoucher cat posted:https://twitter.com/BNODesk/status/1348851298293182469?s=19
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Jan 12, 2021 17:17
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hahaha oh gently caress. i have no confidence this will work: Trump administration reverses stance, will no longer hold back second shots of coronavirus vaccine The expectation is that people will still get their second doses as planned. The concerns about possible hiccups in manufacturing have been allayed by the steady ramp-up so far, while the risks of delay have increased as the pandemic has claimed thousands of lives daily and as a new, more contagious variant of the virus first identified in Great Britain spreads through the United States. 
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Jan 12, 2021 17:21
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Rauros posted:Carl Zimmer did a nice infographic on the NYT. Here is the relevant image. They left out the part (to not scare people) that the immune system recognizes the muscle cell as foreign and destroys it. That's what the soreness is from: the immune system cleaning up and recognizing antigens from the lysed muscle cells. nice this is exactly what I was wondering about
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Jan 12, 2021 17:21
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Tzen posted:lol awaiting some headline along the lines of "Disney+ subscribers can skip the line!" rich moms in new York paying disabled people to stand in line for them. it doesn't get them through any faster, it's just the only way they know how to do disney world anymore
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Jan 12, 2021 17:24
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Fireside Nut posted:hahaha oh gently caress. i have no confidence this will work: quote:The Trump administration has been holding back roughly half the vaccines to ensure sufficient supply for people to get a required second shot. But in draft remarks prepared for a scheduled call Tuesday afternoon with governors and obtained by The Washington Post, Health and Human Services Secretary Alex Azar disclosed the change in plans. The remarks were confirmed by a senior administration official who spoke on the condition of anonymity because they were not authorized to speak publicly. 
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Jan 12, 2021 17:24
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my dad's probably gonna get the vaccine but my mom isn't old enough. Was the detail I read somewhere some time back that you're still a potential carrier of the disease if you're vaccinated still the case? they're not really going to be able to stay separated.
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Jan 12, 2021 17:25
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brugroffil posted:Don't trials usually take longer to determine both safety and efficacy because they're much smaller and there isn't an insanely infectious uncontrolled virus raging through most of the world? We know that Pfizer and Moderna reached their endpoints more quickly than originally anticipated because infections were spiking in October. At the very least they are doing a lovely job of messaging on the vaccines given the high rate of medical professionals turning it down. I know I'm a broken record but everywhere even in this thread, people only seem capable of responding to the standard anti-vaxx arguments rather than the specific situation with this vaccine.
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Jan 12, 2021 17:26
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