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Gonzo McFee posted:Got my first dose coming Saturday fellas Surely the brothels are all closed in lockdown?
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Jan 28, 2021 19:31
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OwlFancier posted:Could you use the mRNA approach to do things other than create vaccines? Like if you can use it to trigger the body to produce viral proteins to trigger an immune response could it be applied to make your body produce other chemicals? mRNA degrades way to quickly to do anything really useful outside of create a large amount of protein to present to your immune system. Now, if we could perfect the process of endosymbiosis that gave us mitochondria (and plants chloroplasts) maybe we could infect people with bacteria that could live inside their cells creating proteins.
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Jan 28, 2021 19:33
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Strom Cuzewon posted:Would it even be that useful? mRNAs + vectors sound much harder to make than just injecting someone with the hormone. Maybe some kind of longish term (days/weeks) hormone like HGF or oestrogen where you want a long term release but also can't just take a pill every day because ??? Reminds me though, I meant to ask ThomasPaine what their thoughts were on the development in artificial pancreas tech over the past couple years, that was another thing that started off very community hacky and has quite recently gone pro. goddamnedtwisto posted:Surely the brothels are all closed in lockdown? e: ^^^ I want chloroplasts. gently caress instant noodles I'll make my own dinner.
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Jan 28, 2021 19:36
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SpaceCommie posted:mRNA degrades way to quickly to do anything really useful outside of create a large amount of protein to present to your immune system.
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Jan 28, 2021 19:42
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OwlFancier posted:I would recommend a bandana if you find the ear loops uncomfortable, I still wear mine when I'm during quiet hours, gives me less of a headache/earache. My head's a bit big for the masks honestly so they pull my lugs quite a lot. A thick snood is good too (and doubles up as a scarf!). You can get snoods with little pockets to put mask filters in too. There were quite a few sellers on Etsy making them in the summer. goddamnedtwisto posted:Surely the brothels are all closed in lockdown? Apparently not. Kent Police issues 729 lockdown fines including to women hiding in cupboard at house party and brothel visitor Oscar Romeo Romeo fucked around with this message at 19:48 on Jan 28, 2021 |
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Jan 28, 2021 19:43
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I can't keep anything on by ear loops. A bit of wide elastic round the back of the head works well though, or of you don't like elastic, narrow cotton strips tied together behind the head, but resting on your ears to stop them slipping down.
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Jan 28, 2021 19:47
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Oscar Romeo Romeo posted:Apparently not. Kent Police issues 729 lockdown fines including to women hiding in cupboard at house party and brothel visitor quote:Also included on that list was a man caught visiting a brothel in Minster, Sheppey at 6pm on Friday. I think this pretty much defines the saying about a town being big enough for a brothel but small enough you wouldn't want to visit it.
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Jan 28, 2021 20:18
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goddamnedtwisto posted:I think this pretty much defines the saying about a town being big enough for a brothel but small enough you wouldn't want to visit it. lmao i've never heard that expression before, it's good
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Jan 28, 2021 20:19
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i need charlies suit from this https://www.youtube.com/watch?v=HbCk8Jr45ZM
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Jan 28, 2021 20:19
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Guavanaut posted:Yeah insulin itself probably isn't the most useful one, it was just the first peptide hormone that came to mind, and it might have been useful in some alt-history where we had mRNA when we were still going through literal tons of pig pancreata for insulin. But you could theoretically do it with tons of different proteins. Could regular doses reverse some types of demyelinating disease or something in the future? No idea. Or it would myelinate the rest of you. Either way, you're not gonna worry about the lack of myelin.
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Jan 28, 2021 20:27
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OwlFancier posted:Could you use the mRNA approach to do things other than create vaccines? Like if you can use it to trigger the body to produce viral proteins to trigger an immune response could it be applied to make your body produce other chemicals? What you're thinking of is just gene therapy, and yes. As others have pointed out, you don't really want to use RNA cause it's too fragile, and your immune system might get arsey about foreigners (especially British immune systems), plus you need a way to get it where it needs to go. That's why one of the few gene therapies approved is Luxturna, a drug that prevents blindness and is injected straight into your eyeballs to avoid the systemic immune response. And then also Zolgensma, which cure spinal muscular atrophy in infants by essentially replacing a defective gene in your neuromuscular system (which is pre-approved by your immune system and is on the inside of the cell so your immune system can't see it anyway). And both of those are delivered using Adeno-associated viruses, tiny viruses which don't tend to make humans sick but are very good at infecting primates
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Jan 28, 2021 20:29
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Jose posted:i need charlies suit from this You can pick up a Tyvek oversuit at any DIY place (or pick up a military NBC suit from Silvermans for 30 quid), and for your air filtration while drinking booze needs might I suggest the M15 NATO gas mask? (I'm sure if you ask Alice on Twitter she'll be able to suggest a cheaper Eastern bloc equivalent with only a little bit of asbestos in i)
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Jan 28, 2021 20:31
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WhatEvil posted:Second or third time I've seen recommendations for double-masking now that the new, more contagious variants of covid are about : Yeah I’ve seen this increasingly recently, and it’s at least driven me to get a better mask that the one I had which was just a single cotton layer, the ones at Vistaprint are two cotton layers with a filter between them and if I ever need to go into a small enclosed building I will definitely be wearing a disposable medical-style one underneath too.
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Jan 28, 2021 20:48
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I'm confused: is the Astra Zeneca vaccine the same thing as the Oxford vaccine?
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Jan 28, 2021 20:58
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Jaeluni Asjil posted:I'm confused: is the Astra Zeneca vaccine the same thing as the Oxford vaccine? Yep. Oxford Vaccine Group developed it, then Bill Gates flew in in his zeppelin (presumably) and convinced them to partner with AZ. The fact that the Bill and Melinda Gates Foundation are a major holder of AZ stock is.purely coincidental
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Jan 28, 2021 21:03
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These are the approved vaccines: https://www.raps.org/news-and-articles/news-articles/2020/3/covid-19-vaccine-tracker BNT162b2 is the first approved one and is mRNA and needs to be kept at dry ice temperatures (maybe) and is by Pfizer/BioNTech/Fosun Pharma. mRNA-1273 is the newly approved mRNA one by Moderna. CoronaVac is the traditional style vaccine that we won't be getting for political reasons. AZD1222 is the one made of tiny primates and is by AstraZeneca and Operation Warp Speed. Oxford University is a lie made up by Cambridge so that they can pretend to have rowing rivals.
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Jan 28, 2021 21:06
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Guavanaut posted:AZD1222 is the one made of tiny primates and is by AstraZeneca and Operation Warp Speed. 
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Jan 28, 2021 21:11
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Failed Imagineer posted:What you're thinking of is just gene therapy, and yes. As others have pointed out, you don't really want to use RNA cause it's too fragile, and your immune system might get arsey about foreigners (especially British immune systems), plus you need a way to get it where it needs to go. Are liposomes still a thing for gene therapy? I remember hearing about them as an alternative to viruses for delivering material to more accessible bits of the body. But that was way back and a cursory search of the literature gives me papers like "Liposomes: Why they're poo poo" and "Viruses: Way better than liposomes"
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Jan 28, 2021 21:19
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Failed Imagineer posted:Yep. Oxford Vaccine Group developed it, then Bill Gates flew in in his zeppelin (presumably) and convinced them to partner with AZ. I dont like how reality is converging with alt-right conspiracy bullshit, but didn't benevolent mr bill also convince them to charge more money for it?
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Jan 28, 2021 21:21
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I don't think so. It varies by country but in the UK the AstraZeneca jab is about £3 per dose, compared to about £15 for the Pfizer one and £25 for the Moderna one.
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Jan 28, 2021 21:25
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Strom Cuzewon posted:Are liposomes still a thing for gene therapy? I remember hearing about them as an alternative to viruses for delivering material to more accessible bits of the body. But that was way back and a cursory search of the literature gives me papers like "Liposomes: Why they're poo poo" and "Viruses: Way better than liposomes" The mRNA vaccines are delivered in liposomes if you want to call that gene therapy. My personal belief is cell-penetrating peptides for gene delivery. When I was still post-doc'ing I started developing a platform for expressing genes which would attach to such a peptide, cross into the cell, and then be released to do their thing. Saying any more would probably jeopardise any hypothetical patent filing, but it's languishing in a freezer somewhere so unlikely to ever see the light of day unless I need a backup plan and want to whore myself to some venture capitalists
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Jan 28, 2021 21:33
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is neil coyle the biggest oval office in the labour party? https://twitter.com/coyleneil/status/1354746063522066433?s=20
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Jan 28, 2021 21:38
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I'm glad its taken less than 12 hours for West Midlands Plod to admit their officer was a lunatic. Very happy that the % of bootlickers in the video comments was so small too.
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Jan 28, 2021 23:31
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serious gaylord posted:I'm glad its taken less than 12 hours for West Midlands Plod to admit their officer was a lunatic. Is that the one with the beard who flipped out when the bloke asked him to turn his body cam on?
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Jan 28, 2021 23:33
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goddamnedtwisto posted:Is that the one with the beard who flipped out when the bloke asked him to turn his body cam on? Yeah, broke basically every rule in the book and chucked him in the back of the car without even arresting him properly. Public apology from WMP from discovery at lunch time to 9pm. Got to be a record.
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Jan 28, 2021 23:48
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peanut- posted:I don't think so. It varies by country but in the UK the AstraZeneca jab is about £3 per dose, compared to about £15 for the Pfizer one and £25 for the Moderna one. That's also because it's easier to make IIRC.
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Jan 29, 2021 00:00
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goddamnedtwisto posted:Surely the brothels are all closed in lockdown? Brothels closed? Does not compute.
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Jan 29, 2021 00:09
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Failed Imagineer posted:
Gene therapy so that your sweat is a hallucinogen when?
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Jan 29, 2021 00:15
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Please don't lick other posters itt.
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Jan 29, 2021 00:21
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Guavanaut posted:Please don't lick other posters itt. That's the February thread title sorted
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Jan 29, 2021 00:29
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Jose posted:is neil coyle the biggest oval office in the labour party? This is some serious psyop poo poo and I don't know why we keep inflicting it on ourselves.
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Jan 29, 2021 00:36
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Ascythian posted:Brothels closed? Does not compute. Camsites?
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Jan 29, 2021 00:40
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TheRat posted:I dont like how reality is converging with alt-right conspiracy bullshit, but didn't benevolent mr bill also convince them to charge more money for it? Reality has been converging with alt-right conspiracy bullshit for almost a decade, the entire birth of the alt-right was some posters correctly noticing problems but then going Full Racist rather than acknowledge economic conditions exist.
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Jan 29, 2021 01:22
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Sorry for the Heil link: source: heil/money/markets/article-9199185/Warning-market-abuse-Reddit-fever-sweeps-Britain.html quote:
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Jan 29, 2021 01:22
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oh nooooo the wrong people are abusing the markets haaalp 
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Jan 29, 2021 01:25
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I know pie chat was a few days ago, but anyway: pie chat redux:
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Jan 29, 2021 02:10
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I'm trying to imagine the kind of grief that some of the Tory right were getting from their Which sounds apt, tbh
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Jan 29, 2021 02:10
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Jedit posted:Which risk group are you in? Frontline healthcare
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Jan 29, 2021 02:26
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Outlawing the act of noticing that hedge funds have managed to nakedly short a company and having behaviour based on that become market abuse could have no ill effects and the FCA are definitely onto a winner there. some people closed out fractional shares at $2600.
Total Meatlove fucked around with this message at 02:39 on Jan 29, 2021 |
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Jan 29, 2021 02:31
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Jaeluni Asjil posted:I know pie chat was a few days ago, but anyway: pie chat redux: The creatures outside looked from pie to man, and from man to pie, and from pie to man again; but already it was impossible to say which was which 
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Jan 29, 2021 09:17
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