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nexous
Jan 14, 2003

I just want to be pure

Tulip posted:

the fact that this was for a storage unit, *famously* one of the easiest, least labor intensive businesses, is a great juxtaposition

buy building
pay uhaul to basically do everything for you
post anti-labor signs
profit

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Joementum
May 23, 2004

jesus christ

Pie Colony posted:

that's just where to find it, which is useful (thanks) but i need the prescription first. havent seen a pcp in years

here's the HHS Test to Treat page

https://aspr.hhs.gov/TestToTreat/Pages/default.aspx

they have a locator that may have a pharmacy near you that will prescribe after a positive test. there's also a phone line you can call 1-800-232-0233

tenderjerk
Nov 6, 2008
Probation
Can't post for 355 days!
:thunk:
https://twitter.com/BNODesk/status/1509936628801974277?t=vr4pmqXMN9CynJRjsn85Mw&s=19

Nocturtle
Mar 17, 2007

This info about how to get the therapeutic treatments is so good, thank you. We got infected at the peak of Omicron in NYC and didn't even bother trying to get any pills at the time as it was likely impossible. However if COVID really is over maybe there will be more opportunity to get treatments for future infections, kind of like how vaccine demand was way below expectation after the initial rollout. Too bad molnupiravir is getting so widely distributed, it's just not that effective.

Unrelated the lack of good mask options for kids gets more obnoxious as variant R0 grows higher. Has anyone ever found a kid's mask with padded nose strip like the Aura? Thinking that might help prevent my 3 year old from having their mask slip down their face constantly. Ideally they'd just wear their Flomask but they got picky recently.

Thoguh
Nov 8, 2002

College Slice

Joementum posted:

here's the HHS Test to Treat page

https://aspr.hhs.gov/TestToTreat/Pages/default.aspx

they have a locator that may have a pharmacy near you that will prescribe after a positive test. there's also a phone line you can call 1-800-232-0233

quoting so I can find this post later

NeonPunk
Dec 21, 2020

.

NeonPunk has issued a correction as of 16:24 on Mar 4, 2023

HAIL eSATA-n
Apr 7, 2007


i'm not even a bird

U-DO Burger
Nov 12, 2007




bird flu is boring, bring back monkeypox tia

tuyop
Sep 15, 2006

Every second that we're not growing BASIL is a second wasted

Fun Shoe

Nocturtle posted:

This info about how to get the therapeutic treatments is so good, thank you. We got infected at the peak of Omicron in NYC and didn't even bother trying to get any pills at the time as it was likely impossible. However if COVID really is over maybe there will be more opportunity to get treatments for future infections, kind of like how vaccine demand was way below expectation after the initial rollout. Too bad molnupiravir is getting so widely distributed, it's just not that effective.

Unrelated the lack of good mask options for kids gets more obnoxious as variant R0 grows higher. Has anyone ever found a kid's mask with padded nose strip like the Aura? Thinking that might help prevent my 3 year old from having their mask slip down their face constantly. Ideally they'd just wear their Flomask but they got picky recently.

I bought some adhesive nose strips for fixing this.

Canadian Amazon but a search for “nose foam” should do it wherever you are.

EBLLPA 50 Pack Microfiber Memory Foam Anti-Fog Nose Bridge Pads for Mask, Self-Adhesive Protection Nose Strip Seal Nose Cushion Sponge Nose Bridge Pads (Black) https://www.amazon.ca/dp/B09JZG7NH8/ref=cm_sw_r_cp_api_i_6KKZT4MQQH5GB76HQGS5

Pittsburgh Fentanyl Cloud
Apr 7, 2003


Was out driving and there was an old guy on a hill at a four way intersection who was stuck. People kept driving around him. I was afraid he was going to get rear ended so I stopped and helped him back his car onto a side street and called someone to come get him since his car was disabled and he was having a senior moment or some poo poo. Apparently people were just driving around this guy and no one stopped to help him.

On the way back to my car someone yelled “nice mask human being!” Feeling great about humanity right now.

Wrex Ruckus
Aug 24, 2015

Pittsburgh Fentanyl Cloud posted:

Was out driving and there was an old guy on a hill at a four way intersection who was stuck. People kept driving around him. I was afraid he was going to get rear ended so I stopped and helped him back his car onto a side street and called someone to come get him since his car was disabled and he was having a senior moment or some poo poo. Apparently people were just driving around this guy and no one stopped to help him.

On the way back to my car someone yelled “nice mask human being!” Feeling great about humanity right now.

unfortunately it is much easier to be a lovely person than to not be one. Thanks for doing the right thing

mdemone
Mar 14, 2001


CDC disagrees.

JAY ZERO SUM GAME
Oct 18, 2005

Walter.
I know you know how to do this.
Get up.


Nocturtle posted:

This info about how to get the therapeutic treatments is so good, thank you. We got infected at the peak of Omicron in NYC and didn't even bother trying to get any pills at the time as it was likely impossible. However if COVID really is over maybe there will be more opportunity to get treatments for future infections, kind of like how vaccine demand was way below expectation after the initial rollout. Too bad molnupiravir is getting so widely distributed, it's just not that effective.

Unrelated the lack of good mask options for kids gets more obnoxious as variant R0 grows higher. Has anyone ever found a kid's mask with padded nose strip like the Aura? Thinking that might help prevent my 3 year old from having their mask slip down their face constantly. Ideally they'd just wear their Flomask but they got picky recently.

where was this? can someone post it again?

Joementum
May 23, 2004

jesus christ

JAY ZERO SUM GAME posted:

where was this? can someone post it again?

here's a link to a place that tracks what pharmacies have anti-COVID medications in stock. https://covid-19-therapeutics-locator-dhhs.hub.arcgis.com/

any doctor can prescribe it. if you get pushback, tell them you have one of the CDC's "certain medical conditions" that put you at higher risk of complications from COVID (not judging but you almost certainly have one of these)

you might not even need a doctor: here's the HHS Test to Treat page https://aspr.hhs.gov/TestToTreat/Pages/default.aspx

they have a locator that may have a pharmacy near you that may prescribe after a positive test. there's also a phone line you can call 1-800-232-0233

JAY ZERO SUM GAME
Oct 18, 2005

Walter.
I know you know how to do this.
Get up.


drat, thank you, I have Monday off so I’ll be getting to work

tenderjerk
Nov 6, 2008
Probation
Can't post for 355 days!

Joementum posted:

here's a link to a place that tracks what pharmacies have anti-COVID medications in stock. https://covid-19-therapeutics-locator-dhhs.hub.arcgis.com/

any doctor can prescribe it. if you get pushback, tell them you have one of the CDC's "certain medical conditions" that put you at higher risk of complications from COVID (not judging but you almost certainly have one of these)

you might not even need a doctor: here's the HHS Test to Treat page https://aspr.hhs.gov/TestToTreat/Pages/default.aspx

they have a locator that may have a pharmacy near you that may prescribe after a positive test. there's also a phone line you can call 1-800-232-0233
hell ueah

WampaLord
Jan 14, 2010

Pittsburgh Fentanyl Cloud posted:

Was out driving and there was an old guy on a hill at a four way intersection who was stuck. People kept driving around him. I was afraid he was going to get rear ended so I stopped and helped him back his car onto a side street and called someone to come get him since his car was disabled and he was having a senior moment or some poo poo. Apparently people were just driving around this guy and no one stopped to help him.

You did your mitzvah for the day, nice job.

Raskolnikov2089
Nov 3, 2006

Schizzy to the matic

JAY ZERO SUM GAME posted:

drat, thank you, I have Monday off so I’ll be getting to work

If you're trying to get it for someone who is sick, you really shouldn't wait the weekend. It's very much a "as early as possible or it's pointless" type drug.

Joementum
May 23, 2004

jesus christ
yeah you need to take it within five days of onset of symptoms. earlier the better.

and there are some drug interactions so best to call your doctor if you have one

Pingui
Jun 4, 2006

WTF?
:capitalism:

https://slate.com/technology/2022/04/covid-uninsured-vaccines-testing-congress-out-of-pocket.html posted:

Uninsured Americans Could Be Faced With a Slew of New COVID-19 Expenses
Funding for more critical supplies is stalled in Congress. Here’s how much tests, treatment, and vaccines could cost out of pocket.
(..)
PCR testing: Quest Diagnostics told ABC News that a nonsubsidized PCR test could cost $125 for an uninsured American.
(..)
Home rapid testing: The cost of home testing also varies by which test you decide to get. The Abbott BinaxNOW test can cost $20 to $24 for a pack of two tests. The Quidel QuickVue test costs $24 for a pack of two as well. Finally, the iHealth test costs $18 for a pack of two.
(..)
Vaccines: The government still has a supply of vaccines, which are provided for free—but the vaccines themselves aren’t the only cost associated with getting the shot. Currently, the Centers for Medicare & Medicaid Services is reimbursing providers about $40 for each shot of the vaccine they administer to cover the labor involved.
(..)
+
(..)
(A BMJ report says that the United States is paying about $15 per dose for Moderna, $19.50 per dose for Pfizer. Fierce Pharma reports that Johnson & Johnson is pricing their vaccine at $10 per dose.) However, there’s no guarantee that this will hold true if consumers are to be expected to pay for their own vaccines.
(..)
Treatments: Monoclonal antibody treatments can be pretty expensive, but up until now, the U.S. government has been paying for them. It’s unclear how much bebtelovimab, a monoclonal antibody made by Eli Lilly, costs per infusion, but its predecessor (which has since been discontinued due to lack of effectiveness against omicron) cost $1,250 per dose. (Eli Lilly did not respond to my request for a number on how much bebtelovimab costs before this article’s publication.) Sotrovimab, a GlaxoSmithKline monoclonal antibody, costs $2,100.

Antiviral treatments aside from antibody treatments are currently provided free of charge, but that status is also at risk due to the congressional stalemate. The government paid about $530 per treatment course of Paxlovid, Pfizer’s COVID pill. Molnupiravir, Merck’s less popular COVID pill, cost the U.S. government about $700 per treatment course.

Nocturtle
Mar 17, 2007

tuyop posted:

I bought some adhesive nose strips for fixing this.

Canadian Amazon but a search for “nose foam” should do it wherever you are.

EBLLPA 50 Pack Microfiber Memory Foam Anti-Fog Nose Bridge Pads for Mask, Self-Adhesive Protection Nose Strip Seal Nose Cushion Sponge Nose Bridge Pads (Black) https://www.amazon.ca/dp/B09JZG7NH8/ref=cm_sw_r_cp_api_i_6KKZT4MQQH5GB76HQGS5

Amazing, thank you.

edit: molnupiravir is more expensive than Paxlovid? Pharma pricing is something.

Nocturtle has issued a correction as of 22:40 on Apr 1, 2022

Pingui
Jun 4, 2006

WTF?

Nocturtle posted:

Amazing, thank you.

edit: molnupiravir is more expensive than Paxlovid? Pharma pricing is something.

It came out first and was hailed as a wonder drug. I guess they sold the entire production capacity almost immediately.

CGI Stardust
Nov 7, 2010


Brexit is but a door,
election time is but a window.

I'll be back
why are you complaining? do you know how many extra variants you're getting for your money? it's great value!

A Bakers Cousin
Dec 18, 2003

by vyelkin

Rutibex posted:

It's pretty arrogant to tell people what their own religious beliefs are.

Bitch, you ascribe to doctrine you better know said doctrine!!!

Nocturtle
Mar 17, 2007

One advantage of molnupiravir is it should be variant proof (I think?), so it's mediocre efficacy should be relatively stable for the foreseeable future. Paxlovid probably will get resisted at some point.

Yeah maybe it makes some new variants too, win some lose some.

The Oldest Man
Jul 28, 2003

Nocturtle posted:

One advantage of molnupiravir is it should be variant proof

Variant-proof or variant-approved

Pie Colony
Dec 8, 2006
I AM SUCH A FUCKUP THAT I CAN'T EVEN POST IN AN E/N THREAD I STARTED

Joementum posted:

any doctor can prescribe it. if you get pushback, tell them you have one of the CDC's "certain medical conditions" that put you at higher risk of complications from COVID (not judging but you almost certainly have one of these)

i talked with my specialist about it a couple weeks ago and they told me "pretty much anyone with any comorbidity will qualify for paxlovid and we would recommend you take it if you ever test COVID positive"

call now since you need to take it within five days of onset of symptoms

Joementum posted:

here's the HHS Test to Treat page

https://aspr.hhs.gov/TestToTreat/Pages/default.aspx

they have a locator that may have a pharmacy near you that will prescribe after a positive test. there's also a phone line you can call 1-800-232-0233

good tips, thanks. i got a prescription! but had it sent to the wrong pharmacy so now i have to wait 1-2 hrs for them to transfer it (which is dumb cause it took them 5 seconds to send it in the first place)

i ended up booking an online appointment through plushcare. didn't even lie, told them i was an alcoholic with a bad heart, and that apparently didn't qualify me (which the page above says it would). but my 27.1 bmi did. they look for >25 so that's probably the easiest option for most goons

JAY ZERO SUM GAME
Oct 18, 2005

Walter.
I know you know how to do this.
Get up.


Raskolnikov2089 posted:

If you're trying to get it for someone who is sick, you really shouldn't wait the weekend. It's very much a "as early as possible or it's pointless" type drug.
i'm not, but thank you

Lacrosse
Jun 16, 2010

>:V


Why Am I So Tired posted:

Hello from Washington State




I love seeing what crazy poo poo Uncle Sam has to say every time I drive past that billboard. It's like finding a Chick Tract in the bathroom of a rest stop.

Animal-Mother
Feb 14, 2012

RABBIT RABBIT
RABBIT RABBIT

NeonPunk posted:

https://mobile.twitter.com/RadioIowa/status/1509990155851112457

Probably nothing to worry about. It's literally just the flu.

"Is that your flu, Mr. President?"

"It's a flu."

fosborb
Dec 15, 2006



Chronic Good Poster
logging in on the desktop for the first time today -- updating the thread title accordingly

Joementum
May 23, 2004

jesus christ

Pie Colony posted:

good tips, thanks. i got a prescription! but had it sent to the wrong pharmacy so now i have to wait 1-2 hrs for them to transfer it (which is dumb cause it took them 5 seconds to send it in the first place)

:toot: hope you feel better soon

Nocturtle
Mar 17, 2007

Pie Colony posted:

good tips, thanks. i got a prescription! but had it sent to the wrong pharmacy so now i have to wait 1-2 hrs for them to transfer it (which is dumb cause it took them 5 seconds to send it in the first place)

i ended up booking an online appointment through plushcare. didn't even lie, told them i was an alcoholic with a bad heart, and that apparently didn't qualify me (which the page above says it would). but my 27.1 bmi did. they look for >25 so that's probably the easiest option for most goons

Never heard of plushcare but good to know. They just need to prescribe some pediatric vaccines off label and they'd be amazing.

Weird that they didn't account for actual heart disease given COVID's cardiovascular impact, but could prescribe based on a BMI measurement. Guessing BMI is a simple number that can be compared against a threshold for treatment.

Greg Legg
Oct 6, 2004

Pittsburgh Fentanyl Cloud posted:

Was out driving and there was an old guy on a hill at a four way intersection who was stuck. People kept driving around him. I was afraid he was going to get rear ended so I stopped and helped him back his car onto a side street and called someone to come get him since his car was disabled and he was having a senior moment or some poo poo. Apparently people were just driving around this guy and no one stopped to help him.

On the way back to my car someone yelled “nice mask human being!” Feeling great about humanity right now.

Some people are poo poo. Thanks for helping that guy out.

Loucks
May 21, 2007

I’m perfectly chill. Perfectly chill. The most innocuous comment set you off, not me. People are shockingly stupid, except for me. If that upsets you please shut the fuck up.
Let my kid sleep over at grandma’s since they agreed to isolate and take rapid tests and mask when others were around if they took him to the playground or something. He comes home and brags about how he was the only one masking when they went out, even his friend and grandma and grandpa went unmasked at the playground and on the drive over. His friend’s mom is a respiratory therapist of some sort and works with Covid patients all day. Guess grandparents dont know how viruses work. Fingers crossed. Literally can trust no one in this world apparently.

Koirhor
Jan 14, 2008

by Fluffdaddy

Loucks posted:

Let my kid sleep over at grandma’s since they agreed to isolate and take rapid tests and mask when others were around if they took him to the playground or something. He comes home and brags about how he was the only one masking when they went out, even his friend and grandma and grandpa went unmasked at the playground and on the drive over. His friend’s mom is a respiratory therapist of some sort and works with Covid patients all day. Guess grandparents dont know how viruses work. Fingers crossed. Literally can trust no one in this world apparently.

did you confront them about this?

Pingui
Jun 4, 2006

WTF?
Some more challenge trial data are in and the key takeaways are (wild type on a young and healthy cohort):
1) It is very infectious.
2) There is no correlation between symptoms and infectiousness.
3) It is detectable in the throat first, but got higher in the nose.
4) Loss/change of smell was very common and lasted at least past 180 days for some.

It is long and dense, so I've cut very heavily (there are also graphs in the article, but they require a lot of text to explain so: snip snip).

https://www.nature.com/articles/s41591-022-01780-9#Sec2 posted:

Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults

Abstract
(..)
Eighteen (~53%) participants became infected, with viral load (VL) rising steeply and peaking at ~5 days after inoculation. Virus was first detected in the throat but rose to significantly higher levels in the nose, peaking at ~8.87 log10 copies per milliliter (median, 95% confidence interval (8.41, 9.53)). Viable virus was recoverable from the nose up to ~10 days after inoculation, on average. There were no serious adverse events. Mild-to-moderate symptoms were reported by 16 (89%) infected participants, beginning 2–4 days after inoculation, whereas two (11%) participants remained asymptomatic (no reportable symptoms). Anosmia or dysosmia developed more slowly in 15 (83%) participants. No quantitative correlation was noted between VL and symptoms, with high VLs present even in asymptomatic infection. All infected individuals developed serum spike-specific IgG and neutralizing antibodies. Results from lateral flow tests were strongly associated with viable virus, and modeling showed that twice-weekly rapid antigen tests could diagnose infection before 70–80% of viable virus had been generated.
(..)
Smell disturbance after SARS-CoV-2 challenge infection
To assess the degree and kinetics of smell disturbance, University of Pennsylvania smell identification tests (UPSITs) were conducted. No smell disturbance was observed during quarantine in uninfected participants (Extended Data Fig. 1d). However, 15 infected participants (83%) reported some degree of smell disturbance (14 of which were detected by UPSIT). Although other symptoms peaked with nasal VLs, the nadir of UPSIT scores was 6–7 days later (Fig. 4a and Extended Data Figs. 4 and 5). Complete smell loss (anosmia) occurred in nine participants (50%), but most improved noticeably before day 28. At day 28, partial smell disturbance was still reported by 11 participants (61%), but, by day 180, this number had fallen to five. Of these, only one participant still had any measurable smell impairment, although this was steadily improving both subjectively and objectively (UPSIT at baseline = 31, at day 11 = 9, at day 28 = 11, at day 90 = 17 and at day 180 = 23; UPSIT maximum score = 40; significant drop > 4). Two of the remaining participants reported mild parosmia, and two had mild subjective reduction in smell (although UPSIT scores had normalized). Six participants (including all five who had prolonged smell disturbance) received smell training advice, including two who also received treatment with short courses of oral and intranasal steroids.
(..)
Discussion
(..)
Early in the pandemic, a World Health Organization Advisory Group published expert consensus guidelines recommending a starting dose of 10^2 TCID50 (ref. 17). Here, based on in vitro data of high viral replication in primary human airway epithelial cells and Syrian hamster data26, we started with a ten-fold-lower dose of 10 TCID50 (equivalent to 55 FFU) and found it sufficient to meet the 50–70% target infection rate.
(..)
In human challenge studies with other respiratory viruses, such as influenza viruses and respiratory syncytial virus, inoculum doses are typically also much higher at 10^4–10^6 TCID50 because all volunteers have been exposed multiple times throughout life to those viruses, with pre-existing immunity reducing susceptibility and resulting in substantially lower peak viral loads at 10^3–10^4 copies per milliliter by PCR8,9.
(..)
Thus, virus was first detected (first in the throat, then the nose) ~2 days before peak symptoms and increased steeply to achieve a sustained peak, in many cases before peak symptoms were reached, consistent with modeling data indicating that up to 44% of transmissions occur before symptoms are noted6. Anosmia was a later symptom, potentially explained by the proposed mechanism whereby only ACE2-expressing and TMPRSS2-expressing supporting cells, rather than neurons themselves, are directly infected, leading to delayed secondary olfactory dysfunction34.
(..)
Furthermore, our data clearly show that SARS-CoV-2 viral shedding occurs at high levels irrespective of symptom severity, thus explaining the high transmissibility of this infection and emphasizing that symptom severity cannot be considered a surrogate for transmission risk in this disease. This remains relevant with the widespread transmission of the Delta and Omicron variants, where antigenic divergence along with waning vaccine-induced immunity lead to VL during breakthrough infection at similarly high levels to those in seronegative individuals.
(..)
Detailed viral kinetics show that some individuals still shed culturable virus at 12 days after inoculation (that is, up to 10 days after symptom onset), and, on average, viable virus was still detectable 10 days after inoculation (up to 8 days after symptom onset). These data, therefore, support the isolation periods of 10 days after symptom onset advocated in many guidelines to minimize onward transmission.
(..)

Also challenge trials are very ethical and cool, which is why this line gets honorable mention:

quote:

Because no medicinal product was being investigated, the study was deemed not a clinical trial according to UK regulations
Really more of a challenge than a trial :ok:

Edit: link to CNN article about it: https://edition.cnn.com/2022/03/31/health/first-challenge-study-covid-19/index.html

Pingui has issued a correction as of 23:40 on Apr 1, 2022

UnfortunateSexFart
May 18, 2008

𒃻 𒌓ð’‰𒋫 𒆷ð’€𒅅𒆷
𒆠𒂖 𒌉 𒌫 ð’®𒈠𒈾𒅗 𒂉 𒉡𒌒𒂉𒊑


Perth, which didn't have widespread covid until this year despite no restrictions other than interstate travel, finds out living with covid actually sucks rear end

https://www.youtube.com/watch?v=FoRhptT1iUU

Pingui
Jun 4, 2006

WTF?
Reencountered this site, it apparently still updates (scroll past the CDC community transmission for the good stuff): https://covid19florida.mystrikingly.com/national-community-profile

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Nocturtle
Mar 17, 2007

Loucks posted:

Let my kid sleep over at grandma’s since they agreed to isolate and take rapid tests and mask when others were around if they took him to the playground or something. He comes home and brags about how he was the only one masking when they went out, even his friend and grandma and grandpa went unmasked at the playground and on the drive over. His friend’s mom is a respiratory therapist of some sort and works with Covid patients all day. Guess grandparents dont know how viruses work. Fingers crossed. Literally can trust no one in this world apparently.

This is too bad, you've been so careful. Hope you avoid it.

Pittsburgh Fentanyl Cloud posted:

Was out driving and there was an old guy on a hill at a four way intersection who was stuck. People kept driving around him. I was afraid he was going to get rear ended so I stopped and helped him back his car onto a side street and called someone to come get him since his car was disabled and he was having a senior moment or some poo poo. Apparently people were just driving around this guy and no one stopped to help him.
this is awesome.

Nocturtle has issued a correction as of 23:52 on Apr 1, 2022

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