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yeah, incalculable harm caused by undermining scientific values and trust due to coercive pressure from capitalism you know, in the comedy thread
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Jul 23, 2022 22:56
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Thesaurus posted:https://twitter.com/molly0xFFF/status/1550576374498353152?s=19 passing on my crypto wallet to my children Bequeathed Wallet Mismanagement an iksar marauder posted:Cumshitter was unjustly permad by the bitchmade mods yeah free cumshitter
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Jul 23, 2022 23:20
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bob dobbs is dead posted:as an early modern thing science depends upon basically 1700s-style "a peeps word is their bond" sorta reputation. works fine in fields of 100 peeps or whatever, where if they pull poo poo like this they're persona non grata, but alzheimers is one of the most significant diseases and alzheimer-studying is like tens of thousands of peeps As we learned the past 5-6 years, the US government and Constitution is seemingly reliant on similar assumptions of “a good man’s honor and they shall not disturb these norms”
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Jul 24, 2022 01:09
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an iksar marauder posted:Hahahaha. Yup it comes down to this. The first person to publish ground breaking research gets published in Nature/Science and makes a career around it. No one cares about the second guy to do it. The staggering thing about this is that according to that article, 200M+ in NIH funding this year went to research grants based on this assumption. Now multiply that by 15 years. Now add in all of the pharma funding/research that went on to this. All of the drug trials. It’s absolutely bonkers.
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Jul 24, 2022 02:23
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hypnophant posted:There are already consequences for fraud in the sciences. Hardly. Go check out Elizabeth Bik's Twitter feed for an ongoing deluge of clearly photoshopped results. All those people will get away, most without even a slap on the wrist, with the most severe punishment a journal can mete out being an expression of concern or a retraction (extremely rare). In the meantime real harm is done. People like that deserve to be unemployable outside of research as well.
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Jul 24, 2022 02:41
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ultrafilter posted:If the left ever ends up in power, they'll do it too. Good
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Jul 24, 2022 02:47
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an iksar marauder posted:People like that deserve to be unemployable outside of research as well. what they deserve is beside the point. No enforcement mechanism is going to be effective when discovering fraud takes over a decade or never happens at all, no matter how harsh you make the punishments. This is tough on crime thinking - if the punishments in place aren’t enough of a deterrent, just make the fines larger, sentences longer, punishments harsher. Anything to avoid having to reform the system everyone acknowledges is broken.
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Jul 24, 2022 05:17
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The people advocating for such increased consequences are not advocating for them alone. And the lack of consequences are entwined with other perverse incentives and power structures. Kevin Hall spent a tremendous amount of money to put out a deliberately misleading study based on openly invalid methods; he's now a section chief at NIDDK.
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Jul 24, 2022 06:19
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Residency Evil posted:https://www.science.org/content/article/potential-fabrication-research-images-threatens-key-theory-alzheimers-disease I don't know anything about Alzheimers but this seems like an important point (from Elizabeth Bik's twitter) https://twitter.com/samuel_marsh/status/1550883405105168386
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Jul 24, 2022 06:36
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the basic difficult part is that every amyloid drug has failed. all of em. so there has got to be a fuckup somewhere and everyone knows there has to be one. you just have the decade-long argument about wheres the fuckup
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Jul 24, 2022 06:40
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If you follow the opposite of my trades you will be a millionaire in no time. posted:HOW is it possible that I've gone over 50% loss on over 90% of my trades this year. I honestly think I'm being watched like I'm on the Truman Show and my life is a big joke. It's insane. None of my trades are options. These are common shares. I've lost a fortune on mega cap stocks, micro cap, energy plays, financial, tech, discretionary, Buffet plays, value, meme stocks, short squeeze plays, momentum, earnings, technical plays, shorting SPY and QQQ, contrarian, etc. Even followed a lot of trade ideas traders and they've all been losers. I'm not kidding. I've lost over $1000 every single day this entire month.... consecutively.. no green days. My entire portfolio right now is down ON AVERAGE 30%. Some positions down 75%. My best position is AMZN and that's down 25%. Again, these are not options. These are shares. It's ridiculous. I am the anti-market. 10 years of savings gone in a month. I'm on the verge of suicide again, but if anyone wants to get rich I am the ultimate indicator. Seriously, I will post my trades. At least someone else can get rich. I believe I'm cursed but it would make me happy to make others bank. There's no indicator in the world that can beat my 90% track record. the OP posted:You don't understand. I've lost a fortune on SHORTING the markets too. Literally 20 or 30 times I've gone short the markets have rallied. Every. Single. Time. I don't know how it's still possible I've lost a on over 900 out of nearly 1000 trades. quote:Lol Friday investments were FAZE, META, COLM, WFC, SNDR, and TRHC. If you want to go opposite of me I went long those. Otherwise enjoy the show. They are not swing plays. Just adding positions and writing calls against. quote:Not even day trading. A lot of positions I've been holding nearly 2 years even and they're still way way way down. Some companies got delisted. quote:So far in my 403b my account is returning less than inflation over 10 years. So not even ideal really. quote:Buddhism has always spoke to me. Thanks friend. edit: I missed this comment from other threads in r/stocks quote:I inherited $200,000 this year. I invested in companies like FB, AMZN, AAPL, but mostly index funds. Pretty much was ready to retire in my 50's. After this year, I may never retire. One more red day as we enter a bear market and I'm just gonna loving kill myself. Vice President fucked around with this message at 08:14 on Jul 24, 2022 |
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Jul 24, 2022 08:09
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Discendo Vox posted:The people advocating for such increased consequences are not advocating for them alone. And the lack of consequences are entwined with other perverse incentives and power structures. Kevin Hall spent a tremendous amount of money to put out a deliberately misleading study based on openly invalid methods; he's now a section chief at NIDDK. But if you just advocate for structural changes you can be smug and know that ultimately nothing will ever change it’s the best of both worlds!
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Jul 24, 2022 08:20
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knox_harrington posted:I don't know anything about Alzheimers but this seems like an important point (from Elizabeth Bik's twitter) In 2019 a Stat+ article discussed the Alzheimer’s ‘cabal’ which had more or less shut down alternative investigations in the disease while failing to produce results. I didn’t know how to evaluate its claims because making a jump from one knowledge system (science) to make claims about it in another less rigorous knowledge system (journalism) is a dangerous move. But if a knowledge system has failed, you HAVE to jump to a different system. I don’t know enough about who this person is to evaluate their twitter thread which is very long and authoritatively voiced. But given that the situation is that the current main line of thinking hasn’t gotten us much in the way of results, and there turns out to have been some fraud along the way, someone’s first response being “oh the fraud didn’t matter much” sets off alarm bells. Meanwhile, my grandmother died with Alzheimer’s and my mother recently told me that she can tell her memory is going. So whatever’s going on, I hope they get their acts together and I hope anyone who drained dollars and time away from legit science loses everything.
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Jul 24, 2022 12:08
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an iksar marauder posted:the most severe punishment a journal can mete out being an expression of concern or a retraction (extremely rare). In the meantime real harm is done. People like that deserve to be unemployable outside of research as well. How long did it take for the journal the published the infamous vaccine/autism bullshit to retract it? As I recall it was YEARS and obviously that damage has been done and continues on today.
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Jul 24, 2022 15:35
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Tis better that society suffer the death and discourse from 100 fraudulent medical research publications than 1 innocent Doctor have to back up their claims under scrutiny. 
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Jul 24, 2022 16:40
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SpartanIvy posted:Tis better that society suffer the death and discourse from 100 fraudulent medical research publications than 1 innocent Doctor have to back up their claims under scrutiny. Wait until you hear how much those paper reviewers get paid!
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Jul 24, 2022 16:55
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Residency Evil posted:Wait until you hear how much those paper reviewers get paid! Back when I was in publishable science (I’m in engineering now, applied stuff isn’t sexy), the other scientists and I would try to guess whether the review comments were from the actual reviewer or if they’d been pawned off to grad students to read on his behalf. Guessing “the actual reviewer” was seldom a winning answer. They almost all ended up being grad student delegates. The unpaid reviewers don’t even do the reviews, but pass them to even less-qualified/interested people.
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Jul 24, 2022 17:16
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Motronic posted:How long did it take for the journal the published the infamous vaccine/autism bullshit to retract it? As I recall it was YEARS and obviously that damage has been done and continues on today. Published 1998, fully retracted in 2010, with some smaller retractions of co-authors in between. He got pretty much every academic punishment you can think of (pulled titles, pulled papers, being unpersoned), but obviously that's where it ends. An infamous fraudster in my country was sentenced to 120 hours of community service, which he appealed and got thrown out, for faking 58 papers and derailing dozens of careers. He now does industry consulting
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Jul 24, 2022 17:32
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an iksar marauder posted:He got pretty much every academic punishment you can think of (pulled titles, pulled papers, being unpersoned), but obviously that's where it ends. He lives in a 8 bedroom mansion in California with one of the OG 1990s supermodels.
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Jul 24, 2022 18:47
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knox_harrington posted:I don't know anything about Alzheimers but this seems like an important point (from Elizabeth Bik's twitter) Yeah I by no means know anything about Alzheimer’s, and claims like this could only be evaluated by Alzheimer’s researchers who were around in the 2000s when this research was published. For what it’s worth, he’s an Alzheimer’s researcher in a closely related area, so he may be right, or he may just be trying to deal with the fact that his current area of study is in jeopardy.
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Jul 24, 2022 19:26
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quote:I've paid almost $19k on my car and the payoff amount has only gone down $400 quote:
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quote:It’s a joke in the military fresh boots out of school checking into their unit, buying a Mustang with double digit APR starting in 2. quote:
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quote:Look at your loan docs. What was the interest rate? Have you made every payment on time (not within the grace period but before the actual due date stated on the note). What was the original amount borrowed? Interest is calculated/charged daily and is always paid first. Take the interest rate divide by 365 than multiply by the principal balance after the last payment and then multiply by the number of days since you made your last payment. That is the interest due and is deducted first from the loan payment you send in. Another post by the same OP where they give out financial advice: quote:Need extra cash so your can feed your family and buy gas to get to work?
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Jul 24, 2022 19:46
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sad dude posted:I inherited $200,000 this year. I invested in companies like FB, AMZN, AAPL, but mostly index funds. Pretty much was ready to retire in my 50's. After this year, I may never retire. One more red day as we enter a bear market and I'm just gonna loving kill myself. Yikes!
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Jul 24, 2022 19:52
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a nationwide rent strike would be impractical to ever organize but very epic
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Jul 24, 2022 20:11
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learnincurve posted:He lives in a 8 bedroom mansion in California with one of the OG 1990s supermodels. Yeah but he can't put dr. in front of his name anymore, so who's the real loser here
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Jul 24, 2022 20:16
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obi_ant posted:Yikes! Putting an inheritance into tech stocks and index funds is better with money than 99% of the posts in this thread. Really bad timing for that guy, though.
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Jul 24, 2022 20:31
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Leon Trotsky 2012 posted:Tesla sold most of their bitcoins at a 58% loss and stopped taking bitcoins as payment. Thank you for this post. It got me off my rear end to sell the little bit of TSLA I had in the "play money" portion of my portfolio before the Twitter lawsuit business causes a potential reckoning and dumping of Tesla stock in a couple months. It received a nice bump with that news which definitely reduced my total losses on that one quite a bit.
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Jul 24, 2022 20:41
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SpelledBackwards posted:Thank you for this post. It got me off my rear end to sell the little bit of TSLA I had in the "play money" portion of my portfolio before the Twitter lawsuit business causes a potential reckoning and dumping of Tesla stock in a couple months. It received a nice bump with that news which definitely reduced my total losses on that one quite a bit. I think this thread has a rule about self posting, but drat if this isn't thread appropriate.
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Jul 24, 2022 20:46
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an iksar marauder posted:Yeah but he can't put dr. in front of his name anymore, so who's the real loser here He was struck off by the GMC but that doesn't remove his medical degree.
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Jul 24, 2022 20:55
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Also he arguably invented the "I was cancelled for saying the truth" media tour and has made being struck off into his entire professional identity.
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Jul 24, 2022 21:11
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knox_harrington posted:He was struck off by the GMC but that doesn't remove his medical degree. You're right, I had him and another guy who actually got his doctorate (but not his MD) pulled confused.
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Jul 24, 2022 22:46
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knox_harrington posted:I don't know anything about Alzheimers but this seems like an important point (from Elizabeth Bik's twitter)
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Jul 24, 2022 23:55
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What kind of affect would a successful Alzheimer’s drug have on one of the massive legacy pharma companies? I know for one of the new, tiny ones, it could be a moonshot, but what if one of the big ones had a successful Alzheimer’s drug get FDA clearance?
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Jul 25, 2022 02:56
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Business as usual. Like the whole point of big pharma research is to try a whole bunch of stuff, lose money on most of it since it doesn't work or there are complications, and make absolute bank off the few things that do actually do what you wanted them to.
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Jul 25, 2022 03:04
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Cacafuego posted:What kind of affect would a successful Alzheimer’s drug have on one of the massive legacy pharma companies? It would be huge. 10% of people over 65 have it, 5.5 million people in the US. A company would charge $50k a year (conservatively)... yeah huge.
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Jul 25, 2022 03:16
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Cacafuego posted:What kind of affect would a successful Alzheimer’s drug have on one of the massive legacy pharma companies? Even if it's just one of a number of irons in the fire for the company as a whole, an individual division of a pharmaceutical company and especially its leadership can make their careers off a successful drug.
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Jul 25, 2022 03:17
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Cacafuego posted:What kind of affect would a successful Alzheimer’s drug have on one of the massive legacy pharma companies? It would be phenomenal amounts of money. The first of the big pharma companies I worked for spent literally $1.25B in a single year for the chance at it, acquiring a drug from a startup / developing it / doing Phase III studies, and the drug ended up doing nothing at all. They were so desperate for it to work that they sunk another $2B into it over the next two years before finally giving up. It'd be a Lipitor-level boon in terms of sheer $$$.
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Jul 25, 2022 04:35
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Sundae posted:It would be phenomenal amounts of money. The first of the big pharma companies I worked for spent literally $1.25B in a single year for the chance at it, acquiring a drug from a startup / developing it / doing Phase III studies, and the drug ended up doing nothing at all. They were so desperate for it to work that they sunk another $2B into it over the next two years before finally giving up. Tell your job I got a line on some really hot NFT stonks and I am open to new angel investors.
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Jul 25, 2022 04:38
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Sundae posted:It would be phenomenal amounts of money. The first of the big pharma companies I worked for spent literally $1.25B in a single year for the chance at it, acquiring a drug from a startup / developing it / doing Phase III studies, and the drug ended up doing nothing at all. They were so desperate for it to work that they sunk another $2B into it over the next two years before finally giving up. ...and on top of that, it would be one of those things that actually generates real value and would thus be worth the cost. Letting millions of people who would otherwise be mentally incapacitated be active members of society would be huge. Like, something that would reverberate through the culture on the same level as the birth control pill. Leon Trotsky 2012 posted:Another post by the same OP where they give out financial advice: I've got a buddy who learned about the concept of a general strike when some folks were arguing for it during COVID, and has basically turned it into his personal eschatology. Everything that is wrong with the world will be fixed once we can make the general strike happen, because then "they" will have to accept our demands. These demands, as far as I can tell, are 1) make things suck less, and 2) reverse all of the consequences of the poor financial decisions that he, personally, has made. And honestly, I sympathize with him to some degree. He made some really bad decisions (some bad because they weren't thought out well, some bad purely because of bad luck) and has had a hard time of it. Unfortunately, now that he can dream about how the general strike would fix everything, it's given him another excuse to put off doing the necessary work to fix his situation.
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Jul 25, 2022 16:40
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Even just disregarding the feasibility, etc. of a national rent/mortgage strike, it's just funny that someone is advertising "don't pay your housing costs" as a neat financial trick with the title "Need extra cash?" And that the person giving that advice has a 28% APR car loan and doesn't know why they are paying higher than the sticker price for the car.
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Jul 25, 2022 16:48
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Leon Trotsky 2012 posted:Even just disregarding the feasibility, etc. of a national rent/mortgage strike, it's just funny that someone is advertising "don't pay your housing costs" as a neat financial trick with the title "Need extra cash?" I don't think I have any credit cards with 28% as it stands right now outside the store cards that I pay off before promo pricing hits.
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Jul 25, 2022 16:53
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