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Sounds like Biden should ask Wray to resign. (USER WAS PUT ON PROBATION FOR THIS POST)
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Feb 2, 2024 05:24
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https://twitter.com/nytimes/status/1753180214077620728 Oregon senate Republicans did another walkout after they passed a ballot initiative to ban walkouts and found out.
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Feb 2, 2024 06:31
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James Garfield posted:https://twitter.com/nytimes/status/1753180214077620728 Is this like a bigger scale version of the do a self-defeating thing ==> complain about it to the base-strategy? They walked out even though they knew it was banned because then it would look like they were being oppressed? That’s the closest I can come up with for a rationale. I don’t like assuming people I disagree with are just stupid, but it’s really hard to do that when they keep getting stymied by simple causality.
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Feb 2, 2024 06:40
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Xiahou Dun posted:Is this like a bigger scale version of the do a self-defeating thing ==> complain about it to the base-strategy? They walked out even though they knew it was banned because then it would look like they were being oppressed? Nobody really campaigned against the ballot measure and I don't think anyone will be very sympathetic to politicians saying having to do their jobs is unfair. I guess they might not care about running for reelection.
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Feb 2, 2024 07:10
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Did Oregon close the loophole that allowed the walkouts to be effective?
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Feb 2, 2024 07:11
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O sure. It is stupid, and gently caress those guys. I was just trying to suss out the internal axioms and emotional levers that could get a bunch of people to do a stupid thing en masse. I’m assuming they think/thought something else will/would happen.
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Feb 2, 2024 07:14
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haveblue posted:Did Oregon close the loophole that allowed the walkouts to be effective? We had a ballot initiative (Measure 113) in 2022 which passed by over 68% that prohibits members of congress from running for re-election after their current term if they have 10 or more absences. The wording was challenged by the Republicans but the intent of the initiative was pretty clear. Some are challenging it in federal court but I don’t think it’s going to go any better for them.
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Feb 2, 2024 07:27
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Xiahou Dun posted:O sure. It is stupid, and gently caress those guys. Their argument was that they thought loving around meant that next term would be their last, not this one. So a bunch of people hosed around because they miscalculated when they would be facing the consequences of their actions.
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Feb 2, 2024 07:30
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Okay, thank you. If I did that in a boardgame it’d haunt me. Holy poo poo.
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Feb 2, 2024 07:49
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Bar Ran Dun posted:Yeah it’s a huge truly insane mistake for the right to go nuts on Swift and the NFL. The "have you no decency" moment hinged on other people having said quality. The conventional wisdom around the MAGA crowd seems to be that they do not, and the polarization of the US voting populace seems to revolve around this. You can pick your favourite three Trump quotes that'd fit the decency bill just as well, and the answer was a resounding "gently caress you, got mine" already.
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Feb 2, 2024 12:09
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Rappaport posted:The "have you no decency" moment hinged on other people having said quality. The conventional wisdom around the MAGA crowd seems to be that they do not, and the polarization of the US voting populace seems to revolve around this. You can pick your favourite three Trump quotes that'd fit the decency bill just as well, and the answer was a resounding "gently caress you, got mine" already. Those moments came and went. The moderates and independents have listened and mostly abandoned trump and the gop. My dad sure as gently caress has. I think a lot of people had some faith the gop would do the right thing afte January 6th and they did for less than half a day and now they have been losing steadily ever since.
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Feb 2, 2024 13:04
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mrchoupon posted:We had a ballot initiative (Measure 113) in 2022 which passed by over 68% that prohibits members of congress from running for re-election after their current term if they have 10 or more absences. I mean, did you change a quorum to be 50%+1 rather than somewhat more than that
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Feb 2, 2024 13:37
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haveblue posted:I mean, did you change a quorum to be 50%+1 rather than somewhat more than that Nope! It'll be a new set of jackasses doing it in a few years though.
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Feb 2, 2024 13:52
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Kagrenak posted:I don't know how we restore our broken institutions and build trust again after regulatory capture. A lot of us in the biomedical field were asking the same questions about CBER after the absurd approval of aducanumab. question about dis. The drug is purportedly* supposed to slow the progression of the disease so I would assume, despite the side effects, it would be given at all stages (at least until sometime this year when supplies out), rather than the case of being approved/tested for people dying who just want to take a shot? With the latter, it seems it would be ethically fraught to give Alzheimer's patients in such an advanced stage the drug or test on them even if they (or their caretakers/medical decision makers) were at the point of throwing things against the wall in desperation. Though I understand some patient advocacy groups were pro-approval. idk the ins and outs of this case and idk who would. Obviously making it economically "viable" for Biogen seemed problematic even after approval so they abandoned it. *evidence did not seem to show this
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Feb 2, 2024 15:02
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Cranappleberry posted:question about dis. The drug is purportedly* supposed to slow the progression of the disease so I would assume, despite the side effects, it would be given at all stages (at least until sometime this year when supplies out), rather than the case of being approved/tested for people dying who just want to take a shot? The problem with aducanumab (imo and in the opinion of most people I've spoken to about it) is that there maybe is potential for it to be efficacious against the progression of the disease. However, the safety signals (mostly brain bleeds) are so large as to make the only somewhat above statistical significance slowing of progression not worthwhile. The other problem is that the mechanism of action which they are using means that the reverse of what you're suggesting is what should have happened. The FDA should have told them to go back and figure out demographic or biomarker indicators for who is most likely to suffer from the brain bleed AEs and go back to a much earlier diagnosed patient population and run a longer trial with more stringent patient selection. Once the amyloid has built up the damage is done and stopping it at the earliest phase is most important. At the same time, we (the scientific community) need to go back and look for an etiology for Alzheimer's which occurs prior to or independent of amyloid beta plaque formation as blocking AB formation seems to only provide very modest disease modification in the best of cases. I will end on the caveat that I have not gone and done much new research on this subject since the aducanumab approval a couple years ago and more promising data about anti-amyloid antibodies may be out from post-marketing approval studies. However, I stand by my position that the data at the time warranted a complete response letter (non-approval) for the BLA telling them to go back and do further studies. The data were so bad many payers would not cover it or only would at a much lower price than they were offering it. I actually just saw this news article as I was typing out this post, as you mentioned they're withdrawing the drug due to lack of patient use. I've got some people to text as I feel very vindicated now lol.
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Feb 2, 2024 15:21
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https://x.com/sprinter99800/status/1751093240021815444?s=46 (USER WAS PUT ON PROBATION FOR THIS POST)
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Feb 2, 2024 19:04
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I think taking the statue down is more silly and performative than anything else, but Jefferson's a complicated guy and he's not from New York, so I have a hard time getting upset by this. He has more than enough statues in Virginia to balance out having one less in a state which came from the colony with the most Loyalists during the Revolutionary War anyways...
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Feb 2, 2024 19:11
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This happened over two years ago and he was a slave owner and rapist anyway
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Feb 2, 2024 19:12
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Kagrenak posted:This happened over two years ago and he was a slave owner and rapist anyway Yeah. I'm not quite sure why it started going viral again recently, but I have seen various tweets like the one shared in this thread about it all this week.
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Feb 2, 2024 19:19
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Eric Cantonese posted:Yeah. I'm not quite sure why it started going viral again recently, but I have seen various tweets like the one shared in this thread about it all this week. probably because its a forgetebble one and they can trick chuds into thinking its recent.
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Feb 2, 2024 19:20
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Interesting pronoun use.
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Feb 2, 2024 19:21
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Why are you posting tweets from Sprinter9980.
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Feb 2, 2024 19:28
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FlamingLiberal posted:It seems like a lot of this anti-Swift thing is coming from Trump specifically. He's just Big Mad that she is way more popular than him. I think part of it too is that the right wants to have some sort of big cultural victory like they had un-making the Dixie Chicks back during W's presidency. Some big feather in their cap they can use to keep pop culture in check.
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Feb 2, 2024 19:32
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Discendo Vox posted:Why are you posting tweets from Sprinter9980. Sprinter9979 was down?
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Feb 2, 2024 19:33
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It's not even the real statue. The actual statue is in the US Capitol Rotunda. New York just got the plaster model that was used as the model for the final statue. In any case, while it rarely catches the attention of the press or politicians, there's another reason for moving the statue - its location in a heavily-used room made it prone to damage, which was noted when it underwent restoration in 2010. Plaster statues are relatively vulnerable to physical damage, compared to the real bronze statue. Sending it to the New York Historical Society would allow it to be protected and conserved properly. Eric Cantonese posted:Yeah. I'm not quite sure why it started going viral again recently, but I have seen various tweets like the one shared in this thread about it all this week. It's an election year, Trump's court cases are going very poorly, and New Hampshire suggests Trump's lead is a lot weaker than expected. The chudosphere has any number of reasons to want to get the base worked up about something relatively unimportant.
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Feb 2, 2024 19:37
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Just to clarify, Sprinter99800 regularly posts lying poo poo and got banned from Twitter for a while for it and also worshiping a Syrian war criminal to the point of having his picture as their profile pic. Probably the worst source you can think of. Look at how they posted the statue thing without even knowing when or why it was done.
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Feb 2, 2024 19:42
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Replace it with a copy of the thirst trap Abe Lincoln statue from the LA Court House
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Feb 2, 2024 19:42
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Talk about a Lincoln log
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Feb 2, 2024 19:51
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Kagrenak posted:The problem with aducanumab (imo and in the opinion of most people I've spoken to about it) is that there maybe is potential for it to be efficacious against the progression of the disease. However, the safety signals (mostly brain bleeds) are so large as to make the only somewhat above statistical significance slowing of progression not worthwhile. this is the info I was looking for (outside of the unlikely case someone posts insider specifics). ty also a thin therapeutic index or potentially horrible side-effects doesnt necessarily invalidate use, especially with a deadly, incurable disease but it does mean going back and doing more testing, just as you said, to narrow down where, how, when, who, as well as dosage and scheduling, as well as identifying proper followup care. but that stuff costs time and money and narrows down potential sales, heaven forfend Cranappleberry fucked around with this message at 21:19 on Feb 2, 2024 |
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Feb 2, 2024 20:00
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I know Trump never follows through with anything but man I wish he had made his statue garden because that would be hilarious
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Feb 2, 2024 20:28
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The US retaliatory strikes have begun, let the war gods feast.
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Feb 2, 2024 22:21
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Zotix posted:The US retaliatory strikes have begun, let the war gods feast. It's helpful to provide a link to the actual developing story when you say things like this. I think most of us had an idea of what you meant but still. https://www.nytimes.com/live/2024/02/02/world/us-iran-strikes-middle-east-news Cranappleberry posted:this is the info I was looking for (outside of the unlikely case someone posts insider specifics). ty np Imo the observed AEs are way too big to be worth the honestly basically clinically irrelevant gain that they only managed to show after a deep messaging of the data. (Read: basically cherry picking). Aducanumab was always doomed. The Lily antibody at least might be right around the breakeven and if they can figure out warning signs of the AEs or properly stratify pt populations then it might be worth it. Why it seems to be better is not entirely clear to me but it likely has to do with epitope selection (where on the amyloid protein the antibody binds to) Kagrenak fucked around with this message at 22:37 on Feb 2, 2024 |
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Feb 2, 2024 22:33
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The Glumslinger posted:Replace it with a copy of the thirst trap Abe Lincoln statue from the LA Court House You could have told me this was intended as a statue of Gavin Newsom and I'd have believed it.
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Feb 2, 2024 22:38
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Shooting Blanks posted:You could have told me this was intended as a statue of Ftfy
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Feb 2, 2024 23:11
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Speaking of statues of rapists....
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Feb 2, 2024 23:24
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https://apnews.com/article/israel-palestinians-poll-biden-war-gaza-4159b28d313c6c37abdb7f14162bcdd1 Joe Biden, Warmonger, is now more extreme than most independents. I wouldn't be surprised if Trump starts running to the left of Biden on this issue since even Republicans are starting to find Israel going too far in notable amounts
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Feb 3, 2024 00:08
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koolkal posted:https://apnews.com/article/israel-palestinians-poll-biden-war-gaza-4159b28d313c6c37abdb7f14162bcdd1 ... the guy who cut palestine aid and moved the embassary to jerusalem? that guy?
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Feb 3, 2024 00:11
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koolkal posted:https://apnews.com/article/israel-palestinians-poll-biden-war-gaza-4159b28d313c6c37abdb7f14162bcdd1 I'm not sure how Joe Biden is a warmonger when he pulled out of Afghanistan and whose military interventions are mainly at the Bill Clinton level? In our life times we had the double invasions of Iraq/Afghanistan, and Trump bringing the US to the brink of conflict with Iran. e: quote:I wouldn't be surprised if Trump starts running to the left of Biden on this issue since even Republicans are starting to find Israel going too far in notable amounts Trump in 2016 ran on an ambiguous platform of being all things to everyone; but ultimately did things like letting Turkey try to genocide the kurds and nearly started WW3 with Iran, and of course reversed Obama's efforts to normalize relations with Cuba (in which it is disappointing that Biden has had the political will or capital to unreverse afaik); and also it was Trump who gave arms to Ukraine when Obama had been hesitant to do for fear of "escalating" things. Trump can run on universal healthcare and trans rights but it doesn't make it remotely plausible that he will do so. Raenir Salazar fucked around with this message at 00:15 on Feb 3, 2024 |
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Feb 3, 2024 00:12
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Raenir Salazar posted:Trump bringing the US to the brink of conflict with Iran. Well you have a point, Biden never brought us to the brink of conflict, he dove right into a conflict.
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Feb 3, 2024 00:15
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koolkal posted:Well you have a point, Biden never brought us to the brink of conflict, he dove right into a conflict. When? (With Iran, directly?)
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Feb 3, 2024 00:16
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