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Leon Trotsky 2012 posted:The first publicly available gene therapy treatment procedures in the U.S. will become available this year. As someone who knows quite a lot about these treatments, its a lot more complicated that a just a single treatment. You're taking their bone marrow, editing it in a lab, then giving them person chemo to wipe out some of their existing bone marrow to make space for the fixed stuff you are re-adding. If you have good uptake, it should last for life and that has generally been true for successful treatments over the past 15-20 years because the fixed cells will continue to pump out whatever protein or correctly made cell that you had previously been unable to make. Part of why the treatments are so expense is that its a lot of initial patient care and that the labs that do the gene editing need to stay fully operational and functioning for very few treatments per year. Its something that should come down quite a bit over time as more things are approved, but that also relies on getting to the point where resources are pooled and you dont have 50 little drug startups each running their own low volume lab.
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# ? Apr 26, 2024 17:46 |
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# ? Jun 8, 2024 08:06 |
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Aztec Galactus posted:Resolves what? Cutting funding for public education is the goal It will be a big deal in FL. Rich places in the state have decent schools and some of the magnet schools are the best in the country. The universities are also fantastically cheap for in state tuition. They don’t want to defund the schools they want to transform them into conservative generating institutions. What they doing at New College is a good example.
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# ? Apr 26, 2024 17:49 |
Bar Ran Dun posted:It will be a big deal in FL. Rich places in the state have decent schools and some of the magnet schools are the best in the country. They absolutely want to defund and privatize secondary and high schools. Can't grift nearly as well on a public.school system.
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# ? Apr 26, 2024 17:55 |
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Lol the fascists will LOVE that Noem story because it's the kind of solution they'd consider. Also casually murdering pets triggers the libs so her stock just went up.
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# ? Apr 26, 2024 18:27 |
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Leon Trotsky 2012 posted:Speaking of Biden's fairly rare sit-down interviews: This is the first good thing Biden's done in years.
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# ? Apr 26, 2024 18:35 |
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How granular is Florida's control over federal education funding? Is it given to the state to be disbursed to various institutions/districts? If so, I expect every dime of that lost funding will be taken away from liberal schools, to preserve the integrity of the conservative ones the state wants to strengthen.
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# ? Apr 26, 2024 18:42 |
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Shooting Blanks posted:How granular is Florida's control over federal education funding? Is it given to the state to be disbursed to various institutions/districts? If so, I expect every dime of that lost funding will be taken away from liberal schools, to preserve the integrity of the conservative ones the state wants to strengthen. If they receive ANY federal funds, then they have to comply with Title IX or else they lose all federal education and grant money. Some of the money, like for school lunches, is technically not "educational" spending and they can keep it, but they would lose everything else they get for education. Nobody has ever refused to have an entire state comply before (because it was strictly about sex discrimination), so there isn't really a precedent for what happens. Some schools have not complied out of laziness or neglect, but they always get warnings and then straighten up rather than outright refuse. It is also on a per institution basis, so DeSantis is going to have to require all public universities and public schools to enforce Florida law and ignore federal law. I don't know the specifics of how Florida law determines how that plays out if he requires it or what he does if some schools comply with federal law and break Florida law. A lot of the specifics are going to be determined by what the Florida legislature and DeSantis decide to do 5 months from now.
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# ? Apr 26, 2024 18:56 |
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Kagrenak posted:I would assume that one just immediately hits their out of pocket maximum. Wouldn't the out-of-pocket maximum be irrelevant if the treatment isn't approved by one's health-insurance policy? Insurers (and self-insured employers) are starting to reject coverage of the new weight-loss drugs except when prescribed for treating diabetes (I'm not sure about pre-diabetes) and those are a pittance of the costs of gene therapies.
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# ? Apr 26, 2024 19:04 |
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Willa Rogers posted:Wouldn't the out-of-pocket maximum be irrelevant if the treatment isn't approved by one's health-insurance policy? That seems insane considering the costs they would avoid by having their customers be at a lower weight.
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# ? Apr 26, 2024 19:09 |
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Hieronymous Alloy posted:They absolutely want to defund and privatize secondary and high schools. Can't grift nearly as well on a public.school system. In general yes, But it’s more complicated in FL specifically. Here’s an example Florida has the best public gifted and talented school in the country. It’s not privatized it’s run by the public school district in Sarasota. That’s that district. Remember crazy moms for liberty married to the Florida head of the GOP and the swinging / her husband raping someone scandal. That school is in her district. That school is also the “curly hair” school fyi https://youtu.be/qpTVyozS7M0?si=12zO0XPJuv4VZI_t Teachers at that school directly inspire young adult fantasy characters. Now look at Ft. Myers and compare, private charters underfunded more minority students. Florida does both things. It runs well funded high end public programs where rich white peoples are and it “defund(s) and privatize(s) secondary and high schools” where poorer and minority students are. Here’s another way get what’s going on. In state tuition at UF is $6,381. https://www.usnews.com/best-colleges/university-of-florida-1535/paying It’s fantastically cheap to goto university in Florida. Who is going into to that affordable university, the kids in the well funded well run public programs from rich areas. The covid response was similar. Desantis rolled out early free easy to get vaccines for rich GOP heavy areas while making GBS threads on vaccines publicly and making it very very hard to get them if one was poor. It’s both things. They want things to be run well where the rich are and to privatize and dismantle where the poor are. Losing title IX funding hurts them in the catering to rich areas like Sarasota side of the equation, and they’ll hear about from those areas.
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# ? Apr 26, 2024 19:13 |
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The NHTSA released the findings of their multiyear study of Tesla self-driving safety and found that Tesla FSD was involved hundreds of crashes and dozens of deaths. The critical distinction they make is that the FSD modes are not necessary directly responsible for all of those incidents, but that Tesla programming and marketing encourage drivers to not pay attention to the road when "Full Self Driving" mode is engaged and instead just put a warning in their manual that Full Self-Driving mode is not actually meant to be fully self-driving. If FSD or autopilot were being used properly, then many of those crashes could have been avoided. However, they assert that FSD and autopilot have features and marketing that are designed to incentivize users to not use them properly. They determined that the "Full Self-Driving" and "autopilot" marketing were both misleading and lead drivers to pay less attention to the road under the assumption that it was fully under control by the FSD system. In most of these Tesla accidents, the drivers had at least 5 seconds to react to avoid the accident, but were not engaged with driving and proceeded to crash. Other manufacturers who have driver-assist technology use different marketing and methods that require drivers to hold the wheel or pay attention and have significantly better safety records. Tesla already issued a voluntary recall and software update for their FSD and autopilot system designed to change some of these features, but the NHTSA has announced a new investigation into Tesla autopilot and FSD safety based on these findings. Tesla is also being investigated for intentionally misleading marketing around their FSD and autopilot systems. quote:Tesla’s Autopilot and Full Self-Driving linked to hundreds of crashes, dozens of deaths https://www.theverge.com/2024/4/26/24141361/tesla-autopilot-fsd-nhtsa-investigation-report-crash-death
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# ? Apr 26, 2024 19:18 |
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Fork of Unknown Origins posted:That seems insane considering the costs they would avoid by having their customers be at a lower weight. A lot of health insurers never provided coverage for the weight-loss drugs from the jump. From January: quote:Most employer insurance plans don’t cover popular GLP-1 medications like Wegovy and Zepbound — or any other medications for weight loss, for that matter. Medicare also doesn’t pay for weight loss medications. https://www.cnn.com/2024/01/08/health/weight-loss-drug-insurance-denials/index.html The story goes on to discuss the long-term benefits of weight management but also mentions that insurers aren't the ones who will be left holding the bag down the road, as well as the unknown longterm effects of the drugs. quote:Still, if treating obesity could lead to such big cost offsets, why aren’t more insurers jumping to cover the new drugs?
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# ? Apr 26, 2024 19:23 |
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Willa Rogers posted:Wouldn't the out-of-pocket maximum be irrelevant if the treatment isn't approved by one's health-insurance policy? Yeah, insurance coverage is a giant question mark here. This is an article about the insurance situation regarding the approved sickle cell treatments: https://nymag.com/intelligencer/article/gene-therapy-casgevy-lyfgenia-elevidys-insurance.html For all of us who've spent time fighting over routine specialist visits and prescriptions, it is more promising than you might intuit, but there's still going to be a lot of uneccessary anxiety and battles over potentially lifesaving treatments. There's not a great way to reduce the costs; gene therapies are an outrageously expensive thing to develop, the diseases are rare, and the winning products need to pay back the costs of the losers (and generate value for shareholders!!!). Even under ideal conditions where this was fully socialized and non-profit with the revenue just paying back development and production costs, it would still be expensive, just not to the patient.
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# ? Apr 26, 2024 19:40 |
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BRAKE FOR MOOSE posted:Even under ideal conditions where this was fully socialized and non-profit with the revenue just paying back development and production costs, it would still be expensive, just not to the patient. Under a fully socialized and non-profit condition there would need to be a decision made whether to support something like this or not.
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# ? Apr 26, 2024 20:24 |
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Reps. Ritchie Torres (D-N.Y.) and Mike Lawler (R-N.Y.) plan to introduce the College Oversight and Legal Updates Mandating Bias Investigations and Accountability (COLUMBIA) Act, in the wake of pro-Palestinian encampments, protests and arrests on college campuses nationwide. The bill would allow the Department of Education to create a third-party monitor for antisemitic activity on college campuses that receive federal funding. The legislation was first reported by Jewish Insider. Torres said in a statement announcing the bill that college antisemitism since Hamas invaded Israel on Oct. 7 has been “at an all-time high” and “American universities are not capable of handling it when left to their own devices.” [i]The bill would allow the Department of Education to create a third-party monitor for antisemitic activity on college campuses that receive federal funding. The legislation was first reported by Jewish Insider. Torres said in a statement announcing the bill that college antisemitism since Hamas invaded Israel on Oct. 7 has been “at an all-time high” and “American universities are not capable of handling it when left to their own devices.” Torres said there are “blatant violation[s] of Jewish students’ civil rights” happening at schools across the country, and the federal government “cannot allow this to continue unchecked.” https://jewishinsider.com/2024/04/ritchie-torres-mike-lawler-campus-antisemitism-legislation-columbia/ edit: Correction accepted, apologies DC is out of control with their Israeli outrage talking points Nonsense fucked around with this message at 20:47 on Apr 26, 2024 |
# ? Apr 26, 2024 20:38 |
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DeadlyMuffin posted:Under a fully socialized and non-profit condition there would need to be a decision made whether to support something like this or not. But it's a much easier thing to justify when you are looking at it over the life of the patient from the socialized medicine standpoint, rather than a 1-year enrollment under your employer-sponsored plan
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# ? Apr 26, 2024 20:38 |
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Nonsense posted:Reps. Ritchie Torres (D-N.Y.) and Mike Lawler (R-N.Y.) plan to introduce the College Oversight and Legal Updates Mandating Bias Investigations and Accountability (COLUMBIA) Act, in the wake of pro-Palestinian encampments, protests and arrests on college campuses nationwide. Ritchie Torres is not the Democratic House Leader. That is Hakeem Jeffries. They are both southern NYC congressmen, but different people. Torres is from a southern NYC congressional district and is always doing whatever he can to promote himself to Dominican and Jewish NYC voters. He tweets constantly about the Dominican Republic and Israel. He loves the camera and this is a easy messaging bill that doesn't really do anything he can attach his name to in order to look good.
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# ? Apr 26, 2024 20:43 |
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Medicare sets the treatment standards for a lot of non-Medicare insurers, and Medicare recently approved weight-loss drugs for some medical conditions:quote:For the first time, Medicare will allow coverage of one of the new blockbuster weight-loss drugs for enrollees in Part D plans. A fully socialized healthcare system also would likely have stricter controls on pharma pricing.
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# ? Apr 26, 2024 20:44 |
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medicare should be allowed to pay for weight loss in general imo
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# ? Apr 26, 2024 20:52 |
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As much as I hate to admit it, I can absolutely understand why insurers would try so hard to keep from covering Ozempic / Wegovy / Mounjaro / etc. Here's a 90-day of my 5mg-dose Mounjaro, as an example. I am fortunate to have good insurance, or I would simply not be able to take the medication. I know the insurers pay a different rate and all, but with how prevalent the weight-loss equivalents of this medication could become with wider adoption, even paying 1/4 of that rate would be catastrophic to their margins. Not that I give a poo poo about their margins, but I understand why they care. quote:medicare should be allowed to pay for weight loss in general imo Yep, at bare minimum it should absolutely cover cases of actual obesity. It's not just a cosmetic thing to get out of the obese range; it's a serious thing and cuts the likelihood of other medical conditions by doing so.
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# ? Apr 26, 2024 20:54 |
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lobster shirt posted:medicare should be allowed to pay for weight loss in general imo They should, but they are barred by law from paying for "purely cosmetic" surgery or weight loss drugs. Congress needs to repeal the law that bans them before they can even think about covering it generally. The new regulation they announced recently is basically their way of trying to legally cover it by sidestepping the law because it is being used "medicinally" to lower heart attacks (by reducing their weight).
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# ? Apr 26, 2024 20:55 |
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Healthier weights lead to better health outcomes but also weight loss is cosmetic. The state of healthcare, ladies and gents.
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# ? Apr 26, 2024 21:03 |
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Professor Beetus posted:Healthier weights lead to better health outcomes but also weight loss is cosmetic. The state of healthcare, ladies and gents. We can charge more for a pound of cure than an ounce of prevention?
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# ? Apr 26, 2024 21:10 |
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Even aside from insurance the whole use of anti-diabetes drugs being used for weight loss is pretty fraught right now because demand has increased far more rapidly than production can spool up, and there's a whole spectrum from people who absolutely need it for health issues not directly related to weight to healthy people who are absolutely using it cosmetically and want the wonder drug that makes it easier to diet, with medically obese people somewhere along the way. I expect it will become a routine part of weight management in the future but right now costs/availability are real weird and insurance companies aren't the primary driver of why.
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# ? Apr 26, 2024 21:11 |
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Professor Beetus posted:Healthier weights lead to better health outcomes but also weight loss is cosmetic. The state of healthcare, ladies and gents. Teeth and eyes aren't related to health either, purely cosmetic.
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# ? Apr 26, 2024 21:14 |
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Uglycat posted:Hey guys It's my understanding that it is reasonably well established in US case law that going limp is called "passive resistance" in most police training, and is usually sufficient for a resisting/interfering charge, and at least enough justification for use of force by police that you're probably not going to have a hope of beating qualified immunity. Not so fun fact. (USER WAS PUT ON PROBATION FOR THIS POST)
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# ? Apr 26, 2024 21:18 |
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Seems to me that medicare's basically done an end run around the weight loss restriction. We can't treat obesity, but we *can* treat the risks caused by obesity...lmao
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# ? Apr 26, 2024 21:33 |
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Devor posted:But it's a much easier thing to justify when you are looking at it over the life of the patient from the socialized medicine standpoint, rather than a 1-year enrollment under your employer-sponsored plan And without having to make a profit. Completely agreed.
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# ? Apr 26, 2024 21:36 |
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TheDeadlyShoe posted:Seems to me that medicare's basically done an end run around the weight loss restriction. We can't treat obesity, but we *can* treat the risks caused by obesity...lmao Only a partial end run for a specific group of people. You have to get heart disease first. Good if you want weight loss drugs and have heart disease. Getting heart disease is probably not worth it just to get free weight loss drugs, though. The rule does open the door for broader general coverage in the future If they can clinically prove other medical benefits or new drugs are invented that do. Leon Trotsky 2012 fucked around with this message at 21:40 on Apr 26, 2024 |
# ? Apr 26, 2024 21:36 |
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Leon Trotsky 2012 posted:Only a partial end run for a specific group of people. You have to get heart disease first. It's something like 50% of Americans with some form of condition that can be labeled cardiovascular disease, since it includes high blood pressure. Though i'm not sure if thats the standard Medicare uses.
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# ? Apr 26, 2024 21:40 |
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Leon Trotsky 2012 posted:Speaking of Biden's fairly rare sit-down interviews: How relevant has Howard Stern been to politics? I haven't paid attention to him since the 90's and I'm pretty sure he had no political interests until his interview with Hillary a few years ago. Is his political interests a recent turn or has he done other notable interviews with political figures that I just completely missed?
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# ? Apr 26, 2024 21:47 |
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Butter Activities posted:It's my understanding that it is reasonably well established in US case law that going limp is called "passive resistance" in most police training, and is usually sufficient for a resisting/interfering charge, and at least enough justification for use of force by police that you're probably not going to have a hope of beating qualified immunity. Not so fun fact. Can any lawyers in the topic speak to this? I can see, by stretching, where to get to going limp is resisting arrest, but going limp being sufficient to justify use of force is a new aspect to the hellscape that's still surprising.
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# ? Apr 26, 2024 21:57 |
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PharmerBoy posted:Can any lawyers in the topic speak to this? I can see, by stretching, where to get to going limp is resisting arrest, but going limp being sufficient to justify use of force is a new aspect to the hellscape that's still surprising. Going limp is not enough to justify use of force, but if you are doing it for the explicit purpose of delaying or avoiding arrest, then it is called passive resistance and can be enough to get you charged with resisting arrest. I'm not familiar with every state law, but many states have a separate charge for "non-violent" resisting arrest that is a class lower than a standard resisting charge.
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# ? Apr 26, 2024 22:00 |
PharmerBoy posted:Can any lawyers in the topic speak to this? I can see, by stretching, where to get to going limp is resisting arrest, but going limp being sufficient to justify use of force is a new aspect to the hellscape that's still surprising. My advice as an attorney is to avoid situations that could result in arrest. Ideally avoid all cops entirely. If they want a reason to charge you they will find one. There is no course of action that will avoid a "resisting arrest" charge if the cop wants to charge you. Later, the way to beat a resisting arrest charge down the road is to beat the underlying charge that gave rise to the arrest, proving the arrest itself was unlawful. Then the resting charge will also have to be dropped. That doesn't do diddly for you at the time of arrest tho. Hieronymous Alloy fucked around with this message at 22:08 on Apr 26, 2024 |
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# ? Apr 26, 2024 22:05 |
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Freakazoid_ posted:How relevant has Howard Stern been to politics? I haven't paid attention to him since the 90's and I'm pretty sure he had no political interests until his interview with Hillary a few years ago. Is his political interests a recent turn or has he done other notable interviews with political figures that I just completely missed? There was that time he ran for governor of New York in 1994, won the Libertarian nomination and then had an "Oh poo poo" moment and backed out of the election
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# ? Apr 26, 2024 22:06 |
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Freakazoid_ posted:How relevant has Howard Stern been to politics? Honest question: how relevant is Howard Stern? We got a 4 month SiriusXM subscription and the music stations are awful and repetitive. I imagine Stern fans get it, but there can’t be enough of them paying $30/mo or whatever… can there?
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# ? Apr 26, 2024 22:06 |
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Hieronymous Alloy posted:My advice as an attorney is to avoid situations that could result in arrest. Ideally avoid all cops entirely. If they want a reason to charge you they will find one. There is no course of action that will avoid a "resisting arrest" charge if the cop wants to charge you. It's great that American media regularly portrays cops as awful people trying to make arrests, looking at you Law and Order franchise, and we're kind of made to think of them as the good guys.
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# ? Apr 26, 2024 22:09 |
Rappaport posted:It's great that American media regularly portrays cops as awful people trying to make arrests, looking at you Law and Order franchise, and we're kind of made to think of them as the good guys. I mean, not to be a cop apologist, but there's a reason they do lots of Law and Order: Special Victims Unit and not so many episodes of Law and Order: Non-Violent Protestors
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# ? Apr 26, 2024 22:34 |
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Hieronymous Alloy posted:I mean, not to be a cop apologist, but there's a reason they do lots of Law and Order: Special Victims Unit and not so many episodes of Law and Order: Non-Violent Protestors That's true! But the Special Victims unit has a specific story where Chris Meloni points out he messed up, and someone is in prison for life for that mistake. And Chris Meloni regularly assaulted people, too. Looked at it from a distance, that show did not paint a good picture of law enforcement in America.
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# ? Apr 26, 2024 22:38 |
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# ? Jun 8, 2024 08:06 |
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Leon Trotsky 2012 posted:The Biden administration released new Title IX regulations governing all public school or schools that receive federal funds in the country. There's gotta be a better way to punish the state than to take away education funding, isn't there? There's an actual person that is making the order to not comply. Why can't that person or persons get hosed instead?
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# ? Apr 26, 2024 22:59 |