[COVID] 1 Million! We did it! :toot: :911:

The Something Awful Forums > Archives > Comedy Goldmine > The Goodmine > [COVID] 1 Million! We did it! :toot: :911:

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Zeriel: Nov 6, 2004

Just make a script to post this every 6 months from now until COVID takes you.

# ? Mar 24, 2022 05:12

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# ? May 30, 2024 14:19

Zugzwang: Jan 2, 2005; You have a kind of sick desperation in your laugh.; Ramrod XTreme

Zeriel posted:

Just make a script to post this every 6 months from now until COVID takes you.

6? Buddy,

# ? Mar 24, 2022 05:12

Platystemon: Feb 13, 2012; BREADS

JAY ZERO SUM GAME posted:

https://twitter.com/bnodesk/status/1506774254322393092?s=21

The cemetery be like

# ? Mar 24, 2022 05:15

Lastgirl: Sep 7, 1997; Good Morning!
Sunday Morning!

triple sulk posted:

https://twitter.com/bnodesk/status/1506836322643808256?s=21

it's happening again

We say the magic words, �Open Biden!� 🪄

# ? Mar 24, 2022 05:16

Palladium: May 8, 2012; Very Good
✔️✔️✔️✔️

That won't be a new waves, if we just have a neverending wave

# ? Mar 24, 2022 05:18

Animal-Mother: Feb 14, 2012; RABBIT RABBIT
RABBIT RABBIT

Platystemon posted:

The cemetery be like

# ? Mar 24, 2022 05:19

ikanreed: Sep 25, 2009; I honestly I have no idea who cannibal[SIC] is and I do not know why I should know.

syq dude, just syq!

Palladium posted:

That won't be a new waves, if we just have a neverending wave

So you agree, it's endemic thus over

# ? Mar 24, 2022 05:21

Trixie Hardcore: Jul 1, 2006; Placeholder.

Palladium posted:

That won't be a new waves, if we just have a neverending wave

Turns out a tsunami isn't quite as noticeable once you move to the middle of the ocean

# ? Mar 24, 2022 05:30

mdemone: Mar 14, 2001

can't have excess deaths if you don't count deaths

*taps skull*

# ? Mar 24, 2022 05:32

spaceblancmange: Apr 19, 2018; #essereFerrari

I have a really good joke for when the inventor of the mp3 dies, nobody steal it

rip

# ? Mar 24, 2022 05:33

Zugzwang: Jan 2, 2005; You have a kind of sick desperation in your laugh.; Ramrod XTreme

Palladium posted:

That won't be a new waves, if we just have a neverending wave

Letting SARS-CoV-2 evolve to this point seems analogous to all the carbon we dumped into the atmosphere. Get ready for sea level rise, baby

# ? Mar 24, 2022 05:38

Rauros: Aug 25, 2004; wanna go grub thumping?

really looking forward to the uncharted territory of no mitigations and testing.

# ? Mar 24, 2022 06:00

Lacrosse: Jun 16, 2010; >:V

Rauros posted:

really looking forward to the uncharted territory of no mitigations and testing.

Covid-19: New Game+

# ? Mar 24, 2022 06:03

Trixie Hardcore: Jul 1, 2006; Placeholder.

https://twitter.com/EnemyInAState/status/1506311077054795787
https://www.youtube.com/watch?v=_6FBfAQ-NDE

# ? Mar 24, 2022 06:03

Trixie Hardcore: Jul 1, 2006; Placeholder.

So weird, to find that getting covid over and over doesn't make you stronger! :iiam:

# ? Mar 24, 2022 06:05

empty whippet box: Jun 9, 2004; by Fluffdaddy

lol it's really gonna turn out to be straight up airborne aids before it's all over. the t cell depletion thing seems more and more likely to be real

# ? Mar 24, 2022 06:05

speng31b: May 8, 2010

Rauros posted:

really looking forward to the uncharted territory of no mitigations and testing.

Also if you wear a mask in public someone named Tucker will try to fight you

# ? Mar 24, 2022 06:06

Zugzwang: Jan 2, 2005; You have a kind of sick desperation in your laugh.; Ramrod XTreme

Trixie Hardcore posted:

So weird, to find that getting covid over and over doesn't make you stronger!

what doesn�t kill you makes you cough more

# ? Mar 24, 2022 06:08

Ruggan: Feb 20, 2007; WHAT THAT SMELL LIKE?!

speng31b posted:

Also if you wear a mask in public someone named Tucker will try to fight you

I wore a mask in a Kwik Trip yesterday and this white neo nazi looking guy walked up behind me and said �oh poo poo�. I turned around scared that I was gonna have him rip my mask off and punch me and call be a big nussy. But anyway I�m pretty sure he said that because he walked past the aisle he meant to go down. Also I�m not sure he was a neo nazi.

# ? Mar 24, 2022 06:09

im saint germain: Jan 30, 2021; i've come from the future to tell you all we have to stop party rock before it returns

only👏 listen👏 to👏 experts👏 who👏 agree👏 with👏 my👏 opinions👏

# ? Mar 24, 2022 06:11

Ruggan: Feb 20, 2007; WHAT THAT SMELL LIKE?!

im saint germain posted:

only👏 listen👏 to👏 experts👏 who👏 agree👏 with👏 my👏 opinions👏

it�s hard to be an expert if you have the wrong opinion imo

# ? Mar 24, 2022 06:12

Platystemon: Feb 13, 2012; BREADS

Rauros posted:

really looking forward to the uncharted territory of no mitigations and testing.

# ? Mar 24, 2022 06:12

Zugzwang: Jan 2, 2005; You have a kind of sick desperation in your laugh.; Ramrod XTreme

Ruggan posted:

it�s hard to be an expert if you have the wrong opinion imo

Love that Matty is propping up an �expert� whose analyses are trash-tier (in a field she has no business stepping into, at that) and whose predictions are rarely correct

I hate that �expert� really has become synonymous with �smart-sounding person who says what I want to hear�

# ? Mar 24, 2022 06:16

Ruggan: Feb 20, 2007; WHAT THAT SMELL LIKE?!

Zugzwang posted:

Love that Matty is propping up an �expert� whose analyses are trash-tier (in a field she has no business stepping into, at that) and whose predictions are rarely correct

I hate that �expert� really has become synonymous with �smart-sounding person who says what I want to hear�

�expert� has always meant this, though - it�s just that armchair experts have unprecedented exposure via online platforms, where they can espouse their lovely ideas and find an audience

# ? Mar 24, 2022 06:19

Daniel Dales Dick: Apr 8, 2020; �With the coldest winter ever recorded, with snow setting record levels up and down the coast, the Nobel committee should take the Nobel Prize back from Al Gore"

empty whippet box posted:

lol it's really gonna turn out to be straight up airborne aids before it's all over. the t cell depletion thing seems more and more likely to be real

People have been talking about that since before Delta. They grow back, you're always making more.

# ? Mar 24, 2022 06:31

mawarannahr: May 21, 2019

Daniel Dales Dick posted:

People have been talking about that since before Delta. They grow back, you're always making more.

yeah they tour the body and poo poo

https://twitter.com/natureportfolio/status/1505959930997747715?s=21

# ? Mar 24, 2022 06:33

i am harry: Oct 14, 2003

what doesn�t kill me makes me weaker!?!

# ? Mar 24, 2022 06:35

Lastgirl: Sep 7, 1997; Good Morning!
Sunday Morning!

Ruggan posted:

it�s hard to be an expert if you have the wrong opinion imo

Expert vs expertise

# ? Mar 24, 2022 06:42

Real Mean Queen: Jun 2, 2004; Zesty.

Look, STIs and unwanted pregnancies aren�t going anywhere. There�s no way to make them not exist, we�re stuck with them, your great grand children will have them, they�re a fact of life. How long are we going to continue to put up with the virtue signaling moral scolds telling us to get tested and use protection just to do things that humans have done forever? I wore cloth condoms for two years, I got chlamydia anyway so they don�t even work, and now I�m immune. It�s over, and I�m not going back.

# ? Mar 24, 2022 06:51

hobbesmaster: Jan 28, 2008

Real Mean Queen posted:

Look, STIs and unwanted pregnancies aren�t going anywhere. There�s no way to make them not exist, we�re stuck with them, your great grand children will have them, they�re a fact of life. How long are we going to continue to put up with the virtue signaling moral scolds telling us to get tested and use protection just to do things that humans have done forever? I wore cloth condoms for two years, I got chlamydia anyway so they don�t even work, and now I�m immune. It�s over, and I�m not going back.

Subaru just got rid of STIa, it�s clearly possible.

# ? Mar 24, 2022 06:55

Dr. Furious: Jan 11, 2001; KELVIN
My bot don't know nuthin' 'bout no KELVIN

Daniel Dales Dick posted:

People have been talking about that since before Delta. They grow back, you're always making more.

This is a gross simplification that ignores how the thymus changes with age, not to mention how individual t cells alter function as they age.

# ? Mar 24, 2022 06:55

Computer Serf: May 14, 2005; Buglord

empty whippet box posted:

lol it's really gonna turn out to be straight up airborne aids before it's all over. the t cell depletion thing seems more and more likely to be real

https://www.mdpi.com/2076-0817/11/4/390

https://www.mdpi.com/2076-0817/11/4/390 posted:

Superantigens and Autoimmunity
Superantigens are implicated in the development of autoimmune diseases [53,54,55,56,57,58]. T-cell clones that are cross-reactive towards the endogenous host and microbial epitopes may be stimulated and migrate to tissue containing an autoantigen, a mechanism believed to play a role in the pathogenesis of rheumatic fever [59,60]. Individuals with autoimmune diseases show an increase in such T-cells in affected organs or peripheral blood [5]. Superantigens stimulate autoantibody production by bridging the MHC Class II molecule of B-cells with the TCR on T-cells [61]. Whether deletion or autoimmunity occurs seems to be a function of dose, persistence, host haplotype and severity of cytokine response [62].
Persistent subcutaneous exposure to a superantigen has been shown to cause a systemic inflammatory disease mimicking systemic lupus erythematosus (SLE) in mice [63]. Superantigens have been shown to trigger or exacerbate SLE [64]. Interestingly, HERV-E has been implicated in SLE [65,66]. HERV-E has been found to be upregulated in the bronchoalveolar lavage fluid of COVID-19 patients [67].
Insulin-dependent diabetes mellitus (IDDM) is a T-cell-mediated autoimmune disease triggered by unknown environmental factors acting on a predisposing genetic background, but there is evidence superantigen-like exposure in the form of HERV-W-env upregulation is implicated in the recruitment of macrophages in the pancreas and beta-cell dysfunction [68]. Antibodies against HERV-W-env precede or overlap with conventional IDDM antibodies in youths who are susceptible to or have the condition.

The issue of whether SARS-CoV-2 contains a superantigen is not settled, but the evidence is accumulating [90,91,92,93,94,95] and SARS-CoV-2 is causing superantigen or superantigen-like clinical presentations and biomarkers. In addition to cytokine storms [96], T-cell activation and deletion [74] and presentation of MIS-C [73,97,98] (similar to Kawasaki disease, a suspected consequence of superantigen exposure [99]), those infected by SARS-CoV-2 who suffer Long COVID following infection manifest symptoms [100] typically seen in autoimmune conditions such as SLE [101,102,103], and autoantibodies [71] and antinuclear antibodies [72] have been detected in a proportion of such individuals [104].
In vitro assessments of SARS-CoV-2�s superantigen-like region may not capture the full physiological effect on the immune system in vivo. For example, lipopolysaccharide (LPS) can potentiate the SEB superantigen effect [105], which could have a synergistic effect on T cells following gut inflammation or injury via LPS translocation [106,107].
SARS-CoV-2 is known to infect gut epithelial cells [108], persist in the gut [79,109,110] and disrupt tight junctions in bronchial epithelial barriers [111]. Indeed, hospitalized non-survivors of SARS-CoV-2 infection had increased LPS detected in blood [112]. While SARS-CoV-2 may not be canonically superantigenic in vitro, the in vivo consequences may be significant due to other danger and death signals [113].
With evidence mounting that SARS-CoV-2 reactivates latent viruses such as Epstein�Barr Virus [114], cytomegalovirus [115,116] and human endogenous retrovirus [36], which are associated with superantigen expression [31,69,117,118,119], it is important to establish whether SARS-CoV-2 is a superantigen or triggering second-order superantigenic responses in susceptible individuals.

Some countries seem willing to tolerate high levels of infection provided their healthcare systems can cope. This approach is predicated on the belief a level of protective population immunity can be achieved and sustained, and the impact of reinfections will be less severe [120]. If SARS-CoV-2 contains a superantigen, superantigen-like protein or triggers a superantigenic host response, this strategy may prove a grave error. The effect of a superantigen is dependent on dose exposure, genetic predisposition, environmental conditions and immune response [6,7,12,62].
There is evidence the toxic effects of superantigens can be inhibited by specific antibodies but protection conferred seems to depend on antibody titer and exposure dose [121]. Recent evidence of a reduction in MIS-C following vaccination supports the protective role of antibodies in preventing a clinical manifestation of a superantigen or superantigen-like infection [122]; however, in the context of waning antibody titers seen following vaccination against [123] or infection [124] by SARS-CoV-2, and ongoing evolution of the virus [125], the impact of repeat exposure may be unpredictable.

https://www.sciencedaily.com/releases/2021/12/211230130944.htm

https://www.technologyreview.com/2021/04/23/1023438/long-term-covid-antibodies-autoantibodies-immunity-cytokines-lupus/

science people posted:

in the end, Heath thinks that what we call long covid may well turn out to be more than one disorder caused by the initial infection. �For sure, your immune system is activating against something,� he says. �And whether it�s activating itself or not, which is the difference between autoimmune and something else, is an open question. It�s probably different in different people.�

Luning Prak agrees that the cause of long covid may well be different in different patients.

�What could be causing long covid? Well, one possibility is you have viral injury and you have residual damage from that,� she says. �Another possibility is that you have autoimmunity.� She adds, �A third possibility is some type of chronic infection; they just don�t completely clear the virus and it allows the virus to kind of chronically set up shop somehow. That�s a really scary and creepy idea for which we have very little evidence.� And, she says, all three might turn out to be true.

# ? Mar 24, 2022 06:57

Daniel Dales Dick: Apr 8, 2020; �With the coldest winter ever recorded, with snow setting record levels up and down the coast, the Nobel committee should take the Nobel Prize back from Al Gore"

Dr. Furious posted:

This is a gross simplification that ignores how the thymus changes with age, not to mention how individual t cells alter function as they age.

Okay. So what?

# ? Mar 24, 2022 06:58

Tzen: Sep 11, 2001

Zeriel posted:

Just make a script to post this every 6 months from now until COVID takes you.

what are you ta-

lking about

# ? Mar 24, 2022 06:59

Zugzwang: Jan 2, 2005; You have a kind of sick desperation in your laugh.; Ramrod XTreme

Daniel Dales Dick posted:

Okay. So what?

It means they don�t grow back as efficiently as you are suggesting, especially if a person gets reinfected too often

# ? Mar 24, 2022 07:03

Dr. Furious: Jan 11, 2001; KELVIN
My bot don't know nuthin' 'bout no KELVIN

Daniel Dales Dick posted:

Okay. So what?

So your conclusion that depletion of t cells is not a concern is based on poor assumptions about their behavior and thus possibly inaccurate.

# ? Mar 24, 2022 07:04

Real Mean Queen: Jun 2, 2004; Zesty.

Zugzwang posted:

Love that Matty is propping up an �expert� whose analyses are trash-tier (in a field she has no business stepping into, at that) and whose predictions are rarely correct

I hate that �expert� really has become synonymous with �smart-sounding person who says what I want to hear�

Something really cool about America is that our system allows for two flavors of everything. We have a cola that represents classic Americana, and a second one that�s the choice of a new generation, so everybody gets to enjoy a cola!

Similarly, you can have a guy who hates experts, and a guy who loves experts, and they both get to have exactly the number of experts they want telling them not to protect themselves against a pandemic that is fairly likely to injure them permanently.

We have something for everybody!

# ? Mar 24, 2022 07:05

Daniel Dales Dick: Apr 8, 2020; �With the coldest winter ever recorded, with snow setting record levels up and down the coast, the Nobel committee should take the Nobel Prize back from Al Gore"

Zugzwang posted:

It means they don�t grow back as efficiently as you are suggesting, especially if a person gets reinfected too often

It means your immune system gets weaker as you age. No poo poo. And a further no poo poo to my response being a simplification, it was barely two sentences.

# ? Mar 24, 2022 07:05

blatman: May 10, 2009; 14 inc dont mez

just buy more t cells with ur stimulus money

# ? Mar 24, 2022 07:07

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# ? May 30, 2024 14:19

Rutibex: Sep 9, 2001; by Fluffdaddy

mawarannahr posted:

https://twitter.com/krisvancleave/status/1506738115855241216?s=21

why should anyone give a gently caress what airline ceos have to say about international health policy

# ? Mar 24, 2022 07:07

The Something Awful Forums > Archives > Comedy Goldmine > The Goodmine > [COVID] 1 Million! We did it! :toot: :911:

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