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JibbaJabberwocky posted:Okay that makes sense, thanks. The problem is that lab-adjacent jobs will usually want lab experience. Examples are lab manager positions, schedulers, quality oversight roles, etc. If you have technical experience, you may be able to get an in-house technician / calibration role for instrumentation stuff. That's a bit too far away from adjacent I think, but it's possible. Most adjacent roles will want someone who already has experience with the main role, though, so not too good of odds there.
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Sep 12, 2019 20:02
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Superhydrophobicbosssuggestsbutitsatrocious?
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Oct 16, 2019 07:16
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My last sterility failure took nine months to resolve and I'm going to be dealing with the fallout for the rest of my life. 
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Oct 18, 2019 21:18
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My purified water system has no water and industrial water is pouring out of my HEPA filters. Happy loving friday, lab rats.
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Nov 8, 2019 19:53
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I called four of my operators in on a Saturday to manufacture an urgent batch, with some of them driving in from 1.5 hours away (bay area madness), and the formulators loving canceled the batch at 10:15AM once everyone was already here. Way to ruin all their weekends, assholes. At least they get 2X OT Pay for the full day for it.
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Nov 23, 2019 19:31
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Rozzbot posted:Are there any thread recommended reads for people who stumble into a position where they suddenly find themselves responsible for setting up a lab? I initially read this as 100 square feet and was going to ask who the hell you pissed off. 
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Nov 26, 2019 06:41
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Lyon posted:Which LIMS? I get a real kick out of you selling LIMS products to this thread for like ten straight years.
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Dec 22, 2019 13:19
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Today, I had the amazing privilege of meeting with a county fire marshal at work to discuss the matter of our entire facility design not meeting fire code and wondering how we ever got approval for it in the first place.  Long story short: The entire facility is based off of one main corridor that goes in a circle but has ingress and egress controls at opposite ends (dividing it into a controlled-access lab area and an uncontrolled office area), with everything based off of that central corridor. I threw together a rough schematic of our office area / airlock for the purposes of this post...  The airlock in the top left comes out of the controlled lab area. Elevators, of course, are not emergency egress routes. That staircase around the corner is the actual lab emergency egress. Ends up that the people who built our facility forgot that the fire code doesn't just say "thou shalt have 44 inches of clearance," but that it also says "emergency routes may not have anything whatsoever, at all, in their path. Nothing of any sort whatsoever may be stored or placed in an emergency egress corridor." Just below that airlock is our newly-determined emergency egress corridor-kitchen. It isn't wide enough to classify as a room, is in an emergency exit route, and also is classified as a kitchen. It has tables, chairs, a fridge, cabinets, water cooler, plants, sinks, shelves, etc. The dotted-line area where all our materials and mail are dropped off. The bottom area is more shelves, cabinets, printers and a photocopier. That's all hallway technically, and it's all emergency route. That conference room placement? Creates more "hallway" for the cubicle-dwellers south of it. The conference room door open outward and can block their shortest emergency exit. (There are actually more offices on the southwest wall too, but I got lazy and didn't draw them.) That large room in the northern middle? It's a lab area that needs to dispose of laboratory waste and hazardous waste daily. Where's the freight/warehouse elevator (can't take waste in a standard personnel elevator)? It's the one over by that airlock in the northwest corner. You know... the one on the other side of the kitchen. The kitchen that hazardous and laboratory waste aren't allowed to pass through because people eat there. I have to work with our site architects to  In a week or two once we figure out the plan (we get 60 days to fix it before they come back to re-inspect), I get to tell the people on my floor that I'm (probably, barring some sort of exception agreement) ripping out their goddamned break room and copier.
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Jan 16, 2020 04:51
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Snack Bitch posted:Well, it seems that the break room and copier are a glitch in the hallway and you are fixing the glitch. No problem But there's a coffee maker in that glitch! 
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Jan 17, 2020 00:26
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How on earth does a QA site lead not know the difference between a real audit and an annual DEA audit/reconciliation? 
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Mar 14, 2020 21:20
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Shrieking Muppet posted:She thinks QA should be in involved in every little thing we do here, she decided one day to write a SOP for DEA visits, EHS said was a dumb idea, seems they were proven right. A previous episode that came up a few years ago is she wanted to restrict us to one brand of pen in blue or black. This was shouted down by purchasing and the admins who realized they wanted to keep her away from there poo poo as much as possible. If you can get me a job as your site lead, I'll make it my first priority to fire her silly rear end.
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Mar 20, 2020 01:17
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Discendo Vox posted:sounds perfect for Sundae! I'm actually not looking right now, at least not actively. It feels like cheating to job hunt while on 100%-paid paternity leave, and I still do like my job. 
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Mar 20, 2020 21:54
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It'd almost be worth it to see the look on our QA dude's face if I tried to use these in a lab... Original Link: https://sfbay.craigslist.org/eby/tls/d/alameda-calibration-weights-set-7-piece/7144783928.html   The Listing posted:Selling a calibration weight set made of stainless steel with a hard case. The weights are 10 lb x 2 pieces, 5 lb x 1 piece, 2 lb x 2 pieces, 1 lb x 1 piece, 8oz x 1 piece. They are all in good condition. I am researching the value of them at this moment. Sell for best offer at this time. "I have somehow come into possession of a specialized set of calibration weights, but none of the paperwork, and have already ruined them. Here's a photograph of me ruining them. They may be Rice Lake. Here's a transcript of Rice Lake saying they don't sell them in that configuration and there aren't serial numbers where they should be. $399 please."
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Jul 8, 2020 00:24
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Epitope posted:I think the ruining is setting them on the driveway, but my quality level is in the poops > 1 time per day level, so I could be mistaken Here's a larger picture.  Didn't use the handling tool, scratches, bird poo poo (?) on at least one of them, and then tossed them on some concrete for the photograph. quote:I can't see from the pics, but did he steal a set of calibration weights and file off the serial numbers? The serial #'s part confuses me. I've never heard of a weight-set without serials, so if it wasn't him polishing them off, someone did.
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Jul 8, 2020 02:50
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SmellOfPetroleum posted:I work for a medical device company and want to run something by this group. Namely, is there any advice for getting people to reliably follow our GDP SOP? Has anyone been in a company that was bad at it but then turned it around? I worked for a pharmaceutical company with GDP issues under consent decree. Our solution was PIPs and mass firings of people who couldn't handle it.
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Feb 5, 2021 05:53
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RadioPassive posted:If you don't have strong GDP culture, I don't know of a short term solution here. Oh absolutely on the error-detect/review as well. We ended up putting in an enormous oversight aspect too, with a full department of batch record reviewers, etc. We also had a broad re-write of the batch records to try to fix poorly-designed pages, remove unnecessary documentation, make it very clear where things needed documentation, blah blah. If operators still couldn't handle documenting things correctly even after that and after human performance analysis during investigations (tl;dr: assume the system failed the human until proven otherwise), then they got kicked to the curb. We didn't just go "here's the system, you're stuck with it, shape up or ship out." That never works.
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Feb 5, 2021 08:23
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Spikes32 posted:Assuming of course you're not in a dumpster fire pharma company. 
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Feb 24, 2021 01:21
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mllaneza posted:If you end up landing in the Bay Area, look into Genentech, we could use more goons. I have to admit, this company does not suck. That's odd for me to say.
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Mar 24, 2021 05:43
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Shrieking Muppet posted:Idk so far Boston’s public transportation seems pretty awesome Lots of articles, every year since 2014 posted:Runners Narrowly Win Race Against Boston Trolley Yeah, I know it's not quite a fair comparison, but it's a fun story. 
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Mar 30, 2021 00:52
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Pain of Mind posted:I always heard weird things about how Genentech was structured compared to other companies (generally not in a positive light). Then again I have never worked there and I only hear stuff from people that left which might introduce some bias. I recall when I my smallish company shut down in 2007 they brought in the entire company for a mass interview. It probably depends heavily on your department and whether Roche has oversight of you or not, but I can definitely say that Genentech is the best place I've ever worked. Every job sucks compared to whatever else we'd enjoy doing with our time otherwise of course, but I would legit call this a good job.
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Apr 23, 2021 04:50
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mllaneza posted:If I remember correctly, yesterday's all-hands department meeting had 2 15 year, and a 20 year anniversary announced. I've seen 2 or 3 30s in the last 18 months. This part isn't something my group has (I mean, apart from the fact that we're a brand-new group and all new hires in the last 6 years). About 70% of my group is made of contractors on 3-yr terms that I'm not usually allowed to renew. (HR says "you can renew critical contractors for one term" but then when you try, they say "if they were critical, they wouldn't be a contractor.) It's a constant source of conflict between me and my upper management, because I can't run an efficient manufacturing operation when I have to replace the operators every time they finally reach full proficiency in the operations.
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Apr 23, 2021 07:09
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Spikes32 posted:Alright I'm officially job hunting in the bay area / full remote for a LIMS admin position. I already checked out Genetech and didn't see any open positions that matched. If anyone has any other leads I'd love to hear about them. Now I get to try and find a not completely terrible recruiter. Yeah you're not likely to get that at Genentech right now. Roche leadership sent out all kinds of e-mails during the pandemic informing us that no, full-remote would not be acceptable except in very limited cases, so expect to go back into the office when possible.
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May 29, 2021 23:53
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If there are any good pharma forums, I don't know about them. I used to get some info from biofind once in a while, but they've been shuttered for like a decade now. The only other one I know is CafePharma, and it's a shithole so deep you'd think it was a 4chan side-project.
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Jul 9, 2021 18:24
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Shrieking Muppet posted:So my current employer does a regular pipetting and volumetric flask refresher. Failed it, which is annoying but ok I can redo it tomorrow, asked what I did wrong and had this conversation. I have had an auditor ask me to provide clear rationales for how Passing and Failing qualifications were decided in a training program. I want that auditor to visit your facility, and I want to be a fly on the wall during that question.
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Jul 15, 2021 20:56
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I am in a safety presentation right now, where they are telling us about the new "two-handled" doorknobs they're installing. One of them is bright red and is marked "GLOVES ONLY" while the other is normal and reads "NO GLOVES." This was their solution to the fact that they've been trying and failing to get scientists to take their goddamned gloves off before exiting the lab, so they don't get whatever they're working on all over the door handle. I'm waiting for the Q&A session at the end so that I can ask why scientists who can't be bothered to show the minimal decency and care to take three seconds to remove their gloves (or wave their hands at the already-existing motion sensors) are going to give any shits at all about the new handle and change their habits. Edit: They got around this by not doing a Q&A at the end. 
Sundae fucked around with this message at 21:04 on Jul 16, 2021 |
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Jul 16, 2021 18:34
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Matryoshka SexDoll posted:Currently enjoying the 1 year of lab experience required for entry level lab job hellride. How long until I resort to a staffing agency contract job? Like 8 years ago.
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Aug 23, 2022 20:15
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A friend of mine is moving from Alabama to San Diego because the lab head for his PhD got a new role out there and is leaving. He could either start over with someone new (assuming anyone else would pick him up in the existing program), or come with his current lab head/chair to San Diego. They are so under-funded that they couldn't hire movers for the lab. He sent me photos of lab equipment in boxes using his personal clothes as bubble-wrap, etc etc. He's in San Diego now, after literally driving a uHaul with his goods plus the lab's stuff across the country. Academia: Not even once.
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Aug 24, 2022 19:44
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I will continue to make dumb jokes about ramen spectroscopy is and nobody can stop me. quote:Found out today that the third party company that checks our eyewashes has been falsifying records and our eyewashes are not in fact operable. 
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Oct 12, 2022 23:21
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Discendo Vox posted:This particular report is "the facility for some reason believed it would not be inspected and had none of the documentation". Observations 5 and 6 (before you even get to the plainly visible contamination) are describing the total absence of basic required documents. Many of the observations are like that. At a guess, this firm was running the facility to either some domestic or third country spec (or just to whatever they made up) and didn't care about US regs (or thought they had bribed someone to not be inspected). Oh god, I love this one. These are my trainwreck-watching materials, definitely. Edit - So, I was going to do a laymen's summary of this one for the thread, but it's so horrible and glorious and it's loving fourteen pages of INSANE asshattery. I don't have the time to do it justice. Edit #2 - lol this is the Lab Rat thread, not the Corporate thread. You guys don't need a laymen's summary anyway.  For reference, Grade B area is not the cleanest of clean, but it's CLEAN AS gently caress. I do drastically better than this in a Grade E / ISO 8 area. Exposed nails and nail-holes would not cut it for a loving storage room, let alone aseptic filling.     Get hosed, Global Pharma Ltd. Get outright hosed for this next one. They sourced at least one API from another vendor, and then didn't check the material when they got it and relied on the vendor's documentation. You cannot do that, ever. You can't even do that for non-API materials or fillers; at bare minimum you have to do identity (prove it's the right material), and for APIs you have to do far more. I mean, get hosed for almost all of this. Someone should be in prison for the summation of these audit findings, or at bare minimum barred from ever working in a regulated environment again.  This one isn't quite clear, but it probably says [para] "You turned around manufacturing on Equipment A from one product to the next based on cleaning verification you performed on Equipment B."  That's not even getting into all the "holy gently caress, our entire facility shouldn't even count as qualified" stuff in Observation 7 or the deficient QC structures in Observations 8 & 9. Sundae fucked around with this message at 02:23 on May 23, 2023 |
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May 23, 2023 02:18
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mllaneza posted:In the Summer of 2019 we were standing up a new drug manufacturing line. The FDA sent 5 auditors out to spend a week inspecting it. In fairness, we've gone and poo poo ourselves a few times since then. For example, "no hot water available for operators of [redacted] to wash their hands" at multiple sites, the joys of the last three years of cleaning investigations around [redacted third-party contractor]," etc etc. Honestly, I'd expect to see more issues in the future. Our budgets are just getting hosed right now for 2023-2025, and with no backfills planned for attrition over the next 12mo+, things may very well start to slip.
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May 23, 2023 04:44
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mllaneza posted:I just hope none of that poo poo sticks to you. Don't worry - if it does, at least I made sure we have hot water and soap in our building.
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May 23, 2023 05:40
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Can someone smarter than me explain why a tape-measure would be designed to measure in tenths of a foot? This is the second one we've found in our inventory, after (the second time) a part came in not matching up to measurements at all. A six-inch valve is not 0.6 feet, and the tape measure is doing that instead of inches. The engineer who did the measurements missed that the tape measure he pulled out wasn't actually doing inches. I don't understand why this is a thing. Anyone who needed decimal values would surely be using metric system, right? RIGHT? 
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Jun 29, 2023 23:13
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Hey SA Goons, how much should I tip my Medical Laboratory Director?
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Jul 30, 2023 02:58
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pmchem posted:move fast, break things, pretend the FDA doesn't exist You forgot one step: "get acquired before Phase III." That's where all the poo poo inevitably comes tumbling down. You can make anything look feasible until Phase III trials, at which point you'd better have a real product or you're about about to get hosed.
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Feb 15, 2024 21:20
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My current employer has decided, in a recent global quality standard update, to classify electronic pipettes as computerized systems. GMP pipettes now need not only calibration, but qualification, computer systems validation and code review. (I've also been told that a flow hood with an on/off switch with a LED light to indicate whether the unit is on counts as an HMI and therefore a computerized system. I have to validate the On/Off switch and review its non-existent code.) I'm loving every second of this, I tell ya. Sundae: "Consumer off-the-shelf (COTS) pipettes do not have accessible source code to review. This requirement is not applicable." QA: "Rejected. Source code review is mandatory for computerized systems." Sundae: "This is not a computer." QA: "Yes it is. It has a display that changes a number in response to your input. That is a HMI and therefore meets the requirements as a computer." Sundae fucked around with this message at 18:33 on May 5, 2024 |
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May 5, 2024 18:30
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| # ¿ May 22, 2024 11:17 |
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crabrock posted:here, chat GPT made this for you. I helpfully had it send a slack message every time you eject a tip to notify the people who are bugging you.  This is absolutely beautiful.
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May 6, 2024 00:39
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