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The story revolves around three teenagers: Nomiya Tomomi, a high school dropout; Togawa Kiyoharu, an ex-sprinter who now plays wheelchair basketball; and Takahashi Hisanobu, a popular leader of the high school's basketball team who now finds himself a paraplegic after an accident.
Real features a cast of characters who find themselves being marginalized by society, but are all united by one common feature: a desire to play basketball, with no place to play it in. Nomiya, being a high school dropout, has no future in his life. Togawa, being a difficult personality, finds himself constantly feuding with his own teammates. Takahashi, once a popular team leader, now finds himself being unable to move from the chest down.
Real also deals with the reality of physical disabilities, and the psychological inferiority that the characters struggle against. The characters break through their own psychological barriers bit by bit.