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Albino Squirrel posted:Heroin is only about 2.5x as strong as morphine; hydromorphone is 5x as strong and we use that all the time. There's nothing wrong with diacetylmorphine as a molecule, relative to other opioids; any objection to it is more about the optics than anything else. That being said, the optics are bad enough that I don't like the option of prescription heroin when hydromorphone exists, and it's a drug that physicians are much more familiar with. It does have some clinical advantages over the slower acting opioids, as per that study regarding intranasal admission in children. It is always good if physicians are more familiar with the drug, as opposed to just believing what's in the pharmacy rep presentation, but lol fucken oxycodone. There's probably less risk of that happening with diamorphine because it's so generic.
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Apr 20, 2017 15:08
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| # ¿ May 15, 2024 07:54 |
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Childhood trauma is the pile of kindling, economic inequality is the oxygen, and government policy was the match. Which makes prescription opioids the chemical chain reaction being as we seem to have fire tetrahedrons now. Which is apt.
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Apr 21, 2017 00:34
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Isn't diacetylnalorphine also a pretty potent and fast-acting opioid antagonist, stronger than naloxone without the agonist effects of diprenorphine? With the disadvantage that we mostly know jack poo poo about it other than it once being considered by the British Pharmacopoeia for overdose and then not.
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May 13, 2017 00:06
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sea of losers posted:honestly i dont think that was the sole reason they went away like the DEA loves to say. benzodiazepines were becoming more commonplace, were safer, and fulfilled the same function that mandrax did, and i think that has more to do with it. ergotamine is heavily controlled but LSD still gets made.
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May 26, 2017 00:52
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The most likely scenario is that someone got hold of one of those imported reciprocating single punch pill presses that charge from a metal horn and didn't do their powder premix properly, leading to a bunch of pills that are mostly filler and a bunch that are unfortunately mostly not.
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Feb 21, 2018 14:43
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Yeah, that's what I'm thinking. Fentanyl was what they had, along with a press that's more suited to dosing something like MDMA or amphetamine. So they has x grams of fentanyl, wanted to make y pills of z mg each, threw in about the right amount of filler to make a bunch of reasonably strong pills, and ran a bad press so most of the fent ended up in a handful of ridiculously dosed pills instead of throughout the batch. It's happened before with some of the high potency RCs.
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Feb 21, 2018 15:08
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They blocked offering any form of heroin/diamorphine to new patients, it's only the ones who were grandfathered in after clinics like John Marks' were shut down (allegedly due to some pressure from the US DEA). There are calls to reallow medical heroin where methadone keeps failing, but I don't know how far along that is. This might be the article that you were thinking of for the low number of UK heroin addicts in the 50s. It's worth noting that there were a fair few more problem users of morphine and naturally occurring opiates at the time, but still overall low compared to post war on drugs.
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Aug 31, 2018 17:54
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It's the "British System" of leaving the decision of whether to substitute, taper, or maintain with prescription diamorphine to doctors and patients, rather than cops or judges, except the British don't do that anymore because the DEA kept leaning on the government and because one doctor in London was abusing it which gave a convenient excuse to shut down the whole thing.
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Dec 2, 2018 16:54
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GreyjoyBastard posted:your sentences seem to be full of words, and they're individually comprehensible, but ??? "How not to get arrested while prescribing opioids!" is a loving weird thing to be teaching doctors. "How to prescribe opioids responsibly and without prejudice" should be what we're teaching doctors, and "how not to arrest doctors or patients when they're prescribing/prescribed opioids" should be what we're teaching law enforcement. Also there should be safe injecting spaces and harm reduction shouldn't be focused around brand names but around generics that work like diamorphine.
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Apr 3, 2019 08:31
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Also they've got the 'Trainspotting Generation' of people who started using in the 80s who are getting into their 50s and 60s now and just keeling over from the chronic effects of hepatitis and polydrug use (also poverty and austerity).quote:Robertson is currently working on a report that follows his original cohort of drug users 30 years on, which will be published next year. His previous studies have shown that one in four had died, almost entirely for reasons linked to long-term drug use, and others were suffering from the effects of hepatitis C and liver and lung disease. One in three was still injecting heroin and two-thirds were on methadone. Less than one in five had come off drugs and of the survivors, most were living in social housing, on benefits or working in low paid jobs.
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Jul 18, 2019 17:26
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