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I think murdering a dog has greatly increased her chances of being Trump's VP pick, for a variety of reasons
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Apr 26, 2024 15:23
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Speaking of Biden's fairly rare sit-down interviews: Biden is doing his first live sit-down interview since March 9th right now. This was previously unannounced and just started about 6 minutes ago. Probably not going to make the NYT happy. https://twitter.com/seungminkim/status/1783861443244208593
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Apr 26, 2024 15:23
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Leon Trotsky 2012 posted:Speaking of Biden's fairly rare sit-down interviews: BABA BOOEY BABA BIDEN
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Apr 26, 2024 15:25
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Really excited about NYT getting so mercilessly dunked on
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Apr 26, 2024 15:28
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Failed Imagineer posted:BABA BOOEY BABA BIDEN Baba Booey indeed made it all happen. Unclear if Biden will ride the sybian or show nips during the hour-long interview. https://twitter.com/KThomasDC/status/1783863590530818360
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Apr 26, 2024 15:29
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Leon Trotsky 2012 posted:Baba Booey indeed made it all happen. Incredible. Pretty sure Joe wouldn't survive the Sybian
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Apr 26, 2024 15:30
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Tiny Timbs posted:Really excited about NYT getting so mercilessly dunked on Sulzberger is going to stroke out
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Apr 26, 2024 15:33
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haveblue posted:The difference is that Romney's story is one dumb decision that stressed out the dog for a time and Noem's story is the sort of thing you'd submit when seeking approval for a 5150 hold The dog also got its revenge by spraying diarrhea all over Mitt's car.
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Apr 26, 2024 15:33
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https://x.com/_waleedshahid/status/1783852614012084476 Normal advocacy, definitely not reminiscent of trying to build a blacklist; an explicit call from the ADL and others to bring the weight of the American surveillance apparatus down on teens for opposing a genocide.
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Apr 26, 2024 15:37
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Oil! posted:The dog also got its revenge by spraying diarrhea all over Mitt's car. good dog
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Apr 26, 2024 15:37
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selec posted:https://x.com/_waleedshahid/status/1783852614012084476 That is a letter from 3 weeks ago, before the recent protests, from when they were debating the FISA bill. It says that they support adding privacy protections and reauthorizing the 702 program because American Jews were the targets of foreign terrorist activities. It has nothing to do with teens, Americans, or the current protests.
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Apr 26, 2024 15:40
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Leon Trotsky 2012 posted:That is a letter from 3 weeks ago, before the recent protests, from when they were debating the FISA bill. It’s still attempting to paint protest after 10/7 as being a foreign incursion, it’s still a request that applies exactly as I’ve described it, unless you think the ADL has pivoted since the campus protests began and agree these are just kids carrying out their first amendment protected activities? This is absolutely how they still feel and what they think should happen. (USER WAS PUT ON PROBATION FOR THIS POST)
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Apr 26, 2024 15:43
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selec posted:It’s still attempting to paint protest after 10/7 as being a foreign incursion, it’s still a request that applies exactly as I’ve described it, unless you think the ADL has pivoted since the campus protests began and agree these are just kids carrying out their first amendment protected activities? It is explicitly not about US student protests, which happened after the letter was released, and they don't call for surveilling American teens as the original tweet claimed. This is another situation where you can believe that the Union of Orthodox Jewish Congregations, the Jewish Women's Organization, and the ADL in their hearts truly want to create a blacklist to imprison American teens, but that is not factually what the tweet says and they are definitely not making an "explicit call from the ADL and others to bring the weight of the American surveillance apparatus down on teens for opposing a genocide." Maybe they secretly do want all of that, but the tweet and that quote are factually wrong that they are explicitly calling for a mass spying program on American teens. I just feel like we need to live on the same factual universe to have a conversation about stuff. Here is the full picture of the letter with the date: 
Leon Trotsky 2012 fucked around with this message at 15:58 on Apr 26, 2024 |
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Apr 26, 2024 15:53
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Leon Trotsky 2012 posted:He's not press hostile in a way that Trump is, but he is very averse to one-on-one interviews and access. He gives very few sit-down interviews, doesn't have a reporter embedded in the White House/campaign, strongly opposes leaking things to the press for stories because he wants staff to hash it out in private, and generally only addresses the press once a day at the morning gaggle + whenever they have a big press conference. I'd be willing to bet part of this is simply whiplash from the Trump years - multiple journalists have bemoaned the fact that Trump's term was basically a rollercoaster of news, with at least one notable event each week. Biden's term has been outright sedate in comparison. I am kind of curious though, did he give many interviews as a senator or a VP under Obama? Is his lack of interviews a new behavior, or a continuation of an old one?
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Apr 26, 2024 15:58
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What a psycho, "I kill any creature that inconveniences me." The dog is acting like an untrained dog and goats are going to do goat things.
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Apr 26, 2024 15:59
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Shooting Blanks posted:I'd be willing to bet part of this is simply whiplash from the Trump years - multiple journalists have bemoaned the fact that Trump's term was basically a rollercoaster of news, with at least one notable event each week. Biden's term has been outright sedate in comparison. I am kind of curious though, did he give many interviews as a senator or a VP under Obama? Is his lack of interviews a new behavior, or a continuation of an old one? He did not give many sit-down interviews as VP either, but the President is also a different job with different expectations than the VP.
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Apr 26, 2024 16:00
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selec posted:It’s still attempting to paint protest after 10/7 as being a foreign incursion, it’s still a request that applies exactly as I’ve described it, unless you think the ADL has pivoted since the campus protests began and agree these are just kids carrying out their first amendment protected activities? the ADL has definitely shown its own rear end recently with declaring pro-palestine jews as race traitors... but you can just post them doing that. the letter is real weak. the letter mentions 'indications of foreign involvement in domestic antisemitic incidents', which is the only thing that even vaguely supports the tweet. but the letter also applauds a '93% reduction in fisa inquiries against US persons under Biden', which is fairly contradictory to the notion that it supports a dramatic increase in domestic surveillance.
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Apr 26, 2024 16:02
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Psawhn posted:NYT Obama hated Maureen Dowd too. https://www.vox.com/2015/2/11/8019227/obama-maureen-dowd-axelrod I think that’s a large portion of this, nobody likes Dowd.
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Apr 26, 2024 16:33
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Bar Ran Dun posted:Obama hated Maureen Dowd too. You have to put this in context, though. Obama’s favorite pundit that he was always trying to impress? David Brooks. Biden? Joe Scarborough. We’ve been so cooked for so long.
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Apr 26, 2024 16:35
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The first publicly available gene therapy treatment procedures in the U.S. will become available this year. This gene therapy for a rare type of hemophilia is the second ever FDA-approved gene therapy treatment. Another gene therapy treatment for treating a specific form of sickle cell is also becoming available in 2024. These gene therapy techniques require only a single dose to treat the disease, but how long that dose lasts is still an open question. In clinical tests it has lasted for over a year, but they will be monitoring the impact on patients for the next 15 years for study. The process has a 60% success rate at fully curing hemophilia. The process has a list price of $3.5 million wholesale, but it isn't clear how much it would actually cost the average patient. https://twitter.com/Reuters/status/1783842256060899815 quote:US FDA approves Pfizer's gene therapy for rare bleeding disorder
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Apr 26, 2024 16:44
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Leon Trotsky 2012 posted:The process has a list price of $3.5 million wholesale, but it isn't clear how much it would actually cost the average patient. Given how American healthcare works, I'd estimate about $10M.
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Apr 26, 2024 16:50
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are talking about protest stuff, reminder to have good tech sec. , if youre going to bring your actually personal device, atleast switch away from biometric locks to a password. if you want to go tinhat, maybe buy a burner phone and stuff.
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Apr 26, 2024 16:54
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CellBlock posted:Given how American healthcare works, I'd estimate about $10M. "First the good news, we've created a drug that can completely cure hemophilia. The bad news: it only requires a single dose."
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Apr 26, 2024 16:55
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Leon Trotsky 2012 posted:Speaking of Biden's fairly rare sit-down interviews: I wonder if this was conceived to specifically get under Trump’s skin, considering how Trump used to be a regular guest on Stern but AFAIK Stern basically trashes him on the air all the time now.
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Apr 26, 2024 16:58
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The Biden administration released new Title IX regulations governing all public school or schools that receive federal funds in the country. The main changes: - Removes a Trump-era rule that required students who claimed to be raped to make themselves available to be cross examined by the person they accused. - Previously, schools were only required to investigate sexual harassment claims that were made through a formal process and met a certain degree of criminal seriousness. Now, they will have to investigate when they are made aware regardless of whether the victim filed a formal report. - Lifts a ban on schools investigating accusations of rape or sexual assault that happened off campus. - Attempts to make transgender students use the bathroom of a gender they don't identify with are considered federal civil rights violations. - Schools cannot require teachers to use the birth name or pronoun of a transgender person if they have a different identity. - All federal requirements for sex discrimination also apply to LGBT students. Florida says it will not comply with the new rules and could lose federal education funding. If Florida does not comply, then they could lose the 13.9% of their annual education budget that comes from the federal government. The rules go into effect in August and Florida has until then to make a final decision. https://twitter.com/thehill/status/1783797190734852338 quote:Florida Gov. Ron DeSantis (R) said Thursday his state “will not comply” with recently unveiled changes to Title IX by the Biden administration.
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Apr 26, 2024 17:01
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Seems wild that in 2024 someone could unironically say, "I have my gene therapy appointment later today, the artificial intelligence that lives in my watch is setting a calendar reminder and analyzing the best route there, and I am plugging the coordinates into my self-driving car. Also, my phone with 2,600x the processing power of the computer that put a man on the moon is functionally useless as a phone and I never answer any calls."
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Apr 26, 2024 17:14
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Well actually, Saburo Arasaka could have oh poo poo, wrong thread, sorry. I'm interested to see how Florida resolves this, since they're allergic to raising taxes to fund education.
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Apr 26, 2024 17:21
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Leon Trotsky 2012 posted:Seems wild that in 2024 someone could unironically say, "I have my gene therapy appointment later today, the artificial intelligence that lives in my watch is setting a calendar reminder and analyzing the best route there, and I am plugging the coordinates into my self-driving car. Also, my phone with 2,600x the processing power of the computer that put a man on the moon is functionally useless as a phone and I never answer any calls." I’m currently playing a game on my phone that I couldn’t install on my computer 25 years ago because it wasn’t powerful enough.
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Apr 26, 2024 17:25
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Leon Trotsky 2012 posted:The first publicly available gene therapy treatment procedures in the U.S. will become available this year. Zolgensma has been available in the US since 2019 - for spinal muscular atrophy in infants . It costs about $2m for the single treatment. Luxturna I think was even earlier - 2017-18, and is a retinal gene therapy that costs about $500k and prevents a form of degenerative blindness. With these therapies, the headline price is usually what the payers end up paying.
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Apr 26, 2024 17:26
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Halloween Jack posted:Well actually, Saburo Arasaka could have oh poo poo, wrong thread, sorry. They have no state income tax and property taxes are set at the county level. It is either going to be up to local counties to raise the money or they will just find a way to get by with 13.9% less money. Since they aren't in compliance with Title IX anymore, then they can shutdown the "money losing" sports programs. My guess is they do a patchwork of cutting spending to public colleges, making local governments cover some of it, eliminating some non-education sports or afterschool programs, and then just eating whatever the remaining gap is with budget cuts.
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Apr 26, 2024 17:30
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Halloween Jack posted:I'm interested to see how Florida resolves this, since they're allergic to raising taxes to fund education. Vouchers for private education
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Apr 26, 2024 17:32
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Failed Imagineer posted:Zolgensma has been available in the US since 2019 - for spinal muscular atrophy in infants . It costs about $2m for the single treatment. You are correct. I misread "the second such therapy" as being the second gene therapy, but they meant the second gene therapy specifically for this type of hemophilia. There are no manufacturer discount programs or any insurance coverage? That would make gene therapy the one thing in American healthcare where the sticker price is the actual real price. I'm wondering who has $3.5 million in cash for out of pocket spending for treatment.
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Apr 26, 2024 17:33
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Leon Trotsky 2012 posted:
By payers I mean usually the insurer or similar, not the patient.
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Apr 26, 2024 17:34
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Failed Imagineer posted:By payers I mean usually the insurer or similar, not the patient. Ah, okay. They list the wholesale price in the article, but no indication on what the average cost is for a patient. Google doesn't seem to have a good estimate either.
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Apr 26, 2024 17:36
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Leon Trotsky 2012 posted:You are correct. I misread "the second such therapy" as being the second gene therapy, but they meant the second gene therapy specifically for this type of hemophilia. After forking over the 3.5 mil you'll have nothing left to bleed out 
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Apr 26, 2024 17:36
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Halloween Jack posted:Well actually, Saburo Arasaka could have oh poo poo, wrong thread, sorry. Resolves what? Cutting funding for public education is the goal
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Apr 26, 2024 17:37
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Aztec Galactus posted:Resolves what? Cutting funding for public education is the goal Usually, they want to cut it to fund tax cuts or vouchers for private education. Most of them probably don't have the goal of just losing 13.9% of the money for nothing. They could accomplish that by just adding a new fire pit section of the budget where they throw in 13.9% of education funding each year.
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Apr 26, 2024 17:40
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Leon Trotsky 2012 posted:Ah, okay. They list the wholesale price in the article, but no indication on what the average cost is for a patient. Google doesn't seem to have a good estimate either. I would assume that one just immediately hits their out of pocket maximum. A few of these gene therapies only charge if it works, which is kind of interesting. I would be pretty interested to see the costs on this if they were operating as a non-profit and just covering costs and R&D. I work too much earlier in the process of drug discovery (not in gene therapy either) to really have a handle on the total costs of programs like this. But I do have some insight into the work involved for each patient and the overall development and these therapies are huge projects and many of these gene therapies have limited patient populations.
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Apr 26, 2024 17:41
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Kagrenak posted:I would assume that one just immediately hits their out of pocket maximum. I work on clinical development of a therapy in the C&G space. It took 6 years after FDA approval to achieve profitability.
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Apr 26, 2024 17:45
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Also, to be fair to Florida, they won't lose all 13.9% of that money. Some of that federal money is for school lunches or special education that won't get taken away for being out of compliance with Title IX. It will still be somewhere around 10% of their current education budget that they could lose, though.
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Apr 26, 2024 17:46
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