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Halloween Liker posted:if everyone uses the reporting app wont everyone have to stay at home for 14 days The CDC changed their recommendation for self quarantine from 14 to 10 days - but not because science supported the change, but because they hoped that more people might at least *try* to quarantine if they reduced it..
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Feb 16, 2021 21:10
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Ah, just like last year, this thread is still bad.
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Feb 16, 2021 21:12
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Salt Fish posted:Yeah, it probably will be. I think obsessing over every base pair mutation is really unhealthy. Ultimately covid mutates quite slowly compared to other common viruses like influenza. Being plugged into social media streams of our modern genetic sequencing technology isn't really that helpful to understanding what is happening. There too much context missing. While it's true that controlling the spread of covid is important to reduce mutation potential, we already knew that right? You're kind of missing the point. Right now I'm trying to understand the relative risk and if it's worth pushing harder to get this trip cancelled. With the CURRENT vaccine efficacy data against this new variant probably months away, combined with the efficacy information for the B variant being significantly reduced (half or less, judging by the Balazs lab graph) it's a really hard call to make. Obviously updated vaccines will have to be produced, as you pointed out, but that doesn't really help with my current dilemma.
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Feb 16, 2021 21:14
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Genderfluent posted:Agreed. The hype over these mutations is out of control. Yes, there are obviously some variants which are concerning with respect to vaccine efficacy, but there is no evidence for many of these emerging variants being worse. We all need to be responsible to make sure that we are taking COVID seriously, but not living in fear because of some 1 base pair mutation on a virus. You seem like an ill informed dipshit, given that E484K, 452L and N501Y and other minor mutations are showing up in increasingly difficult to manage variants. All have dire negative consequences (in terms of either infectiousness or leathality and sometimes both) and are capable of rapidly spreading. Even lovely news is carrying the story about the California variant, but only weeks after it was discovered and documented. That is several doubling intervals of a very likely VOC which hardly anyone knew about. This idea of "being responsible but not living in fear" is the worst kind of ignorant handwaving bullshit. Understanding and evaluating risks is not "living in fear" and being responsible is not blowing poo poo off before you even understand the risks.
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Feb 16, 2021 21:20
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Genderfluent posted:Agreed. The hype over these mutations is out of control. Yes, there are obviously some variants which are concerning with respect to vaccine efficacy, but there is no evidence for many of these emerging variants being worse. We all need to be responsible to make sure that we are taking COVID seriously, but not living in fear because of some 1 base pair mutation on a virus. If you read the paper (and someone correct me if I'm wrong) it sounds like the A variant has managed to overtake all the other variants, including the one out of SA, within 1-2 months. That level of infectiousness is concerning, to say the least.
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Feb 16, 2021 21:38
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Blitter posted:You seem like an ill informed dipshit, given that E484K, 452L and N501Y and other minor mutations are showing up in increasingly difficult to manage variants. All have dire negative consequences (in terms of either infectiousness or leathality and sometimes both) and are capable of rapidly spreading. Even lovely news is carrying the story about the California variant, but only weeks after it was discovered and documented. That is several doubling intervals of a very likely VOC which hardly anyone knew about. Scrolling through twitter for preprints about mutations isn't "understanding and evaluating risks". We're in a really bad situation where you can't trust any messaging from the government health authorities, I mean, if they were even trying to have messaging, so I get it, but at the same time its not meaningful information in the way you're implying either.
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Feb 16, 2021 21:53
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Not every variant is concerning. Some of them are. They are generally not widespread enough to be a threat to you, personally, but chances are that your government isn’t doing anything to stop them, so one day they will be.
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Feb 16, 2021 21:59
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Salt Fish posted:Scrolling through twitter for preprints about mutations isn't "understanding and evaluating risks". We're in a really bad situation where you can't trust any messaging from the government health authorities, I mean, if they were even trying to have messaging, so I get it, but at the same time its not meaningful information in the way you're implying either. C'mon man, I'm not saying to "assess your local risks based on pre-prints" but if i lived in Santa Clara and found out that there was a local variant spreading faster than normal with similar mutations as b.1.1.7 I think its possible to draw your own conclusions, instead of waiting weeks for some lovely media to publish a story. It's hosed up that nobody in the states is getting any kind of timely or valid guidance. There are a lot of reasons why the US with 4% of the world population has loving 20% of the deaths and ignorance is loving high on that list.
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Feb 16, 2021 22:21
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The hosed up part is peole who are in line to be vaccinated around late summer will probably get the current vaccines that will then be impotent against the then predominant variants. And we will start all over with a new vaccine version. But some people will always be behind because we can't jab everyone fast enough. And currently those peoole are the youngish ones.
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Feb 16, 2021 23:41
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Aaaaaaaaannnnnnddddd... we’re waiting for COVID test results for kiddo. Sniffles Friday, 99 fever on sat, cough thru today. Probably just a cold. Probably.
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Feb 16, 2021 23:49
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Forgot, very much recommend the new oral test. Nothing to it.
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Feb 16, 2021 23:50
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Hopper posted:The hosed up part is peole who are in line to be vaccinated around late summer will probably get the current vaccines that will then be impotent against the then predominant variants. I haven't seen anything to suggest that non-AZ vaccines are "impotent" against any of the variants
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Feb 17, 2021 00:19
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First day testing my Northwell 7700 respirator. Looks fairly apoc-fashion but the bright purple colors kind of ruin the look. Filtration is pretty incredible, I walked right past a car exhaust and couldn't even smell the smog, seemed like normal(slightly cold) air. It's uncomfortable around the nose area, don't know if I fit it wrong. It's a hassle to wear it with normal prescription glasses, they don't fit well on top of the nose, kinda trying to put them in the inner section of the resp but overall uncomfortable. Would be much better without glasses. I'll have to alternate days between this and a regular surgical mask - need to get used to it, I suspect my nose is going to be very sore tomorrow. Also apparently I need to disinfect them every day? It's kind of a hassle. I bought some 3M respirator wipes for this. I can wear a face shield on top, and I am. It stops just over the filters, but it covers my eyes. Overkill? Who cares. Best part of this is getting looks from idiots not wearing their masks. Maybe it will light a bulb in their dim dumb brain.
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Feb 17, 2021 00:50
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mrfart posted:Another loving thing to be embarrassed about as a Belgian. Isn't Pfizer making vaccines out of Belgium or something Big lol, if true
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Feb 17, 2021 00:52
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Blitter posted:You seem like an ill informed dipshit, given that E484K, 452L and N501Y and other minor mutations are showing up in increasingly difficult to manage variants. All have dire negative consequences (in terms of either infectiousness or leathality and sometimes both) and are capable of rapidly spreading. Even lovely news is carrying the story about the California variant, but only weeks after it was discovered and documented. That is several doubling intervals of a very likely VOC which hardly anyone knew about. I'm a scientist working in microbiology/aerosols. I understand the risks completely, but I also feel like there is going to be a lot of fatigue now that significant genomic profiling is going on and catching these variants. The fact that these variants are around has zero impact on my day-to-day life. I still wear my N95 mask out in public and take precautions to avoid illness, as I have been doing since March. Being a doomer about everything is not very productive. I accept that certain variants are concerning with respect to vaccine efficacy, but I also believe, especially with mRNA vaccine technology, that there is a path forward to overcome this. I think these issues are very important to virologists and others in the field, but I'm not sure that there is much advantage to the public taking in this data without context.
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Feb 17, 2021 01:17
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Comfy Fleece Sweater posted:Isn't Pfizer making vaccines out of Belgium or something they should have chosen a larger country to make it out of, they're going to run out of belgium soon Mozi fucked around with this message at 01:36 on Feb 17, 2021 |
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Feb 17, 2021 01:30
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If Pfizer doesn’t meet the vaccine quota, it’s going to coat them a hand.
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Feb 17, 2021 01:33
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Mozi posted:they should have chosen a larger country to make it out of, they're going to run out of beligum soon 
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Feb 17, 2021 01:36
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Mozi posted:they should have chosen a larger country to make it out of, they're going to run out of belgium soon They doing them in Kalamazoo, Michigan, USA as well.
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Feb 17, 2021 01:40
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Comfy Fleece Sweater posted:Isn't Pfizer making vaccines out of Belgium or something Not only Pfizer, but one the biggest reasons cited for the AstraZeneca vaccine shortfall in the EU is issues with the lab in Belgium that they were partnering with to produce them. Poor Belgium just cant stay out of the news. While the details of the contract aren't known, it's likely that the UK signed the big AZ contract early in 2020 on the basis that AZ had to prioritise vaccines produced on UK soil for the UK contract.
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Feb 17, 2021 01:41
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Genderfluent posted:I'm a scientist working in microbiology/aerosols. I understand the risks completely, but I also feel like there is going to be a lot of fatigue now that significant genomic profiling is going on and catching these variants. The fact that these variants are around has zero impact on my day-to-day life. I still wear my N95 mask out in public and take precautions to avoid illness, as I have been doing since March. Being a doomer about everything is not very productive. I accept that certain variants are concerning with respect to vaccine efficacy, but I also believe, especially with mRNA vaccine technology, that there is a path forward to overcome this. I think these issues are very important to virologists and others in the field, but I'm not sure that there is much advantage to the public taking in this data without context. This particular variant is having a huge impact on mine, and has the potential to change the ability of vaccinated people to move around in COVID-saturated areas. Just because you're not personally affected doesn't mean it's not important.
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Feb 17, 2021 02:28
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I love it when someone steps up on a forum and it turns out the guy they’re arguing with is an actual expert in that specific field. What a world
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Feb 17, 2021 02:44
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compshateme85 posted:This particular variant is having a huge impact on mine, and has the potential to change the ability of vaccinated people to move around in COVID-saturated areas. do you have any proof of this or are you just doomposting
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Feb 17, 2021 03:08
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Bape Culture posted:I love it when someone steps up on a forum and it turns out the guy they’re arguing with is an actual expert in that specific field. What a world Microbiology/aerosols is not an expert in virology, infectious disease, or epidemiology. I have an MS in neuroscience, but I know jack poo poo about like, alzheimers. Genderfluent didn't post any data in support of what they are saying, it was a lot of "I feel" and "I believe". I too believe that we will eventually get ahead of it, however that doesn't help my particular situation which is being greatly impacted by what's going on with the variants right now. Genderfluent, if you are studying viruses being transmitted by aerosols, or any of the above, I apologize, but I would also like to see data backing up what you are saying.
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Feb 17, 2021 03:11
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I think being sick is bad, and we should try to be not that. My backup data is that pissing from my rear end is suboptimal.
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Feb 17, 2021 03:17
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Comfy Fleece Sweater posted:Isn't Pfizer making vaccines out of Belgium or something Inactive Ingredients: Belgium.
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Feb 17, 2021 03:27
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Inept posted:do you have any proof of this or are you just doomposting From last page: Platystemon posted:It’s pretty impressive that B.1.351 manages to evade the antibodies induced by mRNA vaccines better than even the original SARS. But I guess it's a pre print, no need to say, consider how this might change your risk assessment after you get vaccinated, especially if you have to travel .. or if you are in the US. Media and government are not going to keep you well informed, but hey can't be a doomer, right?
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Feb 17, 2021 06:17
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Blitter posted:From last page: That’s the South African variant. Other poster is posting about some Ugandan variant for some trip they have coming up.
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Feb 17, 2021 06:24
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Inept posted:That’s the South African variant. Other poster is posting about some Ugandan variant for some trip they have coming up. Right, so a significant spike mutation with a very real potential of being similar in aiding escape as the E484K in the SA variant. Bear in mind the A.23.1 lineage just gained the E484K in liverpool the other week, something that has also happened elsewhere. Do you think that warrants caution? https://www.medrxiv.org/content/10.1101/2021.02.08.21251393v1.full.pdf posted:The novel sub-lineage (A.23.1) reported here encodes multiple spike, nsp6, ORF8 and ORF9 protein changes, and some of the replacements are predicted to be functionally similar to those observed inlineage B VOCs Naah, there is no definitive evidence yet, so best just to ignore it. Blitter fucked around with this message at 06:49 on Feb 17, 2021 |
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Feb 17, 2021 06:38
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Platystemon posted:Not every variant is concerning. Yeah there's thousands and thousands of identified variations floating around, but most of them are still similar enough to the original "wild type" SARS-CoV-2 that they're pretty much the same in layman's terms. There's a bunch of worrying mutations that have been occurring in certain strains, and then you've got the strains which combine several of the worrisome mutations together. 501Y.V1 is the UK B.1.1.7 strain, 501Y.V2 is the South Africa B.1.351 strain and 501Y.V3 is the Brazil P.1 strain. The UK strain has a hell of a foothold in the US already:  https://nextstrain.org/ncov/global Genderfluent posted:I'm a scientist working in microbiology/aerosols. I understand the risks completely, but I also feel like there is going to be a lot of fatigue now that significant genomic profiling is going on and catching these variants. The US is sequencing less than half a percent of their cases, a lot of the talk about the strains in the US and how widely they've spread is guesswork and extrapolation 
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Feb 17, 2021 07:06
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Just had an aunt and uncle test positive 3 weeks after Pfizer dose 1. No clue where they picked it up as they've been doing all the right things since last March. I know you don't get to 95% protection until two weeks after dose two, but this still seems like pretty bad luck.
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Feb 17, 2021 07:54
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Lester Shy posted:Just had an aunt and uncle test positive 3 weeks after Pfizer dose 1. No clue where they picked it up as they've been doing all the right things since last March. I know you don't get to 95% protection until two weeks after dose two, but this still seems like pretty bad luck. Symptomatic? Age?
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Feb 17, 2021 07:59
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In person shopping in a cloth or surgical mask?
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Feb 17, 2021 08:04
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Woodsy Owl posted:Symptomatic? Age? Mild flu-like symptoms. 78/80. SchnorkIes posted:In person shopping in a cloth or surgical mask? AFAIK they do grocery pickup and zero social calls, but they have all the requisite doctor visits and medical procedures that come with being that age.
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Feb 17, 2021 08:09
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Late Fees posted:I haven't seen anything to suggest that non-AZ vaccines are "impotent" against any of the variants Not yet, that is in part me speculating about what's coming next. And in part because guess what Germany is planning on giving people under 60? After everybody 60+ is vaccinated, which they want to achieve by June. Of course they will use all 3 vaccines, but we don't get to chose which one we want. We already have seen the start of an argument not to vaccinate doctors and nurses with AZ because they are in contact with too many infected and the reduced efficacy is not good enough - which is a good argument - followed by "but it should be good enough for young people with less risk contacts" which is a dicey argument given the fact that the SA variant is at our doorstep already and we even closed some borders to keep it out. Which will totally work of course. Give it 6 months and I bet we will find at least 2 more new fun variants some vaccine has "reduced" usefulness against. It would appear those people saying "it is just the flu" were right in a way, only not about the "just" but about the fact that the virus is going to need modified vaccines every "season".
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Feb 17, 2021 08:37
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Comfy Fleece Sweater posted:First day testing my Northwell 7700 respirator. Looks fairly apoc-fashion but the bright purple colors kind of ruin the look.
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Feb 17, 2021 15:08
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USA just hit a half mill deaths on worldometers https://www.worldometers.info/coronavirus/country/us/
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Feb 17, 2021 15:12
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CSM posted:What's the point though, why not wear ordinary facemasks? Do these kind or respirators even protect others? Facemask type respirators with valves don't. But I guess this is something different? Because normal face masks do not protect the wearer as well as respirators do. And you yourself are the only one who gives a poo poo about you and will protect you, that much is clear by now.
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Feb 17, 2021 15:26
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Also the valves seemingly protect others as well as a cloth mask which is unfortunately the bar in the US
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Feb 17, 2021 15:40
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Snowglobe of Doom posted:USA just hit a half mill deaths on worldometers 
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