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Mr. Nice! posted:didn’t a study just drop today that moderna is still like 80% effective for breakthroughs against delta and most breakthroughs are pfizer people? what about the jannsen junkies
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Aug 11, 2021 19:54
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Mr. Nice! posted:didn’t a study just drop today that moderna is still like 80% effective for breakthroughs against delta and most breakthroughs are pfizer people? no it found pfizer about 76% effective. both vaccines are more or less identical, it's just that moderna has a slightly larger dose of the same juice but your takeaway from the moderna data should be that the vaccines are waning and nothing is safe right now when transmission is high. not a loving restaurant meal, not a "we'll just have the parents and family over for dinner (safely)", etc. vaccinated people are spreading. vaccinated people are getting sick. vaccinated people are not as protected as they think and they act they are. past about six months consider yourself totally unvaccinated again and act appropriately
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Aug 11, 2021 19:55
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Can't believe how much we hosed up the vaccine opportunity lol. This could all be over for realStevie Lee posted:what about the jannsen junkies They need prayers
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Aug 11, 2021 19:55
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Stevie Lee posted:what about the jannsen junkies i think the study only looked at mrna vaccines.
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Aug 11, 2021 19:56
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Zeroisanumber posted:So the ones choking out in the ICU are just really unfortunate or...? Crisis actors
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Aug 11, 2021 19:56
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I could swear there was an article in which Fauci uses the "There is no evidence masks work" phrasing in implicitly warning against masks in order to protect the mask supply, at the start of pandemic, and I'm sure it's out there, but I can't find it, and it's driving me a little nuts today. Can anyone else find it? All I could find regarding from January-March was https://www.usatoday.com/story/news...nds/4787209002/ https://www.factcheck.org/2021/02/scicheck-video-wrong-about-fauci-covid-19/ (scroll down to Fauci's comments on masks) The second link contradicts the first one, presumably because they missed that Fauci had already started to switch rhetoric by then.
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Aug 11, 2021 19:56
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Stevie Lee posted:what about the jannsen junkies We're hosed. Get a booster.
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Aug 11, 2021 19:56
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i started reading this thread again 1 week ago and now have been psychically damaged enoujgh to be unable to participate in regular society, leave my home, or do my job effectively. thats badass.
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Aug 11, 2021 19:57
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mod sassinator posted:no it found pfizer about 76% effective. both vaccines are more or less identical, it's just that moderna has a slightly larger dose of the same juice Yeah Moderna is 100uG vs 30 uG Pfizer dose. So Moderna is a better choice if you care about "value" when being a vaccine junkie.
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Aug 11, 2021 19:57
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Smythe posted:i started reading this thread again 1 week ago and now have been psychically damaged enoujgh to be unable to participate in regular society, leave my home, or do my job effectively. thats badass. your welcome
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Aug 11, 2021 19:58
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Mr. Nice! posted:didn’t a study just drop today that moderna is still like 80% effective for breakthroughs against delta and most breakthroughs are pfizer people? this is a baseless, prejudiced attack, typical of moderna people
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Aug 11, 2021 19:58
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mod sassinator posted:no it found pfizer about 76% effective. both vaccines are more or less identical, it's just that moderna has a slightly larger dose of the same juice oh yeah i’m not going out or doing anything. i’m basically sitting at home all day or at my girlfriend’s apartment. here’s where i got 42%: quote:
https://www.reuters.com/business/he...ime-2021-08-09/
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Aug 11, 2021 19:58
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galenanorth posted:I could swear there was an article in which Fauci uses the "There is no evidence masks work" phrasing in implicitly warning against masks in order to protect the mask supply, at the start of pandemic, and I'm sure it's out there, but I can't find it, and it's driving me a little nuts today. Can anyone else find it? All I could find regarding from January-March was the surgeon general jerome adams had an twitter post that explicitly said STOP BUYING MASKS. THEY ARE NOT EFFECTIVE: https://thehill.com/policy/healthcare/485332-surgeon-general-stop-buying-masks
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Aug 11, 2021 19:58
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got my respirator in the mail today, filters should be in tomorrow. a lot comfier than I expected, certainly better than the full face chem mask I had to practice with too many times.
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Aug 11, 2021 19:59
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Mr. Nice! posted:oh yeah i’m not going out or doing anything. i’m basically sitting at home all day or at my girlfriend’s apartment. ah yeah it's probably closer to 42% effective after a few months. israel data has a very clear month by month drop from mid 80s 1 month after 2nd dose down to 16% (yes, really) 6+ months after the 2nd dose
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Aug 11, 2021 19:59
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Tzen posted:https://twitter.com/artneu/status/1425519552503427075 I’ll wear your face diapers but rear end masks are going too far!
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Aug 11, 2021 20:00
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What I want to see is death counts. The long game for COVID isn't acute antibodies, it's gonna be memory cell mediated immunity. And if memory cell mediated immunity is decently strong than we should see reduced death counts in the face of increased case counts. Last year we were seeing 3000+ deaths per day around the same time we were seeing 200k cases per day, so that's kind of the crossover point I'm looking for.
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Aug 11, 2021 20:00
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Smythe posted:i started reading this thread again 1 week ago and now have been psychically damaged enoujgh to be unable to participate in regular society, leave my home, or do my job effectively. thats badass. well covid would do that too lol
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Aug 11, 2021 20:01
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Thanks to whoever suggested getting in touch with industrial supply. I think something's up with their order processing or w/e, the guy I talked to said it definitely should have been shipped out by now having ordered Friday. Definitely worth contacting them if you've placed an order and it hasn't gone out within a day or so.
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Aug 11, 2021 20:01
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mod sassinator posted:the surgeon general jerome adams had an twitter post that explicitly said STOP BUYING MASKS. THEY ARE NOT EFFECTIVE: https://thehill.com/policy/healthcare/485332-surgeon-general-stop-buying-masks Thank you, I'm just specifically interested in Fauci because I came across a post by some liberal who wanted to absolve him for his part https://twitter.com/jjhalpin/status/1425491804254875652 Interestingly, I came across an article which says that a study existed at the time on mask effectiveness NYT posted:Dr. Mark Loeb, an infectious disease specialist at McMaster University in Hamilton, Ontario, said a study during an outbreak of the SARS coronavirus found that any type of protection — whether a mask or a respirator — reduced the risk of infections in health care workers by about 85 percent.
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Aug 11, 2021 20:01
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israel didn’t use moderna, though. afaik almost all moderna use has been inside the usa and it seems to be the most long lasting of the various vaccines.
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Aug 11, 2021 20:01
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Notorious R.I.M. posted:I don't think SARS-CoV-2 is evolutionarily "boxed in". On the Spike protein there are primarily neutralizing epitopes on the N-terminal domain and the Receptor binding domain. There are numerous immune-escpae mutations that show up on both of these (see: Recurrent Deletion Regions on the N-Terminal Domain and RBD escape mutations across three classes of monoclonal antibodies). So overall we're looking at several groups of mutations on the RBD that need to occur to escape several groups of antibodies, and several deletion regions on the N-Terminal Domain that escape several groups of antibodies. Adding one or two of these at a time will cause some antibody efficacy decrease, but adding all of them together is almost complete immune escape. Thanks for breaking this down so clearly. However regarding the spike-protein antibody escape mutations, you're pointing out that COVID can readily mutate it's spike to avoid antibodies but that was the exact subject of the video I linked. If I understand the video's content, which is dubious, they specifically discuss a set of 20 mutations that added together lead to total immune escape of immature, but not affinity matured, convalescent+vaccinated plasma. That was the original motivation for my saying COVID might be somewhat "boxed" in, there appear to be at least some antibodies it might not be able to fully escape according to these neutralization experiments. It's quite possible that was an unfounded interpretation, but what you've written here doesn't seem to directly contradict what I wrote. edit: Here's a preprint for the research described in the video: quote:High genetic barrier to escape from human polyclonal SARS-CoV-2 neutralizing antibodies Nocturtle has issued a correction as of 20:08 on Aug 11, 2021 |
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Aug 11, 2021 20:02
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galenanorth posted:Thank you, I'm just specifically interested in Fauci because I came across a post by some liberal who wanted to absolve him for his part Fauci legitimately said he didn't think masks worked in one of the FOIA e-mails that dumped. I'm sure you can dig it up with some looking. He didn't recommend them, but he was literally so loving dumb he thought they wouldn't be valuable.
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Aug 11, 2021 20:03
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Mr. Nice! posted:israel didn’t use moderna, though. afaik almost all moderna use has been inside the usa and it seems to be the most long lasting of the various vaccines. yeah they ended up not using most of their Moderna stock due to Pfizer winning what was essentially a exclusive fastrack contract. Life hack was paying the greedy Pharma bastards $26 per dose instead of $10 - $13 on the EU contract
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Aug 11, 2021 20:03
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SchrodingersCat posted:What I want to see is death counts. The long game for COVID isn't acute antibodies, it's gonna be memory cell mediated immunity. And if memory cell mediated immunity is decently strong than we should see reduced death counts in the face of increased case counts. it's slightly an artifact of us not accurately tracking breakthrough cases, but uhhhh the CFR is not changing in vaccinated vs. unvaccinated groups. keep looking at recent state data, like massachusets (1.25% CFR of their 8000 breakthrough cases), LA, seattle, etc. it's all showing even in breakthrough cases we see 5-7% hospitalized and 1-1.5% die. that's exactly the same as OG covid against the unvaccinated population HOPEFULLY it's just because we have way, way more asymptomatic breakthrough cases than can be tracked... but who knows. it really could end up that the vaccines gave us a short window of immunity and now people have blown it all by acting immune and getting sick again
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Aug 11, 2021 20:04
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PostNouveau posted:It's all downhill from here baby 
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Aug 11, 2021 20:04
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SchrodingersCat posted:Movies that portray vaccines and medical research as destroying society (I Am Legend, Sweet Tooth, etc.) are probably doing more to increase vaccine distrust than any anti-vax celebrity. I'm still mad I Am Legend didn't actually adapt the book.
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Aug 11, 2021 20:04
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galenanorth posted:Thank you, I'm just specifically interested in Fauci because I came across a post by some liberal who wanted to absolve him for his part jesus christ what a poisoned poo poo lib. there are white house briefings with jerome, fauci, and birx all on the podium together and saying and agreeing to exactly that fact not to buy masks. maybe if you try to find some of those early march coronavirus task force videos you can see some good ones with fauci
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Aug 11, 2021 20:06
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Smythe posted:i started reading this thread again 1 week ago and now have been psychically damaged enoujgh to be unable to participate in regular society, leave my home, or do my job effectively. thats badass. I was experiencing a complete system breakdown of my mental and physical being before it was cool
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Aug 11, 2021 20:06
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Nocturtle posted:Thanks for breaking this down so clearly. However regarding the spike-protein antibody escape mutations, you're pointing out that COVID can readily mutate it's spike to avoid antibodies but that was the exact subject of the video I linked. If I understand the video's content, which is dubious, they specifically discuss a set of 20 mutations that added together lead to total immune escape of immature, but not affinity matured, convalescent+vaccinated plasma. That was the original motivation for my saying COVID might be somewhat "boxed" in, there appear to be at least some antibodies it might not be able to fully escape according to these neutralization experiments. It's quite possible that was an unfounded interpretation, but what you've written here doesn't seem to directly contradict what I wrote. You can generate antibodies against more than one part of a virus, so as long as some of your antibodies can slow the virus down your body can adapt to the newly presented antigens and clear them out. It's why we can get sick with the cold, and also why it doesn't kill us. It takes a while to spin up a response from memory cells. The problem is when a novel pathogen like COVID shows up and kills 20 million people as part of that process. It's also a problem when you have a half-assed vaccination program putting enhanced evolutionary pressure on the virus to rapidly mutate away from the known antigens, and a half assed mitigation program that allows novel variants that might die in vivo to spread. Edit: It's also why a vaccine that only targets one specific antigen on the viral capsid may not be effective in the long-term when combined with the aforementioned half-assed programs that basically FORCE the virus to evolve, and render the vaccine and resulting memory cells with less or even nil efficacy. SchrodingersCat has issued a correction as of 20:11 on Aug 11, 2021 |
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Aug 11, 2021 20:06
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I'm just being glad for returning back to WFH. Plus being back for 2 months made me realize how worthless the various supervisor, middle managers and other hanger ons are in the company.
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Aug 11, 2021 20:07
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Smythe posted:i started reading this thread again 1 week ago and now have been psychically damaged enoujgh to be unable to participate in regular society, leave my home, or do my job effectively. thats badass. welcome. buy a respirator 
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Aug 11, 2021 20:07
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etalian posted:I'm just being glad for returning back to WFH. u hirin
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Aug 11, 2021 20:08
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genericnick posted:I'm still mad I Am Legend didn't actually adapt the book. Same but World War Z.
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Aug 11, 2021 20:08
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Make sure to fill out your time card!
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Aug 11, 2021 20:08
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 ah
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Aug 11, 2021 20:09
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etalian posted:I'm just being glad for returning back to WFH. those guys are gonna crack and demand people back in offices in october, right before we kick back up again for halloween and thanksgiving
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Aug 11, 2021 20:09
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Nothus posted:Same but World War Z. Same but every movie ever
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Aug 11, 2021 20:10
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euphronius posted:maybe 5% mask usage in my office So - I work in a 10 person, 100% libs office that was WFH from March 20 to June 1 2021... everyone came back, not a single mask to be found anywhere. Now that Ohio caseloads are trending way up, the entire office has panic'd in the last 2 days and has gone to 100% masks wearing-rate (except at lunch and in someone's office of course, lmfao). We have an office 100% vaccination rate. lmfao
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Aug 11, 2021 20:12
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mod sassinator posted:those guys are gonna crack and demand people back in offices in october, right before we kick back up again for halloween and thanksgiving Commercial property owners are doing nothing but high-pitched ear bleeding screeching at the government to open Biden more
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Aug 11, 2021 20:12
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