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Karl Sharks
Feb 20, 2008

The Immortal Science of Sharksism-Fininism

mynameisjohn posted:

EPO increases the amount of red blood cells (which transport oxygen), that's their "thickening action" (here's more on how those blood cells are formed [epo modifies hemocytoblast production] http://www.interactive-biology.com/3969/erythropoiesis-formation-of-red-blood-cells/). Thick blood is measured by an increased hematocrit score which is the amount of red blood cells you have per cl of blood. A greater quantity of red blood cells allows more oxygen to be delivered to the muscles which allows for greater recovery and less fatigue.

thickening your blood kills your heart because it has to work harder. EPO will never be safe except in patients with lowered red blood cell counts.

For some reason I thought it was more complicated than that. That's pretty nuts that it causes that much of an increase in just the number of red blood cells to elicit that sort of effect.


Is it used acutely or only really effective when it's sustained at that higher level (meaning you could just increase levels for a couple days to recover, then go back to normal)? If it's the former, do users also try to balance it with blood thinners?

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straight up brolic
Jan 31, 2007

After all, I was nice in ball,
Came to practice weed scented
Report card like the speed limit

:homebrew::homebrew::homebrew:

Karl Sharks posted:

Is it used acutely or only really effective when it's sustained at that higher level (meaning you could just increase levels for a couple days to recover, then go back to normal)? If it's the former, do users also try to balance it with blood thinners?
I have no idea about the latter, but it can be used acutely (per the study I quoted on the previous page). they basically had them run a 10km race immediately after an infusion and their performance dramatically increased.

straight up brolic
Jan 31, 2007

After all, I was nice in ball,
Came to practice weed scented
Report card like the speed limit

:homebrew::homebrew::homebrew:

also this thread in the TRP is good and funny re: PED use in soccer

http://forums.somethingawful.com/showthread.php?threadid=3637793

leokitty
Apr 5, 2005

I live. I die. I live again.
The baseball chat in this thread is getting shouted down by people who watch baseball because whenever people want to talk about it they focus only on dingers.

advanced statsman
Dec 26, 2012

ISLAM FC
I really don't give a poo poo about baseball. They can dope their mothers for all I care. On the other hand, it'd be interesting if someone could talk about the doping situation in rugby. From what I've read, rugby is the sport that suffers from the biggest impact of doping in France at all levels. Something that seemed funny though was that cannabis was considered a doping substance and by far the most commonly consumed. Other common substances seem to be growth hormone and steroids.

African AIDS cum
Feb 29, 2012


Welcome back, welcome back, welcome baaaack
Doping should be a 10 year ban on first offense. At least WADA are raising it to 4 now. But a lot of the effects are permanent even after stopping usage, so there has to be a huge incentive not to ever do it. All American pro sports should adhere to the WADA code and have blood passport and random tests utilizing a whereabouts program. Way too much money in these sports for a clean athlete to ever have a chance.

Jose
Jul 24, 2007

Adrian Chiles is a broadcaster and writer
Is it possible to scam a blood passport? Like dope yourself with EPO/blood doping right at the start when its taken so they measure enhanced levels and think its normal?

Carrier
May 12, 2009


420...69...9001...
Mornacle has taught me that Performance Enhancing Drugs have been misnamed by Doctors worldwide as they don't actually improve performance because nobody has been arsed to see if someone has done a specific study on their favourite sport that they love and want to kiss that would make their favourite player of that sport look bad.

African AIDS cum
Feb 29, 2012


Welcome back, welcome back, welcome baaaack

Jose posted:

Is it possible to scam a blood passport? Like dope yourself with EPO/blood doping right at the start when its taken so they measure enhanced levels and think its normal?

They can inject saline right before a blood test to lower their hematocrit so it doesn't get flagged

straight up brolic
Jan 31, 2007

After all, I was nice in ball,
Came to practice weed scented
Report card like the speed limit

:homebrew::homebrew::homebrew:

Jose posted:

Is it possible to scam a blood passport? Like dope yourself with EPO/blood doping right at the start when its taken so they measure enhanced levels and think its normal?
epo increases your rbc count to such levels that the blood is visibly thicker. i mean its an increase of over 9000. they'd just immediately know that you were doping, but you can lower your score.

African AIDS cum
Feb 29, 2012


Welcome back, welcome back, welcome baaaack
There is an epidemic of recently retired Italian soccer players getting Lou Gherig's disease

http://www.theguardian.com/football/2008/oct/08/europeanfootball.serieafootball

Italian soccer was filthy in the 90's. Hell, probably still is.

straight up brolic
Jan 31, 2007

After all, I was nice in ball,
Came to practice weed scented
Report card like the speed limit

:homebrew::homebrew::homebrew:

vaginal culture posted:

There is an epidemic of recently retired Italian soccer players getting Lou Gherig's disease

http://www.theguardian.com/football/2008/oct/08/europeanfootball.serieafootball

Italian soccer was filthy in the 90's. Hell, probably still is.
my Physical Therapist mostly deals with mma fighters and was talking to me about how they're all pissing their pants because a ton of their friends are former users and are getting lou gehrig's and they're all making bucket lists of poo poo to do before they turn 40 just in case. its hosed up poo poo for sure Tom.

African AIDS cum
Feb 29, 2012


Welcome back, welcome back, welcome baaaack

mynameisjohn posted:

my Physical Therapist mostly deals with mma fighters and was talking to me about how they're all pissing their pants because a ton of their friends are former users and are getting lou gehrig's and they're all making bucket lists of poo poo to do before they turn 40 just in case. its hosed up poo poo for sure Tom.

Makes me wonder how many of the poor health outcomes we are seeing in retired NFL players can be blamed by the substances they used. I don't think it is 100% concussions. I bet there are also unknown interactions between the painkillers they use. Retired Pro Bodybuilders overall seem pretty healthy compared to NFL players/WWF wrestlers etc.

TelekineticBear!
Feb 19, 2009

vaginal culture posted:

There is an epidemic of recently retired Italian soccer players getting Lou Gherig's disease

http://www.theguardian.com/football/2008/oct/08/europeanfootball.serieafootball

Italian soccer was filthy in the 90's. Hell, probably still is.

considering the amount of matches they were fixing, doping was the lesser of the two crimes and I cant imagine they've made any effort to stop it

http://www.4dfoot.com/2013/02/09/doping-in-football-fifty-years-of-evidence/ heres a pretty good list of notable doping cases in football

Mr.Nice
Apr 28, 2006
In the Puerto affair they found a powder that allow to fake EPO test, it's called "polvos de la madre Celestina" (poussières de la mère Célestine in french) : Small grains you put in your dicks before pissing, it's a protease that destroy the protein peptide bond like EPO.

How good are steroids.

Over 10 weeks :
Group 1 did NOT do any form of exercise, and did NOT receive any form of steroids or drugs. (Natural guys doing no weight training.)
Group 2 did NOT do any form of exercise, but they received weekly injections of 600 mg of testosterone enanthate. (Drug users doing no weight training.)
Group 3 DID exercise, but they did NOT receive any form of steroids or drugs. (Natural guys doing weight training.)
Group 4 DID exercise, and they also received weekly injections of 600 mg of testosterone enanthate. (Drug users doing weight training.)

Result :

Group 1 (no exercise, natural) experienced no significant changes. No surprise there.
Group 2 (no exercise, drug use) was able to build about 7 pounds of muscle. That’s not a typo. The group receiving testosterone injections and NOT working out at all gained 7 pounds of muscle.
Group 3 (exercise, natural) was able to build about 4 pounds of muscle.
Group 4 (exercise, drug use) was able to build about 13 pounds of muscle.

PED + No Training > hard training with no PED (and that's with "only" 600mg).

http://www.aworkoutroutine.com/steroids-vs-natural/

Here is an example of steroids cycle the pros use in body building these days (only sport it's almost openly talked about) :

quote:

1st, 2nd, 3rd, 4th week:
ANDROGENIC/ANABOLIC:
SUSTANON (or OMNADREN) 250 mg - every other day
TESTOSTERON UNDECANOATE - 1000 mg (4ml shot, 250 mg/ml injections) - every Sunday
TRENBOLONE ACETATE 400 mg per week
DECA-DURABOLIN (Nandrolone Decanoate) 900 mg per week
OXANDROLONE (tablets) 60 mg/day (20 mg every 8 hours)
TURINABOL (tablets) 60 mg/day (20 mg every 8 hours)

ANTI-ESTROGENS:
2 mg ARIMIDEX (Anastrozole) per day
50 mg CLOMID (Clomiphene Citrate) - every day 25 mg in the morning + 25 mg 12 hours later

OTHER HORMONES:
Growth Hormone - 4 IU's ON EMPTY STOMACH and as many times a day as possible (up to 12 IU's a day)
Insulin - HUMALOG, 20 units 1 hour before every training, as scheduled

Thyroid:
T3 (Triiodothyronine) - 25 mcg per day (12.5 mcg morning + 12.5 mcg 12 hours later in the evening), first 2 weeks, than 37.5 mcg per day (25 mcg morning + 12.5 mcg 12 hours later in the evening) week #3 + week #4
T4 (Thyroxine)- 50 mcg per day (25 mcg in the morning + 25 mcg 12 hours later) first 2 weeks, than 100 mcg per day (50 mcg in the morning + 50 mcg 12 hours later) week #3 + week #4

XYREM - every night before sleep - 4.5 grams

5th, 6th, 7th, 8th week:
ANDROGENIC/ANABOLIC:
TESTOSTERONE Propionate 100 mg - every day
TESTOSTERON ENANTHATE 200 mg - every other day
TRENBOLONE Acetate 400 mg per week, week #5 + week #6
PRIMOBOLAN (Methelnolone) 600 mg per week, week #7 + week #8
EQUIPOSE (Boldenone) 600 mg per week
WINSTROL (Stanozolol) (tablets) 60 mg every day (20 mg every 8 hours)
OXYMETHOLONE (tablets) 150 mg per day (50 mg every 8 hours)

ANTI-ESTROGENS:
2-3 mg ARIMIDEX (Anastrozole) per day (1 mg in the morning, 1mg 12 hours later)

OTHER HORMONES:
Growth Hormone - 3-4 IU's ON EMPTY STOMACH and as many times a day as possible (12 to 16 units per day)
Insulin - HUMALOG, 15-20 units 1 hour before every training, as scheduled (depending on condition)

Thyroid:
T3 (Triiodothyronine) - 50 mcg per day (25 mcg morning + 25 mcg 12 hours later in the evening), first 2 weeks, than 75 mcg per day (37.5 mcg morning + 37.5 mcg 12 hours later in the evening) week #3 + week #4
T4 (Thyroxine)- 150 mcg per day (75 mcg in the morning + 75 mcg 12 hours later) first 2 weeks, than 200 mcg per day (100 mcg in the morning + 100 mcg 12 hours later) week #3 + week #4

XYREM - every night before sleeping 4.5 grams

9th, 10th, 11th, 12th week
ANDROGENIC/ANABOLIC:
TESTOSTERONE PROPIONATE 200 mg - every day
MASTERON (Drostanolon Propionate) 600 mg per week
OXANDROLONE (tablets) 60 mg every day (20 mg every 8 hours)
PRIMOBOLAN (Methelnolone) 600 mg per week, week #9 + week #10
HALOTESTIN (Fluoxymesterone) (tablets) 30 mg/day (10 mg every 8 hours)
PROVIRON (Mesterolone)(tablets) 150 mg/day (50 mg every 8 hours)
WINSTROL (Stanozolol) (injections) 50mg every day on week #9, 100mg every day on week #10, 150 mg every day on week #11...

ANTI-ESTROGENS:
3 mg ARIMIDEX (Anastrozole) per day (1 mg in the morning, 1mg 12 hours later)

OTHER HORMONES:
Growth Hormone - 3-4 IU's ON EMPTY STOMACH and as many times a day as possible (12 to 16 units per day)
Insulin - HUMALOG, 10 - 20 units 1 hour before every training, DEPENDING ON CONDITION

Thyroid:
T3 - (Triiodothyronine) - DEPENDS ON YOUR CONDITIO T4 (Thyroxine) - DEPENDS ON YOUR CONDITION

XYREM - every night before sleeping 4.5 grams

JFairfax
Oct 23, 2008

by FactsAreUseless

This is a cool, good and interesting article - the sort of summary that I have been looking for.

straight up brolic
Jan 31, 2007

After all, I was nice in ball,
Came to practice weed scented
Report card like the speed limit

:homebrew::homebrew::homebrew:

Mr. Nice coming through with the knowledge bomb. Good posting, drat good in fact.

tbp
Mar 1, 2008

DU WIRST NIEMALS ALLEINE MARSCHIEREN
I know a bunch of kids who had relatively short experiences taking steroids - like a year or two in college - would they have long term effects, or most likely be okay?

TelekineticBear!
Feb 19, 2009

tbp posted:

I know a bunch of kids who had relatively short experiences taking steroids - like a year or two in college - would they have long term effects, or most likely be okay?

Im guessing its all dependent on the dosages and the drugs, college kids just taking test or dbol or something for a year or two will most likely be perfectly fine so long as they had no major side effects at the time

JFairfax
Oct 23, 2008

by FactsAreUseless

tbp posted:

I know a bunch of kids who had relatively short experiences taking steroids - like a year or two in college - would they have long term effects, or most likely be okay?

why did they decide to stop transitioning?

Charlotte Hornets
Dec 30, 2011

by Fritz the Horse

Mr.Nice posted:

In the Puerto affair they found a powder that allow to fake EPO test, it's called "polvos de la madre Celestina" (poussières de la mère Célestine in french) : Small grains you put in your dicks before pissing, it's a protease that destroy the protein peptide bond like EPO.

How good are steroids.

Over 10 weeks :
Group 1 did NOT do any form of exercise, and did NOT receive any form of steroids or drugs. (Natural guys doing no weight training.)
Group 2 did NOT do any form of exercise, but they received weekly injections of 600 mg of testosterone enanthate. (Drug users doing no weight training.)
Group 3 DID exercise, but they did NOT receive any form of steroids or drugs. (Natural guys doing weight training.)
Group 4 DID exercise, and they also received weekly injections of 600 mg of testosterone enanthate. (Drug users doing weight training.)

Result :

Group 1 (no exercise, natural) experienced no significant changes. No surprise there.
Group 2 (no exercise, drug use) was able to build about 7 pounds of muscle. That’s not a typo. The group receiving testosterone injections and NOT working out at all gained 7 pounds of muscle.
Group 3 (exercise, natural) was able to build about 4 pounds of muscle.
Group 4 (exercise, drug use) was able to build about 13 pounds of muscle.

PED + No Training > hard training with no PED (and that's with "only" 600mg).

http://www.aworkoutroutine.com/steroids-vs-natural/

Here is an example of steroids cycle the pros use in body building these days (only sport it's almost openly talked about) :

ah yes, let's do GHB (Xyrem) to get a good night's sleep.

straight up brolic
Jan 31, 2007

After all, I was nice in ball,
Came to practice weed scented
Report card like the speed limit

:homebrew::homebrew::homebrew:

Charlotte Hornets posted:

ah yes, let's do GHB (Xyrem) to get a good night's sleep.
lmao thats unbelievable

Sour Grapes
Dec 29, 2002

All you kids out there...

vaginal culture posted:

But a lot of the effects are permanent even after stopping usage

What PEDs have permanent effects?

vaginal culture posted:

All American pro sports should adhere to the WADA code and have blood passport and random tests utilizing a whereabouts program. Way too much money in these sports for a clean athlete to ever have a chance.

Money is the root of the doping in sport issue here, people like to talk about fair play and all of that poo poo, but really they want to see records shattered, 150 mile an hour slap shots, and a bunch of 260 lb sides of beef smashing each other to a pulp. The people pulling the strings need to do the dance and pretend to care just enough to make it look like they care, but how many people would continue to tune in if there was no chance something exceptional was going to happen?

bewbies
Sep 23, 2003

Fun Shoe
As someone who has yet to form a strong opinion on PEDs this thread has been a very interesting read.

Also it is pretty baffling to me that people continue to argue that Bonds/Sosa/et al did not benefit massively from the drugs that they used. I mean...argue that it was acceptable under the rules of the sport, or that it is an OK thing to do regardless, or that it makes the sport more interesting to watch, or...whatever. Arguing that they didn't have an effect on the performance of the athlete though, that's one of the least compelling things I've ever seen the internet produce.

Jose
Jul 24, 2007

Adrian Chiles is a broadcaster and writer

vaginal culture posted:

There is an epidemic of recently retired Italian soccer players getting Lou Gherig's disease

http://www.theguardian.com/football/2008/oct/08/europeanfootball.serieafootball

Italian soccer was filthy in the 90's. Hell, probably still is.

Can you talk about all the Barca players doping back when Guardiola was a player?

Grittybeard
Mar 29, 2010

Bad, very bad!

tbp posted:

I realize the irony considering I earlier asked about boxing, though.

Since no one really answered this I will. I think most people believe Manny is or has doped fairly often, Juan Manuel Marquez is almost certainly juiced to the gills (along with drinking his own piss), and you get guys pissing hot directly before fights now and then because they're complete and total loving idiots like Lamont Peterson a couple of years ago. It wouldn't surprise me too much if the vast majority of name guys are juicing.

Of course more than any other sport you're giving up your future quality of life if you're a boxer so I don't know how much most people care unless they believe one guy's clean and another isn't. And like you or whoever noted the sport has so many completely hosed up and horrible problems and has for its entire existence that it can get lost pretty easily in the heap of poo poo that is everything boxing.

African AIDS cum
Feb 29, 2012


Welcome back, welcome back, welcome baaaack

Sour Grapes posted:

What PEDs have permanent effects?


To simplify things, all of them basically. Anabolics have permanent effects as does oxygen vector doping.

Jordan7hm
Feb 17, 2011




Lipstick Apathy

bewbies posted:

As someone who has yet to form a strong opinion on PEDs this thread has been a very interesting read.

Also it is pretty baffling to me that people continue to argue that Bonds/Sosa/et al did not benefit massively from the drugs that they used. I mean...argue that it was acceptable under the rules of the sport, or that it is an OK thing to do regardless, or that it makes the sport more interesting to watch, or...whatever. Arguing that they didn't have an effect on the performance of the athlete though, that's one of the least compelling things I've ever seen the internet produce.

He's pretty much trolling (or at least playing extreme devil's advocate). There isn't any good way to quantify just what impact PEDs have on elite level athletes though, because nobody publishes actual results (for obvious reasons). Instead we get anecdotes and studies that test drugs out on athletes (or just regular individuals) who are far below elite level.

So maybe the drugs are worth 5 homers or maybe they're worth 30. Who knows?

serious gaylord
Sep 16, 2007

what.

Jordan7hm posted:

He's pretty much trolling (or at least playing extreme devil's advocate). There isn't any good way to quantify just what impact PEDs have on elite level athletes though, because nobody publishes actual results (for obvious reasons). Instead we get anecdotes and studies that test drugs out on athletes (or just regular individuals) who are far below elite level.

So maybe the drugs are worth 5 homers or maybe they're worth 30. Who knows?

Cycling has been pretty open with displaying the power readings for dopers compared to 'clean*' riders. After the big busts in the 90's you saw times tumble throughout the peloton to the point that its taken nearly 15 years to even get close again through 'marginal* gains'.

To be honest, if you get caught pissing hot, you should be banned for life. I dont give a flying gently caress that Contador is favourite to win the Tour De France this year because hes been banned for doping, and him taking 2 years off from the sport wont change the fact the doping has permanently changed his v02 max.

stickyfngrdboy
Oct 21, 2010

Grittybeard posted:

Since no one really answered this I will. I think most people believe Manny is or has doped fairly often, Juan Manuel Marquez is almost certainly juiced to the gills (along with drinking his own piss), and you get guys pissing hot directly before fights now and then because they're complete and total loving idiots like Lamont Peterson a couple of years ago. It wouldn't surprise me too much if the vast majority of name guys are juicing.

Of course more than any other sport you're giving up your future quality of life if you're a boxer so I don't know how much most people care unless they believe one guy's clean and another isn't. And like you or whoever noted the sport has so many completely hosed up and horrible problems and has for its entire existence that it can get lost pretty easily in the heap of poo poo that is everything boxing.

Boxing is rife with doping, almost certainly. Floyd Mayweather constantly asking for random tests, aimed, mostly, at Manny Pacquiao, means he is either using something he knows is undetectable, or he's sure there are boxers out there (like Pacquiao?) using PEDs regularly, or maybe it's a little of both. Why was Pacquiao so adamant he wouldn't allow blood testing? I can't think of a genuine reason that doesn't implicate him. Vitali Klitschko took steroids (which he claims were for a leg injury), Roy Jones Jr very likely took steroids (one positive test, the two following both negative); these were fighters that were a class above those around them but still (probably) doped. If they've done it, they all are.

serious gaylord
Sep 16, 2007

what.
Anything from the late 80's to the end of the 90's needs a massive asterix next to it in my opinion. There was just no way to test for the stuff on the market at the time.

Grittybeard
Mar 29, 2010

Bad, very bad!

stickyfngrdboy posted:

Why was Pacquiao so adamant he wouldn't allow blood testing?

If I remember right he made up some bullshit about believing blood tests would hurt his training. Like the process of losing a tiny amount of blood 14 days before the fight would make him too weak or something along those lines. And since it's boxing you can almost buy that he would believe that since there are so many myths around training and all.

But yeah, in reality I think almost everyone thinks the blood tests would hurt his training since he'd have to stop pumping himself full of whatever.

stickyfngrdboy
Oct 21, 2010

Grittybeard posted:

If I remember right he made up some bullshit about believing blood tests would hurt his training. Like the process of losing a tiny amount of blood 14 days before the fight would make him too weak or something along those lines. And since it's boxing you can almost buy that he would believe that since there are so many myths around training and all.

But yeah, in reality I think almost everyone thinks the blood tests would hurt his training since he'd have to stop pumping himself full of whatever.

Yeah I remember what his excuses were. I'd love to see those two go at it, as I'm sure most boxing fans would be. Some say that Mayweather was simply making his excuses before any potential loss, but the fact that Pacquiao refused says a lot, to me.

African AIDS cum
Feb 29, 2012


Welcome back, welcome back, welcome baaaack

serious gaylord posted:

Anything from the late 80's to the end of the 90's needs a massive asterix next to it in my opinion. There was just no way to test for the stuff on the market at the time.

Earlier than that, steroids and blood transfusions have been around since the 70's at least.

serious gaylord
Sep 16, 2007

what.

vaginal culture posted:

Earlier than that, steroids and blood transfusions have been around since the 70's at least.

They were massive in the body building scene, but how prevalent were they in sports culture? I was always of the opinion that they didnt really infect the pro sports world outside of the endurance and strength disciplines until the 80's.

Feels Villeneuve
Oct 7, 2007

Setter is Better.

Jordan7hm posted:

He's pretty much trolling (or at least playing extreme devil's advocate). There isn't any good way to quantify just what impact PEDs have on elite level athletes though, because nobody publishes actual results (for obvious reasons). Instead we get anecdotes and studies that test drugs out on athletes (or just regular individuals) who are far below elite level.

So maybe the drugs are worth 5 homers or maybe they're worth 30. Who knows?

Probably true. However, the weird baseball fan logic seems to be "The effect can't be quantified precisely, therefore it must not exist", which is asinine.

African AIDS cum
Feb 29, 2012


Welcome back, welcome back, welcome baaaack

serious gaylord posted:

They were massive in the body building scene, but how prevalent were they in sports culture? I was always of the opinion that they didnt really infect the pro sports world outside of the endurance and strength disciplines until the 80's.

Finnish distance runner Lasse Virin won gold in 72 using blood transfusions, I think he was one of the first. Steroids were kicking around back then too.

Kalli
Jun 2, 2001



Fag Boy Jim posted:

Probably true. However, the weird baseball fan logic seems to be "The effect can't be quantified precisely, therefore it must not exist", which is asinine.

Honestly, from reading most of the baseball threads on the issue, I think it's more that most posters loath the MLB's hypocrisy and framing of the issue that they're willing to push any steroid talk into the typical sportswriter view of them being magic dinger juice.

Sour Grapes
Dec 29, 2002

All you kids out there...

vaginal culture posted:

To simplify things, all of them basically. Anabolics have permanent effects as does oxygen vector doping.

Care to expand or link me something? I haven't read that much, but I thought the effects of anabolics tapered after a while off-cycle due to a number of factors (i.e.; decreased capacity for training, eating, lowered aggression/focus, etc.).

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TelekineticBear!
Feb 19, 2009

serious gaylord posted:

They were massive in the body building scene, but how prevalent were they in sports culture? I was always of the opinion that they didnt really infect the pro sports world outside of the endurance and strength disciplines until the 80's.

The football link posted earlier suggests that they were being used in the 60's and 70's, particularly for the two most successful clubs of those periods, Ajax and Bayern Munich

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