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Necc0 posted:is that what i think it is um no it's a foldable rolling pin
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Jun 10, 2015 00:36
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oh uh yeah that's just my foldable rolling pin that i keep under the bed
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Jun 10, 2015 00:40
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Necc0 posted:is that what i think it is what does your heart tell you?
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Jun 10, 2015 00:40
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im the crushing realisation in 10 years when he realises he was throwing his mums double ended dildo around the room
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Jun 10, 2015 00:40
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Linux Pirate posted:the worst a man can get This post is 
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Jun 10, 2015 00:56
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Optimus_Rhyme posted:to unfortunately quote kevin smith: you like the music you started fuckin' to chris rock said the same thing in bigger and blacker in 1999 so maybe its best to make that attribution?
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Jun 10, 2015 00:57
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https://www.youtube.com/watch?v=Nf97-sVZCiE hey i remember this guy, he looks terrible in hd 
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Jun 10, 2015 01:07
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my ex's best friend is a 35 year old juggalette. she got one of the worst tattoos ive ever seen. its of the running man logo they have, right on her chest, done by some meth head at one of their concerts in a trailer outside.
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Jun 10, 2015 01:08
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Linux Pirate posted:i miss the helicopter rides, maybe the pilots didnt like getting paid in garbage bags full of cash. https://www.youtube.com/watch?v=3ZicomCP3gM So you're telling me that laughing at this is wrong? I don't want to be right
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Jun 10, 2015 01:20
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Juan Berenguer posted:https://www.youtube.com/watch?v=3ZicomCP3gM classic episode
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Jun 10, 2015 01:24
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Stymie posted:laughing at juggalos is still mighty drat gbs and classist to boot I'm poor as gently caress and it's okay to talk poo poo about juggalos
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Jun 10, 2015 01:38
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SmokaDustbowl posted:I'm poor as gently caress and it's okay to talk poo poo about juggalos look at what youve loving done
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Jun 10, 2015 01:44
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pram posted:look at what youve loving done https://www.youtube.com/watch?v=TJ7hkC10RZQ
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Jun 10, 2015 01:51
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Jun 10, 2015 02:14
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http://i.imgur.com/9tuiIvf.webm sleep tight pupper
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Jun 10, 2015 02:15
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Panty Saluter posted:http://i.imgur.com/9tuiIvf.webm meanwhile, his owner would suffer a tibial compound fracture if he tried to jump 6 inches into the air
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Jun 10, 2015 02:20
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SmokaDustbowl posted:I'm poor as gently caress and it's okay to talk poo poo about juggalos sleep tight pauper
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Jun 10, 2015 02:21
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lmfao
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Jun 10, 2015 02:21
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wayfinder posted:sleep tight pauper also, lol lots of lols to be had itt today uhm, i should probably contribute  ok there done
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Jun 10, 2015 02:22
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Panty Saluter posted:http://i.imgur.com/9tuiIvf.webm new Assassins Creed enemies looking adorably annoying as hell
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Jun 10, 2015 02:22
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Jun 10, 2015 02:24
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I did a thing e: shrimp and white wine
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Jun 10, 2015 02:27
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Jun 10, 2015 02:46
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that was a cool room in half-life
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Jun 10, 2015 02:47
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akadajet posted:https://www.youtube.com/watch?v=Nf97-sVZCiE he ain't gorgeous no more
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Jun 10, 2015 02:47
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whoa, original content? in my yospos?
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Jun 10, 2015 02:48
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Jun 10, 2015 02:50
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Freakin epic!!!
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Jun 10, 2015 02:52
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https://www.youtube.com/watch?v=zxq2ztkE0eE
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Jun 10, 2015 03:04
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akadajet posted:https://www.youtube.com/watch?v=Nf97-sVZCiE hoo baby!
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Jun 10, 2015 03:33
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https://www.youtube.com/watch?v=xSm5TUKr4L8
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Jun 10, 2015 03:37
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wait gorgeous george isn't dead yet? how'd that happen?
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Jun 10, 2015 03:38
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Cold on a Cob posted:wait gorgeous george isn't dead yet? how'd that happen? Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice Saul A Villeda, Kristopher E Plambeck, Jinte Middeldorp, Joseph M Castellano, Kira I Mosher, Jian Luo, Lucas K Smith, Gregor Bieri, Karin Lin, Daniela Berdnik, Rafael Wabl, Joe Udeochu, Elizabeth G Wheatley, Bende Zou, Danielle A Simmons, Xinmin S Xie, Frank M Longo & Tony Wyss-Coray Nature Medicine 20, 659–663 (2014) doi:10.1038/nm.3569 Received 08 February 2014 Accepted 16 April 2014 Published online 04 May 2014 As human lifespan increases, a greater fraction of the population is suffering from age-related cognitive impairments, making it important to elucidate a means to combat the effects of aging1, 2. Here we report that exposure of an aged animal to young blood can counteract and reverse pre-existing effects of brain aging at the molecular, structural, functional and cognitive level. Genome-wide microarray analysis of heterochronic parabionts—in which circulatory systems of young and aged animals are connected—identified synaptic plasticity–related transcriptional changes in the hippocampus of aged mice. Dendritic spine density of mature neurons increased and synaptic plasticity improved in the hippocampus of aged heterochronic parabionts. At the cognitive level, systemic administration of young blood plasma into aged mice improved age-related cognitive impairments in both contextual fear conditioning and spatial learning and memory. Structural and cognitive enhancements elicited by exposure to young blood are mediated, in part, by activation of the cyclic AMP response element binding protein (Creb) in the aged hippocampus. Our data indicate that exposure of aged mice to young blood late in life is capable of rejuvenating synaptic plasticity and improving cognitive function.
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Jun 10, 2015 03:46
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gently caress yeah make me some lab-grown blood and fill me full until overflowing I'm going to live forever
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Jun 10, 2015 03:50
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BangersInMyKnickers posted:gently caress yeah make me some lab-grown blood and fill me full until overflowing I'm going to live forever cheaper if you get the blood free-range
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Jun 10, 2015 03:54
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Vampires are real! 
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Jun 10, 2015 04:02
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gently caress yes real life bloodborne
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Jun 10, 2015 04:09
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I guess I might need to have a kid after all
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Jun 10, 2015 04:12
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keyboard vomit posted:real men surf superior real dead men u mean
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Jun 10, 2015 04:21
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Jun 10, 2015 04:27
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