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i mean i guess there's not much difference between forced alcohol withdrawl and straight up seizures anyway
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# ? Sep 7, 2016 16:03 |
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# ? May 13, 2024 06:21 |
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SynthOrange posted:Where's the unforgivable porn? I'm assuming on your drive in the folder marked "To do later"
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# ? Sep 7, 2016 16:07 |
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Graff posted:Picrotoxin and gabazine just give u seizures straight up. I managed to induce ictal weirdness in acute brain slices with it is this some kind of catholic guilt in pill form or something?
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# ? Sep 7, 2016 16:10 |
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Graff posted:Picrotoxin and gabazine just give u seizures straight up. I managed to induce ictal weirdness in acute brain slices with it https://www.youtube.com/watch?v=ub6LGfFTnmc
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# ? Sep 7, 2016 16:15 |
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# ? Sep 7, 2016 16:21 |
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# ? Sep 7, 2016 16:40 |
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oh wow forgot about the little dancing coke machines
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# ? Sep 7, 2016 16:48 |
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GATOS Y VATOS posted:is this some kind of catholic guilt in pill form or something? it's been so long since I did any pharmacology / went out with a catholic boy. I'd love to sound authoritative about it, but i'd be talking out of my arse
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# ? Sep 7, 2016 16:56 |
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hump day fellow desk drones https://i.imgur.com/YpsPXwy.gifv
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# ? Sep 7, 2016 17:59 |
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https://i.imgur.com/zWydNi6.gifv
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# ? Sep 7, 2016 18:03 |
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SmokaDustbowl posted:lmao does the US not have bottle deposit or something most places that used to have it switched to just doing normal recycling collection
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# ? Sep 7, 2016 18:38 |
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Graff posted:it's been so long since I did any pharmacology / went out with a catholic boy. I'd love to sound authoritative about it, but i'd be talking out of my arse I can do it! it's basically been said already, but GABA is the main inhibitory neurotransmitter in the brain, ~90% of your neurons are GABAergic. alcohol (relatively) gently and positively affects all of these and it's hard to reverse these effects without going overboard and causing seizures, as suppression of inhibition causes widespread overactivation. opioids are different because they only affect a very specific and tiny proportion of neurons, so shutting them all down with naloxone doesn't gently caress your whole brain. same with cannabinoids
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# ? Sep 7, 2016 18:49 |
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theflyingexecutive posted:I can do it! it's basically been said already, but GABA is the main inhibitory neurotransmitter in the brain, ~90% of your neurons are GABAergic. alcohol (relatively) gently and positively affects all of these and it's hard to reverse these effects without going overboard and causing seizures, as suppression of inhibition causes widespread overactivation. opioids are different because they only affect a very specific and tiny proportion of neurons, so shutting them all down with naloxone doesn't gently caress your whole brain. same with cannabinoids yes yes but what about the catholic boys
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# ? Sep 7, 2016 18:51 |
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# ? Sep 7, 2016 18:53 |
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but yeah basically gabaergic tone keeps the gain set for what would otherwise be a whole mess of interconnected positive feedback loops so it's under ridiculously tight physiological control. stuff that potentiates gaba's effects or release like booze or benzos is compensated for by dialing down the whole system, then you withdraw and there's not enough gaba around and its screaming howls of feedback everywhere
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# ? Sep 7, 2016 18:57 |
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im the font
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# ? Sep 7, 2016 18:58 |
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Graff posted:yes yes but what about the catholic boys Catholic boys have zero guilt, it comes on with age
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# ? Sep 7, 2016 19:00 |
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it's such a strong effect that I'd see highly correlated firing and seizure like fields in the cortical regions of pretty thin brain slices when I artificially hosed about with gaba tone with picrotoxin (classic, cheap, permanent) or gabazine (hipster as gently caress, expensive, partially reversible)
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# ? Sep 7, 2016 19:02 |
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theflyingexecutive posted:Catholic boys have zero guilt, it comes on with age this was not my dating experience
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# ? Sep 7, 2016 19:03 |
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theflyingexecutive posted:Catholic boys have zero guilt, it comes on with age
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# ? Sep 7, 2016 19:03 |
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Kenny Logins posted:or with priests I never went out with any priests that's too weird even for me
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# ? Sep 7, 2016 19:05 |
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# ? Sep 7, 2016 19:12 |
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now that's customer service
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# ? Sep 7, 2016 19:20 |
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is it warmed inside owen's rear end or mouth? this is important; asking for a friend
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# ? Sep 7, 2016 19:22 |
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"depilation" is my word of the day and every euphemism for female genitalia is extremely cringeworthy.....just say "pussy hole" and quit trying to be cute
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# ? Sep 7, 2016 19:26 |
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Robot Pride posted:is it warmed inside owen's rear end or mouth? this is important; asking for a friend don't be disgusting it's his pits
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# ? Sep 7, 2016 19:27 |
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Robot Pride posted:"depilation" is my word of the day and every euphemism for female genitalia is extremely cringeworthy.....just say "pussy hole" and quit trying to be cute the best way to get people to smile in a group photograph is to get them to repeat ROCK N' ROLL PUSSY HOLE
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# ? Sep 7, 2016 19:28 |
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how and where was this made? I must know.
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# ? Sep 7, 2016 19:38 |
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# ? Sep 7, 2016 19:43 |
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# ? Sep 7, 2016 19:47 |
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tracks 4, 5 and 9 lo to tha mothafuckin' marf
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# ? Sep 7, 2016 19:56 |
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spankmeister posted:im the font hosed up goofy fonts help people who got dyslexia or whatever
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# ? Sep 7, 2016 20:13 |
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SmokaDustbowl posted:god it's going to be worse than vape cloud people Wore the same shirt today, maybe it's a uniform. netwerk23 fucked around with this message at 20:19 on Sep 7, 2016 |
# ? Sep 7, 2016 20:16 |
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# ? Sep 7, 2016 20:58 |
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yeah, gently caress the arts!!!
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# ? Sep 7, 2016 21:02 |
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lolllllll
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# ? Sep 7, 2016 21:09 |
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ugh just hit prtsc
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# ? Sep 7, 2016 21:11 |
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yeah art and artists suck. sure they can create such breathtaking beauty that it makes you weep for joy and gives meaning to the otherwise cold and futile hell that we call conscious existence, but can art build a bridge or sequence a genome? no, and that's why i'm a javascript developer
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# ? Sep 7, 2016 21:16 |
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H.P. Hovercraft posted:
if this is real it seems perfectly reasonable to me "hey you probably don't know that your funny internet meme shares a name with a long standing african american heritage thing here, so be aware that you may inadvertently insult some people"
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# ? Sep 7, 2016 21:16 |
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# ? May 13, 2024 06:21 |
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that they had to come out and say "the harambe floor is a real place in our school plz stop exposing yourself there to strangers" is p lol tho
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# ? Sep 7, 2016 21:20 |