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Moist von Lipwig
Oct 28, 2006

by FactsAreUseless
Tortured By Flan
i mean i guess there's not much difference between forced alcohol withdrawl and straight up seizures anyway

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GATOS Y VATOS
Aug 22, 2002


SynthOrange posted:

Where's the unforgivable porn?

I'm assuming on your drive in the folder marked "To do later"

GATOS Y VATOS
Aug 22, 2002


Graff posted:

Picrotoxin and gabazine just give u seizures straight up. I managed to induce ictal weirdness in acute brain slices with it

is this some kind of catholic guilt in pill form or something?

KoRMaK
Jul 31, 2012



Graff posted:

Picrotoxin and gabazine just give u seizures straight up. I managed to induce ictal weirdness in acute brain slices with it


https://www.youtube.com/watch?v=ub6LGfFTnmc

Antlerhill
Nov 6, 2012

Smellrose

H.P. Hovercraft
Jan 12, 2004

one thing a computer can do that most humans can't is be sealed up in a cardboard box and sit in a warehouse
Slippery Tilde

graph
Nov 22, 2006

aaag peanuts

oh wow


forgot about the little dancing coke machines

Graff
May 10, 2012

GATOS Y VATOS posted:

is this some kind of catholic guilt in pill form or something?

it's been so long since I did any pharmacology / went out with a catholic boy. I'd love to sound authoritative about it, but i'd be talking out of my arse

DrPossum
May 15, 2004

i am not a surgeon
hump day fellow desk drones

https://i.imgur.com/YpsPXwy.gifv

DrPossum
May 15, 2004

i am not a surgeon
https://i.imgur.com/zWydNi6.gifv

fishmech
Jul 16, 2006

by VideoGames
Salad Prong

SmokaDustbowl posted:

lmao does the US not have bottle deposit or something

most places that used to have it switched to just doing normal recycling collection

theflyingexecutive
Apr 22, 2007

Graff posted:

it's been so long since I did any pharmacology / went out with a catholic boy. I'd love to sound authoritative about it, but i'd be talking out of my arse

I can do it! it's basically been said already, but GABA is the main inhibitory neurotransmitter in the brain, ~90% of your neurons are GABAergic. alcohol (relatively) gently and positively affects all of these and it's hard to reverse these effects without going overboard and causing seizures, as suppression of inhibition causes widespread overactivation. opioids are different because they only affect a very specific and tiny proportion of neurons, so shutting them all down with naloxone doesn't gently caress your whole brain. same with cannabinoids

Graff
May 10, 2012

theflyingexecutive posted:

I can do it! it's basically been said already, but GABA is the main inhibitory neurotransmitter in the brain, ~90% of your neurons are GABAergic. alcohol (relatively) gently and positively affects all of these and it's hard to reverse these effects without going overboard and causing seizures, as suppression of inhibition causes widespread overactivation. opioids are different because they only affect a very specific and tiny proportion of neurons, so shutting them all down with naloxone doesn't gently caress your whole brain. same with cannabinoids

yes yes but what about the catholic boys

Inexplicable Humblebrag
Sep 20, 2003



Graff
May 10, 2012

but yeah basically gabaergic tone keeps the gain set for what would otherwise be a whole mess of interconnected positive feedback loops so it's under ridiculously tight physiological control. stuff that potentiates gaba's effects or release like booze or benzos is compensated for by dialing down the whole system, then you withdraw and there's not enough gaba around and its screaming howls of feedback everywhere

spankmeister
Jun 15, 2008







im the font

theflyingexecutive
Apr 22, 2007

Graff posted:

yes yes but what about the catholic boys

Catholic boys have zero guilt, it comes on with age

Graff
May 10, 2012

it's such a strong effect that I'd see highly correlated firing and seizure like fields in the cortical regions of pretty thin brain slices when I artificially hosed about with gaba tone with picrotoxin (classic, cheap, permanent) or gabazine (hipster as gently caress, expensive, partially reversible)

Graff
May 10, 2012

theflyingexecutive posted:

Catholic boys have zero guilt, it comes on with age

this was not my dating experience

Kenny Logins
Jan 11, 2011

EVERY MORNING I WAKE UP AND OPEN PALM SLAM A WHITE WHALE INTO THE PEQUOD. IT'S HELL'S HEART AND RIGHT THEN AND THERE I STRIKE AT THEE ALONGSIDE WITH THE MAIN CHARACTER, ISHMAEL.

theflyingexecutive posted:

Catholic boys have zero guilt, it comes on with age
or with priests

Graff
May 10, 2012

Kenny Logins posted:

or with priests

I never went out with any priests that's too weird even for me

H.P. Hovercraft
Jan 12, 2004

one thing a computer can do that most humans can't is be sealed up in a cardboard box and sit in a warehouse
Slippery Tilde

duTrieux.
Oct 9, 2003


now that's customer service

Robot Pride
Aug 2, 2010

by exmarx

is it warmed inside owen's rear end or mouth? this is important; asking for a friend

Robot Pride
Aug 2, 2010

by exmarx

"depilation" is my word of the day and every euphemism for female genitalia is extremely cringeworthy.....just say "pussy hole" and quit trying to be cute

H.P. Hovercraft
Jan 12, 2004

one thing a computer can do that most humans can't is be sealed up in a cardboard box and sit in a warehouse
Slippery Tilde

Robot Pride posted:

is it warmed inside owen's rear end or mouth? this is important; asking for a friend

don't be disgusting

it's his pits

H.P. Hovercraft
Jan 12, 2004

one thing a computer can do that most humans can't is be sealed up in a cardboard box and sit in a warehouse
Slippery Tilde

Robot Pride posted:

"depilation" is my word of the day and every euphemism for female genitalia is extremely cringeworthy.....just say "pussy hole" and quit trying to be cute

the best way to get people to smile in a group photograph is to get them to repeat ROCK N' ROLL PUSSY HOLE

Optimus_Rhyme
Apr 15, 2007

are you that mainframe hacker guy?


how and where was this made? I must know.

Optimus_Rhyme
Apr 15, 2007

are you that mainframe hacker guy?

vodkat
Jun 30, 2012



cannot legally be sold as vodka

Robot Pride
Aug 2, 2010

by exmarx

tracks 4, 5 and 9

lo to tha mothafuckin' marf

fishmech
Jul 16, 2006

by VideoGames
Salad Prong

hosed up goofy fonts help people who got dyslexia or whatever

netwerk23
Aug 22, 2000
I spelled 'network' wrong.

SmokaDustbowl posted:

god it's going to be worse than vape cloud people
Time to walk the kids to elementary school, while representing the vape lifestyle.


Wore the same shirt today, maybe it's a uniform.

netwerk23 fucked around with this message at 20:19 on Sep 7, 2016

H.P. Hovercraft
Jan 12, 2004

one thing a computer can do that most humans can't is be sealed up in a cardboard box and sit in a warehouse
Slippery Tilde

Glorgnole
Oct 23, 2012


yeah, gently caress the arts!!!

Moist von Lipwig
Oct 28, 2006

by FactsAreUseless
Tortured By Flan

lolllllll

H.P. Hovercraft
Jan 12, 2004

one thing a computer can do that most humans can't is be sealed up in a cardboard box and sit in a warehouse
Slippery Tilde


ugh just hit prtsc

big scary monsters
Sep 2, 2011

-~Skullwave~-

yeah art and artists suck. sure they can create such breathtaking beauty that it makes you weep for joy and gives meaning to the otherwise cold and futile hell that we call conscious existence, but can art build a bridge or sequence a genome? no, and that's why i'm a javascript developer

bump_fn
Apr 12, 2004

two of them

H.P. Hovercraft posted:



ugh just hit prtsc

if this is real it seems perfectly reasonable to me

"hey you probably don't know that your funny internet meme shares a name with a long standing african american heritage thing here, so be aware that you may inadvertently insult some people"

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H.P. Hovercraft
Jan 12, 2004

one thing a computer can do that most humans can't is be sealed up in a cardboard box and sit in a warehouse
Slippery Tilde
that they had to come out and say "the harambe floor is a real place in our school plz stop exposing yourself there to strangers" is p lol tho

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