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oliveoil posted:This is old, but you could always just have a single truck-driver make the trip to ensure the route is wide enough and tall enough for a truck. That's perfectly sensible for long-haul trucking, but you'd have to make a lot of trips to cover, say, all the ways to get to a major mall, with variations to account for traffic and detours.
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Sep 8, 2016 06:40
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Adventure Pigeon posted:That being said, I do understand some of the basics. I think it's a case where they're not being dishonest, but they're overemphasizing one part of the problem compared to all the others. I can see how narrowing down the list of small molecules that need to be tested against a particular target before one is found that works could speed up drug discovery. Of course, if you have a target receptor, and you have an idea of what molecule it binds in nature, then creating artificial small molecules that will probably target it based on the structure of the native signal molecule isn't exactly a blind process to begin with. Her method is probably a good way to come up with drugs when the target is already known, but that means most drugs will probably be improvements on existing treatments rather than entirely new treatments. This is basically what fragment based drug discovery is about and which have been going for like 10-20 years or so. Although it have only started to get real traction the last 10 or so.
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Sep 8, 2016 06:51
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Arsenic Lupin posted:That's perfectly sensible for long-haul trucking, but you'd have to make a lot of trips to cover, say, all the ways to get to a major mall, with variations to account for traffic and detours. Perhaps some sort of app? Shouldn't be hard to fart out TruQ or whatever and get the public to answer quick questions on things like bridge heights in exchange for little handouts a la google rewards.
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Sep 8, 2016 07:29
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We have cars that can park themselves. Here we are talking about cars that can detect and avoid other cars and pedestrians. You don't think a sensor that detects if a crossing is less than X ft tall is impossible in that case, do you?
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Sep 8, 2016 08:00
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Kerbtree posted:Perhaps some sort of app? Shouldn't be hard to fart out TruQ or whatever and get the public to answer quick questions on things like bridge heights in exchange for little handouts a la google rewards. Alternatively:
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Sep 8, 2016 08:06
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oliveoil posted:This is old, but you could always just have a single truck-driver make the trip to ensure the route is wide enough and tall enough for a truck. Cool idea, now redo your calculations with an eye to the fact that we don't live on an MMO server where areas do not exist unless instanced for the player. What I'm trying to get across here is that local conditions change. Frankly any automated system that can't handle roughly as much autonomous decision making as a new to the road driver without damaging itself, the cargo, the surroundings, or bystanders is not worth deploying.
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Sep 8, 2016 11:46
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Continuing with the topic of academic articles: h https://www.theguardian.com/science/2016/may/28/eu-ministers-2020-target-free-access-scientific-papers http://futurism.com/eu-announces-that-all-european-scientific-articles-should-be-freely-accessible-by-2020/ quote:This week was a revolutionary week in the sciences—not because we discovered a new fundamental particle or had a new breakthrough in quantum computing—but because some of the most prominent world leaders announced an initiative which asserts that European scientific papers should be made freely available to all by 2020. Of course, the scope is limited, as it only affects papers from the EU, and which were publicly funded (even if partially). The report says nothing about the archives though, meaning that data published before 2020 would not be required to be freely available.
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Sep 8, 2016 12:52
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The US already did that too, right?
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Sep 8, 2016 12:55
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You can already get a lot of papers on that uzbek site.
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Sep 8, 2016 15:04
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Cardiac posted:This is basically what fragment based drug discovery is about and which have been going for like 10-20 years or so. Although it have only started to get real traction the last 10 or so. Ah, ok, that makes sense. I wonder if this computational approach to identifying small molecules will end up being an improvement or a complementary approach that identifies a different set of targets. Probably a bit of both, but I don't see it being a replacement.
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Sep 8, 2016 15:16
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Subjunctive posted:The US already did that too, right? Yes, at least the NIH has. namaste faggots posted:You can already get a lot of papers on that uzbek site. The difference is that's incredibly illegal.
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Sep 8, 2016 16:46
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Discendo Vox posted:The difference is that's incredibly illegal. It's objectively a superior service compared to the typical university access. Until academic publishers make an equivalent of Netflix for papers and textbooks, they'll bleed like the music or movie industry.
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Sep 8, 2016 16:48
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I CANNOT EJACULATE WITHOUT SEEING NATIVE AMERICANS BRUTALISED!
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Has anyone been sued for downloading papers about panda loving illegaly? Not that I'd encourage it because that would be wrong but seems like a neat thing for broke students or independent researchers.
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Sep 8, 2016 16:57
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blowfish posted:It's objectively a superior service compared to the typical university access. Until academic publishers make an equivalent of Netflix for papers and textbooks, they'll bleed like the music or movie industry. Sounds like it's time for you to start talking to venture capitalists.
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Sep 8, 2016 17:03
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iirc Holmes' dad is a high up CIA spook which is a big reason she could get in the door with Kissinger et al
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Sep 8, 2016 17:09
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mobby_6kl posted:Has anyone been sued for downloading papers about panda loving illegaly? Not that I'd encourage it because that would be wrong but seems like a neat thing for broke students or independent researchers. It just so happens that most users of Sci-Hub are located at universities which already have access to most journals. This is just as much a user experience issue as it is a public access issue.
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Sep 8, 2016 17:10
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Adventure Pigeon posted:Ah, ok, that makes sense. I wonder if this computational approach to identifying small molecules will end up being an improvement or a complementary approach that identifies a different set of targets. Probably a bit of both, but I don't see it being a replacement. I am pretty doubtful that any computational approach to drug design is going to work until we have actually solved the protein folding problem. People have been talking about rational drug design, structure based drug design for the last 20 years without any actual ab initio success. The basiic approach is still to screen a large number of chemical using various methods and then pick out good hits for further refinement, In these steps computational tools are great tools, but they need something to start from. Fragment based drug discovery is basically the idea that instead of using large complex molecules in your screen, you use small fragments which then serve as building blocks for developing new drugs. The latest thing in fragment screening is to soak crystals with various fragments and then collect data on each crystal in a synchotron since synchotrons become better and more automatized.
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Sep 8, 2016 17:23
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mastershakeman posted:iirc Holmes' dad is a high up CIA spook which is a big reason she could get in the door with Kissinger et al Any citations for this cia anecdote?
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Sep 8, 2016 18:12
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namaste faggots posted:Any citations for this cia anecdote? from wikipedia: "Her father, Christian Rasmus Holmes IV, worked at Enron[3] as well as in the United States, Africa, and China in governmental agencies such as USAID." USAID is functionally a CIA front organization
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Sep 8, 2016 18:47
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gingrich posted:from wikipedia: "Her father, Christian Rasmus Holmes IV, worked at Enron[3] as well as in the United States, Africa, and China in governmental agencies such as USAID." I knew my grandfather wasn't just teaching the Pakistanis to make soap with fancy American equipement! Lever Brothers is where they get all the best (recently naturalized) spies. USAID has some spooks, but it is mostly a front for the chamber of commerce and the export import bank. Which, by the way, also makes you some good connections.
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Sep 8, 2016 19:04
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mobby_6kl posted:Has anyone been sued for downloading papers about panda loving illegaly? Not that I'd encourage it because that would be wrong but seems like a neat thing for broke students or independent researchers. Yes. It's hard to trace, though, and people like to rationalize why it's ok to do something illegal if it benefits them.
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Sep 8, 2016 19:09
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Used to be the best way to get papers was to email the author, now I'm spoiled since I've worked somewhere with access to everything for so long I don't know if that still works.
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Sep 8, 2016 19:43
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Tars Tarkas posted:Used to be the best way to get papers was to email the author, now I'm spoiled since I've worked somewhere with access to everything for so long I don't know if that still works. It still works but it takes longer than 10 seconds. Discendo Vox posted:Yes. It's hard to trace, though, and people like to rationalize why it's ok to do something illegal if it benefits them. I wouldn't even go so far as to expect rationalisation, it's more "I need this paper now and I don't care how". If it goes to the stage of rationalisation more people would probably agree with "publishers are parasites and nothing of value will be lost if russian hackers kill elsevier" than with "we must defend the journal copyrights on other people's papers". suck my woke dick fucked around with this message at 20:11 on Sep 8, 2016 |
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Sep 8, 2016 20:06
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Turns out, one good way to keep you unlicensed hotel from getting trashed is to exclude  certain folk https://news.ycombinator.com/item?id=12453298
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Sep 8, 2016 20:34
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Paul MaudDib posted:Turns out, one good way to keep you unlicensed hotel from getting trashed is to exclude The urban market stole my TV once you know.
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Sep 8, 2016 20:39
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gingrich posted:from wikipedia: "Her father, Christian Rasmus Holmes IV, worked at Enron[3] as well as in the United States, Africa, and China in governmental agencies such as USAID." Yeah it's also that her dad didn't do any actual NGO work then suddenly is high up in USAID , then combine w/ all the military contacts. Basically just word of mouth whisperings though
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Sep 8, 2016 21:00
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Yet she couldn't get funding from the cia vc arm. Hmmmm
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Sep 8, 2016 21:15
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Paul MaudDib posted:Turns out, one good way to keep you unlicensed hotel from getting trashed is to exclude There is a slight point here in that if you're renting a room out of the house you live in the normal housing discrimination rules are relaxed. ie, if you're a woman you can choose to only rent to women if you live there for example. AirBnB has a bit of a problem with the "totally not a hotel, except actually a hotel" thing.
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Sep 8, 2016 21:23
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Truck driving is super, super heavily subsidized - as in, the fees, tolls, etc. paid by trucks comes no where close to covering the wear and tear trucks put on roads. If that subsidy was removed the cost per mile could nearly double from that alone. Is the expectation that this continues for automated vehicles? If so, it's a tough sell now while those subsidies function as a backdoor jobs program, what's the justification when they don't? Remember that all of those now-displaced truckers still get to vote and none of the trucks do.
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Sep 8, 2016 22:22
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Buffer posted:Remember that all of those now-displaced truckers still get to vote and none of the trucks do. Most likely situation is the truckers don't get to vote, second most likely is that drones do.
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Sep 8, 2016 22:35
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Buffer posted:Truck driving is super, super heavily subsidized - as in, the fees, tolls, etc. paid by trucks comes no where close to covering the wear and tear trucks put on roads. If that subsidy was removed the cost per mile could nearly double from that alone. Is the expectation that this continues for automated vehicles? If so, it's a tough sell now while those subsidies function as a backdoor jobs program, what's the justification when they don't? Remember that all of those now-displaced truckers still get to vote and none of the trucks do. Companies would pass on the increased transportation costs to consumers, so it would have close to the same effect as raising the sales tax.
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Sep 8, 2016 23:41
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mastershakeman posted:iirc Holmes' dad is a high up CIA spook which is a big reason she could get in the door with Kissinger et al her family's the heir to the fleischmann yeast fortune and have a hospital named after them her dad was the cfo of the epa under bush the elder
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Sep 9, 2016 07:56
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mobby_6kl posted:Has anyone been sued for downloading papers about panda loving illegaly? Not that I'd encourage it because that would be wrong but seems like a neat thing for broke students or independent researchers. Sorry. Personal soft spot of mine. (heck, his wiki page even compares the sweet Kazakh site to his work.) DACK FAYDEN fucked around with this message at 17:21 on Sep 9, 2016 |
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Sep 9, 2016 17:17
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90% of ~free the papers~ talk is pure nerd ideology; access for researchers in poorer/less developed institutions is a serious issue and the journals are a PITA, but most people discussing don't care about access for practical reasons
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Sep 9, 2016 18:14
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DACK FAYDEN posted:Never forget Aaron Swartz. Former partner of Reddit, man who downloaded three-quarters-ish of JSTOR to a server at MIT, hounded by the government until he killed himself. If ever a unicorn was one of the good ones... "hounded by the government" meaning was subject to an entirely conventional criminal prosecution for scraping massive amounts of information from a non-profit digital library. lancemantis posted:90% of ~free the papers~ talk is pure nerd ideology; access for researchers in poorer/less developed institutions is a serious issue and the journals are a PITA, but most people discussing don't care about access for practical reasons 
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Sep 9, 2016 19:55
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namaste faggots posted:Yet she couldn't get funding from the cia vc arm. Hmmmm In-Q-Tel actually vets things.
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Sep 9, 2016 20:02
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lancemantis posted:90% of ~free the papers~ talk is pure nerd ideology; access for researchers in poorer/less developed institutions is a serious issue and the journals are a PITA, but most people discussing don't care about access for practical reasons It's not just researchers overseas. I'm getting a M.S. at a state school and don't have access to some of the major publishers. No critical primary sources for me!
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Sep 9, 2016 20:15
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Maera Sior posted:It's not just researchers overseas. I'm getting a M.S. at a state school and don't have access to some of the major publishers. No critical primary sources for me! Uh, go talk to a librarian. Thats literally their job.
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Sep 9, 2016 20:17
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Talk to another human being? That sounds pretty triggering.
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Sep 9, 2016 20:19
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hobbesmaster posted:Uh, go talk to a librarian. Thats literally their job. Hah. You still expect the university to be paying for all those publications in print when they can do a bulk order of some of them without sacrificing any shelf space? FWIW, I've had decent luck emailing the authors and asking for a copy, but sometimes the copies show up in dead tree format and I can't imagine them being willing to do that for someone overseas. Maera Sior fucked around with this message at 20:29 on Sep 9, 2016 |
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Sep 9, 2016 20:26
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