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not an endorsement posted:i think that's a completely valid thing to investigate in doing a systematic review of inpatient cases released v. dead, but the potential mediation effect of bcg on a lethal respiratory inflammation cascade doesn't even fit the narrative that people are leaping to that having the vaccine decreases likelihood of being a case at all, just mortality figures Wouldn't the bcg be causing people to be more mild or asymptomatic carriers? I feel like that's a pretty big win since the whole concern with this virus is clogging up hospitals and the deaths from the severe cases... Edit and they probably wouldn't be "cases" because they wouldn't get tested with mild to no signs of infection.
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Apr 11, 2020 12:01
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WarEternal posted:I wonder why the % of positive tests and hospitalizations are decreasing in NY but people dying at home is increasing and their average weekly deaths are way above rate. well it's all just a numbers game until we get our testing up to snuff!! *defunds testing support*
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Apr 11, 2020 12:02
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Hot Karl Marx posted:its because the economy, people need to get back to work asap 
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Apr 11, 2020 12:03
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Apr 11, 2020 12:06
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Hot Karl Marx posted:its because the economy, people need to get back to work asap B-b-b-but why would Cuomo lie? He's a Democrat, they're the good guys. He would make Trump look bad if he could. Even Cuomo loves Trump's response to virus crisis, he's doing a very good job! Back to work everyone! It will be very safe in just a couple weeks, unbelievably safe.
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Apr 11, 2020 12:06
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twoday posted:Yeah my hunch is that it reduces mortality figures mostly, rather than case rates. However, if this mechanism reduces the ability of the virus to multiply in the lungs then it would also reduce viral load and prevent spread, by effectively inducing herd immunity Dixville posted:Wouldn't the bcg be causing people to be more mild or asymptomatic carriers? I feel like that's a pretty big win since the whole concern with this virus is clogging up hospitals and the deaths from the severe cases... i don't see how any of what you linked can be interpreted as influencing morbidity, just the onset of ards -- which at that point the person would not be mobile anyway. it's not as if the entirety of the upper respiratory symptoms rely on this massive release of interleukins (see this paper someone just spat out on biorxiv, like, yesterday): https://www.biorxiv.org/content/10.1101/2020.04.06.027854v1 quote:The most vulnerable group in corona epidemic is elderly, malnourished, hypertensive, diabetic, immune compromised, cancer and cardiovascular patients, as well as pregnant women. Despite wide spread COVID-19 infection, the numbers of fatally infected children cases are less reported so far, possible mechanism might be an unknown protective interaction between immune system and respiratory pathway.5 COVID-19 spreads through droplet infection and fomites, from infected person during coughing and sneezing. Majority of symptoms are sore throat, breathing difficulty and fever, although GI and musculoskeletal system are also involved.6,7 Clinical course is somehow showing a predictable pattern. On around day five, flu like symptom starts, common are fever, headache, dry cough, myalgia (and back pain), nausea (without vomiting), abdominal discomfort with some diarrhea, loss of smell, anorexia and fatigue. Around same time symptoms can worsen leading to shortness of breath due to bilateral viral pneumonia from direct viral damage to lung parenchyma. Around day 10, cytokine storm kicks in, subsequently acute respiratory distress syndrome (ARDS) and multi organ failure ensues. This degradation usually happens in matter of hours. Hospitalized patients in moderate to severe cases usually come in hypoxic stage without dyspnea. China reported 15% cardiac involvement and serious final outcome. In most of the chest X-rays, bilateral interstitial pneumonia or ground glass opacities are seen. Hypoxia mostly does not correlate well with the chest x-ray findings. Chest auscultations are not of great help. Blood reports show, in the most cases, WBC is low, i.e. mostly lymphocytopenia, low platelet count whereas pro-calcitonin are mostly normal. Most consistently, CRP and ferritin levels are elevated and similarly CPK, D-dimer, LDH, ALKphos/AST-ALT levels are also high. It has been seen a ratio of absolute neutrophil count to absolute lymphocyte count, greater than 3.5, may be the highest predictor of poor outcome. An elevated level of IL-6 is of grave concern of cytokine storm.8,9 anyway, regardless: the point is that individuals should not attempt to haphazardly apply preliminary works without consensus on their own lives, and feel as if they are in danger if they are not taking a particular medication/vaccine/lifestyle factor that's been reported twice in small sample sizes at most
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Apr 11, 2020 12:06
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Dixville posted:Wouldn't the bcg be causing people to be more mild or asymptomatic carriers? I feel like that's a pretty big win since the whole concern with this virus is clogging up hospitals and the deaths from the severe cases... This would explain the statistics in eastern Europe pretty well
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Apr 11, 2020 12:06
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not an endorsement posted:i don't see how any of what you linked can be interpreted as influencing morbidity, just the onset of ards -- which at that point the person would not be mobile anyway. it's not as if the entirety of the upper respiratory symptoms rely on this massive release of interleukins (see this paper someone just spat out on biorxiv, like, yesterday): https://www.biorxiv.org/content/10.1101/2020.04.06.027854v1 I agree! My suspicion is that it influences mortality, not morbidity. If you don't enter the second phase of the illness, maybe you think that you just had a cold for a few days (I call this the "just the flu bro" effect) As for the second point, I am just investigating mechanisms that could potentially explain the correlation studies that have been coming out, that's why I'm sharing this on c spam Just spitballing, looking for feedback twoday has issued a correction as of 12:13 on Apr 11, 2020 |
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Apr 11, 2020 12:09
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Apr 11, 2020 12:09
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6G will give you a big dicks/titties
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Apr 11, 2020 12:10
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Hot Karl Marx posted:6G will give you a big dicks/titties count me in
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Apr 11, 2020 12:11
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oh god the germans are goign to kill us all i KNEW it!
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Apr 11, 2020 12:11
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Hot Karl Marx posted:6G will give you a big dicks/titties i knew surviving through this 5g pandemic would be worth it!! (i assume with the slash you meant AND)
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Apr 11, 2020 12:12
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twoday posted:I agree! My suspicion is that it influences mortality, not morbidity i think with what you posted it deffo could possibly maybe reduce the chance of dying from your immune system having a party if you're a hospitalized case anyway it's fun to see how many papers are being spammed into preprint atm: https://www.biorxiv.org/search/sars-cov-2 https://www.medrxiv.org/search/sars-cov-2
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Apr 11, 2020 12:12
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gimme a third hand because that's a lot to fondle
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Apr 11, 2020 12:13
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not an endorsement posted:i think with what you posted it deffo could possibly maybe reduce the chance of dying from your immune system having a party if you're a hospitalized case yah i feel that's what twoday has been posting about the vaccine leading to some difference in immune response that doesn't end up with a persons immune system drowning itself i dunno!!!! im dumber than hell
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Apr 11, 2020 12:14
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here is a cool animation with calligraphy that i, bulgakov, made right now using my fountain pen (??? ive already forg0t)
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Apr 11, 2020 12:16
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Bulgakov posted:yah i feel that's what twoday has been posting about Yeah I guess so I also have no idea what I'm talking about and a month ago I thought my lungs were pretty much bagpipes made of meat
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Apr 11, 2020 12:20
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Funerals are high risk, about the first thing that got cancelled in places with lock-downs. Do people still have them? how stupid is that. Bulgakov posted:here is a cool animation with calligraphy that i, bulgakov, made right now using my fountain pen (??? ive already forg0t) Theres really one quote for everything.
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Apr 11, 2020 12:23
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twoday posted:
Are you a doctor or anything? Is there a reason you think you should be doing medical research by just randomly searching things on google? 
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Apr 11, 2020 12:24
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Tei posted:Funerals are high risk, about the first thing that got cancelled in places with lock-downs. Do people still have them? how stupid is that. here in LA they are still taking the covid bodies to mortuaries. A woman I work with, her daughter is an undertaker and has been picking up lots of covid bodies.  she said they are extra super wrapped up but still.
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Apr 11, 2020 12:26
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Owlofcreamcheese posted:Are you a doctor or anything? Is there a reason you think you should be doing medical research by just randomly searching things on google? No, that's why I am posting this on the c-spam subforum of the something awful dot com comedy website and not trying to submit this to a medical journal This is a very advanced and niche type of shitposting
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Apr 11, 2020 12:27
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not an endorsement posted:i don't see how any of what you linked can be interpreted as influencing morbidity, just the onset of ards -- which at that point the person would not be mobile anyway. it's not as if the entirety of the upper respiratory symptoms rely on this massive release of interleukins (see this paper someone just spat out on biorxiv, like, yesterday): https://www.biorxiv.org/content/10.1101/2020.04.06.027854v1 That's true. We still don't have a lot of info. I also have no idea how feasible it is to start giving everyone BCG or the possible side effects of it so maybe it's a moot point. Would be good if there is something, anything that can possibly keep so many frickin people from dying though. We can also possibly use immune modulating/suppressing drugs that work at IL6 and IL8 for the severe ARDS cases instead of taking the time to implement some kind of BCG vaccine system I suppose. Don't know how much thise have been used. Here's a basic article that talks about tocilizumab possibly being used that way... https://www.livescience.com/coronavirus-covid-19-treatments.html
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Apr 11, 2020 12:28
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I know he or she is probably just another poor paycheck-to-paycheck millennial, but I really feel that Steakumms tweeter should be the first person against the wall
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Apr 11, 2020 12:28
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twoday posted:Yeah I guess so I also have no idea what I'm talking about and a month ago I thought my lungs were pretty much bagpipes made of meat i thought you were like dutch american not a scot!!
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Apr 11, 2020 12:28
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will we see an Easter Bump?
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Apr 11, 2020 12:28
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Owlofcreamcheese posted:Are you a doctor or anything? Is there a reason you think you should be doing medical research by just randomly searching things on google? Was the D&D thread not thrilling enough for you today?
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Apr 11, 2020 12:29
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i am doing a phd but its on omics of human neuromuscular disorders and not viruses do i still get a google certificate, is my ethos big enough
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Apr 11, 2020 12:29
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Mr. Pizza posted:will we see an Easter Bump? easter bumpy
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Apr 11, 2020 12:30
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i love how woke brand media twitters have migrated into trying to tie the brand into actually caring about people when they support the capitalist system that is destroying us, stupid loving woke brand media account
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Apr 11, 2020 12:31
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and all the dumbass morons poisoned by capitalism will think its a good idea steakums or w/e is saying this stuff
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Apr 11, 2020 12:31
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2000 deaths in a single day and the US is certainly undercounting. christ.
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Apr 11, 2020 12:32
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Hot Karl Marx posted:and all the dumbass morons poisoned by capitalism will think its a good idea steakums or w/e is saying this stuff those peoples boss's boss's boss's franchise owners' boss's boss's boss investment fund owner prolly has zero idea that their company has a twitter and from there infinitely less idea what some BRAND ACCOUNT is saying
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Apr 11, 2020 12:33
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Apr 11, 2020 12:33
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Bulgakov posted:those peoples boss's boss's boss's franchise owners boss's boss's boss investment fund owner prolly has zero idea that their company has a twitter and from there infinitely less idea what some BRAND ACCOUNT is saying nah these decisions come from the top asking how they can fit in with the woke kids on twitter
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Apr 11, 2020 12:34
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Owlofcreamcheese posted:Are you a doctor or anything? Is there a reason you think you should be doing medical research by just randomly searching things on google? It's perfectly reasonable for people to do research on their own as long as they're honest about their knowledge, and totally is noncomparable with hucksters selling snake oil for profit. Acting like this is some sort of heinous crime rather than engaging honestly, even if that engagement is a similar "I dunno, and I think the data are too unclear to support any of this", is anti-intellectual, authoritarian, elitist bullshit.
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Apr 11, 2020 12:34
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love to capitalize on a crisis with woke branding in order to sell stuff during a pandemic 
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Apr 11, 2020 12:35
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this is the weirdest timeline
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Apr 11, 2020 12:35
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Dixville posted:I also have no idea how feasible it is to start giving everyone BCG or the possible side effects of it I mean, we used to, and "you get a little scar" is the usual side effect. It's incredibly safe, comparatively.
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Apr 11, 2020 12:36
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Hot Karl Marx posted:and all the dumbass morons poisoned by capitalism will think its a good idea steakums or w/e is saying this stuff it could help shift the overton window, maybe just like there's no ironic racism there's no ironic socialism either
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Apr 11, 2020 12:38
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