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Judakel posted:I loving hate this virus. hes the president
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Apr 23, 2020 05:30
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hallebarrysoetoro posted:my money is on survivorship bias that smokers who aren’t dead from related smoking diseases are genetically predisposed to better immune response I'm guessing it has something to do with the ability of nicotine to suppress proinflammatory cytokines, if true fermun posted:it's the funniest possible medicine for this 
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Apr 23, 2020 05:30
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Notorious R.I.M. posted:Casinos, the place so canonically bad for disease transfer it was used for the initial outbreak in Contagion. yeah but contagion was wrong about basically everything
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Apr 23, 2020 05:30
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Notorious R.I.M. posted:I wonder if the "otherwise healthy" people are desat'ing without knowing it or if they're clotting up while spO2 is good. if china was testing with chest xrays or cat scans or whatever that means the lungs are at the point of some low grade pulmonary fibrosis and with the stress of infection on the body they probably should instantly be on oxygen at a minimum lol just to make sure kidneys heart and brain don’t suffer damage
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Apr 23, 2020 05:31
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twoday posted:I'm guessing it has something to do with the ability of nicotine to suppress proinflammatory cytokines, if true or maybe it is because the virus suffocates when there is smoke or maybe it is because viruses are Air element an smoke is Fire element
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Apr 23, 2020 05:32
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fermun posted:it's the funniest possible medicine for this, so i'm choosing to believe it's true, that we will live in a future where only people that smoke or dip survive. There was a study that was published where they said nicotine has the potential help with patients who had infectious myocarditis (viral infection of the heart). Granted this study was only done on rats, it does lead to some interesting theories. https://www.nature.com/articles/srep15895 quote:
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Apr 23, 2020 05:33
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twoday posted:I'm guessing it has something to do with the ability of nicotine to suppress proinflammatory cytokines, if true maybe but nothing about roni reads cytokine swarm. it’s basically a spot check on cardiovascular system given all the poo poo with comorbidities. like why would beetus and heart disease be bad for roni but nicotine be good
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Apr 23, 2020 05:34
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snoo posted:lmao my wife's on a med that increases risk of clots lmao weeee Most women are, it’s like the #1 side effect of the birth control pill
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Apr 23, 2020 05:35
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Stereotype posted:or maybe it is because the virus suffocates when there is smoke or maybe it is because viruses are Air element an smoke is Fire element It's the ACE2 receptor. Nicotine binds to it in the same way the virus uses that receptor for entry. If you have readily available nicotine to bind, the virus multiplies at a lower rate while your body gets time to respond. I hypothesized this 3 weeks ago in jest when I saw that this was how the virus operates not thinking there'd be any momentum behind investigating it cause smokers bad.
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Apr 23, 2020 05:35
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Notorious R.I.M. posted:I wonder if the "otherwise healthy" people are desat'ing without knowing it or if they're clotting up while spO2 is good. Hmm I'm gonna guess thicker blood actually is more efficient at meeting tissue oxygen needs and is one of the reason we see reports of people walking and talking normally while hypoxic right up until they stroke out
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Apr 23, 2020 05:38
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Sanlav posted:It's the ACE2 receptor. Nicotine binds to it in the same way the virus uses that receptor for entry. If you have readily available nicotine to bind, the virus multiplies at a lower rate while your body gets time to respond. that makes more sense if it slows the massive buildup of the virus before the body responds to it (is it me or is one of the most insane things it takes up to two weeks before you show symptoms and you can die from it 2 weeks later lol)
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Apr 23, 2020 05:38
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Stereotype posted:or maybe it is because the virus suffocates when there is smoke or maybe it is because viruses are Air element an smoke is Fire element tobacco smoke is both hot and dry, and according to Aristotle is thus predisposed towards providing the ideal conditions which would lead to the sustenance of life, yet just as the salamander is cold and damp and seeks out the flame to affect a balance, so too must the tobacco smoke only work in those who are by means of their astrological tendencies aligned to the water elements
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Apr 23, 2020 05:39
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I've got your large vessel stroke right here
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Apr 23, 2020 05:43
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can I post about it outside of cspam without getting probated now?
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Apr 23, 2020 05:45
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*slaps lungs* these bad boys can fit so much loving phlegm in them
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Apr 23, 2020 05:45
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Notorious R.I.M. posted:quick what is the best over the counter anticoagulant booooooze
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Apr 23, 2020 05:46
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Notorious R.I.M. posted:I wonder if the "otherwise healthy" people are desat'ing without knowing it or if they're clotting up while spO2 is good. They're 49 and have serious respiratory illness, I guess. I wish they had a better breakdown than over 50 and under 50. Also what they consider serious. Is mild diabetes counted? Obesity?
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Apr 23, 2020 05:46
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Notorious R.I.M. posted:quick what is the best over the counter anticoagulant there is a few you can get that are not rat poison (aspirin and others)
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Apr 23, 2020 05:48
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hallebarrysoetoro posted:maybe but nothing about roni reads cytokine swarm. it’s basically a spot check on cardiovascular system given all the poo poo with comorbidities. like why would beetus and heart disease be bad for roni but nicotine be good because coronavirus seems to kill people by causing a cytokine storm? https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30628-0/fulltext https://www.idse.net/Covid-19/Article/03-20/COVID-19-Brings-Cytokine-Storm/58061 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161506/ https://www.ncbi.nlm.nih.gov/pubmed/32283152 http://news.mit.edu/2020/proteins-cytokine-storms-covid-19-0416 and nicotine suppresses proinflammatory cytokines? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592351/ https://www.ncbi.nlm.nih.gov/pubmed/8930570 https://www.jimmunol.org/content/167/11/6518/tab-figures-data I don't know if this is true, it's just what I have been reading twoday has issued a correction as of 05:50 on Apr 23, 2020 |
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Apr 23, 2020 05:48
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LMAO when liquor, cigarettes, beans, and chaotic levels of stress-induced cortisol production turn out to defeat the roni and cspam emerges completely brokebrained but the sole survivors of corona.
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Apr 23, 2020 05:49
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A HORNY SWEARENGEN posted:LMAO when liquor, cigarettes, beans, and chaotic levels of stress-induced cortisol production turn out to defeat the roni and cspam emerges completely brokebrained but the sole survivors of corona. please happen faster
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Apr 23, 2020 05:54
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twoday posted:Yeah, don't read into it too much until they complete a study. Right now they're not even sure why it works, if it does; everyone is just frantically spitballing. There are other possible explanations for this data. yeah that's what I was thinking the like snake venom -> rabies -> roni thing seemed extremely galaxy brained to point where I'm looking at how, I guess, thorough and coherent the hypothesis is at face value and I'm like drat that's either really specious or really compelling, but I have no way to evaluate definitely hilarious if true. I'm glad they're at least doing the nicotine thing and seeing what happens. I don't know that the US would have
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Apr 23, 2020 05:54
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it owns. i'm already driving around without a seatbelt just to be 100% sure.
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Apr 23, 2020 05:56
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one of my favorite parts of this pandemic is wondering how the medication im on (verapamil, a calcium channel blocker) will effect the disease
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Apr 23, 2020 05:56
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eighty-four merc posted:
what was that?
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Apr 23, 2020 05:56
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twoday posted:I'm guessing it has something to do with the ability of nicotine to suppress proinflammatory cytokines It's because smoking makes u cool and tough
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Apr 23, 2020 05:58
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Ringo Roadagain posted:one of my favorite parts of this pandemic is wondering how the medication im on (verapamil, a calcium channel blocker) will effect the disease it won't do poo poo. avoidance/prevention is the best cure.
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Apr 23, 2020 06:00
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eighty-four merc posted:yeah that's what I was thinking Regardless of whether or not it turns out to be true, it's still funny that this possibility is being seriously considered, of all places, in France
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Apr 23, 2020 06:00
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Celexi posted:can I post about it outside of cspam without getting probated now? love watching the other forums get extremely mad about any possible indication that nicotine may be good, actually.
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Apr 23, 2020 06:00
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SKULL.GIF posted:it won't do poo poo. avoidance/prevention is the best cure. its less that Im hoping that it will save me and more that Im hoping its not gonna help the virus kill me lol
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Apr 23, 2020 06:02
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it's the 20s. we're bringing back economic crashes, socialism, and smoking
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Apr 23, 2020 06:03
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I am literally going 10 days between going out for food. I live in a low risk region. This poo poo has a 2-5% chance of killing you. Obviously we know oblivion is inevitable but I want to live to see the demise of the forsaken American empire, give me that loving much at minimum. all this poo poo, all this talk about just barely maybe I have a chance??????? is delusion. embrace death, embrace oblivion, embrace meaninglessness. it's coming whether you like it or not
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Apr 23, 2020 06:05
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Celexi posted:what was that? "that french paper about trialing nicotine patches posted:To further investigate the molecular aspects of Covid-19 propagation in the brain and its pharmacology, we have been aided by abundant studies on rabies virus (RABV) a negative polarity, single-strand RNA virus that is distinct from the coronaviruses [18-20]. nAChRs were shown to be the first receptors for RABV [21]. Structural studies further revealed that a short region in the ectodomain of the rabies virus glycoprotein shows sequence similarity to some snake toxins [20, 22] that were initially used to isolate the nAChR from fish electric organs [23]). take a look at the paper. I don't understand it lmao but like I said it's just real galaxy brained so it'd be real funny if it's right
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Apr 23, 2020 06:09
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my medicinal vape
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Apr 23, 2020 06:11
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SKULL.GIF posted:all this poo poo, all this talk about just barely maybe I have a chance??????? is delusion. embrace death, embrace oblivion, embrace meaninglessness. it's coming whether you like it or not 
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Apr 23, 2020 06:15
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twoday posted:because coronavirus seems to kill people by causing a cytokine storm? They don't have to be exclusive: 1) Patient with HTN, diabetes, 70+, the stress of the virus kills the person by organ failure 2) 20 year-old healthy patient with antibodies that enhance the viral infection (antibody dependent enhancement) generates a cytokine storm, their lungs become fibrotic due to the inflammation, and they asphyxiate Both die due to the virus but by different mechanism
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Apr 23, 2020 06:27
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Fix posted:It's the dumbest timeline, which means that they'll make a vaccine that causes autism so Trump can be right. actually there's surprisingly good evidence that Tylenol causes autism as in like, the amount of tylenol in cord blood is hugely predictive of autism in children once they grow up (on average having detectable levels triples the chance), and the uptick in autism cases happens exactly when people stopped giving aspirin to small children due to the risk of Reye's syndrome so yeah the antivaxx parents MIGHT have actually spotted a causal link but blamed the vaccine given to the kid, instead of the tylenol that's routinely given alongside it
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Apr 23, 2020 06:27
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fosborb posted:there's no loving way there's an Iowa State Fair this year. the fairgrounds are full of temporary housing for one, but also, imagine the liability. at the very least it's in Des Moines City limits so despite all else the mayor can declare "gently caress off with 100,000 people packed into a flat 300 acres" I love the Iowa State Fair, it’s a fried food bacchanal. I can’t imagine what a “safe” version of the fair could look like and I sure as gently caress couldn’t be convinced to attend. Hopefully they’ll work out some sort of delivery system so I can get a corn brat & some totchos before we all die from blood clots. Azathoth posted:That raises some really important questions regarding spread via farm animals as well, unless there's something I don't know about cats and humans having really similar respatory systems that isn't shared by other animals. The reason the virus is spreading so rapidly in pork/chicken/beef meatpacking plants is because the virus spreads really easily between humans and the floor of a meatpacking plant is filled with workers standing shoulder to shoulder. There’s no way in most industrial plants to distance workers especially in an industry that isn’t known for worker safety. I don’t think there’s any evidence that we can give this to pigs or chickens or cows so idk why you would assume they are spreading it as opposed to human to human. China even tried super hard to give it to pigs, chickens, ducks & cats by near drowning them in the virus and only cats caught it. What I read on why cats can get it is that investigators think that covid19 spent some time in a civet cat before moving on to a pangolin. We can give it to cats, cats can give it to each other but so far no evidence they can give it back to humans even though we deserve it.
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Apr 23, 2020 06:27
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Hello. I am very wealthy and my cat would like a covid19 test please.
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Apr 23, 2020 06:30
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Trixie Hardcore posted:I love the Iowa State Fair, it’s a fried food bacchanal. I can’t imagine what a “safe” version of the fair could look like and I sure as gently caress couldn’t be convinced to attend. Hopefully they’ll work out some sort of delivery system so I can get a corn brat & some totchos before we all die from blood clots. SARS-CoV-1 had an apparent reservoir in the civet. The lineage from SARS-CoV-1 to SARS-CoV-2 is less clear, but apparently may have involved bats or pangolin. The common component between species would be the ACE-2 receptor homology between species and the ability of the virus to recognize it (and hence replicate).
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Apr 23, 2020 06:32
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