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I've closed the door now but the horse is still gone?
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Jun 24, 2020 20:43
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I think the takeaway is, we are all gonna die.
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Jun 24, 2020 20:43
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Gologle posted:This thread and the protests thread are literally my top sources of information as to what's going on in the country and losing them would both probably be better for my mental health and also probably be really bad for my physical health. New York Times has made their coronavirus articles free, I highly recommend getting news from proper news outlets such as them. Ditching social media for at least the coronavirus news really is better for mental health because outlets like NYT very rarely have “We Are All Gonna Die” in their headlines. I noticed this already back in January when that Suleimani guy got killed: all social media started posting memes about world war 3 starting any minute now, but in NYT they explicitly said that war between US and Russia over that incident was very unlikely. The whole tone was just so much more rational than what went on on social media.
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Jun 24, 2020 20:47
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Delta-Wye posted:The simple obvious big brain solution is to wind down testing over the next few weeks and then declare victory over the viral menace. Earlier post from early May, finally the government has figured out the end of testing means no more corona in the US! Very good news indeed.
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Jun 24, 2020 20:48
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A friend posted this: SARS-CoV-2 binds to the cell surface protein ACE2 (angiotensin I converting enzyme 2). As the name implies, this protein cleaves angiotensin I involved in regulating blood pressure. (It is the target of ACE inhibitors that reduce blood pressure.) The coronovirus spike protein binds through it's receptor-binding domain (RBD) and the crystal structure of the RBD-ACE2 interaction has recently been solved by Chinese scientists (Lan et al. 2020). Most coronoviruses don't bind strongly to ACE2 but SARS-CoV-2 evolved a strong binding interaction similar to that of SARS-CoV (responsible for the SARS outbreak). It looks like an example of convergent evolution. Lan, J., J. Ge, J. Yu, S. Shan, H. Zhou, S. Fan, Q. Zhang, X. Shi, Q. Wang and L. Zhang (2020). "Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor." Nature 581(7807): 215-220. doi: 10.1038/s41586-020-2180-5 
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Jun 24, 2020 20:52
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Also: SARS-CoV-2 is evolving at a normal rate from the initial isolate first identified and sequenced in China. Tung Phan at the University of Pittsburgh (USA) has compared the sequences of 86 strains from all over the world and he has identified a total of 93 mutations including three deletions (see figure below). Forty-two of these mutations are missense mutations located in the ORF1ab polyprotein gene, the spike surface glycoprotein gene, the matrix protein gene, and the nucleocapsid protein gene. No mutations in the envelope protein genes were found. Phan, T. (2020). "Genetic diversity and evolution of SARS-CoV-2." Infection, genetics and evolution 81: 104260. [doi: j.meegid.2020.104260]  It means that it’s possible to track the various strains of the virus; for example, it’s clear that most of the infections in New York came from Europe. It also means that the virus is not hypermutating like the influenza viruses so a vaccine against the current strains is likely to be effective if it truly blocks virus entry or replication. On the other hand, we are very unlikely to get an effective vaccine because none have ever been developed against coronaviruses. Rust Martialis fucked around with this message at 20:56 on Jun 24, 2020 |
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Jun 24, 2020 20:53
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what am i to do with this information
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Jun 24, 2020 20:54
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Mons Hubris posted:what am i to do with this information perish
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Jun 24, 2020 20:56
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Rust Martialis posted:On the other hand, we are very unlikely to get an effective vaccine because none have ever been developed against coronaviruses. SARS-1: Burned out real fast, nobody cared anymore MERS: Not very transmissible between humans, no one cares Garden variety coronaviruses: Causes common cold in almost all cases, nobody cares Yeah there were trials of some vaccines showing antibody-dependent enhancement, blah blah, but that does not at all mean it's impossible or that people keep getting stymied the way they do with HIV. Zugzwang fucked around with this message at 21:33 on Jun 24, 2020 |
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Jun 24, 2020 21:31
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Somehow I figured I'd catch the Rona and die before the forums, but here we are. It's been a pleasure shitposting with all of you
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Jun 24, 2020 21:46
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Iron Crowned posted:Somehow I figured I'd catch the Rona and die before the forums, but here we are. It's been a pleasure shitposting with all of you ~~And The Virus Ronied On~~
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Jun 24, 2020 22:06
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Zugzwang posted:This gets thrown around a lot. It's because nobody really gave a gently caress until very recently. A big issue is that a lot of the research into vaccines is via private corporations and if they can't see any profits in following through they'll just drop it and wait for some more profitable disease to appear, because of course they're not going to spend all that money and time and resources for  the good of humanity , that'd be unthinkable.Here's a relevant post from a while back: Snowglobe of Doom posted:I noticed the other day the chairman of the White House Council for Economic Advice (the idiots who released that stupid fuckin' "Cubic Fit" virus model) tweeted this in support of Operation Warp Speed:
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Jun 24, 2020 22:06
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Snowglobe of Doom posted:A big issue is that a lot of the research into vaccines is via private corporations and if they can't see any profits in following through they'll just drop it and wait for some more profitable disease to appear, because of course they're not going to spend all that money and time and resources for
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Jun 24, 2020 22:20
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Iron Crowned posted:Somehow I figured I'd catch the Rona and die before the forums, but here we are. It's been a pleasure shitposting with all of you Amazing isn't it? 2020 continues to pour poo poo and piss on us from a great height.
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Jun 24, 2020 22:38
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If the roni vaccine isn't a profitable venture I don't see what is.
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Jun 24, 2020 23:01
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Snowglobe of Doom posted:A big issue is that a lot of the research into vaccines is via private corporations and if they can't see any profits in following through they'll just drop it and wait for some more profitable disease to appear, because of course they're not going to spend all that money and time and resources for I was briefly part of the development of a SARS CoV 2 vaccine candidate that is starting with animal trials soon so I got a glimpse of the costs involved. For just going through the setup, production and registration processes one basically needs the full backning of a well funded company and/or venture capital. Because getting that kind of money from grants for narrow high risk projects is basically impossible. If states would want to fund things like this it would easily be possible, but if you can make a buck on your idea you are expected to do so and then you have to do it through the private sector. Zudgemud fucked around with this message at 23:13 on Jun 24, 2020 |
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Jun 24, 2020 23:08
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unpacked robinhood posted:If the roni vaccine isn't a profitable venture I don't see what is. How so? If someone else releases a successful vaccine and your team is still 12 months away, or stuck in a dead end, then that was an unprofitable venture
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Jun 24, 2020 23:14
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Zudgemud posted:I was briefly part of the development of a SARS CoV 2 vaccine candidate that is starting with animal trials soon so I got a glimpse of the costs involved. For just going through the setup, production and registration processes one basically needs the full backning of a well funded company and/or venture capital. Because getting that kind of money from grants for narrow high risk projects is basically impossible. Here in Australia we had a pretty large federally funded agency called the Commonwealth Scientific and Industrial Research Organisation (CSIRO) which pretty much did random-rear end research into stuff they felt was important for it's 100+ years of existence until our current lovely conservative government defunded the gently caress out of them and reorganised them so that they only conducted 'profitable' research because they couldn't stomach wasting all that money on dumb nerd science poo poo.  My favourite CSIRO story is that a bunch of space nerds did a ton of research into detecting black holes and after years of work their study was a complete failure and it turns out that their theories had just been wrong so on paper it sounds like the entire thing was a huge waste of time and resources and money, but it just so happened that some of the tech they developed for unscrambling astonomy radio waves was also super useful for this new tech called "wi fi" which ended up being used in tens of billions of devices and they ended up making billions and billions of dollars on the patents. Of course under the current government's "profitability" guidelines the original study into this extremely obscure nerd stuff that was never intended to event effect anything terrestrial would never have been approved. unpacked robinhood posted:If the roni vaccine isn't a profitable venture I don't see what is. It wasn't profitable until 2020, and by the time anyone realised that it was much much too late Snowglobe of Doom fucked around with this message at 23:31 on Jun 24, 2020 |
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Jun 24, 2020 23:24
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zer0spunk posted:I think the takeaway is, we are all gonna die. Hazo posted:perish 
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Jun 24, 2020 23:28
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Dog on Fire posted:New York Times has made their coronavirus articles free, I highly recommend getting news from proper news outlets such as them. I mean, news media also said the novel coronavirus wasn’t going to leave China while people on this forum were buying beans and masks.
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Jun 24, 2020 23:30
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QuarkJets posted:How so? If someone else releases a successful vaccine and your team is still 12 months away, or stuck in a dead end, then that was an unprofitable venture Not if one is more effective than another, results in fewer side effects, can be used on more people (live vs. dead virus), is cheaper to produce, etc. The competitive space isn’t just “is a vaccine or not”
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Jun 24, 2020 23:34
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Fallom posted:Not if one is more effective than another, results in fewer side effects, can be used on more people (live vs. dead virus), is cheaper to produce, etc. The competitive space isn’t just “is a vaccine or not” Fine but see the part where I mention dead ends; most efforts will never release a vaccine, clearly those ventures would be unprofitable
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Jun 24, 2020 23:37
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QuarkJets posted:Fine but see the part where I mention dead ends; most efforts will never release a vaccine, clearly those ventures would be unprofitable Ok Companies are trying for a piece of the pie. That’s why it’s called a venture. I don’t think anyone’s arguing they’re guaranteed success.
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Jun 24, 2020 23:39
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Fallom posted:Ok That's what unpacked robinhood appears to be saying
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Jun 24, 2020 23:42
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QuarkJets posted:Fine but see the part where I mention dead ends; most efforts will never release a vaccine, clearly those ventures would be unprofitable Heck no, some of those are the most profitable. There's been a bunch of cases recently where pharma corps have announced that they were close to a breakthrough and the market responded by immediately pumping the price of their stocks which no doubt was a huge windfall for their stock holders. They usually announce a week or two later that their vaccine has stalled at the next level of testing but they made a shitload of money and they didn't have to lose a ton of finances in expanding their manufacturing capabilities, the system is working exactly as intended!!
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Jun 24, 2020 23:56
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This thread has been my main way of absorbing COVID news without having a mental breakdown, I hope the forums don't go away regardless of Lowtax apparently being a shithead. If I have to get my virus news from serious news articles instead of goons' funny takes I will be extremely sad.
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Jun 25, 2020 00:02
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https://www.youtube.com/watch?v=SM8dtQjAvRE E: https://twitter.com/TheDukeIsALie/status/1275852231208828929 Snowglobe of Doom fucked around with this message at 00:41 on Jun 25, 2020 |
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Jun 25, 2020 00:05
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Why the gently caress are people such babies about masks I could barely tell I was wearing one when I had that ubiquitous blue surgical mask on. If my 80+ year old grandfather with a cold had no problem wearing one to see my grandmother in hospice (who by the way died of pneumonia and that was real loving tough to watch, one reason I'm so proactive about covid) I don't see why so many relatively young and healthy people are like omg it's so hard to breathe in one. The N95 type ones, yes, those get real stuffy a few hours in but 30 minutes in a grocery store in a paper mask? Come the gently caress on. This has been my daily covid rant thanks
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Jun 25, 2020 01:49
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this is the boring-est apocalypse
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Jun 25, 2020 02:00
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21st Cherry boy posted:Why the gently caress are people such babies about masks Some people have real mental issues with stuff on their faces. Most people are just afraid to admit their own mortality to themselves, resulting in massive misbehavior. Sorry about your grandma.
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Jun 25, 2020 02:11
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21st Cherry boy posted:Why the gently caress are people such babies about masks They're bug chasers
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Jun 25, 2020 02:23
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Raskolnikov2089 posted:They're bug chasers pos my neg lungs
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Jun 25, 2020 02:26
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Poz my neg mouth hole.
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Jun 25, 2020 02:26
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21st Cherry boy posted:Why the gently caress are people such babies about masks Because 9/11.
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Jun 25, 2020 02:30
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https://twitter.com/majorityfm/status/1275867327825920005?s=09
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Jun 25, 2020 02:33
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The US just had its highest ever single day of reported cases, and even the rolling seven day average is higher than it was during the 'peak' back in early April.  https://www.worldometers.info/coronavirus/country/us/
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Jun 25, 2020 02:36
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buy some beans, stay inside, and just let ‘em die at this point
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Jun 25, 2020 02:39
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Disneyland announced an indefinite postponement of reopening the theme park. Downtown Disney shopping and dining area opening per plan.
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Jun 25, 2020 03:23
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Burn Florida to the ground.
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Jun 25, 2020 03:57
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Snowglobe of Doom posted:https://www.youtube.com/watch?v=SM8dtQjAvRE Extremely good timing when today cops in a different AZ city released a video of them smothering a man to death with plastic blankets https://tucson.com/news/local/tucso...543340e4d4.html
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Jun 25, 2020 04:31
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