Steve Yun posted:

https://www.nytimes.com/2021/07/28/health/pfizer-booster-shots.html?smid=tw-share

emgeejay posted:

inferis posted:

I’ve been in a doctors office and watched them close a tab that was literally just them googling symptoms

emgeejay posted:

Testvan posted:

this turd got updated today





here is the earliest one with a Aug 15 prediction:

emgeejay posted:

RudeCat posted:

Hell yeah, got this game in the garage.

Try and stop me.

You Fool!

quote:

Efficacy peaked at 96.2% during the interval from 7 days to <2 months post-dose 2, and declined gradually to 83.7% from 4 months post-dose 2 to the data cut-off, an average decline of ~6%
every 2 months

McNugget Buddy posted:

It's important to note that Pfizer's 3rd-dose data shows huge increases for titers against Wild Type and Beta after one week, but their figures showing a huge increase in titers against Delta was at the one month mark.

So it's super important to not get infected in the 4 weeks after the third shot.

Nocturtle posted:

Posted this already but you might want to look at this lancet article:
https://twitter.com/EricTopol/status/1427764114386944000?ref_src=twsrc%5Etfw
Graph A is neutralization from "homologous" plasma ie original AZ + AZ booster and B is from "heterologous" plasma ie AZ + Pfizer booster. AZ is an adenovirus vaccine just like JJ, though IIRC JJ did report better clinical trial efficacy. This is a very small study but you don't want to have antibodies like those in graph A.

sonatinas posted:

uh “all” gonna need clarification here

Testvan posted:

this turd got updated today





here is the earliest one with a Aug 15 prediction:

zegermans posted:

any news on a Johnson and Johnson booster or are they just going to abandon that one and tell you to start over after you've lost immunity

Google Butt posted:

Hey can you repost your respirator post from the last thread

Steve Yun posted:

The Legend of Titers Maximus

mastershakeman posted:

You sure on that? I thought it was antibodies started fading a month after the dose and the body relies on tcells and whatnot to make more antibodies later

Edit Steve yun made same point

Snowglobe of Doom posted:

https://i.imgur.com/sGtoZDT.gifv

Snowglobe of Doom posted:

https://i.imgur.com/sGtoZDT.gifv

Snowglobe of Doom posted:

https://i.imgur.com/sGtoZDT.gifv

Joementum posted:

oh there is absolutely evidence that you should get a booster shot. i was talking about the switch from six months to the biden admin's new eight month delay

Steve Yun posted:

EVERYONE WHO IS WONDERING WHY THEY PICKED 8 MONTHS FOR YOUR BOOSTER

Pfizer did that recent 6 month study of efficacy:
https://www.medrxiv.org/content/10.1101/2021.07.28.21261159v1.full.pdf

They're probably extrapolating the 8 months based on how much effiacy declined after 6 months, since the study says 6% effiacy drop every month after the 4 month mark after the second dose, that would suggest a 24% efficacy drop in the 8th month after the second dose

And observing that antibodies dropped off to rely on memory cells, which is not ideal against the front-loaded delta variant

Steve Yun posted:

EVERYONE WHO IS WONDERING WHY THEY PICKED 8 MONTHS FOR YOUR BOOSTER

quote:

But by July the Israeli miracle sobered up, revealing that fully vaccinated people were protected against severe disease and death but not necessarily against infection. In early July, the Ministry of Health announced effective immunity among the fully vaccinated had dropped to 64 percent, from the 95 percent level measured two months previously. Then, on July 17, the ministry reported a surge in breakthrough cases involving the delta variant. Most cases occurred in people either who had been fully vaccinated more than four months previously, indicating the waning immunity problem, or who were just completing their shots in July, too recently to be completely effective.

quote:

According to Israel, and to Pfizer, vaccine-induced immune response shifts from a powerful form replete with neutralizing antibodies drifting in the bloodstream to the quieter B cell memory type within about four months’ time after the second dose. Neutralizing antibody production declines, Pfizer says, about 6 percent per month, hitting 84 percent vaccine efficacy by month six. By eight months, it’s all about memory, which leaves the individuals highly vulnerable to infection.

In other words, the two-dose vaccinated individuals may have primed immune systems that can make neutralizing antibodies against SARS-CoV-2, but the enemy is coming at them in such massive numbers, and surging inside their bodies so rapidly, that some six to eight months after completing vaccinations, they may be unable to muster adequate defenses to prevent illness, even long-haul COVID-19.

quote:

All this is why Israel is starting a third round of national vaccination and why Pfizer wants the CDC and FDA to approve the same for the United States. According to data Pfizer presented to stock shareholders recently, the company estimated that a third booster shot had the potential to increase neutralization of the delta variant by up to a hundredfold, compared with before the third dose.

It also appears that the United States may have blundered by setting the time interval between the first two doses at 21 days—a decision made by the CDC and FDA under the Trump administration. For reasons having less to do with science than with the rush to get as many British at least partially protected as rapidly as possible, Boris Johnson’s government chose a far longer time interval between doses—months. And that may explain why the delta variant’s dire impact seems to be reversing in the U.K., with daily incidence of new cases dropping rapidly. Plotkin, the vaccine inventor, says longer times between jabs—perhaps six months—give the immune system time to settle into its lulled memory status before getting another jolt of fake infection (which, after all, is what a vaccine is), prompting the manufacture of neutralizing antibodies. That length-of-interval issue has arisen with other vaccines, he says, consistently showing months, not days, are required between doses.

thedavid posted:

So I thought I'd ask my cspam virologists their opinion....

I'm fully vaxxed with that sweet moderna slut juice, as is my wife. We have three kids at home that are under 12, which doesn't matter because kids don't get covid.

Anyway, I have had headaches for the past three days, as well as a light cough. Last night I've gotten some awesome sore throat that's persisted through today.

My littlest, 1 year old, has been a snot factory and has been in general irritable for the past few days. Too young to tell us what's wrong.

I have been masking (no respirator crew) and have been wondering if I should be getting a test and if we should be quarantining.

At the same time, two of the kids go to school starting next week, and it's a "highly recommended but not mandated mask rule" district. So I figure we're going to get it anyway.

I'm at a loss as to what to do. Should I get a test?

thedavid posted:

So I thought I'd ask my cspam virologists their opinion....

I'm fully vaxxed with that sweet moderna slut juice, as is my wife. We have three kids at home that are under 12, which doesn't matter because kids don't get covid.

Anyway, I have had headaches for the past three days, as well as a light cough. Last night I've gotten some awesome sore throat that's persisted through today.

My littlest, 1 year old, has been a snot factory and has been in general irritable for the past few days. Too young to tell us what's wrong.

I have been masking (no respirator crew) and have been wondering if I should be getting a test and if we should be quarantining.

At the same time, two of the kids go to school starting next week, and it's a "highly recommended but not mandated mask rule" district. So I figure we're going to get it anyway.

I'm at a loss as to what to do. Should I get a test?

thedavid posted:

So I thought I'd ask my cspam virologists their opinion....

I'm fully vaxxed with that sweet moderna slut juice, as is my wife. We have three kids at home that are under 12, which doesn't matter because kids don't get covid.

Anyway, I have had headaches for the past three days, as well as a light cough. Last night I've gotten some awesome sore throat that's persisted through today.

My littlest, 1 year old, has been a snot factory and has been in general irritable for the past few days. Too young to tell us what's wrong.

I have been masking (no respirator crew) and have been wondering if I should be getting a test and if we should be quarantining.

At the same time, two of the kids go to school starting next week, and it's a "highly recommended but not mandated mask rule" district. So I figure we're going to get it anyway.

I'm at a loss as to what to do. Should I get a test?

actionjackson posted:

I've gotten several of these. I'm a biostatistician lol

RedneckwithGuns posted:

I'll be honest, as someone on the front lines of vaccinations (pharmacist) I hope this boosters for everyone thing doesn't end up being necessary because the initial roll out this spring was hell and if they approve this poo poo on top of flu shot season pharmacies are going to start dropping like flies and you'll be waiting two weeks for any prescription to get filled, let alone how much extra risk that adds for mistakes to happen.

Snowglobe of Doom posted:

https://i.imgur.com/sGtoZDT.gifv