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Brute Squad
Dec 20, 2006

Laughter is the sun that drives winter from the human race

https://twitter.com/nytimes/status/1464356137390809112

I had no idea he wrote songs for Dick Tracy. And that he won an academy award for Madonna's song in Dick Tracy.

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Platystemon
Feb 13, 2012

BREADS
Moderna has announced plans.

quote:

The recently described Omicron variant includes mutations seen in the Delta variant that are believed to increase transmissibility and mutations seen in the Beta and Delta variants that are believed to promote immune escape. The combination of mutations represents a significant potential risk to accelerate the waning of natural and vaccine-induced immunity. A booster dose of an authorized vaccine represents the only currently available strategy for boosting waning immunity. The Moderna COVID-19 vaccine (mRNA-1273) is authorized as a booster for many populations at the 50 µg dose level. The Company is working rapidly to test the ability of the current vaccine dose to neutralize the Omicron variant and data is expected in the coming weeks.

Since early 2021, Moderna has advanced a comprehensive strategy to anticipate new variants of concern. This strategy includes three levels of response should the currently authorized 50 µg booster dose of mRNA-1273 prove insufficient to boost waning immunity against the Omicron variant.

First, Moderna has already tested a higher dose booster of mRNA-1273 (100 µg) in healthy adults. Moderna has completed dosing of 306 participants in a safety and immunogenicity study of this high dose (100 µg) booster. The 100 µg dose of mRNA-1273 has also recently been studied by the National Institutes of Health (NIH) in the U.S. and has generally resulted in the highest neutralizing titers against prior SARS-CoV-2 strains. Moderna is working to rapidly test sera from its high dose booster recipients in neutralizing assays to determine if the 100 µg dose provides superior neutralizing protection against Omicron.

Second, Moderna is already studying two multi-valent booster candidates in the clinic that were designed to anticipate mutations such as those that have emerged in the Omicron variant. The first candidate (mRNA-1273.211) includes several mutations present in the Omicron variant that were also present in the Beta variant of concern1. The Company has completed dosing in a potentially pivotal safety and immunogenicity study of mRNA-1273.211 at the 50 µg (N=300) and 100 µg (N=584) dose levels. A second multi-valent candidate (mRNA-1273.213) includes many of the mutations present in the Omicron variant that were also present in the Beta and Delta variants2. The Company has completed dosing at the 100 µg (N=584) dose level and also plans to explore the 50 µg dose level in approximately 584 participants. Moderna will rapidly expand testing of sera from completed and ongoing multi-valent booster studies to determine if these multi-valent candidates are able to provide superior neutralizing protection against Omicron.

Third, Moderna will rapidly advance an Omicron-specific booster candidate (mRNA-1273.529). This candidate is part of the Company’s strategy to advance variant-specific candidates for a subset of variants of significant concern. During 2021 this has already included Beta- and Delta-specific boosters. The Company has repeatedly demonstrated the ability to advance new candidates to clinical testing in 60-90 days.

https://investors.modernatx.com/news-releases/news-release-details/moderna-announces-strategy-address-omicron-b11529-sars-cov-2

Best Friends
Nov 4, 2011

Vax doesn't go to large parts of the world > new variant > new vax > rich govs shell out for new vax for their own people > repeat

Thwomp
Apr 10, 2003

BA-DUHHH

Grimey Drawer

60-90 days to clinical trials for a vaccine. Modern miracles.



Also, my inner 80s child is freaking out that the human race must now face Omicron.

facialimpediment
Feb 11, 2005

as the world turns

Best Friends posted:

Vax doesn't go to large parts of the world > new variant > new vax > rich govs shell out for new vax for their own people > repeat

Not the case with this one, apparently! (with apologies for using a Matty link)

https://twitter.com/mattyglesias/status/1464416307810607107

https://www.usnews.com/news/world/articles/2021-11-24/exclusive-south-africa-delays-covid-vaccine-deliveries-as-inoculations-slow

Can't find the source I had earlier - but South Africa apparently skews heavily younger than most other countries and the Youngs are playing the hesitancy card. So their terrible vaccination rate isn't a matter of supply, it's a matter of demand. Supply is a general problem, of course, but this appears to be a variant made by hesitancy (if it indeed came from that part of Africa).

Platystemon
Feb 13, 2012

BREADS

facialimpediment posted:

So their terrible vaccination rate isn't a matter of supply, it's a matter of demand.

There’s also the issue that this variant has been stewing for a long time, greater than one year.

It’s far from certain that it would have been stopped even if every country in southern Africa had had Israel‐level vaccine deployment.

We absolutely should strive to do better, but this one probably still would have come for us.

We need not just vaccines for the global south, but also therapeutic drugs, some of which will be in extremely short supply in the near future, but also the HIV antivirals that we have little excuse for not sharing more widely.

Biden plans to buy ten million courses of Paxlovid. That’s not even a scratch in the problem.

Platystemon fucked around with this message at 06:57 on Nov 27, 2021

shame on an IGA
Apr 8, 2005

I mean, we've already seen the potential worst case for mortality for closely related genetics on this thing and it's frankly a goddamn miracle that it hasn't turned into MERS again yet

Tyro
Nov 10, 2009

Thwomp posted:

Also, my inner 80s child is freaking out that the human race must now face Omicron.

My brain just auto-fills "Omicron Persei 8"

CRUSTY MINGE
Mar 30, 2011

Peggy Hill
Foot Connoisseur

BIG HEADLINE
Jun 13, 2006

"Stand back, Ottawan ruffian, or face my lumens!"
There was another proposed name for the variant but it was rejected for ~reasons~: https://www.firstpost.com/world/why-who-chose-to-skip-nu-and-xi-and-named-new-covid-19-variant-as-omicron-10169131.html

piL
Sep 20, 2007
(__|\\\\)
Taco Defender

I think Greek letters may be a poor naming system.

US Berder Patrol
Jul 11, 2006

oorah

piL posted:

I think Greek letters may be a poor naming system.

The good news is that we'll be out of greek letters soon

bulletsponge13
Apr 28, 2010

Tyro posted:

My brain just auto-fills "Omicron Persei 8"




Same.

Duzzy Funlop
Jan 13, 2010

Hi there, would you like to try some spicy products?
Speaking of the new variant, they yesterday temporarily quarantined two KLM flights from South Africa (after RSA was declared a "virus variant region"), let the passengers sit on the plane for four hours before deplaning and PCR-testing them.
All passengers on the flights had been previously cleared as "3G" (our classification/admission system, think of it as Roni-DEFCON, 3G means your either vaxxed, recovered or tested, 2G means only vaxxed or recovered folks are admitted, recovered folks need to get vaxxed after 3 (?) months to not lose their "status").

https://www.spiegel.de/wirtschaft/neue-corona-variante-ist-omikron-schon-in-deutschland-a-fd549e3f-22e9-467b-9704-6e9b3a69152b (sorry for the German link, should translate decently via Chrome/Google)

61 out of 600 passengers were tested positive for Covid. Authorities are still pointing out that the viruses from the infected folks haven't been sequenced yet, so there's no confirmation that it's all Omicron (like the news are masturbating over), or that any of the cases are Omicron, but my optimism has taken a serious shellacking over the last two years, and I feel like it's almost certain that the variant is now on the move in pretty much every country on the planet that had travellers return from RSA in the past month.

Gonna try to stay positive and believe in the possibility that this variant and its edginess may be the thing to actually convince our government to stop pussyfooting around vaccine mandates and serious measures.

Crab Dad
Dec 28, 2002

behold i have tempered and refined thee, but not as silver; as CRAB


Holy gently caress. Finally fully vaccinate my whole family for air travel and now this.

Grip it and rip it
Apr 28, 2020

Duzzy Funlop posted:

Speaking of the new variant, they yesterday temporarily quarantined two KLM flights from South Africa (after RSA was declared a "virus variant region"), let the passengers sit on the plane for four hours before deplaning and PCR-testing them.
All passengers on the flights had been previously cleared as "3G" (our classification/admission system, think of it as Roni-DEFCON, 3G means your either vaxxed, recovered or tested, 2G means only vaxxed or recovered folks are admitted, recovered folks need to get vaxxed after 3 (?) months to not lose their "status").

https://www.spiegel.de/wirtschaft/neue-corona-variante-ist-omikron-schon-in-deutschland-a-fd549e3f-22e9-467b-9704-6e9b3a69152b (sorry for the German link, should translate decently via Chrome/Google)

61 out of 600 passengers were tested positive for Covid. Authorities are still pointing out that the viruses from the infected folks haven't been sequenced yet, so there's no confirmation that it's all Omicron (like the news are masturbating over), or that any of the cases are Omicron, but my optimism has taken a serious shellacking over the last two years, and I feel like it's almost certain that the variant is now on the move in pretty much every country on the planet that had travellers return from RSA in the past month.

Gonna try to stay positive and believe in the possibility that this variant and its edginess may be the thing to actually convince our government to stop pussyfooting around vaccine mandates and serious measures.

o.O that seems very bad.

A Festivus Miracle
Dec 19, 2012

I have come to discourse on the profound inequities of the American political system.

No point in staying positive or hoping for the best when the past two years have delivered nothing but news wildly past our worst expectations. I fully expect this new COVID variant to ravage the planet, again, because people would literally rather die choking to death on their own fluids than wear a mask or get a free shot.

Crab Dad
Dec 28, 2002

behold i have tempered and refined thee, but not as silver; as CRAB


A Festivus Miracle posted:

No point in staying positive or hoping for the best when the past two years have delivered nothing but news wildly past our worst expectations. I fully expect this new COVID variant to ravage the planet, again, because people would literally rather die choking to death on their own fluids than wear a mask or get a free shot.

Should start selling tasteful grave plaques with “ I owned the libs” engraved.

RFC2324
Jun 7, 2012

http 418

Crab Dad posted:

Should start selling tasteful grave plaques with “ I owned the libs” engraved.

Should be a hot seller, considering the number of Confederate types

CRUSTY MINGE
Mar 30, 2011

Peggy Hill
Foot Connoisseur
Make "lib = owned" plaques for the millennials ignoring the vaccine.

Defenestrategy
Oct 24, 2010

A Festivus Miracle posted:

No point in staying positive or hoping for the best when the past two years have delivered nothing but news wildly past our worst expectations. I fully expect this new COVID variant to ravage the planet, again, because people would literally rather die choking to death on their own fluids than wear a mask or get a free shot.

Honestly back in 2016-2019 I was fully expecting Trump and the erosion of the state department to have basically caused an international emergency to such a degree where the rest of the world decided the US was too stupid to live and locked the US out of the global market the response to which would be war to annihilation and a crack down of civil liberties ending with the embrace of the atom.

I could not have predicted plague and nurgilites.

Terrifying Effigies
Oct 22, 2008

Problems look mighty small from 150 miles up.

Those cookie-cutter mass produced Confederate monuments they pumped out in the (19)20s but it's a guy in a MAGA hat and Gadsden shirt burning a mask.

Crab Dad
Dec 28, 2002

behold i have tempered and refined thee, but not as silver; as CRAB


CRUSTY MINGE posted:

Make "lib = owned" plaques for the millennials ignoring the vaccine.

I’m seeing this first hand with young men. It’s just run of the mill lol I’m invincible stupidity than political.

Milo and POTUS
Sep 3, 2017

I will not shut up about the Mighty Morphin Power Rangers. I talk about them all the time and work them into every conversation I have. I built a shrine in my room for the yellow one who died because sadly no one noticed because she died around 9/11. Wanna see it?
Men are shockingly dumb mother fuckers and it's hilarious we aren't gelded, let alone given positions of power

TheWeedNumber
Apr 20, 2020

by sebmojo

Milo and POTUS posted:

Men are shockingly dumb mother fuckers and it's hilarious we aren't gelded, let alone given positions of power

Duzzy Funlop
Jan 13, 2010

Hi there, would you like to try some spicy products?

A Festivus Miracle posted:

No point in staying positive or hoping for the best when the past two years have delivered nothing but news wildly past our worst expectations. I fully expect this new COVID variant to ravage the planet, again, because people would literally rather die choking to death on their own fluids than wear a mask or get a free shot.

I mean, I get the sentiment, and I've had my very own crack-ping moment not even two weeks ago regarding global news, but I've gotten this weird boost of optimism from the fact that this new development is so extraordinarily scary that it may just push our government over the edge and brute-force this poo poo now. Our election year is over (ironically enough, the loving election year and the fact that any party in contention wouldn't touch anticipatory containment measures is what got us here), and now they're back to not giving a poo poo for the next couple of years.

I mean, they've literally agreed to legalize weed despite ~~~conservative values voters~~~ in this dumb country, might as well push through the vaccine mandate and draconic containment measures.

Best Friends
Nov 4, 2011

Modern democracy just can't handle viral pandemics imo. Everyone is too atomized, you can't reach everyone with information. You can't make people get vaccinated. Not every person on Earth can have their government afford vaccination in a market-based, closed IP system. And capitalism likes fostering far right movements and parties that will inherently agitate against any mass action, even ones that don't impede capital, like masks, let alone making meaningful shut downs impossible.

Duzzy Funlop
Jan 13, 2010

Hi there, would you like to try some spicy products?

Best Friends posted:

Modern democracy just can't handle viral pandemics imo. Everyone is too atomized, you can't reach everyone with information. You can't make people get vaccinated. Not every person on Earth can have their government afford vaccination in a market-based, closed IP system. And capitalism likes fostering far right movements and parties that will inherently agitate against any mass action, even ones that don't impede capital, like masks, let alone making meaningful shut downs impossible.

Yes, you absolutely can.

That's what bugs me quite a bit about our current situation. Our politicians decided that everyone would eventually get vaccinated on their own, because it's the right choice, and felt like pushing a mandate would be overly authoritarian or whatever. They decided this during a time where the world had experienced upwards of four years of fake news and social media contrarian bullshit having gone into overdrive, and then realized their messaging was absolute rear end, but it was an election year, so ~naturally~ they couldn't force a mandate.

I'm well aware that a vaccine mandate wouldn't have prevented a scenario like this, but it would have saved countless lives, and prevented the impact covid has had on us this year.
Despite the early reports and media circlejerking, I'm fully assuming that vaccines won't be completely useless against the Omicron variant, and if we'd had a population sufficiently vaccinated, we'd probably be in a less lovely situation.

If you look at the loving miracle of modern science that mRNA vaccines are, we're all but guaranteed to be able to deal even with the new variant, but sure enough, we sat on our asses for the longest while, and now we're gonna have to eat another poo poo sandwich.

Best Friends
Nov 4, 2011

In America at least, even if you made a law saying everyone had to be vaccinated, the conservative movement would prevent that from being implemented at every level and it would formally die in the courts. But such a law wouldn't happen in the first place either, because the liberals also work at the beck and call of capital. There is nothing here preventing capital from getting what it wants at all times, and capital has decided covid is fine. Other countries that have some small smidgen of socialism still may have better luck. (In time, there will be "reforms" until every democracy has our free market paradise)

Platystemon
Feb 13, 2012

BREADS
https://twitter.com/alexmeshkin/status/1464604739291783174

There is no realistic possibility that this is anything other than the first case of Omicron to be found in the United States.

Vincent Van Goatse
Nov 8, 2006

Enjoy every sandwich.

Smellrose
If that s-gene hadn't dropped out this wouldn't have happened!

Pigsfeet on Rye
Oct 22, 2008

I'm meat on the hoof

Vincent Van Goatse posted:

If that s-gene hadn't dropped out this wouldn't have happened!

Yeah, shoulda listened to the other genes and stayed in school

Platystemon
Feb 13, 2012

BREADS
Should’ve gotten its GED like Alex. :colbert:

That Works
Jul 22, 2006

Every revolution evaporates and leaves behind only the slime of a new bureaucracy


https://twitter.com/florian_krammer/status/1464550752991514624?s=20

maffew buildings
Apr 29, 2009

too dumb to be probated; not too dumb to be autobanned
https://streamable.com/h46l18

pretty massive news/breakthrough not sure why media is ignoring this unless they just want to keep stoking fear

TheWeedNumber
Apr 20, 2020

by sebmojo

maffew buildings posted:

https://streamable.com/h46l18

pretty massive news/breakthrough not sure why media is ignoring this unless they just want to keep stoking fear

skimmed for a minute, ya got me

Oxygenpoisoning
Feb 21, 2006

maffew buildings posted:

https://streamable.com/h46l18

pretty massive news/breakthrough not sure why media is ignoring this unless they just want to keep stoking fear

I lather myself in old bay crab salt nightly so I’m basically immortal at this point.

Comrade Blyatlov
Aug 4, 2007


should have picked four fingers





Well, it's in the UK
https://www.bbc.com/news/uk-59445388

piL
Sep 20, 2007
(__|\\\\)
Taco Defender

maffew buildings posted:

https://streamable.com/h46l18

pretty massive news/breakthrough not sure why media is ignoring this unless they just want to keep stoking fear

Just mainlining Old Bay like a Marylander

Edit:

Oxygenpoisoning posted:

I lather myself in old bay crab salt nightly so I’m basically immortal at this point.

:crabdrugs:

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Wasabi the J
Jan 23, 2008

MOM WAS RIGHT

Oxygenpoisoning posted:

I lather myself in old bay crab salt nightly so I’m basically immortal at this point.


https://www.youtube.com/watch?v=xMJMDEDXwec

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