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Which horse film is your favorite? This poll is closed. |
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|---|---|---|---|
| Black Beauty |
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2 | 1.06% |
| A Talking Pony!?! |
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4 | 2.13% |
| Mr. Hands 2x Apple Flavor |
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117 | 62.23% |
| War Horse |
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11 | 5.85% |
| Mr. Hands |
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54 | 28.72% |
| Total: | 188 votes | ||
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Charles 2 of Spain posted:Is there anything stopping the government from just sending guys round to put tests in every postbox or something? Having to apply (online as well lmao) seems kind of long-winded. Supply of tests.
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Jan 18, 2022 23:07
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Solkanar512 posted:Supply of tests. Also possibility of getting fake tests (which is becoming a problem) and tests not being able to survive long-term exposure in a mailbox.
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Jan 18, 2022 23:12
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Solkanar512 posted:Supply of tests. Also ensuring that your limited supply of tests don't go into the mailboxes of people who think covid is a fake China disease cooked up by the The Libs and who will toss them straight into the trash.
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Jan 18, 2022 23:18
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How are u posted:Also ensuring that your limited supply of tests don't go into the mailboxes of people who think covid is a fake China disease cooked up by the The Libs and who will toss them straight into the trash. The government wants us to put those sticks into our nose. What is their agenda? Will we get infected by something thus way. Better burn that stuff before it enters our house.
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Jan 18, 2022 23:20
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https://twitter.com/pookleblinky/status/1483519646363963396 A basic breakdown of how utterly unserious'4xhousehold' is for the scale of the issue, chuds or no. Also, another significant issue: https://twitter.com/bransfordalex/status/1483533595201449992 And folks in apartment buildings are kind of max priority here?
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Jan 18, 2022 23:34
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Henrik Zetterberg posted:Family of 7 here. Gotta pick my favorite kids I guess. Just mix up all their snot and put it on a single test strip. Then if it pops a positive you just have to guess which one has it.
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Jan 18, 2022 23:38
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So with Omnicron having COVID cases higher than ever before, it makes me curious why hospitals aren't overfilled with people to the point where they're just not taking in people and leaving them to die like in Spain two years ago. Is Omnicron not as dangerous or is there another factor stopping that from occurring on such a serious scale?
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Jan 18, 2022 23:40
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punk rebel ecks posted:So with Omnicron having COVID cases higher than ever before, it makes me curious why hospitals aren't overfilled with people to the point where they're just not taking in people and leaving them to die like in Spain two years ago. Seems to be a combination of it causing a less severe disease due to it not attacking the lungs as much as prior variants, high vaccination rates giving a lot of people good protection from severe illness, and a lot of people having some degree of immunity from a prior covid infection. Edit: there’s probably also some better treatment options available for hospitalised people now that weren’t available in previous waves, MABs being less effective against omicron notwithstanding. gay picnic defence fucked around with this message at 23:47 on Jan 18, 2022 |
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Jan 18, 2022 23:43
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The caveat is that we can't expect the wildtype vaccine to hold indefinitely, and our current strategies likely lose us useful life.
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Jan 18, 2022 23:47
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StratGoatCom posted:Also, another significant issue: https://twitter.com/DorchesterEsq/status/1483502587810877445?s=20 Seems the apartment issue was people using an old form that's since been fixed
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Jan 18, 2022 23:49
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StratGoatCom posted:Also, another significant issue: It's utterly absurd that condo/apartment management could prevent residents from using the mail. Of course, I'm relatively certain that I've got a family member who won't be able to get these, either, because they just have a post office box in town, and no mailbox at their house in the middle of nowhere.
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Jan 18, 2022 23:54
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StratGoatCom posted:The caveat is that we can't expect the wildtype vaccine to hold indefinitely, and our current strategies likely lose us useful life. No, but it looks like there’s a number of second generation vaccines in development that will be more effective against current and emerging variants. In addition, the hybrid immunity from vaccination + infection seems to be very strong in most people so I think it’s unlikely we’ll have the same issues with a future variant that we’re having with omicron.
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Jan 18, 2022 23:55
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gay picnic defence posted:Just mix up all their snot and put it on a single test strip. Then if it pops a positive you just have to guess which one has it. If it pops positive, test 3 of them together. If that's negative, test 2 of the remaining 4. If that's positive, test 1 of the group. If it's negative, test 1 of the 2 you didn't test. If the 3-test is positive, test 2 and then either it's the remaining one (negative) or do another test with 1 of the 2 (positive) Assuming only one of them has it, of course
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Jan 18, 2022 23:57
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FWIS supposedly the Pfizer Omicron specific vaccine will be ready in March and they're already pivoting manufacturing towards it.
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Jan 18, 2022 23:58
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punk rebel ecks posted:So with Omnicron having COVID cases higher than ever before, it makes me curious why hospitals aren't overfilled with people to the point where they're just not taking in people and leaving them to die like in Spain two years ago. That's literally happening in some places. turns out it's very easy to ignore human suffering when you just make a point to not look for it
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Jan 18, 2022 23:59
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gay picnic defence posted:No, but it looks like there’s a number of second generation vaccines in development that will be more effective against current and emerging variants. In addition, the hybrid immunity from vaccination + infection seems to be very strong in most people so I think it’s unlikely we’ll have the same issues with a future variant that we’re having with omicron. Unless we get another Omicron scenario and get sidestepped by variant from a clade we'd been neglecting again.
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Jan 19, 2022 00:11
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gay picnic defence posted:Seems to be a combination of it causing a less severe disease due to it not attacking the lungs as much as prior variants, high vaccination rates giving a lot of people good protection from severe illness, and a lot of people having some degree of immunity from a prior covid infection. Great points, thank you. A big flaming stink posted:That's literally happening in some places. turns out it's very easy to ignore human suffering when you just make a point to not look for it The Death Rate for COVID is still notably lower than it was during the two other waves despite many more infected.
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Jan 19, 2022 00:15
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Hospitals are overloaded in places because 1) so many people are still unvaccinated, and 2) omicron is so transmissible that everyone's getting it at once.
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Jan 19, 2022 00:18
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goethe.cx posted:Hospitals are overloaded in places because 1) so many people are still unvaccinated, and 2) omicron is so transmissible that everyone's getting it at once. To add onto point 2 on this post, this also includes staff/frontline workers. Which seems to be a contributor for bottlenecks as well. Kalit fucked around with this message at 00:37 on Jan 19, 2022 |
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Jan 19, 2022 00:30
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StratGoatCom posted:Unless we get another Omicron scenario and get sidestepped by variant from a clade we'd been neglecting again. It’s possible, but given omicron was more divergent than even the most nightmareish scenarios dreamed up by scientists and first gen vaccines still provide significant protection against serious illness I don’t think we’ll get too much trouble from an emerging variant before a universal covid vaccine is developed.
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Jan 19, 2022 00:37
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In the gooniest possible observation on the pandemic, anecdotally speaking the fast food system falling apart. Everyone I know on facebook is pointing out how bad things have gotten, and my fat rear end conducted a survey twice this weekend. A lot of workers are out sick, or just straight not willing to risk their lives so you can get a big mac.
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Jan 19, 2022 00:40
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Jaxyon posted:In the gooniest possible observation on the pandemic, anecdotally speaking the fast food system falling apart. Yeah, this is another result of everyone getting omicron at once. When half your staff pops positive it's hard for customers to get their gross burgers in a timely fashion. I expect things will improve over the next few weeks as we get over the peak
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Jan 19, 2022 00:43
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punk rebel ecks posted:Great points, thank you. Dude how are you blind to the reams of testimonies of every bed in a 3 hour radius being full? The exact scenario you called upon--hospitals so filled they literally can't take any more patients--is a daily occurrence now
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Jan 19, 2022 00:46
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gay picnic defence posted:It’s possible, but given omicron was more divergent than even the most nightmareish scenarios dreamed up by scientists and first gen vaccines still provide significant protection against serious illness I don’t think we’ll get too much trouble from an emerging variant before a universal covid vaccine is developed. there's no way evolution can wiggle out of this one.
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Jan 19, 2022 00:47
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gay picnic defence posted:It’s possible, but given omicron was more divergent than even the most nightmareish scenarios dreamed up by scientists and first gen vaccines still provide significant protection against serious illness I don’t think we’ll get too much trouble from an emerging variant before a universal covid vaccine is developed. It was hardly so, folks were calling what it could do with some accuracy from existing research elsewhere in the drat github virus tracker page. It was mutated as all gently caress, but we knew that at least some of its power set existed in seperate forms elsewhere, as I recall. If memory serves, there is a good chance that reason we got owned is that we didn't make an alpha jab for the public - not the best, but there is some reason to suspect that it would have performed a drat sight better then wildtype. I might add that there are some profoundly frightening possible evolutions we've created in laboratory contexts that are worth watching for: https://www.nature.com/articles/s41564-021-00954-4 a study in possible covid biologics based on spike proteins posted:SARS-CoV-2 variants of interest and concern will continue to emerge for the duration of the COVID-19 pandemic. To map mutations in the receptor-binding domain (RBD) of the spike protein that affect binding to angiotensin-converting enzyme 2 (ACE2), the receptor for SARS-CoV-2, we applied in vitro evolution to affinity-mature the RBD. Multiple rounds of random mutagenic libraries of the RBD were sorted against decreasing concentrations of ACE2, resulting in the selection of higher affinity RBD binders. We found that mutations present in more transmissible viruses (S477N, E484K and N501Y) were preferentially selected in our high-throughput screen. Evolved RBD mutants include prominently the amino acid substitutions found in the RBDs of B.1.620, B.1.1.7 (Alpha), B1.351 (Beta) and P.1 (Gamma) variants. Moreover, the incidence of RBD mutations in the population as presented in the GISAID database (April 2021) is positively correlated with increased binding affinity to ACE2. Further in vitro evolution increased binding by 1,000-fold and identified mutations that may be more infectious if they evolve in the circulating viral population, for example, Q498R is epistatic to N501Y. We show that our high-affinity variant RBD-62 can be used as a drug to inhibit infection with SARS-CoV-2 and variants Alpha, Beta and Gamma in vitro. In a model of SARS-CoV-2 challenge in hamster, RBD-62 significantly reduced clinical disease when administered before or after infection. A 2.9 Å cryo-electron microscopy structure of the high-affinity complex of RBD-62 and ACE2, including all rapidly spreading mutations, provides a structural basis for future drug and vaccine development and for in silico evaluation of known antibodies. I don't know how this would perform in vivo, but.... well, it's also worth noting that these are somewhat taxonomically close to Omicron, as one can verify for themselves from nextstrain: https://nextstrain.org/ncov/gisaid/global not toooo close, but far closer then I'd like. I do not know if the precursors to that spike predate the split between those families, but Omicron is radiating at dramatic speed; I don't know if we'll see an ACE2 atavism or a recombo with a more human ACE2. Other possibilities are maybe further developments of its immune evasion? (https://www.nature.com/articles/s41423-021-00836-z) StratGoatCom fucked around with this message at 01:25 on Jan 19, 2022 |
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Jan 19, 2022 00:54
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StratGoatCom posted:Also, another significant issue: Excellent, landlords and the "disruption" industry teaming up yet again to immiserate more poor families.
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Jan 19, 2022 01:34
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Vox Nihili posted:Excellent, landlords and the "disruption" industry teaming up yet again to immiserate more poor families. I posted that the issue had been fixed, yet people have ignored my post to complain about dems and landlords or whatever
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Jan 19, 2022 01:36
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StratGoatCom posted:Unless we get another Omicron scenario and get sidestepped by variant from a clade we'd been neglecting again. You've complained about this frequently, which clades should vaccines be made for and in what quantities? Who gets which shot and why? How much will you blame the Biden administration for people who get the "wrong" vaccination?
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Jan 19, 2022 01:40
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Solkanar512 posted:You've complained about this frequently, which clades should vaccines be made for and in what quantities? Who gets which shot and why? How much will you blame the Biden administration for people who get the "wrong" vaccination? We need formulas in the wings approved and ready to gear up to basically every major clade, at least until we can figure out a multiclade jab. That way, we have something to throw into the gap until we have a specific variant jab ready to go. Omicron has demonstrated that attacks are possible from any taxonomic direction of the virus that still exists. StratGoatCom fucked around with this message at 01:48 on Jan 19, 2022 |
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Jan 19, 2022 01:43
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goethe.cx posted:I posted that the issue had been fixed, yet people have ignored my post to complain about dems and landlords or whatever The Tweet you posted didn't address the issue with those who rely on this "Fetch" service at all. Here is a recent Tweet from the guy who mentioned that: https://twitter.com/bransfordalex/status/1483535115238182916
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Jan 19, 2022 01:44
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Stop trying to make Fetch happen.
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Jan 19, 2022 01:58
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goethe.cx posted:Hospitals are overloaded in places because 1) so many people are still unvaccinated, and 2) omicron is so transmissible that everyone's getting it at once. and 3) the vaccinated are getting infected
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Jan 19, 2022 01:58
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gay picnic defence posted:Just mix up all their snot and put it on a single test strip. Then if it pops a positive you just have to guess which one has it. We all peed on it. I hear that works as well and seemed much easier.
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Jan 19, 2022 01:59
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StratGoatCom posted:We need formulas in the wings approved and ready to gear up to basically every major clade, at least until we can figure out a multiclade jab. That way, we have something to throw into the gap until we have a specific variant jab ready to go. How in the hell do you do that in time to make a difference, especially in cases where the clade doesn't exist yet? What additional benefit are you expecting that we don't already get from the current vaccine?
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Jan 19, 2022 02:03
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Solkanar512 posted:How in the hell do you do that in time to make a difference, especially in cases where the clade doesn't exist yet? to answer your questions: By throwing the closest relatives at the thing you can guess. That it may work against future high evasive variants of highly derived clades
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Jan 19, 2022 02:07
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Ruggan posted:and 3) the vaccinated are getting infected They are but they’re not the bulk of people clogging hospitals
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Jan 19, 2022 02:14
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goethe.cx posted:They are but they’re not the bulk of people clogging hospitals Yep, for the vaccinated it's generally not a big deal at all. Other than for kids under 5 who are not yet eligible, the unwillingly-unvaccinated, and for folks who would otherwise need to go to the hospital; it truly is a pandemic of the unvaccinated at this point. Wild.
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Jan 19, 2022 02:31
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goethe.cx posted:They are but they’re not the bulk of people clogging hospitals It is a drat worrisome sign for the future though.
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Jan 19, 2022 02:32
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Not a big deal, unless you need a hospital.
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Jan 19, 2022 02:39
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Charles 2 of Spain posted:Not a big deal, unless you need a hospital. Due to the unvaccinated overflowing hospitals, yes
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Jan 19, 2022 02:55
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