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Pennywise the Frown posted:Anything special about this vaccine? I got 3 of the pfizer and don't really care which ones I got. There’s nothing really special about it for you or I. It presents the whole length of the Wuhan-Hu-1 spike and causes a similar immune response. Unlike the vaccines currently available in the Anglosphere, it’s a protein subunit vaccine. It doesn’t rely on your own cells to make the spike. The spike was made in moth cells in the laboratory, then separated and purified. These proteins are more stable than is RNA, and even more stable than the modified adenovirus used in J&J’s and AstraZeneca’s vaccines, so it’s attractive to purchasers for that reason, but not to the public.
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Feb 1, 2022 03:57
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Raskolnikov2089 posted:https://www.frontiersin.org/articles/10.3389/fimmu.2018.02569/full These articles are interesting but they don't bear out the OP's concern that covid-19 is routinely causing cumulative and permanent loss of naive t-cell quantities. Obviously it sucks that long covid sufferers basically have to regrow lost immune function but that's a separate (and still very serious) concern
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Feb 1, 2022 04:04
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Novavax is potentially attractive to anyone who bought into the "ITS OVERWRITING YOUR DNA" bullshit or the "UNTESTED VACCINE TECHNOLOGY" bullshit, but not enough of the other nonsense to be completely closed to any vaccines at all. That's going to be a least some people, but not a large chunk of the unvaccinated.
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Feb 1, 2022 04:04
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On this whole "Naive T-cell depletion" note, how does getting covid a few times compare to, say, getting the flu every other year for 60 years?
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Feb 1, 2022 04:19
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Stickman posted:Novavax is potentially attractive to anyone who bought into the "ITS OVERWRITING YOUR DNA" bullshit or the "UNTESTED VACCINE TECHNOLOGY" bullshit, but not enough of the other nonsense to be completely closed to any vaccines at all. That's going to be a least some people, but not a large chunk of the unvaccinated. Yeah there's a lot who bought into the whole 'experimental gene therapy' thing who are happy (apparently) to get this one because it's just a protein. Of course it was also attractive to a bunch of people who felt they could justify their unvaccinated status by saying they weren't anti-vax as such, they were just waiting for the one that was possibly never going to arrive.
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Feb 1, 2022 04:23
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HolHorsejob posted:On this whole "Naive T-cell depletion" note, how does getting covid a few times compare to, say, getting the flu every other year for 60 years? how many times is "a few", and does it affect your answer when you remember that most people have already caught it at least as many times as they've caught the flu over the last two years, under the most effort at containment we're ever going to see? A Wizard of Goatse fucked around with this message at 04:37 on Feb 1, 2022 |
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Feb 1, 2022 04:25
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Novavax is probably a very good vaccine, maybe in par with mrna vaccines, but certainly the promise of quick production turned out to be less than true. Hopefully once it's up to scale it can be made as cheaply and easily as they have claimed. Better yet of course if they could pivot to an omicron-specific one, though I think they're just too far behind.
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Feb 1, 2022 04:26
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Shinjobi posted:How is Ring Fit? I hadn't really considered it since for a while they were impossible to find I think it's okay. I don't think it's better than the peloton app ($13 a month) and a cheap exercise bike and a yoga mat though. The instructors for Peloton are fantastic.
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Feb 1, 2022 04:27
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Comfy Fleece Sweater posted:First time I played Assassin's Creed Odyssey I let the family with the plague live, because come on, the priests were about to kill them, and maybe they'd still live or something There's a very small Witcher 3 sidequest where you rescue a guy who's job is to cart away plague bodies and you advise him to burn his cart and wash himself thoroughly, he insists he'll be fine and that no blight can touch him. If you go back to his house a few days later he's dying of the plague and begs you to put him out of his misery.
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Feb 1, 2022 04:53
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wonder if vax chasers is a thing yet
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Feb 1, 2022 05:11
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Philthy posted:wonder if vax chasers is a thing yet "It was around my 6th vax injection when I realized I had a problem..."
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Feb 1, 2022 05:14
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Shinjobi posted:How is Ring Fit? I hadn't really considered it since for a while they were impossible to find Late responding, but other posters covered the highs and lows p much. I like it a lot as someone with chronic pain and a hosed up arm from a motorcycle wreck, I can play it at my pace and if I need a break I can easily take one. It doesn't "shame" you for skipping days, and it's thoughtful in that if you've been doing a lot of a certain type of exercise it'll focus your cooldown stretches in those areas. It's like any other exercise thing though, you have to keep doing it to get benefit, but I like the jogging through the pretty levels and how good it feels to slap the monsters with the exercises I found mine on Amazon at MSRP direct from Nintendo
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Feb 1, 2022 05:38
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Having experienced the miracles of breakthrough measles and whooping cough, I have no wish to further test the gap between public policy and personal outcome.
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Feb 1, 2022 05:51
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Xlorp posted:Having experienced the miracles of breakthrough measles and whooping cough, I have no wish to further test the gap between public policy and personal outcome. That was me and Mumps. Had it three separate times, AFTER getting the shot. Also got Rubella.
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Feb 1, 2022 06:38
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Genesplicer posted:That was me and Mumps. Had it three separate times, AFTER getting the shot. Also got Rubella. Shame Obama didn't double tap on that one. 
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Feb 1, 2022 06:53
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A Wizard of Goatse posted:my prediction is that the disease that mutates rapidly and tends to cause systemic organ failures in most of its current forms will simply stop mutating once it reaches a relatively harmless variant and we accept it permanently into our lives I've analyzed all of the covid data and found that everyone on record who has caught covid or died of covid has done so in the past. My dataset does not contain a single record of anyone dying of covid or even catching covid after today, thus covid is over tomorrow.
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Feb 1, 2022 09:04
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On my wife's "moms who care" group, one particularly caring lady posted that even though her daughter and probably herself are positive, lunch is still on and you're welcome to join if you don't mind getting covid. This wasn't a joke either, it was a sincere open invitation to all.
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Feb 1, 2022 09:57
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Weirdly cute story, some dude has had six vaccines* in the span of a year! *three for covid, one for the flu, two for shingles https://www.aftonbladet.se/nyheter/a/QyXlrW/gavlebon-inge-waxin-har-vaccinerat-sig-sex-ganger-pa-ett-ar  Meet Inge Waxin! He is adorable and totally down for a fourth covid shot “if offered”. Quick Swedish lesson: his name sounds similar to “inget vaccin” - ”no vaccine”, in Swedish. It has caused some mishaps, needless to say! Let Inge have a fourth shot, as a treat.
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Feb 1, 2022 10:10
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Pfizer to submit data as soon as today on a two shot regimen for under 5's. The idea is to get two shots approved by the end of the month, and then you get the three shot efficacy data by the end of March and approved shortly thereafter. https://www.washingtonpost.com/health/2022/01/31/coronavirus-vaccine-children-under-5/
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Feb 1, 2022 14:05
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gay picnic defence posted:Yeah there's a lot who bought into the whole 'experimental gene therapy' thing who are happy (apparently) to get this one because it's just a protein. It also reportedly has less side effects. My 2nd and 3rd moderna shots killed me so I'm hoping this is easier on me. And, it doesn't need ultra cold storage which is a problem in many countries.
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Feb 1, 2022 14:57
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CarlosTheDwarf posted:It also reportedly has less side effects. My 2nd and 3rd moderna shots killed me so I'm hoping this is easier on me. I thought they determined that the mRNA vaccines didn't need as crazy cold storage as they initially thought, either. Edit: Yeah, they changed that somewhat back in June. quote:The vaccine was the first to receive WHO Emergency Use Listing on 31 December 2020, but according to data submitted as part of this application, the vaccine had to be shipped at temperatures between -80°C and -60°C (-112°F and -76°F), could only be kept in a normal freezer at -20°C (-4°F) for two weeks, and unopened vials could only be stored at refrigerated temperatures of between 2-8°C for five days, before either being used or thrown away. Very few countries had the capacity to manage a vaccine requiring ultra-cold storage.
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Feb 1, 2022 16:28
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England is now breaking down (and has back-dated) infections between first infections and possible re-infections (possible reinfections being classified as a positive test 90 days or more after the first positive test) and it's fairly interesting, but not surprising. Because they don't specifically break it down like this, I've plotted the percentage of cases that are possible reinfections over time:  and yeah, Omicron is *way* better at evading prior immunity than Delta - in fact I'm a little surprised it's not even higher and it might be a good sign that it's "only" 10%. However it's not impossible that this is simply because - as widespread as Delta got - Omicron has completely smashed it's numbers and so it's just not finding enough previously-infected people to reinfect. To check this theory, I took the total amount of infections on December 1st, as a divider between Delta and Omicron, and plotted the percent of reinfections of that number (i.e. the percentage of (total cases December 1st/total reinfections-total reinfections on December 1st) to give this:  To me, that does at least suggest that Omicron is just waltzing past prior infection, but I need to work out a way of accounting for the fact that people infected previously will, by definition, be more likely to be exposed (i.e. if you assume risk of exposure stays constant then people infected in previous waves must have been exposed more than people infected in the current wave and therefore are still at higher risk of exposure) - I'll have a think about that and see if I can come up with anything. The other problem with the data is that it still doesn't account for multiple reinfections, and of course it can't account for the effect of vaccination, NPIs and other variables.
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Feb 1, 2022 18:06
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brugroffil posted:Pfizer to submit data as soon as today on a two shot regimen for under 5's. oh this is fantastic news i have been so worried about my daughter with my son being back in class
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Feb 1, 2022 19:00
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goddamnedtwisto posted:England is now breaking down (and has back-dated) infections between first infections and possible re-infections (possible reinfections being classified as a positive test 90 days or more after the first positive test) and it's fairly interesting, but not surprising. Another thing to keep in mind is that the reinfection % is very likely to be an underestimate, perhaps by a significant amount. Since infection does offer some protection against serious disease, reinfections are probably less likely to test than initial infections. This goes especially for Omicron, where a greater % of cases has less severe symptoms, pcr testing was difficult to obtain, and rapid tests were untracked. There’s also some sequence-documented cases of Delta->Omicron reinfection <90 days apart, but I suspect they’re not a significant portion of reinfections.
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Feb 1, 2022 19:08
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teen witch posted:Weirdly cute story, some dude has had six vaccines* in the span of a year! When I traveled to Borneo in 2013 I got 13 shots. It was supposed to be 8 initially, but it turned out I missed the shots I was supposed to get in my late teens and didn't realize it until I received my vaccination records prior to travel. I had to carry my vaccine record with me if I wanted to get health insurance coverage while traveling in certain areas, and it was also a university field school so if we didn't have their required list of shots, we weren't allowed to go. Endemic to some areas were yellow fever, Japanese encephalitis, dengue fever, diphtheria and others I cant remember right now, got a pre-emptive tetanus shot, got my hepatitis shots finished, took anti-malarial medication while there. Two of the shots required a booster 6 months later, I forget which ones though.
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Feb 1, 2022 19:17
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goddamnedtwisto posted:England is now breaking down (and has back-dated) infections between first infections and possible re-infections (possible reinfections being classified as a positive test 90 days or more after the first positive test) and it's fairly interesting, but not surprising. https://www.youtube.com/watch?v=pcM_u4eV05g
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Feb 1, 2022 19:31
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We were just informed that my step-daughter was in contact with a confirmed case of COVID-19 on Sunday. Right now she has a fever and sore throat. It's mild enough that we do not qualify to get tested, and have been advised to assume we have it and self-isolate. Really though, the writing is on the wall. I'm scared for my 4-year-old, who is not old enough to be inoculated, and whose age group has had a disproportionate increase in cases from Omicron. I'm angry, because I'm way behind at work and really don't have time for this. I'm...tired and defeated, because I was really careful and took as few chances as I could. I've been wearing N95's, eye protection, minimizing contact as much as I possibly can, I didn't even visit my dying grandparents for 6 months because our region had a high case rate. I've had fights with my ex-wife, because I refused to take the kids to their dance competition at the end of the month, as case numbers were exploding. Most of all I'm just exhausted. I've been obsessively checking COVID-19 data, following reputable health advice, and trying to make sure we're managing our risk appropriately. I was at least hoping I could keep us from being infected until May, when my youngest turns 5 and we can relax a little once he's inoculated. But now he's going to get it without any protection. I hate all of this. I just loving hate it.
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Feb 1, 2022 19:50
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Stickman posted:Another thing to keep in mind is that the reinfection % is very likely to be an underestimate, perhaps by a significant amount. Since infection does offer some protection against serious disease, reinfections are probably less likely to test than initial infections. This goes especially for Omicron, where a greater % of cases has less severe symptoms, pcr testing was difficult to obtain, and rapid tests were untracked. Apart from a few days around Christmas PCR testing wasn't that hard to obtain (at least in London), and LFTs definitely were (and are) traced - you can see the proportions of them here, for positive cases, and here for total tests. (Note the change in policy of not requiring a followup PCR test for a positive LFT from the 10th)
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Feb 1, 2022 19:54
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mom and dad fight a lot posted:I hate all of this. I just loving hate it. If it helps, of the 1.1 million cases in Denmark in December and January, nobody under 20 died. And we don't vaccinate under 5s either.
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Feb 1, 2022 20:01
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I'm not worried about him dying. I'm worried about what other organs in his body are being affected, especially if his age group has had a disproportionate increase in cases. But thanks, I'm probably just working myself up. https://twitter.com/Protect_BC/status/1479522361355354113?s=20&t=pSU3P7HEWfHnG74ujNAGpQ I've been oddly tired today. I haven't been sleeping that great, but I'm especially tired today. Feels like all the blood is draining from my face.
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Feb 1, 2022 20:29
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mom and dad fight a lot posted:We were just informed that my step-daughter was in contact with a confirmed case of COVID-19 on Sunday. Right now she has a fever and sore throat. It's mild enough that we do not qualify to get tested, and have been advised to assume we have it and self-isolate. Really though, the writing is on the wall. * He started isolating immediately after we got home. He was positively contagious on Saturday and Sunday, but still - headed to his room with no problem. Lots of video calls that night and through the day Tuesday. * The rest of the family got tested Tuesday morning. We figured we either all had it or none of us did, so didn't isolate/mask/etc Monday evening until getting the results on Tuesday night. * Wife tested positive with results around 7:30 pm that night (it's a really quick saliva-based PCR test, for the record.) Younger son and I both were negative. She started isolating, but my older son had company now, so they both enjoyed that. I started sleeping on the couch. Skipping forward to today... * Neither my younger son or I have tested positive yet and we've taken a few. The isolation and whatever protection our vaccinations provided seem to have been up to the task. I know both are probably still contagious but less so by now, so I am a lot less worried. * My older son is doing fine. He has a bit of a cough still but never got a fever or bad symptoms. No ill effects that we've noticed. The school wanted him back yesterday but I kept him home one more day. He's there today and not thrilled about it, and neither am I, but he's missed 3 weeks now - two for close contacts, one for actual covid - so they want him back. * My wife is still congested and I am wondering if she has a sinus infection now or something. She never got a fever; fatigue and head cold stuff are all she got. I'd just suggest isolating as best you can. It's not inevitable the rest of you will get it, and odds are really good you'll all weather it just fine. I also had a lot of fatigue, etc last week but it turns out it was just ... well, stress, anxiety, etc.
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Feb 1, 2022 21:02
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Appreciate it. I guess I'm just wound up too tight from all this. Sorry.
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Feb 1, 2022 21:21
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mom and dad fight a lot posted:Appreciate it. I guess I'm just wound up too tight from all this. Sorry. There's a weird thing here where if you aren't catastrophizing about the worst things covid has done, and assuming it will all happen to you if you get it, you aren't taking it seriously enough. And for keeping your eye on the ball when you're trying to avoid infection, that's all well and good. But it's also extremely lovely for your mental health and anxiety levels if you are actually dealing with having it, or with a family member having it. Isolate as best you can, wear those N-95s when you absolutely need to be around one another, care for your family and their emotional needs, and you've done all you can. And you will almost definitely end up okay and on the other side of it in (a very long, but finite) 10-14 days.
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Feb 1, 2022 21:32
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Covid test update: negative, it really was just terrible allergies. I bombed myself out with zyrtec and multiple prescription nasal sprays today and only sniffled while crying, A+ would do again
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Feb 2, 2022 04:43
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It feels like loving everyone around me has COVID. We had a virtual board game night and every single family that had kids in school was being ravaged by COVID. The one guy was so exhausted that he kept lying down and having his wife take all his turns. She sounded like she swallowed a bag of frogs. The rest of them sounded horrible too. Entire departments are going dark at work. But we're not shutting down, of course. We've been classified as "low risk for spread" and all those cases are from socializing in other environments, that's all. I was in a zoom meeting waiting for a presentation to start and all the presenters were chatting during setup about how many family members have COVID. "My son has COVID right now." "Mine does too!" "My brother was on life support for 14 days and he made it through but he's still got lots of issues, of course." "I'm feeling shaky and have a sore throat and I"m worried because I have pre-existing lung issues..." But it's fine. No need to close the schools because COVID respects education and won't spread in a classroom.
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Feb 2, 2022 16:23
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teen witch posted:Weirdly cute story, some dude has had six vaccines* in the span of a year! And it’s uh one for the flu, two for the shingles, three for the Covid and go go go, don’t you Step on my healthy lungs 🫁
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Feb 2, 2022 16:25
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Tagra posted:
Schools should be the last thing to close in a good society because education is important Perhaps casinos, bars, and whorehouses should take a break before children learning to read
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Feb 2, 2022 16:26
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2nd shift is down to three people from 9 in my department, 3rd is still at full staff ("full staff" of 5), first is back at full staff of 10 after last week.
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Feb 2, 2022 16:28
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Tagra posted:It feels like loving everyone around me has COVID. On top of all the death and disablement coming out of these vast numbers of infections, it's looking like Omicron confers garbage immunity to itself: https://twitter.com/PeterHotez/status/1488481935965970437?s=20&t=a9DuLHVrdwsbslDfq74zhQ Until and unless we start seriously clamping down on infections or get a vaccine with excellent sterilizing immunity, I don't see how we get out of this cycle of endless sickness. Yet we're still being gaslit in the media by "this is all fine" people who somehow managed to get MDs or ivy league PhDs despite being some of the dumbest loving people on the planet. Zugzwang fucked around with this message at 16:41 on Feb 2, 2022 |
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Feb 2, 2022 16:35
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Comfy Fleece Sweater posted:Schools should be the last thing to close in a good society because education is important My kids have seen Encanto like four times (at least the first 30 minutes) because of how many teachers are out and being replaced by subs. This is middle and high school. Education ain't happening too much right now. But they know all the words to 'We Don't Talk About Bruno' so gg.
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Feb 2, 2022 16:46
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