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Skyscraper Raccoon posted:Leisure Class demands more leisure I'm not going to recommend I go back to working person just because you have to work in person, sorry.
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Feb 10, 2022 19:53
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MrQwerty posted:MABs were only forwarded as a COVID treatment because a lot of people with a lot of money and power bet on them knowing nothing about them because Donald Trump said Remdesivir made him feel like a billion dollars (it was dexamethasone). MABs were never going to do poo poo for COVID outside helping a few people because they got lucky with the viral variant and timing of infusion. One advantage of mAbs is that they bind to the target you want with extremely high specificity (ie they have negligible binding to anything else). The downside there is that if the target changes, the antibody can fail to bind to the new target (or can still bind but with less affinity, so it doesn’t work as well). This is why variants like Omicron can make entire mAbs obsolete. Like, the epitope (antibody binding site) on the spike protein changes in a big enough way and then whoopsie, Regeneron just doesn’t work anymore. So far, nothing has been able to break the vaccines in quite the same way because exposing your body to the entire spike protein (or the entire virus, for inactivated ones) makes you generate antibodies that can bind to a variety of sites. The virus is evolving much faster than we’d like. The more people it gets to infect, the faster it can evolve. This has unfortunately led to a positive feedback loop where the time between new variants is getting shorter, and it’s getting better at reinfecting people too. All the more reason why easing restrictions and letting ‘er rip is a terrible idea.
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Feb 10, 2022 19:59
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Skyscraper Raccoon posted:Leisure Class demands more leisure I will never go back to an office and nothing will change that. I've spent 2 years doing my job from my living room and like hell am I going into the covid cubicles. Sorry your job doesn't let you do that, that really sucks. But don't poo poo on people who are taking advantage of something in order to not get exposed and sick from a virus. If you want lower spread, why would you not support working from home for those who can? Real sour grapes and crab bucket mentality here
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Feb 10, 2022 20:44
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Basically since the advent of the internet and especially broadband no office worker has EVER needed to be in the office. But boomers gonna boomer ya know? It took a goddamn global pandemic that killed millions to finally cause some movement in the right direction. If you work a job that can't be done at home, I feel for you I really do. But that doesn't change the fact that my job doesn't need to be done at an office. If you think the home has too many distractions to be an effective workplace then you've obviously never worked in an office. No fellow office drone, I do not care about the results of the big sportsball game last night. No gossipy rear end secretary lady, I do not care who is dating who in the office. I have loving work to do and deadlines. No I do not want to go to the loving company happy hour. Now all that, that's some goddamn distractions.
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Feb 10, 2022 23:48
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Oh lol also we had another covid mAb clinical trial start up in January and like 3 weeks in they stopped even trying to get patients because their poo poo didn't work against omicron. e: one of my patients really wanted to join this study because god forbid you get the vaccine, why not go for experimental treatments and a 50/50 chance of getting nothing more potent than an injection of saline instead. coronatae fucked around with this message at 00:15 on Feb 11, 2022 |
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Feb 11, 2022 00:08
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I plan on always doing hybrid work from now on - I can't imagine being office-bound 100% of the time after this. My work sometimes benefits from in-person meetings, but as long as I can still bill for remote I intend to find a livable balance between the two.
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Feb 11, 2022 00:42
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A Strange Aeon posted:Are there any promising trends in therapeutics? From the post earlier, it seems like sotromivab isn't effective against the omicron variant and it was the only one of them that I thought had efficacy against regular omicron. There are interesting developments in the labs, it’s just that they’re months or years away from the pharmacy. Remember, Paxlovid works great, we just can’t get enough of it. Here’s one of the interesting therapeutic approaches that I wrote about last week for the C‐SPAM thread. Platystemon posted:Targeting conserved N-glycosylation blocks SARS-CoV-2 variant infection in vitro
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Feb 11, 2022 10:12
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Snowglobe of Doom posted:Omicron subvariant BA2 (which is gaining ground on BA1 and is already the dominant subvariant in some countries) is resistant to most monoclonal treatments, including sotrovimab which was effective against BA1 Update: Sotrovimab’s manufacturer claims it's still efficacious against omicron subvariant BA2 but haven't released any numbers to back that up yet
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Feb 11, 2022 11:51
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Skyscraper Raccoon posted:Leisure Class demands more leisure Not this derail again.  HonorableTB posted:I will never go back to an office and nothing will change that. I've spent 2 years doing my job from my living room and like hell am I going into the covid cubicles. Sorry your job doesn't let you do that, that really sucks. But don't poo poo on people who are taking advantage of something in order to not get exposed and sick from a virus. If you want lower spread, why would you not support working from home for those who can? Real sour grapes and crab bucket mentality here No, you're replying to a troll account. Don't do that.
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Feb 11, 2022 12:42
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Homers are so thin-skinned for being a class of people that gets to dodge the plague
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Feb 11, 2022 13:00
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I’m going to step absolutely outside my usual aggressive shrug of an IK role and decree that we are done with this topic.
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Feb 11, 2022 13:21
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Snowglobe of Doom posted:Update: Sotrovimab’s manufacturer claims it's still efficacious against omicron subvariant BA2 but haven't released any numbers to back that up yet Another possibly stupid question about monoclonals - do they (as I recall reading when Florida went all-in on them) prevent you from actually developing immunity, or at least severely reduce your chances of developing immunity? The thinking was that because they take care of the infection before your own immune system gets its boots on that your body never really learns to recognise and attack the virus next time it sees it. If so that's actually an almost perfect scam on the part of the companies pushing them, the kind of poo poo people always accuse BIG PHARMA of in fact.
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Feb 11, 2022 13:23
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Neighbors got it. Like the flu pretty much (for the vaccinated)
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Feb 11, 2022 13:32
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Zeluth posted:Neighbors got it. Like the flu pretty much (for the vaccinated) Single case anecdotes can't really tell you much about the overall severity of any disease. Your average unvaccinated person's most likely outcome of COVID is a mild case followed by full recovery. (Absolutely not saying that vaccines don't have a big effect, just that vaccinated people can and are hospitalized or worse, even with Omicron).
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Feb 11, 2022 13:34
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My coworker thought she could smell something sour yesterday, but that quickly passed and she was back to nothing again
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Feb 11, 2022 13:36
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enki42 posted:Single case anecdotes can't really tell you much about the overall severity of any disease. Your average unvaccinated person's most likely outcome of COVID is a mild case followed by full recovery. (Absolutely not saying that vaccines don't have a big effect, just that vaccinated people can and are hospitalized or worse, even with Omicron). Among the people I know who’ve gotten it (all of whom are boosted if they are old enough to get the third shot), it has so far ranged from “zero symptoms” to “a lovely few days” to “a really lovely week.” Or “I’m really glad my brain fog seems to be receding,” which is a potential outcome type that has always been extremely concerning for me as a knowledge worker. One of my parents had zero symptoms and the other had it fairly mild, despite both being in not-spectacular health otherwise. I’m hoping that bodes well for me if I catch it, though who the gently caress knows. Also, fingers crossed for everyone else re: long-term effects because we just don’t know there either. Notably, with two exceptions, everyone I know who got it did so in the last six weeks…
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Feb 11, 2022 14:11
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Hardawn posted:My coworker thought she could smell something sour yesterday, but that quickly passed and she was back to nothing again There's several possible results when people lose their smell and/or taste due to covid, in some cases they just lose the ability to smell or taste anything, for other people it makes things smell or taste like garbage or rotting flesh or sewerage. Some people lose those senses for just a week, others lose them for months and months
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Feb 11, 2022 14:19
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Snowglobe of Doom posted:There's several possible results when people lose their smell and/or taste due to covid, in some cases they just lose the ability to smell or taste anything, for other people it makes things smell or taste like garbage or rotting flesh or sewerage. Yeah the tiktoks of people joking about lost taste and then it flashes forward a year later and they are still without are pretty haunting.
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Feb 11, 2022 14:24
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Seeing social media posts about going out again and knowing when/if you get covid you'll be ok bc you are vaxxed and boosted and it won't be worse than a cold https://youtu.be/oHC1230OpOg
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Feb 11, 2022 16:21
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Didn't you hear? Omicron is mild. It's no worse than the common cold.
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Feb 11, 2022 16:30
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HonorableTB posted:I will never go back to an office and nothing will change that. I've spent 2 years doing my job from my living room and like hell am I going into the covid cubicles. Sorry your job doesn't let you do that, that really sucks. But don't poo poo on people who are taking advantage of something in order to not get exposed and sick from a virus. If you want lower spread, why would you not support working from home for those who can? Real sour grapes and crab bucket mentality here Posters like "I deserve to work from home because I made good life choices" poster from a few days ago make that pretty tough. It's incredibly emotionally frustrating sometimes to read things like that, or the fifteen million twitter posts where someone harrowingly describes their first trip to the grocery store in two years, etc and kinda carries the implication that certain lives and families are worth more than others. My fiancée in particular worked at two warehouses and did instacart until recently. Literally risking her life to support the computer-toucher class every day. Our current industry still requires both of us to cater to irresponsible assholes who make multiple times our income. That we haven't gotten omicron yet is a miracle. I got first wave NYC covid and I do not want to repeat it. It drives home that there are haves and have-nots. It can sometimes feel like people think their families are more worthwhile than the plebs they "responsibly" send into the covid mines for their own benefit. And it's all doubly frustrating because intellectually, you know that nobody wants to throw your life away- we're all on the same side. Almost everybody who cares about covid enough to be reading this thread is doing right. People who can work from home should be, and they're not just protecting themselves, they're protecting the rest of us. There's nothing to be upset about. But still, it can get upsetting when people go "actually covid lifestyle rules, I can send emails and do spreadsheets from home, I'm doing great."
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Feb 11, 2022 16:33
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Zugzwang posted:two shots do gently caress all for preventing Omicron infection. Is there any data about whether it's the third shot that provides Omicron protection, or just a "recent" shot? Like if someone wasn't able to get the first round of vaccines (like, say, one of the poorer countries that did not have access) and now gets a two shot dose, would their antibodies be relatively 'fresh' and high enough to compare to the booster dose vs Omicron? Or will they still need the third shot even if the first two are fresh?
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Feb 11, 2022 16:34
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Tagra posted:Is there any data about whether it's the third shot that provides Omicron protection, or just a "recent" shot?
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Feb 11, 2022 16:40
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goddamnedtwisto posted:Another possibly stupid question about monoclonals - do they (as I recall reading when Florida went all-in on them) prevent you from actually developing immunity, or at least severely reduce your chances of developing immunity? The thinking was that because they take care of the infection before your own immune system gets its boots on that your body never really learns to recognise and attack the virus next time it sees it. I mean, until there are reviewed studies on this specific topic the answer is  , but the whole point of a MAB is to introduce an antibody that you don't have to do work for you. I'd imagine MABs actually partially negated your natural antibody production if you are one of the few cases where you got a MAB that worked against COVID at exactly the right window - that study sounds really loving hard (impossible) to do now lol. We'll probably never know much about the efficacy of MABs on COVID-19 in the first two years of the pandemic for real, but what we will know 100% for certain is that MABs for respiratory coronaviruses are a investment scam.
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Feb 11, 2022 16:47
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Edgar Allen Ho posted:
I'm privileged that I can do some of my work from home, but I've really been breaking lately because people in my company working from home has made my life and most of my work so much more loving difficult. I have to spend a lot of time making up for the people working from home, but I'm expected to still meet the same timelines. Some tasks that used to take me one hour now takes ten or more, and all in the lab and not at home. Mentally I'm at the point of, I don't give a poo poo about how they feel, everyone back to the office because I'm tired of carrying the extra weight and stress.
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Feb 11, 2022 17:51
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Edgar Allen Ho posted:Posters like "I deserve to work from home because I made good life choices" poster from a few days ago make that pretty tough. It's incredibly emotionally frustrating sometimes to read things like that, or the fifteen million twitter posts where someone harrowingly describes their first trip to the grocery store in two years, etc and kinda carries the implication that certain lives and families are worth more than others. My fiancée in particular worked at two warehouses and did instacart until recently. Literally risking her life to support the computer-toucher class every day. Our current industry still requires both of us to cater to irresponsible assholes who make multiple times our income. That we haven't gotten omicron yet is a miracle. I got first wave NYC covid and I do not want to repeat it. It drives home that there are haves and have-nots. I'm WFH for now and I 100% agree with all of this. If you're lucky enough to WFH you need to recognize how lucky and privileged you are. At the same time I don't blame anyone for fighting hard for WFH against WFO'ers who say "if I need to be in the office, everyone does".
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Feb 11, 2022 18:01
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Involuntary Sparkle posted:I'm privileged that I can do some of my work from home, but I've really been breaking lately because people in my company working from home has made my life and most of my work so much more loving difficult. I have to spend a lot of time making up for the people working from home, but I'm expected to still meet the same timelines. Some tasks that used to take me one hour now takes ten or more, and all in the lab and not at home. They made my HR department WFH and she tried to make us come to work during a snowstorm it took 2nd shift 4-6 hours to drive home in, while sitting at her house in the most hard-hit part of the city; telling my boss the roads were fine as it was dumping and the temp dropped to 16 at 5PM, when we go to work at 10PM last week. Do not loving take your WFH poo poo for granted.
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Feb 11, 2022 18:04
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i don't understand how that's a response to what they posted
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Feb 11, 2022 18:08
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Mozi posted:i don't understand how that's a response to what they posted You get to sit in your loving house instead of go to work through a pandemic, yeah it sucks how everyone took advantage of that to make your work day longer and everything is inefficient as gently caress, at least you aren't actively working through outbreaks and being told 6 days later you had close exposure. At least you aren't dealing with people who work from home who have completely lost perspective on everything related to in-person because you get to work from home.
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Feb 11, 2022 18:11
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MrQwerty posted:You get to sit in your loving house instead of go to work through a pandemic, yeah it sucks how everyone took advantage of that to make your work day longer and everything is inefficient as gently caress, at least you aren't actively working through outbreaks and being told 6 days later you had close exposure. That's literally what I'm doing though. I take one day a week at home to do my paperwork but the rest of it is in person in the lab with everyone else in my lab and taking the bus to and from work. And I work longer days every day because of the people who are 100% at home.
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Feb 11, 2022 18:14
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https://www.theguardian.com/world/2022/feb/11/world-experts-react-to-england-ending-covid-curbsquote:The UK’s prime minister, Boris Johnson, announced this week that he aimed to abolish all Covid regulations, including the requirement to isolate after testing positive, in England from 24 February. Here’s what experts around the world think of that plan, which would make Britain something of an outlier when it comes to coronavirus precautions. Some savage stuff here lol, all of it true
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Feb 11, 2022 18:14
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Involuntary Sparkle posted:That's literally what I'm doing though. I take one day a week at home to do my paperwork but the rest of it is in person in the lab with everyone else in my lab and taking the bus to and from work. And I work longer days every day because of the people who are 100% at home. I misread, sorry. That's a load of poo poo, and WFH has really elevated a class separation unlike anything I've ever seen.
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Feb 11, 2022 18:16
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Barry Foster posted:https://www.theguardian.com/world/2022/feb/11/world-experts-react-to-england-ending-covid-curbs The bolded quote from Germany really doesn't mince words.
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Feb 11, 2022 18:41
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Bonafide evidently hired some new staff, because 150 of the 200 masks I ordered last month are delivering today.
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Feb 11, 2022 18:59
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Uh, what https://twitter.com/HeidiNBC/status/1492206246551769096
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Feb 11, 2022 19:52
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Super duper sucks. I look forward to buying a kid-sized PAPR for my daughter in the near future Zugzwang fucked around with this message at 20:02 on Feb 11, 2022 |
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Feb 11, 2022 19:56
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Edgar Allen Ho posted:Posters like "I deserve to work from home because I made good life choices" poster from a few days ago make that pretty tough. It's incredibly emotionally frustrating sometimes to read things like that, or the fifteen million twitter posts where someone harrowingly describes their first trip to the grocery store in two years, etc and kinda carries the implication that certain lives and families are worth more than others. My fiancée in particular worked at two warehouses and did instacart until recently. Literally risking her life to support the computer-toucher class every day. Our current industry still requires both of us to cater to irresponsible assholes who make multiple times our income. That we haven't gotten omicron yet is a miracle. I got first wave NYC covid and I do not want to repeat it. It drives home that there are haves and have-nots. I feel seen. Thank you. No one asks to be born in a small town with few job prospects and little hope for moving up in the world except trying to save up enough between financial disasters to leave. When I said my piece a few days ago I had just heard my favorite co-worker got out of the hospital, who thanks to complications from covid cannot walk anymore and might never regain that ability. They're lucky to be alive and he's vaccinated, too. It's going to be years if not decades after the pandemic before we really understand the impact it has had on society and culture and not just by the numbers of dead or infected. Whole lot of cracks in society got widened.
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Feb 11, 2022 19:58
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Why not start the process of two doses now? What's the point of delaying? They know at least two doses will be approved, and likely the dosage, just.... why? I'm so angry at this bullshit.
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Feb 11, 2022 20:00
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The family I know that has their toddler in the Pfizer study said they just got their 3rd shot a few weeks ago, so hopefully it isn't too long for everyone with small kids.
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Feb 11, 2022 20:03
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Admit edit: nope. (USER WAS PERMABANNED FOR THIS POST)
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Feb 11, 2022 20:05
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