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# ? Mar 24, 2022 20:53 |
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# ? Jun 2, 2024 02:08 |
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# ? Mar 24, 2022 20:54 |
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# ? Mar 24, 2022 20:55 |
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Nice new thread OP! Sorry in advance for the lengthy post. I've been summarizing PASC research studies for my own understanding and previously posted my notes in the old thread but thought worth posting here too in case it's of interest. Please let me know if you're aware of any large scale PASC study not included here, I'd be interested in learning more. TLDR: long-term COVID impacts ie "long COVID" or "Post-Acute Sequelae of SARs-COV-2 infection" (PASC) affects ~10-30% of people with symptomatic infections. >1%-10% of COVID infections result in “significant” long term impacts, with large uncertainties in actual rates but these are likely lower bounds. Vaccines did not protect against all PASC conditions (estimates vary between 50% reduction to no protection). PASC overview -PASC encompasses a range of conditions that might occur after a COVID infection -conditions include cardiovascular, neurological and immune disorders https://www.frontiersin.org/articles/10.3389/fmicb.2021.698169/full https://www.nytimes.com/interactive/2022/02/19/science/long-covid-causes.html -PASC rate post-infection highly uncertain, estimates vary between 10%-30% at ~6 months -the impact of potentially relevant factors like vaccination also have large uncertainties -several large scale studies and labor force analyses attempt to evaluate PASC rate, severity -PASC isn’t COVID mortality, mortality is better understood and effectively reduced with vaccines PASC rate estimates from major studies -focus here on PASC rates for mild cases in <65 year olds where possible -ideally account for vaccination impact, most large completed studies done pre-vaccine Post-acute symptoms, new onset diagnoses and health problems 6 to 12 months after SARS-CoV-2 infection: a nationwide questionnaire study in the adult Danish population -large scale study, 152880 participants, evaluated at 6-12 months, pre-vaccine availability -long-term symptoms maximal for 30-60 year old -”significant” post-infection symptoms: -~40% risk of physical exhaustion, 35% risk of mental exhaustion -~28% chance of memory and concentration issues -~8% fatigue Long COVID in a prospective cohort of home-isolated patients -followed 312 home-isolated (non-hospitalized) Norwegian patients from the early pandemic -52% (32/61) of home-isolated young adults, aged 16–30 years, had symptoms at 6 months -”significant” post-infection symptoms: -impaired concentration (13%, 8/61) -memory problems (11%, 7/61) -fatigue (21%, 13/61) Physical, psychological and cognitive profile of post-COVID condition in healthcare workers, Quebec, Canada -~6000 COVID positive HCWs in Quebec between July 2020 and May 2021 pre-vaccines -had controls, claims less bias than similar studies because participants recruited pre-COVID ~40% reported at least one post-infection symptom at 12 weeks -10-20% described at least one “severe” post-infection symptom, did not decrease with time -”significant” post-infection symptoms: -cognitive dysfunction ~15% at 25 weeks -fatigue ~25% at 25 weeks Incidence, co-occurrence, and evolution of long-COVID features: A 6-month retrospective cohort study of 273,618 survivors of COVID-19 -analyzed health records of 81 million US patients, idenitified 273000 COVID cases -cases would have been for people that sought treatment, so worse than overall population -”significant” post-infection symptoms: -fatigue/malaise (12.82%; 5.87% -cognitive symptoms (7.88%; 3.95%), Prevalence, determinants, and impact on general health and working capacity of post-acute sequelae of COVID-19 six to 12 months after infection: a population-based retrospective cohort study from southern Germany -persons aged 18-65 years with PCR confirmed infection between Oct 2020 and March 2021 -11,710 subjects, reported symptom rates before, during infection and at later time -”significant” post-infection symptoms: -neurocognitive impairment (PD 31.3%) -fatigue (PD 37.2%) Persistence, prevalence, and polymorphism of sequelae after COVID-19 in young adults -501 participants, median age of 21 years (range 19-29) -compared 177 COVID cases after 6 months with controls, recent infection, asmptomatics -found a significant trend towards metabolic disorders, higher Body Mass Index (BMI) (p=0.03), lower aerobic threshold (p=0.007), higher blood cholesterol (p<0.001) and low-density lipoprotein LDL levels -there were no significant differences in psychosocial questionnaire scores Long-term cardiovascular outcomes of COVID-19 -157000 VA patients, predominantly older white males -also includes contemporary and historical control groups -study period 2020-2021, pre-vaccine -4.5% elevated risk of any cardiovascular outcome in entire cohort -roughly 2.5% elevated risk of any cardiovascular outcome for mild cases Risks and burdens of incident diabetes in long COVID: a cohort study -181280 participants with COVID-19 between March 1, 2020, and Sept 30, 2021 -note average participant age of ~61 years old -had contemporary and historical control -people with COVID-19 had increased risk (HR 1.40, 95% CI 1.36–1.44) of diabetes -excess burden (13.46, 95% CI 12.11–14.84, per 1000 people at 12 months) of diabetes ie roughly ~1% of cases -Risks and burdens increased according to the severity of the acute phase of COVID-19 Six-month sequelae of post-vaccination SARS-CoV-2 infection: a retrospective cohort study of 10,024 breakthrough infections -10024 vaccinated individuals, 9479 matched against unvaccinated controls -no uninfected control group -evaluated pre-Omicron -this study is focused on evaluating difference in long-term outcomes between vaccinated vs unvaccinated and not so much the absolute rates -two doses of vaccine had no impact on “long-COVID” features, several other disorders Presence of Symptoms 6 Weeks After COVID-19 Among Vaccinated and Unvaccinated U.S. Healthcare Personnel -participants had COVID-19 with either verified mRNA vaccination or no vaccination -among 681 eligible participants, 419 (61%) completed survey ~6 weeks after illness onset -~71% reported one or more COVID-like symptoms 6 weeks after illness onset -lower prevalence of long-term symptoms among vaccinated participants -”significant” post-infection symptoms: -fatigue ~30% -cognitive symptoms: 25% Indirect PASC impacts from labor statistics Is ‘long Covid’ worsening the labor shortage? -assumes ~100 million workers infected by Oct 2021 -roughly estimates ~1.1 million people out of work due to long COVID at any given time COVID-19 Likely Resulted in 1.2 Million More Disabled People by the End of 2021 -additional 1.2 million people in the US civilian institutional population with a registered disability in 2021 compared to 2020 -total labor force without disability is down ~2 million since the start of the pandemic -large increase in workers with disability likely due to PASC, ~1% of infected workers Summary -PASC research suggests >10% chance of “significant” long-term impact from COVID infection, esp fatigue and cognitive symptoms (estimates vary around 10-20%) -additional risk of cardiovascular disease after mild infection is ~2.5% -vaccines did not protect against all PASC conditions (estimates vary between 50% reduction to no protection) -vaccine protection has likely not improved with Omicron dominant given relatively worse protection against symptomatic infection -labor statistics suggest >1% of infected workers either disabled or too sick to continue working at least temporarily -current overall picture is >1%-10% of COVID infections result in “significant” long term impacts, with large uncertainties in actual rates but these are likely lower bounds
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# ? Mar 24, 2022 20:55 |
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places the positive wife and presumed positive i have been in the past week: 1. dentist (no masks, but masks for staff w/portable hepa filters running on full) 2. grocery store (just her, but in an aura in a still mask-dominant area of the country) 3. a home nannyshare, where everyone tests routinely and is pretty careful. all have tested negative recently. welp. two years of locking down in every way we could without quitting our jobs down the drain. right after the moderna news, too. awesome.
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# ? Mar 24, 2022 20:56 |
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# ? Mar 24, 2022 20:57 |
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Probably a top-5 COVID meme
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# ? Mar 24, 2022 20:57 |
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Hey I didn't read this thread yet but it is only going to get longer and I wanted y'all to know that my therapist said it is ok to be concerned about covid and that therapists probably shouldn't be counseling people to take stupid risks with poor tradeoffs. Working hard thank you!!!!
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# ? Mar 24, 2022 20:57 |
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# ? Mar 24, 2022 20:57 |
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Brunch is BACK
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# ? Mar 24, 2022 20:58 |
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Should add this to the OP IMHO The old metrics for transmission: The new metrics for transmission:
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# ? Mar 24, 2022 20:58 |
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it feels like forever ago, but this was right as Delta was growing in the US. telling people to wear masks when this video was made could have saved hundreds of thousands of lives then omicron hit, and aside from a couple weeks where the biden admin offered a few n95s (if you found an approved location and went to pick them up yourself), their policy on masks essentially hasn’t changed. biden himself still doesn’t wear a mask much of the time a third of the kids that have died from covid have died in the last two months. that’s before BA.2, which is much deadlier for unvaccinated kids under 5. but don’t worry: 99% of schools are currently doing in person learning!
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# ? Mar 24, 2022 20:58 |
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Covid is in the water. I do not drink this. Covid is in the earth. I do not eat this.
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# ? Mar 24, 2022 20:59 |
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^^^ dirt is delicious lol remember madjackal holding that up as proof that he was right about unmasking gently caress
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# ? Mar 24, 2022 20:59 |
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right hand side is a good look for vp 👍
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# ? Mar 24, 2022 21:00 |
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Insanite posted:places the positive wife and presumed positive i have been in the past week: I'm sorry to hear this! Hope you can take it very easy for a while. Also if you haven't already maybe consider isolating/masking at home. There's so much uncertainty and nothing definitive but there has been consistent speculation that reducing early viral load might help minimize the chance of longer term impacts. edit: it's really important to emphasize parents haven been put into an impossible position recently and someone doing their best to avoid infection in that context isn't to blame. Nocturtle has issued a correction as of 21:04 on Mar 24, 2022 |
# ? Mar 24, 2022 21:00 |
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I reminded several people about this and they had no recollection of it. Google returns almost nothing but local news stations. YouTube isn't in a hurry to find it.
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# ? Mar 24, 2022 21:01 |
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Animal-Mother posted:I reminded several people about this and they had no recollection of it. Google returns almost nothing but local news stations. YouTube isn't in a hurry to find it. google’s brain fog has been getting pretty bad these last few years
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# ? Mar 24, 2022 21:02 |
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Fly Molo posted:google’s brain fog has been getting pretty bad these last few years it’s pretty alarming but idk what can be done. oh well
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# ? Mar 24, 2022 21:03 |
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Nocturtle posted:I'm sorry to hear this! Hope you can take it very easy for a while. yeah, we're in auras right now. air filters are running. isolating from the toddler is hard to impossible. rules. most recent nasal vs. throat + nasal swab comparison: throat's nice and dark. Insanite has issued a correction as of 21:08 on Mar 24, 2022 |
# ? Mar 24, 2022 21:05 |
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mawarannahr posted:it’s pretty alarming but idk what can be done. oh well Yeah it isn't like anyone knows how these things work or can be held accountable... Wait what's that you say? There's a whole field of research on explainability in ai systems??? Ah, well, nevertheless
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# ? Mar 24, 2022 21:07 |
U-DO Burger posted:this last month has been such a shitshow. just off the top of my head sorry for your mental illness op
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# ? Mar 24, 2022 21:07 |
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Animal-Mother posted:I reminded several people about this and they had no recollection of it. Google returns almost nothing but local news stations. YouTube isn't in a hurry to find it. I wonder if the tweet is still up. The screenshot has the account and date/time
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# ? Mar 24, 2022 21:08 |
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reading through one of the older threads, march 10 2021 these were some simpler times fosborb posted:
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# ? Mar 24, 2022 21:08 |
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Does anyone have the go to source for needing to swab the throat? My parents refuse to listen to me and my dad is actively sick right now.
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# ? Mar 24, 2022 21:08 |
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Tzen posted:reading through one of the older threads, i remember, sir
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# ? Mar 24, 2022 21:09 |
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Animal-Mother posted:I reminded several people about this and they had no recollection of it. Google returns almost nothing but local news stations. YouTube isn't in a hurry to find it.
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# ? Mar 24, 2022 21:09 |
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Insanite posted:yeah, we're in auras right now. air filters are running. isolating from the toddler is hard to impossible. rules. That sucks rear end and I fully expect to make the same post within the next month, two if I’m lucky.
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# ? Mar 24, 2022 21:09 |
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TehSaurus posted:Yeah it isn't like anyone knows how these things work or can be held accountable... are you going to hold Google accountable ? to what??? what can the ai explain about all this?
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# ? Mar 24, 2022 21:09 |
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Do the genetically COVID-immune have a responsibility to birth and rear a new and superior race? And should the rest of humanity step aside? Just some Wednesday thoughts
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# ? Mar 24, 2022 21:11 |
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Insanite posted:places the positive wife and presumed positive i have been in the past week: Insanite posted:yeah, we're in auras right now. air filters are running. isolating from the toddler is hard to impossible. rules. also Thoguh posted:That sucks rear end and I fully expect to make the same post within the next month, two if I’m lucky.
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# ? Mar 24, 2022 21:11 |
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not_superiority posted:got my honeywell full face in last night. felt invincible when i tried it on. I pretend I'm in TENET and moving inverted back to 2019 for that sweet Classic Blackened Shrimp Alfredo from Applebees(tm).
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# ? Mar 24, 2022 21:12 |
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if joe biden's state of the union kills clarence thomas then I'll have to begrudgingly say biden did a good thing as president
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# ? Mar 24, 2022 21:13 |
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I feel like it took a while for the government to acknowledge 1 milly dead…..
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# ? Mar 24, 2022 21:14 |
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https://twitter.com/gorskon/status/1507056402044538884
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# ? Mar 24, 2022 21:14 |
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Martin Luther, Whether One May Flee From a Deadly Plague, 1527 posted:They are much too rash and reckless, tempting God and disregarding everything which might counteract death and the plague. They distain the use of medicines; they do not avoid places and persons infected by the plague, but lightheartedly make sport of it and wish to prove how independent they are. They say that it is God’s punishment; if he wants to protect them he can do so without medicines or our carefulness. This is not trusting God but tempting him. God has created medicines and provided us with intelligence to guard and take good care of the body so that we can live in good health. Engels, Condition of the Working Class in England, 1845 posted:When one individual inflicts bodily injury upon another such that death results, we call the deed manslaughter; when the assailant knew in advance that the injury would be fatal, we call his deed murder. But when society places hundreds of proletarians in such a position that they inevitably meet a too early and an unnatural death, one which is quite as much a death by violence as that by the sword or bullet; when it deprives thousands of the necessaries of life, places them under conditions in which they cannot live – forces them, through the strong arm of the law, to remain in such conditions until that death ensues which is the inevitable consequence – knows that these thousands of victims must perish, and yet permits these conditions to remain, its deed is murder just as surely as the deed of the single individual; disguised, malicious murder, murder against which none can defend himself, which does not seem what it is, because no man sees the murderer, because the death of the victim seems a natural one, since the offence is more one of omission than of commission. But murder it remains. A.D. Condo, The Outbursts of Everett True, 1918 Something Awful, COVID Thread, 2022 posted:Something that scares me about covid that we don’t talk about as often: covid as an object lesson about the capability and role of the government. Everybody old enough to pay attention to the news spent the last couple years watching the government say we needed to take action, try to do that for a minute, quickly give up, and switch all the messaging to either “I hate this and you do too so it’s over” or “I hate this and you do too so we’ll make it go away just as soon as we can.” There’s no burly protector with a sure hand on the wheel up there making the tough choices, it’s a bunch of rich idiots who are not only tired of masks themselves, but also financially dependent on placating the dumbest people in the country.
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# ? Mar 24, 2022 21:15 |
the, ugly people, the
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# ? Mar 24, 2022 21:16 |
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Shear Modulus posted:if joe biden's state of the union kills clarence thomas then I'll have to begrudgingly say biden did a good thing as president hell I’ll even say I’ll vote for him
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# ? Mar 24, 2022 21:18 |
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It's incredible how much these guys hate their fans
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# ? Mar 24, 2022 21:20 |
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# ? Jun 2, 2024 02:08 |
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Pittsburgh Fentanyl Cloud posted:It is insanely mentally unwell to be concerned about the disease that is the #1 leading non-natural cause of death in the United States going on three years now, which our government has told us that they no longer will fund any sort of efforts to mitigate.
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# ? Mar 24, 2022 21:20 |