(Thread IKs:
PoundSand)
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The Oldest Man posted:A lot of organ damage from viral infections is persistent inflammation, which could subside (at least somewhat) if the virus is wiped out and provide symptom relief. Good study. It is a design that makes sense if you don't have any other biomarker beyond organ damage, because with organ damage you need very substantial effects to not wind up with an under powered study showing no statistically significant effect. It isn't difficult to imagine an ongoing infection being wiped out and further damage gets curbed, while damage already sustained is permanent or only marginally healed. I subsequently think they would have been much better off testing the effect of Paxlovid on (admittedly very newly discovered) biomarkers indicating said inflammation, instead of using the consequences thereof as biomarker. I think your framing is implicitly demonstrating the issue, with your parenthesis highlighting a potential low grade effect and your mentioned aim being symptom relief. They aren't "just" looking for symptom relief, they are looking for hard objective data of effect (or the group would be different) and that effect needs to be profound to be statistically significant with a relatively small cohort of 400, presumably with disparate forms of long COVID (or alternatively running the risk of a particular form not responding).
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# ? Oct 11, 2023 12:16 |
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# ? May 25, 2024 09:25 |
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Obviously this is just an excuse for having cut staff to less than a skeleton crew, but also lmao at the very smart privatization of the vaccination effort overloading said skeleton crews even though the uptake is going to be gently caress all.https://fortune.com/well/2023/10/10/cvs-pharmacist-walkout-caused-by-pandemic-burnout-covid-booster-demand-xbb15-omicron/ posted:CVS CEO says pharmacist burnout led to a walkout: ‘We are at the same level of demand as we were in 2021’ for COVID shots
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# ? Oct 11, 2023 12:49 |
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GDQ has updated their COVID policy to basically be worthless. https://gamesdonequick.com/covid https://x.com/GamesDoneQuick/status/1711841460444959046?s=20 There's a surprising amount of pushback in the replies.
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# ? Oct 11, 2023 12:51 |
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Gamers Die Quick [20%, death abuse]
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# ? Oct 11, 2023 12:54 |
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hi, sorry, is there a better way to find novavax boosters than the https://www.vaccines.gov/ site, which is currently not showing any anywhere (but maybe that will be fixed by end of week?)
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# ? Oct 11, 2023 13:00 |
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Petey posted:hi, sorry, is there a better way to find novavax boosters than the https://www.vaccines.gov/ site, which is currently not showing any anywhere (but maybe that will be fixed by end of week?) Steve Yun posted:Novavax has launched their own vaccine finder, no idea if it’s any better:
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# ? Oct 11, 2023 13:13 |
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Pingui posted:
It's unprecedentedly the same again, no one could have seen this coming!
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# ? Oct 11, 2023 13:18 |
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The Ghoul posted:There's a surprising amount of pushback in the replies. My favorite ones are the ones that mention what year it is. Like bad things just expire bro. Bro, that was what we did in 2021.
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# ? Oct 11, 2023 13:28 |
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Diamonds On MY Fish posted:With how obsessed this thread is with CO2 levels, I don't think any kind of venting is pointless! Ooohhhh this fuckin guy
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# ? Oct 11, 2023 13:30 |
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I'll never forget the GDQ chair sniffer https://www.youtube.com/watch?v=DJzgTZ68g9g
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# ? Oct 11, 2023 13:44 |
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The issues with kid PASC rates mentioned in this piece, are and have always been, a major concern to me. I think I've mentioned it a few times over the threads, if not explicitly in regards to children, certainly in regards to the adult research. Either way the caveats mentioned here are important to keep in mind when reading any PASC research. Great article, brought here in full due to the subject matter. "Not 'little adults': Experts say long COVID undercounted, misdiagnosed in kids" https://www.cidrap.umn.edu/covid-19/not-little-adults-experts-say-long-covid-undercounted-misdiagnosed-kids posted:Research on long COVID in children is limited, and reported prevalences range widely, from less than 1% to 70%. And while it's a relatively new condition in an evolving field, experts say it could be better defined and measured through well-designed longitudinal studies that take children's unique presentations into account.
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# ? Oct 11, 2023 14:32 |
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Pingui posted:"My advice leads to infection prevention," he said. "It's really easy to clean air, it's really easy to put HEPA [high-efficiency particulate air] filters in classrooms, it's really easy to use UV [ultraviolet] lights." I'm trying to understand how this makes money?
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# ? Oct 11, 2023 14:53 |
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Bruce Hussein Daddy posted:I'm trying to understand how this makes money? look, number can still go up, it's just up in the other direction.
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# ? Oct 11, 2023 14:55 |
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Bruce Hussein Daddy posted:I'm trying to understand how this makes money? Put it under the purview of DoD or NSA and the graft structures are built-in and ready to leech money from the get-go. Let children build their credit score early and incentivize capital by funneling the cost into undischargeable student loan payments. Simple as.
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# ? Oct 11, 2023 15:11 |
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Our elementary school is proud to announce its new partnership with Visa and our new line of school-branded credit cards. Get double points with purchases of school supplies from approved vendors. Purchase your lunches with confidence with the no-contact RFID feature! The school canteen offers replacement UV light bulbs and HEPA filters your child can purchase when the personal air purifier under their desk needs service.
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# ? Oct 11, 2023 15:24 |
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Petey posted:hi, sorry, is there a better way to find novavax boosters than the https://www.vaccines.gov/ site, which is currently not showing any anywhere (but maybe that will be fixed by end of week?) There was one small pharmacy here that was planning to have them, but they changed their minds because the 5-dose vials are too much of a financial risk for them.
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# ? Oct 11, 2023 15:30 |
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The Ghoul posted:GDQ has updated their COVID policy to basically be worthless. https://gamesdonequick.com/covid how are you surprised? everyone everywhere is acting like covid doesn't exist while people keep dying of it.
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# ? Oct 11, 2023 15:32 |
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Do we even have updated death numbers anymore? seems like everyone stopped updating them a year and a half ago
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# ? Oct 11, 2023 15:46 |
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Pittsburgh Fentanyl Cloud posted:Do we even have updated death numbers anymore? seems like everyone stopped updating them a year and a half ago
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# ? Oct 11, 2023 15:48 |
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https://covid19.who.int/region/amro/country/us This says 1.127m deaths which was essentially where the trackers were a year and a half ago
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# ? Oct 11, 2023 15:53 |
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Pittsburgh Fentanyl Cloud posted:https://covid19.who.int/region/amro/country/us that says 0 new cases in the past 7 days!! : )
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# ? Oct 11, 2023 15:59 |
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covid: over
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# ? Oct 11, 2023 16:00 |
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168603/ this has total deaths for 2022 at 3,273,705, which is ~8970 a day, which is pretty elevated from the prepandemic norm of ~7700 a day It's hard to find total weekly deaths for the US for more recent periods and the excess mortality statistics are useless
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# ? Oct 11, 2023 16:04 |
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5G trip report. I did it at a CVS in a target so it wouldn’t just be sick people and stale air but lol they had me go in to a tiny room with no ventilation to get jabbed by a maskless tech. Another win for being the first person of the day, I guess, so there hadn’t been a bunch of other people in that room recently. Would have preferred to be a Moth Man right now but Pfizer was available so Pfizer it is.
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# ? Oct 11, 2023 16:24 |
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Pingui posted:The issues with kid PASC rates mentioned in this piece, are and have always been, a major concern to me. I think I've mentioned it a few times over the threads, if not explicitly in regards to children, certainly in regards to the adult research. Either way the caveats mentioned here are important to keep in mind when reading any PASC research. Great article, brought here in full due to the subject matter. uhh, what
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# ? Oct 11, 2023 16:29 |
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Polymerase Chain Reaction, the protocol used to amplify pieces of genomic material from 200 thousand year old Neanderthal skulls, doesn't work unless you're tripping over template DNA. lol
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# ? Oct 11, 2023 16:32 |
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Pingui posted:It is a design that makes sense if you don't have any other biomarker beyond organ damage, because with organ damage you need very substantial effects to not wind up with an under powered study showing no statistically significant effect. It isn't difficult to imagine an ongoing infection being wiped out and further damage gets curbed, while damage already sustained is permanent or only marginally healed. I subsequently think they would have been much better off testing the effect of Paxlovid on (admittedly very newly discovered) biomarkers indicating said inflammation, instead of using the consequences thereof as biomarker. I think casting a wide net is a way better idea since I don't think anyone has done that with pax which is, to be honest, crazy. 400 is too small a study for that though, I agree with that part.
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# ? Oct 11, 2023 16:36 |
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Pittsburgh Fentanyl Cloud posted:https://covid19.who.int/region/amro/country/us Yesterday Somebody in the I/P thread posted about how ‘We accepted 7 million deaths worldwide from COVID’ and I lol’d
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# ? Oct 11, 2023 16:52 |
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Thoguh posted:5G trip report. I did it at a CVS in a target so it wouldn’t just be sick people and stale air but lol they had me go in to a tiny room with no ventilation to get jabbed by a maskless tech. Another win for being the first person of the day, I guess, so there hadn’t been a bunch of other people in that room recently. Would have preferred to be a Moth Man right now but Pfizer was available so Pfizer it is. Did the same yesterday, but they just had a little booth with a curtain instead of a enclosed room. Got my flu shot too. Arm was sore yesterday and almost better today. I woke up at 6am freezing cold, took an ibuprofen and felt better once it hit. Pretty much the same as all the other mRNA shots I've had. The moth juice is much better side effect wise, but I didn't want to wait anymore and availability of novavax being completely in the air if/when I could find it.
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# ? Oct 11, 2023 17:07 |
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Thoguh posted:Yesterday Somebody in the I/P thread posted about how ‘We accepted 7 million deaths worldwide from COVID’ and I lol’d https://covid.cdc.gov/covid-data-tracker/#maps_percent-covid-deaths If you drill down into the data, we have "data not available" for many states, so this is only an average of the data for the states that reported a percentage of deaths due to COVID. However, https://data.cdc.gov/NCHS/Weekly-Provisional-Counts-of-Deaths-by-State-and-S/muzy-jte6 makes it look like CDC all-cause death data is around 60k a week so if we just do the math there, 2.7% of that is 1620 deaths from COVID. If we assume that's covering all cases and representive of a full year (strong assumptions, sure) that's 84,000 deaths a year. If that's anywhere near accurate that is both catastrophic and unprecedented enough in modern times that it ought to be hair-raising to anyone paying attention, and, also a small enough percentage of the ~3million deaths per year we have, that it's very easy to not pay attention if it's not someone you know dying.
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# ? Oct 11, 2023 17:08 |
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Bruce Hussein Daddy posted:I'm trying to understand how this makes money? The air filter industry really needs to hire some lobbyists. They could make a killing if they could get some indoor air quality standards set and enforced. Though realistically since we live in hell world most of the money would end up going to grifters.
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# ? Oct 11, 2023 17:10 |
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The Oldest Man posted:I think casting a wide net is a way better idea since I don't think anyone has done that with pax which is, to be honest, crazy. Hence which is why they should use the generic inflammation markers and ensure it works on those first, as it would require a much smaller cohort if it directly translates and would also have a more immediate result. Jumping directly to the complexities of disparate organ damage is not a good design for testing Paxlovid, as stopping the progression of disease by curbing the instigator would result in a null result, if the cohort symptoms are contingent on slowly or non-repairable organ damage. I think measuring the effects on the commonality of inflammation, rather than the specifics of organ damage, is the wider net here and I don't understand why you think the opposite. I suppose we could just have different ideas of the depth of the eventual research, where you assume the would test for the biomarkers etc., rather than what I imagine which is essentially focusing on the organ damage itself. If that is the case, I agree, more tests = wider net = more data = better than.
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# ? Oct 11, 2023 17:28 |
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thanks. looks like nothing on it yet...
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# ? Oct 11, 2023 18:01 |
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Novavax corporate vax tracker now just saying "Coming to a pharmacy near you," lol
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# ? Oct 11, 2023 18:20 |
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Covid is over
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# ? Oct 11, 2023 18:25 |
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just a few pages back an article was shared saying novavax is shipping next week, or later this week, maybe available next week. Can't be bothered to look for it right now. Just maybe that's why yall can't find it.
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# ? Oct 11, 2023 18:56 |
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My friend who works in an elementary school just got got for the 6th or 7th time in the last two years. I'm feeling hella fatigued today but my deeply stroked, expires-in-3-months RAT was negative, for whatever that's worth (probably nothing). Going to have another espresso to see if that helps. Really not a fan of this timeline
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# ? Oct 11, 2023 19:17 |
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if I’ve been storing tests in the fridge way past expiration, do I know if they’re still working if I get a decent C line when testing?
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# ? Oct 11, 2023 19:25 |
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Might need to give in and go to urgent care because due to some stomach problems i cant seem to eat much or keep much food in me and im so drat tired and dont want to risk getting covid. poo poo sucks so bad. Also the absolute dread of hospital bills.
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# ? Oct 11, 2023 19:28 |
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# ? May 25, 2024 09:25 |
silicone thrills posted:Might need to give in and go to urgent care because due to some stomach problems i cant seem to eat much or keep much food in me and im so drat tired and dont want to risk getting covid. that really loving sucks. I know you’ll be careful but I hope you’ll be lucky too.
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# ? Oct 11, 2023 19:42 |