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Kuri
Jun 26, 2009
I posted a few hundred posts ago about being diagnosed in my late 20s. So far, I've been on varying doses of Adderall, finally settling on 10mg XR 3x a day. I can control timing and peak doses rather well now, and despite being about the most expensive way to get 30mg of Adderall XR, I've been very happy with this approach. My life has really come together, my mood has dramatically improved, and my attempts at going back to school for an advanced degree have been going swimmingly.

Just got out of my quarterly prescription appointment with my GP, where I brought up Intuniv. He's had good success as an adjunct to other drugs and agreed to trying a trial to see how it would work for me. Even better, he provided samples so I don't have to even shell out cash to try it.

I'm following the 1-2-3-4mg titrating dose; he thinks that we might have to go as high as 6mg due to weight (I am a fair bit taller than the standard patient that those doses were calculated for). As I go through the ramp up, I'll post a few times about how it is working for me.

As is, the Adderall has been rather mild for me; I get a minor increase in heart rate, but my blood pressure has actually gone down since I started due to the immense drop in anxiety. My appetite is reduced during dosing, but I eat if I actively think about it. Trip report coming soon!

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Kuri
Jun 26, 2009
poo poo like that is scary. I have a toddler and, even though I'm looking for early signs so he can avoid the "fun" I had as a kid, I can tell the difference between being two and having ADHD.

My doctor is awesome, though. He's been completely willing to modify treatment as I see fit; it helps that I'm keeping my doseof adderall as low as possible. Hell, I could go for the big guns and get Desoxyn if I really wanted; I'll save that for later. I moved 60 miles away from where I used to live, but still head back to see him just because of how great he is.

Kuri
Jun 26, 2009
Intuniv trial
Day Four: Sleepy. Taking the pill at night is definitely a requirement as your body gets used to the guanfacine; I took 3-4 hour naps on the weekend above the 8 hours of sleep each night. My heart rate is down about 5-8 BPM, blood pressure down about 8/5. The adderall slightly raises my HR, but intuniv kills that. The drug supposedly takes up to two weeks, but I've found some effects, albeit slightly. I came into work this morning and noticed I had all of yesterday's work in nice, neat piles in folders in lieu of piles, as normal.

Side effects: aside from the somnolence and the reduction of HR and BP, I'm a little thirstier and a bit more anorexic. Adderall caused the later somewhat, but the effect seems compounded with Intuniv. I'll be curious to see if it continues.

So far so good.

Kuri
Jun 26, 2009
Why, hello thread!

I decided to give it a bit more time before the trip report after the addition of Intuniv (guanfacine) to my drug regimen. Two months in, I'm relatively satisfied with it along with my Adderall.

/wall of text
My diagnosis started when my GP, in the middle of an appointment about a nasty ingrown toenail, noticed my absolute inability to focus for more than 15 seconds. This rather astute observation led to my diagnosis in my late twenties (combined-type). He started me on Adderall, which has been an absolute God-send, and after trying different dosing schedules, I've settled on 10mg Adderall XR tid. It allows me to control when the medication truly hits, and the small XR ensures I can minimize the total amount in my system at any one time. This is amazingly helpful since I all but avoid any rebound effects at the end of the day due to the tapered schedule.

My GP, again being awesome, has essentially opened the door to any treatment I am interested in. I have a paramedic certification (which I use for volunteering), so he knows I at least am not a mouthbreather when we've talked about the possible treatment avenues. I brought up the idea of Intuniv due to what I'd seen about guanfacine's efficacy with ADHD symptoms, and he was interested in seeing how it worked for me.

Super GP loaded me up with a month's worth of samples to try, and had his secretary get a prescription ready in case I wanted to continue. Guanfacine was typically used for hypertension, but the common agreement is that it also limits norepinephrine release in a certain portion of the brain, thereby helping with symptoms of impulsivity and inattention in ADHD. Intuniv is simply time-release guanfacine. Some people take the standard generic, but that usually involves two doses a day and has more of a peak effect on blood-serum levels.

Due to the effects on blood pressure, there is a titrating period involving a slow increase to the full dose. Given my size (over six feet tall and ~225 pounds), we aimed for a 4mg dose based on the study information from the FDA. In all, it works, but there are some fun side-effects that are mainly only noticeable when I don't take my Adderall on the weekends.

My heart rate is MUCH better now than previously; even with the Adderall, my HR stays below 70 when resting, whereas without the Intuniv, it would sit around 75-80. However, during the weekends, I am generally more somnolent, but at least I can claim the Intuniv makes me need a nap...I think my wife knows better, but it is a good enough excuse.

It took a good month to notice a difference, but it is certainly there. My organization ability is tremendously improved; I walked into my office at work one day and didn't recognize it since everything was neatly arranged, papers were in folders, etc. By itself, I don't think it would do nearly enough alone, but coupled with my daily stimulant, I'm very happy with the Intuniv.
/end wall of text

tl;dr Anti-hypertensive works well with stimulant for range of ADHD symptoms.

Kuri
Jun 26, 2009
Part of the problem may be in taking it with food; any of the amphetamines are susceptible to stomach pH and urinary pH. A stomach that is less acidic will absorb the drug faster, while a less acidic bladder will excrete it slower (typically 50% or so of amphetamines are excreted un-metabolized via urination).

Citrus fruits, along with drinks like cranberry juice, can cause you to literally piss out the Adderall much faster than you would otherwise. Dairy causes a big hit to urinary pH. Combined with a slower intake (food in the stomach will temporarily lower your gastric pH until the acidic environment overtakes the volume), you might be a victim of timing.

I typically get up at 0530 and eat breakfast right away. Then, as I am about to roll into work at 0700, I'll take my first Adderall; this allows my stomach to clear out some and I avoid the same problem. When I first started taking the medicine, I would take it with food...and I noticed it felt like nothing was happening some days. Offsetting the timing did wonders for the efficacy. I know some people will take their medication as soon as they wake up, then eat 1-2 hours later, but my appetite gets slaughtered until afternoon, so I have to eat first. YMMV.

Edit: Small change. Some juices, such as orange juice, actually cause your urine to become more alkaline due to how the body handles the acids.

Kuri fucked around with this message at 04:45 on May 6, 2011

Kuri
Jun 26, 2009

Chin Strap posted:

Thanks for this. Lately I've started taking my Ritalin with food because of a schedule shift, and I was noticing less effect. Trying to take it an hour before, so far so good.

I know I would get the classic "OMG ACID REFLUX" effect when I first started taking it, but I have to avoid food with my cat drugs to ensure I actually get an effect.

Kuri
Jun 26, 2009
Another correction: I meant to say food in the stomach RAISES gastric pH, which is the same as lowers the acidity...you get the idea.

Kuri
Jun 26, 2009

Qu Appelle posted:

IANAL or HR Specialist.

However, here's a good summary from Additude Magazine, a magazine about ADHD.

Bad article redacted

Read this over and see if you think it fits. One key component - if medication 'fixes' the condition, you may not be considered 'disabled' in terms of accommodation. This is addressed in the article. I believe that you just started some new medication; if that ends up helping your ADHD issues at work, then you're golden. If you have more questions and are concerned about work issues, your doctor might be a good resource for info on this.

I just so happen to work in civil rights for...someone in the US.

The article, while formerly true, is now wrong. While there are some limitations on liability under the Americans with Disabilities Act (as amended by the...Americans with Disabilities Act Amendments Act [ADAAA]) for smaller employers (14 or less), the majority of employers have some major requirements to provide accommodations for employees with disabilities.

The ADAAA of 2008 (with final rule-making guidelines issued by the EEOC earlier this year) was enacted specifically to protect the broad definition of disability, codify the near disregard for consideration of mitigating factors when determining if a medical condition rises to the level of disability, and several other factors.

Fact Sheet on the EEOC’s Final Regulations Implementing the ADAAA posted:


With one exception (“ordinary eyeglasses or contact lenses”), the determination of whether an impairment substantially limits a major life activity shall be made without regard to the ameliorative effects of mitigating measures, such as medication or hearing aids.

Neurobehavioral disorders, such as ADHD, can be very easily defined as a disability; the ADAAA defines disability as a physical or mental impairment that substantially limits one or more major life activities of such individual, with a major life activity including, but not limited to: caring for oneself, performing manual tasks, seeing, hearing, eating, sleeping, walking, standing, lifting, bending, speaking, breathing, learning, reading, concentrating, thinking, communicating, and working. In addition, the definition includes major bodily functions, including but not limited to: functions of the immune system, normal cell growth, digestive, bowel, bladder, neurological, brain, respiratory, circulatory, endocrine, and reproductive functions.

As long as you have an active diagnosis of ADHD, regardless of the type, it by very definition and diagnosing criteria, would be a disability.

/walloftext

Kuri
Jun 26, 2009
No worries; like I said, the article used to be correct, but the ADAAA fixed the issues that resulted from a narrow interpretation by SCOTUS on a few cases.

It helps that part of my normal job involves the laws, regulations, policies, and other relevant guidance on civil rights; a large number of the people in my field don't keep up to date, and if the people being paid to do it don't know, I wouldn't expect many laypersons to know either.

Kuri
Jun 26, 2009
There's a reason why I didn't go into too far about accommodations. :D They are simple on the surface, but can be a large goat rope when the sum total of the differing viewpoints start coming together. The Rehabilitation Act (Federal employment or Federally-funded activities) and the ADAAA both require accommodations when needed by the employee/applicant/student/random bike jockey; the main issues arise when determining what accommodation best suits both the receiver and the organization.

There isn't a requirement in law for a medical professional to rule as to the efficacy of a given accommodation; although they can be consulted if there are differing opinions as to the best action out of a given set of accommodations, the absolute requirement. Especially in light of the ADAAA, accommodations are provided unless there is a demonstrable undue hardship by the organization (yes, educational accomodations typically fall under Sec. 504 of the Rehab Act, but the guiding principles of the ADAAA are applied). In the case of a student, they simply have to prove they have a bona fide disability (the various Disability Student Services organizations within universities to ease the administrative load of each professor having to confirm medical issues).


Agedashi Tofu posted:

Anyone have inconsistent results with XR meds and better luck with IR?
...
I'm wondering if I should talk to the doctor about having more frequent IR doses or a higher XR dose? I like XR because when it works the effects come and go gradually, but I would prefer consistent results.

My Adderall XR seems largely affected by my food intake; originally, I started off at 20mg XR, and after trying a lot of dosing schedules, have come to settle on 10mg XR three times a day. Although expensive as hell, I can control the timing very well with practice. If I have a dose that doesn't seem to hit like it should, I still have two more doses that are available.

I've considered switching to Vyvanse, but this method (and drug) works, and my doctor is perfectly fine with letting me set my dosing schedule since my days are filled with work, school, volunteering as a medic, etc. Plus, since the 30mg is essentially six 5mg doses, I don't have to pick up 180 pills for the month (since even 90 comes in a big rear end bottle).

Anyone have experiences switching from Adderall to Vyvanse?

Kuri
Jun 26, 2009

Kylra posted:

In my research for the new op, I ran across a newish non-stimulant medication for ADHD besides Strattera, Intuniv. I don't know much about it though because it's pretty new as far as having an indication for ADHD and I'm not exactly a doctor whose job relies on keeping up with this (though in my experience with doctors it would surprise me none if they did not know about it). It may help you out if you don't respond well to stimulants or can't tolerate the side effects.

I talked about being on Intuniv a few dozen...dozen...posts back. Guanfacine and clonidine are both alpha-2-adrenergic agonists, and are thought to help with the impulsiveness and hyperactivity through both otherwise unknown action on the brain and due to the fact that THEY MAKE YOU A TIRED MOTHERFUCKER.

I take Intuniv and Adderall XR, and typically take the weekends off from the Adderall. The Intuniv does indeed help avert the "Oooh, shiny!" syndrome (along with general organization), but I usually take a nap on both Saturdays and Sundays from the decreased heart rate and blood pressure. I definitely would not be able to take it if I wasn't on the Adderall; I'd go from spastic monkey on a bike to a narcoleptic slug.

As for Wellbutrin/buproprion, it has a similar range of effects to how some of the stimulant medications are thought to most benefit for people with ADHD (norepinephrine/dopamine receptors), but what is also interesting is the effects on the nicotinic receptors. One or two of Big Pharma are working on nicotinic-receptor specific ADHD medications (without the side effects of regular nicotine). Off label, but not uncommon.

Kuri
Jun 26, 2009

Hamburglar posted:

Oh dear God the Strattera literally stopped working over night. I'm at the max dose so I guess I can count it out, now. All the old symptoms are back, minus the depression. I futz around in bed, I can't sleep, I'm fidgety as gently caress, I can't concentrate.

Hoping to hell Intuniv works for me. Thank God it's the weekend.

Edit: Welp, Intuniv is only for people under 17, there goes that idea :negative:

I'm almost 30 and I take Intuniv. My doctor prescribed it and my insurance hasn't balked yet. Tenex, instant release guanfacine, can be taken twice a day in lieu of the much more expensive Intuniv.

Clonidine works, but not as directly, and is typically for hypertension like guanfacine (Intuniv).

By the way, the alpha-2-adrenergic agonists (clonidine, guanfacine) take approximately 3-4 weeks to reach full efficacy. The immediate effects people report come from the fact that you will be tired on either drug...I slept 14 hours a day until my body adjusted due to sheer exhaustion.

Kuri
Jun 26, 2009

Hamburglar posted:

Thanks for this info. I was going to try Intuniv, but their website said for ages 6-17, and they won't even send me a free sample. I am aware it will take a few weeks to work, but that's what I actually want. Strattera was that way, too. Is there any benefit to taking Intuniv instead of Tenex ?

My doctor actually hooked me up with the initial month (since you titrate the dose up from 1mg/day to 4mg/day).

Intuniv is simply extended release guanfacine, whereas Tenex is instant release. With Intuniv, you take one pill a day (DEAR GOD TAKE IT IN THE MORNING) while you would take two with Tenex.

Obviously, the less pills you have to remember to take with a disorder that affects your ability to remember to take the pills in the first place can be helpful. That said, generic guanfacine (instant release) is substantially cheaper...it all depends on if taking one less pill is worth the extra cash for you.

Now, Intuniv helps with my impulsiveness and my organization, but absolutely nothing for my actual inattention or physical movements (foot-tapping, exagerated response to stupidity, etc). Strange, but there it is.

Kuri
Jun 26, 2009
Intuniv and Kapvay (extended release guanfacine and clonidine) do indeed cause somnolence...about 14-18 hours after you take it (more guanfacine than clonidine, as I believe clonidine hits a little faster due to the more generalized method of action).

When I started Intuniv (alongside my Adderall), I thought, "Hey! This will make me tired, so I'll take it with my vitamins right before bed." Two things wrong with that: one, as I said, Intuniv doesn't cause somnolence until much later than you'd expect; and two, guanfacine's absorption is increased when there is a high-fat environment. I had to look up the results from the FDA testing, and other first-hand reports from people taking guanfacine to isolate the timing issues.

Since I take my vitamins, including fish oil, right before bed and I don't eat anything after five or so, I was getting hit with wicked sleepiness mid-afternoon. It was horrendous.

Even though you'd think a few fish oil capsules wouldn't make a noticeable difference, that was the first thing I moved around. Although the drowsiness subsided a little, moving my dose to first thing in the morning made a tremendous difference. The peak effects (even with the titrated dosage after three months now) hit mid-morning and last until late evening.

One other mild benefit to guanfacine or clonidine? Your heart rate and blood pressure are much less affected by stimulants, so some of the more annoying side-effects aren't as bad for some people. Granted, this could also indicate that you are partially cancelling out the stimulants, but the combo has worked for me.

Kuri
Jun 26, 2009

Tab8715 posted:

If you don't abuse the drug, this won't happen.

Yeah, that's utter bullshit. I often take less than I am prescribed and I still get the end-of-the-day crashes, even with extended-release formulations.

Kuri
Jun 26, 2009

2508084 posted:

Really? I get a tad grumpy for an hour, but I wouldn't call anything that happens a 'crash.' Most people are referring to something akin to a three day meth bender type crash in my experience

A lot depends on sleep, food intake (lack thereof!), and a few other factors. Taking three 10mg XR throughout the day helps because of a relative build-up and drop, but with a single larger dose pill (20mg XR) and end of the day dinner/exercise, I would go from "normal" to "Oh, GOD I'M DONE!". My wife would giggle when I would go from cleaning dutifully to dozing in my dinner chair. It could be very sudden on normal, therapeutic doses.

The crash is relative. It will still rear its ugly head for me every so often, even 18 months into taking Adderall.

Actually, now that I think about it, the Intuniv has helped as well since it limits some of the peripheral effects of the Adderall.

All that said, people who abuse amphetamines certainly have the crash, but part of that comes from the body not being accustomed to the introduced stimulation. My continued crashes stem from my drug holidays (weekends) and the factors mentioned above.

Sorry, my earlier response was a bit more stern than I meant it to be. :D

Kuri
Jun 26, 2009

TheBigBad posted:

I had this anxiety as well. I actually was kicking myself for trying too hard on some of the tests that were determining. Just dont worry too much about it, and what will be will be. Let us know.

If it helps, the anxiety is normal. My BP and HR went down once I was diagnosed and started medication. Like TheBigBad said, what happens happens, and no amount of worrying will change it now.


Fake Edit: Double-post!

Kuri
Jun 26, 2009

Qu Appelle posted:

Yeah, welp. That didn't work. I've been wheezing all day. (This is 'annoyance' wheezing where I've been taking my inhaler, not OMG Call 911 wheezing. Just wanted to make that clear.)

This is nice. I enjoy spending money on a drug that I can only take 1 dose of. I think realistically, Dexedrine is going to be the one I go back to. The only bad side effect I get from that is the heartburn, and I already take Omeprazole for that on a daily basis in the am. If I take breaks on the weekends and possibly a week off here and there, I might be able to make it work.

At least the diagnosis of ADHD is still accurate; we checked for that at my appointment last week.

Edit, now that more time has passed. Aside from the asthma, this drug worked like a charm. So next I may try something like Concerta. I tried that drug many years ago, and the only side effect I had was bad spasticity, because I was also on Wellbutrin. I'm no longer on that drug, and my general spasticity levels have been way down lately.

I'm on my phone, so pardon the massive quote: your concurrent use of omeprazole and an amphetamine might be one of the sources of your issues with stimulants. The Prilosec raises gastric pH, increasing absorption of the amphetamine, causing a feedback loop further exacerbating any effects you feel, good or ill.

Have you discussed the secondary effects of this with your GP?

Kuri
Jun 26, 2009

Qu Appelle posted:

Haven't discussed it with the GP, but I asked my Psychiatrist about it, and he said that it was safe. I can ask my Gastroenterologist about it. My GERD is chronic, whenever I try to go off the Omeprazole, it comes back with a vengeance. And I'm also treating my GERD by avoiding spicy foods, sleeping on a wedge pillow. Etc.

But I'd love to hear about this connection. Because this could be the thing screwing everything up, and I might be able to switch to another GERD medication. Is it specifically Omeprazole, or all GERD drugs?

It all goes with how amphetamines are absorbed in the GI tract - higher pH environments lead to increased absorption. Given your history with sensitivity to low dosages, this might be a contributing factor. I'd definitely speak to your prescribing physician again about it.

On a separate note, I've had to drop my Intuniv dose from 4 mg to 2 mg. My heart rate (resting) was in the high 40s and my BP was, after a particularly fun syncopal episode involving a flight of stairs, 87/49. It definitely helps with organization, but it still has a heavy side-effect profile for me. I tried two weeks without it, but the absence only underscored how useful it can be for my ADHD.

Kuri
Jun 26, 2009
Yay for the loving Adderall shortage. I haven't been able to fill my scripts since...late December.

Plus, my new insurance inexplicably doesn't automatically cover any of the amphetamine-based drugs. They cover methylphenidate, but not my staple. I'm appealing this bizarre policy now, but between the shortage and this, I'm going to my doctor today to switch to Ritalin. The plus side is that I'll be able to get the drat drug through the mail-order option, so at least it is something (assuming it works).

Has anyone had a positive experience with Wellbutrin (buproprion) helping their ADHD? I know a second-order metabolite is an amphetamine product, but I've heard good things about it (plus it helps combat the dreaded Ritalin/Adderall-dick that can occur).

Kuri
Jun 26, 2009
One week into the Ritalin Replacement Retinue™...and I am less than impressed. When I saw my GP, he was very annoyed with my insurance company and is having his office manager call/email/send severed horse heads to expedite my amphetamine coverage appeal.

In the mean time, between the shortage of Adderall on the East Coast and the insurance annoyance, we've switched my medication over to Ritalin for the time being. I was on Adderall XR 10mg and IR 5mg BID (each) for a total of 30 mg throughout the day. I was able to time the dosing with work/school/etc and things just worked. Adderall did two things: first, it quieted the mental static; and second, it helped get me motivated to actually accomplish something. Between the two, I was able to properly identify the important items and actually get them done instead of kvetching over something for weeks.

With the Ritalin, instead of getting a properly tuned radio station, my thought pattern feels more like a wet blanket has been tossed on top and just blunts everything. Further, the crash at the end of the dose is much more pronounced. We started with 36mg Concerta (once a day) and 10mg IR Ritalin (b.i.d), with the idea of titrating up to find the best dose. In line with studies and anecdata from others, 72mg looks to be the minimum daily dose of methylphenidate I'll need to get something even close to resembling a positive effect.

Even though the Ritalin doesn't seem to be as helpful, it is still 10x better than nothing. Once funny thing, I always have the paradoxical somnolence with Adderall (especially on the first dose of the day), but Ritalin downright puts me into narcolepsy for the first hour of the dose.

TL;DR - Insurance capriciousness and drug shortage sucks.

Kuri
Jun 26, 2009
That's part of it - some doctors will look for the paradoxical reaction (whether it is from reduced stress or from the way the drugs affect those with ADHD) to determine if a patient truly has ADHD or if it is something else. Most "normal" people, when given amphetamines, will have the expected stimulation since the drugs are bloody amphetamines. Normally, drugs effect me exactly as they're supposed to - amphetamines and methylphenidate (to an extent) have the paradoxical reaction.

When I first started medication, I had to avoid driving within 30 minutes of the onset of the medication - I would have serious trouble staying awake for about a 15-30 minute time frame. It has gotten better, but I still have the somnolence after two years.

Kuri
Jun 26, 2009
That's as good an explanation as I've heard. Both methylphenidate and amphetamines block dopamine reuptake, thereby increasing available levels (which is one of the theorized reasons why the drugs work on ADHD, but who knows!).

It's strange that Ritalin, et al, produce more somnolence for me than Adderall since the amphetamines also work to increase dopamine efflux from the cells into the synaptic space, whereas Ritalin only has the former effect. This could be due to the additional stimulation coming from the levo-amphetamine in Adderall, but that's only a guess.

Kuri
Jun 26, 2009
OmNom, I replied to your PM about Intuniv.

Having been on Adderall for two years and Ritalin for the last month due to shortages (and sorting out the new insurance), I can say that the amphetamines work better for me and my ADHD. I have combined type, and the adderall alone answers most of it in one fell swoop.

When I describe my ADHD to people, I use the analogy of radio or television static; essentially, there is just a constant noise and instead of listening to one station, I pick up the fragments of five or six, and so my attention naturally jumps around on a whim.

While the Ritalin (instant release and time release as Concerta) helps with quieting the static, it feels like a mental wet blanket, or as if the radio was just turned down a bit. The static is quieter, but still there. With Adderall, the station gets tuned in and just works better.

Both work, the adderall just works better...for me.

My doctor uses methylphenidate in kids, but favors the mixed amphetamine salts in adults. He feels that he gets better responses and, anecdotally, I agree. OmNom, your psych sounds like a good one because he's willing to work with you. Just be willing to try a few medications before you find something that works best. However, if the Focalin works - awesome.

No drug is a miracle cure, but my god is life better.

Kuri
Jun 26, 2009
Yep. Dexedrine is less physically taxing, but much shorter lived. That's why Adderall has the mixture of enantiomers - the levo-amphetamine lasts longer than the dextro-amphetamine, but it has more of a physical/peripheral nervous system response.

I think that's one of the big side effects that helped my fidgeting more than anything. I'd mentally and physically get honed in on getting things done instead of having to hop up and move around all the time.

Ritalin! :argh:

Kuri
Jun 26, 2009
I typically take drug holidays over the weekends, but my wife will often say, "You're not medicated today, are you? Maybe you need to take a small dose..."

Kuri
Jun 26, 2009
Magnesium supplements are supposed to help as well (assuming you don't have issues that prevent this). I could tell a marked difference after I started with a decent additional dose along with my multivitamin and fish oil regimen and I didn't have to increase my dose of Adderall for the nearly two years that I took it, YMMV.

On a related note, I'm still working on my insurance and their odd non-coverage of any amphetamines, but I talked to my doctor and we've bumped the dose of methylphenidate to about 74 mg/day (54mg Concerta and 10mg IR b.i.d). I was on 30-35 mg Adderall, so this goes along with the few studies I've seen showing a 1:2 ratio in terms of efficacy.

Also, we added buproprion (Wellbutrin/Zyban) to the mix. Although I don't like taking three separate medications (methylphenidate, guanfacine, and now buproprion), they all seem to target different aspects of my ADHD and life is just getting better. The buproprion kicked in quickly and helps tremendously with the evening crash/morning fog; also, my wife even said I seem more agile whereas I tended to be insular before. To top it off, I don't get seem to be as quick to get annoyed when interrupted or delayed by others (driving, writing, etc.).

We'll see how things are in a few more weeks, but...huzzah so far.

Fake edit: I've heard that DXM does help with maintaining sensitivity. If I began to develop tolerance, I'd certainly try it as well.

Kuri fucked around with this message at 19:54 on Mar 6, 2012

Kuri
Jun 26, 2009

porcellus posted:

The above two posts are the first time I've heard of dxm and tolerance. Is there a link to a somewhat credible source baacking this and where did this idea originate? I'd like to hear more about peoples dosages/ how long they've been on it and frequency of drug breaks to cut the tolerance. For me its 70 mg, two months, one med break per week so far and its not enough.

DXM is the only OTC NMDA antagonist, and has been shown to block tolerance of amphetamines.

Development of both conditioning and sensitization of the behavioral activating effects of amphetamine is blocked by the non-competitive NMDA receptor antagonist

Coadministration of MK-801 with amphetamine, cocaine or morphine prevents rather than transiently masks the development of behavioral sensitization


Search Google Scholar for NMDA antagonist and amphetamine. It's there.

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Kuri
Jun 26, 2009
...and, scene!

My insurance "agreed with" my stance that they were annoying douche-nozzles and rescinded their blanket ban of amphetamines. No more Ritalin! While it worked, it really came to be my safety date of ADHD medications.

It only took the better part of three months to complete, but hey; all's fair in healthcare and odd bureaucracy.

On another note - the Wellbutrin has been working better than expected. It helps to significantly reduce the crash at the end if the day, and it helps on the weekends when I take the standard drug holiday. While I wasn't depressed before, it has helped me as an adjunct to the primary medication. I'll be curious to see how it works with adderall.

blueblaze posted:

I've been getting incredibly tired after a week of using adderall, like during weekends. Does anyone else experience this? Im worried that this could mean adderall is pushing my body to work twice as hard and ends up exhausting me physically. I don't get this tired on just Dexedrine or vyvanse!

Are you taking the drugs all week, or is the fatigue on a day when you don't take the medication? Adderall does have a secondary peripheral nervous system stimulation that could be at least partially to blame. I know when I take it, I'll have some slight muscle tension along my neck and shoulders that definitely gets sore, especially in conjunction with exercise.

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