Silver Alicorn posted:

I've noticed a megadose of st johns wort gives me a mild hallucinogenic effect

echinopsis posted:

idk how easy they are to get these days but some of the 2c drugs emulated some of the trippier superficial parts of psychedelics without the total mind gently caress

would have been fun to gently caress around with

SpaceClown posted:

i had the worst experience of my life on nbomb which is a 2ci analogue. would not recommend.

just take a sufficiently low enough dose of lsd and you'll be fine. 50ug gets you cool stuff like the flashing lights and tracers but not be so overbearing that you start thinking undecipherable garbage.

SmokaDustbowl posted:

I like to do drugs responsibly, and you shouldn't do drugs to increase your productivity because that is a fake idea

SpaceClown posted:

you're a goddamned moron for unironically recommending research chemicals tbqh

Cybernetic Vermin posted:

the thing is, i don't mind the drugs so much, but this thing about productivity sounds like downright disturbing bourgeois poo poo

spankmeister posted:

Alcohol is a pretty hard drug when you think about it, it's just that it's so easy to make (it just happens by itself p much) and we've been using it for thousands of years.

I think heroin itself might even be a lot healthier for you, considering the side effects. Alcohol really does a number on your health if you use it too much. Heroin is mostly dangerous because of tolerance (OD's) and secondary risks such as bloodborne diseases when mainlining (dirty needles), infections, purity of product due to it being illegally sourced and socioeconomic issues from it being expensive and addictive (might make you put yourself at risk when wanting to score).

Cat Face Joe posted:

poasting to congratulate tumor looking batty on an extremely successful honeypot

SpaceClown posted:

nah. booze has nothing on the way heroin systematically fries your CNS. heroin destroys your kidneys, too. and yes, just as severely as booze destroys your liver. opiates aren't something to gently caress around with.

WrenP-Complete posted:

there's a relationship in longitudinal data between bone loss and long term opiate use. it's not clear that what if any the mechanism of causation would be, other than bone problems causing pain which leads to long term opiate use. maybe calcium issues?

H.P. Hovercraft posted:

lol maybe that's why junkies are so whiny instead of just that whole "no coping mechanisms except heroin" thing

SpaceClown posted:

except i did and it doesnt change that there is 100% a link to it, but cause you're a big fat idiot like that manchild with the childrens cartoon av you don't understand the difference between inconclusive and more study being needed.

there's a similar asterisk in the neurology report too, but your dumbass was too eager to try and claim "OH NO MY PRECIOUS OPIATES ARE COMPLETELY SAFE AND CAUSE NO ADVERSE PHYSIOLOGICAL AFFECTS"

you're right, heroin won't give you necrosis like krokodil but you're an idiot if you seriously think that "hmm well it could be these factors and so long as there's a chance i won't stand for people slandering heroin's good name!"

Stymie posted:

alcohol is a scourge and the shame of a nation

pr0zac posted:

ended up wasting 45 minutes reading about smoking heroin cause of this just being a 17 year old case study about a single individual and wondering more about the underlying issue

seems like it is probably not caused by heroin but a contaminant or maybe something created very rarely when heating it, researchers still aren't sure, but: "The primary hypothesis is that leukoencephalopathy is caused by a contaminant in the heroin or a combustion by-product"

also weirdly despite smoking heroin first starting in se asia the brain damage thing is apparently super super rare there with the first known case being in 2015 but even that having unusual differences compared to the normal manifestation

kind of an interesting unsolved mystery

Smythe posted:

echinopsis posted:

this is the only good thing you posted

echinopsis posted:

alcohol is what's known as a dirty drug, much like tricyclics although in more of a brute force rather than highly flexible sense

it binds to opioid receptors which contribute to its good feelings and drive for people to drink more. give people opioid blocking drugs and people stop drinking early in the evening and don't automatically professed to getting trashed. it's quite possible that there is a significant aspect where it's acting as a solvent and destabilising cell membranes .. holy poo poo

also one of the least potent drugs we all know is paracetamol/apap and the max dose is like 4g in a day but even a single standard drink is 10g of ethanol so a dozen beers is 120g of drug. it's an absolute miracle your liver can deal with it at all. the liver enzymes are acting under total saturation hence why alcohol is metabolised in a linear sense and not a half life sense like everything else

i also highly suspect that eating food especially fatty food will put ah extra huge load in the liver which can make hangovers worse i suspect

alcohol metabolism also inhibits gluconwogeneis which is wheee te liver makes glucose for the body and this is the primary risk for babies who drink, they can go hypoglycaemic and die

fructose also has a similar effect on the liver but no where near as bad. both can contribute to fatty liver

tips for drinking healthily

when you're not drinking (during the day) eat highly nutritious high fivre foods like bean salads and other cool things.. then we drink for evening stop eating and only drink. if you're not drinking beer add water. don't eat

get up after night and have a coffee.. and maybe pain relief

alcohol ties up enzymes that primarily metabolise paracetamol/apap and shunts apap metabolism down a path which produces a hepatotoxic metabolite which is why you're not meant to take any while drinking.




it's absorbed through the stomach lining so can get yo/ drunk like 7 minutes ??

pr0zac posted:

thats interesting cause i get no pleasurable effects from opiates but i really really like alcohol to the point where i generally avoid it now

brains are weird man

Improbable Lobster posted:

i am already regretting not bringing my weed to mississauga

spankmeister posted:

Hmm idk I usually feel better the next morning if I eat a fatty food after drinking. Usually some kebab or gyros or summat. Also breakfast with some eggs & bacon helps.

My goto hangover drink is ayran, which is a turkish yoghurt drink it contains water, salt, proteins and fat. So rverything you need. It's also delicious.

Smythe posted:

how bout u take a macrodose of GBS, BITCH!!!!!!!!!!!!!