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Platystemon
Feb 13, 2012

BREADS

facialimpediment posted:

NYPD Union: 10,000 cops aren't going to go with your tyrannical vaccine mandate!

NYPD head: lol it was 34 because the other few thousand are being processed for exemptions like usual

34 ÷ 10000 = 0.0034

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Platystemon
Feb 13, 2012

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McNally posted:

Eh, just respond with video of Trump falling asleep during a state dinner with Queen Elizabeth.

Or you could go the “throat GOAT” route.

Try to get them arguing that Trump slept more presidentially.

Platystemon
Feb 13, 2012

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Immanentized posted:

The reporting reads as though there isn't much evidence or thread to the idea that the boyfriend "sold" the daughter. There's a statutory situation for sure based on the reported ages, but the trafficking bit seems wholly manufactured by Q-brain.

What’s the age of the girl?

It’s not in the WaPo article.

Platystemon fucked around with this message at 04:43 on Nov 3, 2021

Platystemon
Feb 13, 2012

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What is that alternative treatment? I’m glad you asked.

https://twitter.com/betsey3000/status/1455937726239305733

Platystemon
Feb 13, 2012

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Arven posted:

At least we won't go back to the days of hookworm being endemic in the south if they're all already taking ivermectin.

The U.S. never truly eliminated it.

It just got pushed out of sight and out of mind, to poor black communities.

Platystemon
Feb 13, 2012

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Platystemon
Feb 13, 2012

BREADS

CRUSTY MINGE posted:

Youngkin's underage son tried to vote twice for his daddy.

Maybe he tried to vote for the other guy.

Could you blame him?

Platystemon
Feb 13, 2012

BREADS

Best Friends posted:

I am not really following the rules or standards. Am I, a healthy guy who does not work with the public, allowed to get the booster? Is it still restricted to people with special needs or risk factors, or is that by state?

Nearly every American adult qualifies under one criterion or another, because criteria include:

Being overweight (body mass index over twenty‐five, qualifying seventy‐three percent of Americans)

Have anything to do with children or the elderly

Live in a place with high rates of community transmission and/or low vaccine prevalence (that’s most counties in the U.S.)

Would experience “inability to work or meet other personal obligations when infected, even if not severely ill with COVID-19”


So if you live on a trust fund with no obligations to anyone, you may potentially not qualify, but realistically, it’s everyone.

If you truly have no personal obligations, PM me and I’ll send you a houseplant so you have something to live for.

Platystemon fucked around with this message at 04:15 on Nov 7, 2021

Platystemon
Feb 13, 2012

BREADS
While we’re on the subject of boosters, this week we got a study of VA patients that sheds some light on how the vaccines are holding up.



quote:

For the period February 1, 2021 to October 1, 2021, vaccine effectiveness against infection (VE-I) declined over time (P < 0.01 for time dependence, Table 1), even after adjusting for age, sex, and comorbidity. VE-I declined for all vaccine types (Fig. 1), with the largest declines for Janssen followed by Pfizer-BioNTech and Moderna. Specifically, in March, VE-I was 86.4% (95% CI: 85.2% to 87.6%) for Janssen; 89.2% (95% CI: 88.8% to 89.6%) for Moderna; and 86.9% (95% CI: 86.5% to 87.3%) for Pfizer-BioNTech. By September, VE-I had declined to 13.1% (95% CI: 9.2% to 16.8%) for Janssen; 58.0% (95% CI: 56.9% to 59.1%) for Moderna; and 43.3% (95% CI: 41.9% to 44.6%) for Pfizer-BioNTech.

Folks, if you got J&J’s shot, you really want to get a Pfizer or Moderna booster without delay.

I should have mentioned this in my last post, but CDC says that anyone who got J&J’s shot at least two months ago should get a booster, not just consider it based on the totality of circumstances, but go and get it, period, irrespective of anything else.

The decline in J&J’s efficacy against infection (and to a lesser degree the others) holds up across all age groups. It’s not just the elderly that are getting breakthroughs.



Someone in D&D misunderstood this one, so to be clear, the sharp bend that all the curves take toward the end of July is Delta running roughshod over the U.S.. Breakthroughs are related to changes in the spacing between the vaccinated and unvaccinated curves, not directly to the height of the curve.

As for the consequences of breakthroughs, in the words of the study’s authors,

quote:

Risk of death after SARS-CoV-2 infection was highest in unvaccinated Veterans regardless of age and comorbidity (Fig. 3). However, breakthrough infections were not benign, as shown by the higher risk of death in fully vaccinated Veterans who became infected compared to vaccinated Veterans who remained infection-free.

Platystemon fucked around with this message at 04:21 on Nov 7, 2021

Platystemon
Feb 13, 2012

BREADS
https://twitter.com/ShamsCharania/status/1457410772666044417

Platystemon
Feb 13, 2012

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stackofflapjacks posted:

Sorry, in case I want to take a trip down memory lane, what movie is this?

Independence Day

e: Or is the joke that it can’t possibly be that because it’s not everything you could hope for and the effects do not hold up?

Platystemon
Feb 13, 2012

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Did he have any legal issues that would compel him to relinquish control of firearms?

I wouldn’t put it past him to fake a theft to “pull a fast one” on the law.

Platystemon
Feb 13, 2012

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Bored As gently caress posted:

No, there are actual use of force experts. It's just that a lot of people claim to be one when they're absolutely not.

The Active Self Protection guy is one. His videos should be watched by anyone who carries a firearm or wants to know self defense principles.

That guy said some very questionable things about “antifa” in 2020.

Platystemon
Feb 13, 2012

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MazelTovCocktail posted:

I also read about people paying docs in Greece to get water injections and fake vax cards, but a bunch of doctors don't want to piss off the Government...so they just gave them the regular covid shots. lol

quote:

Similarly, when a certain merchant had sold glass gems as real to his wife, and she (after discovering the trick) wanted him to be punished, Gallienus ordered that the merchant be seized and thrown to the lions. Then, a chicken was sent up from the amphitheater’s holding cage. When everyone was marveling at such an absurd sight, Gallienus ordered the herald to declare, ‘He has committed an imposture, and suffered one in turn.'

The source of the above is Historia Augusta, which means that it didn’t happen, but it’s a good story.

Platystemon
Feb 13, 2012

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Milo and POTUS posted:

Albertans are trash garbage people. At least Texans have the excuse of being from texas

Alberta keeps their territory free of rats.

Texas elects Canadian rats to represent them in Washington.

Platystemon
Feb 13, 2012

BREADS

Xenoborg posted:

Haven't really been paying attention to Covid news, are the boosters still recommended for 8 months after first dose, or just free for all now?

Six months for Pfizer and Moderna recipients, two months for J&J.

J&J recipients have no further requirements. All adults who got J&J’s shot at least two months ago should (CDC’s bold) go and get a booster.

Colorado, New Mexico, and California have explicitly opened boosters to all adults who got Pfizer/Moderna second doses at least six months ago.

In other states, you’re supposed to weigh your own risk factors. Being overweight is one of them, and that’s three quarters of American adults.

Basically, boosters are appropriate for very nearly everyone, it’s just not put into so few words. If you’re six months out from your second shot and at least eighteen years of age, go and get one. Those are the only hard criteria. You will self-attest on a form at the pharmacy, “yes, a booster is appropriate for my physical and living conditions” and that’s it. You don’t have to bring pay stubs or a doctor’s note or anything like that.

Platystemon
Feb 13, 2012

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Buttigieg has the “High Hopes” crew, but does anyone like Harris?

Platystemon
Feb 13, 2012

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PeterCat posted:

How did the Republicans shaft the blue states with the 2017 bill? The SALT deduction doesn't lower the person's tax liability to the state, it lowers their tax liability to the Federal Government.

The federal government is a vast income redistribution scheme, taking from the blue and giving to the red.

Cutting SALT takes more from the blue.

Platystemon
Feb 13, 2012

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Platystemon
Feb 13, 2012

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MazelTovCocktail posted:

This is not good.

U.S. Warns Allies of Possible Russian Incursion as Troops Amass Near Ukraine

Western intelligence officials are increasingly convinced that the Russian president wants to take control of a larger swath of territory.


https://www.nytimes.com/2021/11/19/us/politics/russia-ukraine-biden-administration.html?referringSource=articleShare

We need to get the writer of this 1997 WIRED graphic on the line to tell us what’s happening next.

Platystemon
Feb 13, 2012

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This is the article it’s from and this is the good timeline:

Platystemon
Feb 13, 2012

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The Eyes Have It posted:

The widespread cancer one's box to check is "it would overwhelm the health system" and we kinda get two for one on that one since COVID did that too.

(And since it was 1997 I think widespread cancer was probably really "what if it turns out that cell phones and power lines ACTUALLY DO cause cancer?")

I don’t think it’s fair to include the present pandemic as counting for the cancer scenario, in spirit, because there’s already a specifically enumerated pandemic on the list.

It’s a nice touch of them to suggest it’s “a modern‐day influenza epidemic or its equivalent”. Influenza was by far the favorite for respiratory viruses with pandemic potential. Coronaviruses were a complete backwater till SARS came along in 2003.

If the author had a specific threat in mind, besides influenza, it was probably paramyxoviruses like Nipah virus.

Platystemon
Feb 13, 2012

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SMEGMA_MAIL posted:

Definitely a terror attack of some kind

Maybe it’s like that Las Vegas guy whose motive was that he likes killing people.

Platystemon
Feb 13, 2012

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facialimpediment posted:

What really gets me is this CDC study on two doses + placebo versus two doses + booster that I linked a few days ago:

https://twitter.com/EricTopol/status/1461786768131465219

The ~90% efficacy of the two doses keeps you out of the hospital, then the protection wanes. Then *on top of that*, the booster has a 95% efficacy *compared to* two doses. In a study of ~9400, 123 two-dosers caught covid and of the equivalent booster population, the grand total of covid cases was... 6.

And this is all happening in a Delta environment! This poo poo is feat-of-humankind level numbers. And there are still people going WAAAAH I DON'T WANT TO GET A BOOSTER AND BE SICK A DAY

The booster is so loving good.

I hate the continuing pandemic, but it could have been so much worse.

Platystemon
Feb 13, 2012

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Cugel the Clever posted:

Got nothing more than a sore arm from either Modena shot. Getting booster this Saturday, hopefully will be the same.

Though I've heard low reaction potentially indicates lower effectiveness?

Almost half of the population gets no systemic side effects, yet the vaccine is way more effective than fifty percent.

Don’t sweat it.

Platystemon
Feb 13, 2012

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piL posted:

What's a DV charge?

Domestic violence

Platystemon
Feb 13, 2012

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Electric bikes are dope.

Pedalling on flat ground is one thing, but when hills are involved, the assistance is to die for.

Platystemon
Feb 13, 2012

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There’s an interesting variant of SARS-CoV-2 showing up in southern Africa, christened B.1.1.529. Specifically, it was sequenced in Botswana and South Africa, plus found in a visitor upon his return to his home in Hong Kong.

https://twitter.com/janemerrick23/status/1463493119257763845

There’s not much to go on for characteristics in the wild so far, but it’s something to keep an eye on because its suite of spike mutations looks like a Swiss Army knife.

Platystemon
Feb 13, 2012

BREADS
The B.1.1.529 situation is unfolding rapidly, in part because a quirk of the variant’s genetics and PCR testing allow South African health authorities to reanalyze recent test data and find many more cases.

https://twitter.com/miamalan/status/1463846528578109444

Platystemon
Feb 13, 2012

BREADS
This thread knew about the new variant before Biden did.

This is an improvement over 2019-nCoV itself, where WHO announced pneumonia of unknown origin in Wuhan on New Year’s Eve and the thread noticed it on January fourth.

Platystemon
Feb 13, 2012

BREADS
The branch length of this thing is just out of this world.



https://twitter.com/jcbarret/status/1463975711153262594

Platystemon
Feb 13, 2012

BREADS

pantslesswithwolves posted:

So for those of you scienticians who know how to speak Science- what does this functionally mean? Is it just the sheer number of mutations that’s bad or are people starting to figure out what their impact could be ahead of any formal findings by CDC or WHO?

It’s where the mutations are and what they do to the three‐dimensional structure of the spike, and to the charges at these positions. Some of the changes are relatively well‐studied because they’d been seen or theorized in the past. Some of them are new and exciting innovations.

Computer modelling shows it’s going to hurt the binding potential of many commercial antibodies.

What’s somewhat up in the air is what this means for the polyclonal antibodies generated by the vaccines, but it’s not good. It’s varying degrees of bad. Maybe it’s a modest efficacy drop for the average person e.g. comparable to that seen by six‐months‐stale vaccines. Maybe it’s bigger.

https://twitter.com/jbloom_lab/status/1464005676842184705

This thread by Trevor Bedford is also good.

https://twitter.com/trvrb/status/1464353224417325066

Platystemon fucked around with this message at 06:01 on Nov 27, 2021

Platystemon
Feb 13, 2012

BREADS
Take the figure itself with a grain of salt because it’s an extrapolation based on limited data and limited understanding of the underlying mechanisms, but Yaneer Bar-Yam is not a fool.

https://twitter.com/yaneerbaryam/status/1464267983166058500

South Africa says they’re not seeing horrific death rates yet (or rather, horrifically above background), but there’s a lot of uncertainty.

Even meeting it the projection in the middle would be just awful.

Platystemon
Feb 13, 2012

BREADS
Moderna has announced plans.

quote:

The recently described Omicron variant includes mutations seen in the Delta variant that are believed to increase transmissibility and mutations seen in the Beta and Delta variants that are believed to promote immune escape. The combination of mutations represents a significant potential risk to accelerate the waning of natural and vaccine-induced immunity. A booster dose of an authorized vaccine represents the only currently available strategy for boosting waning immunity. The Moderna COVID-19 vaccine (mRNA-1273) is authorized as a booster for many populations at the 50 µg dose level. The Company is working rapidly to test the ability of the current vaccine dose to neutralize the Omicron variant and data is expected in the coming weeks.

Since early 2021, Moderna has advanced a comprehensive strategy to anticipate new variants of concern. This strategy includes three levels of response should the currently authorized 50 µg booster dose of mRNA-1273 prove insufficient to boost waning immunity against the Omicron variant.

First, Moderna has already tested a higher dose booster of mRNA-1273 (100 µg) in healthy adults. Moderna has completed dosing of 306 participants in a safety and immunogenicity study of this high dose (100 µg) booster. The 100 µg dose of mRNA-1273 has also recently been studied by the National Institutes of Health (NIH) in the U.S. and has generally resulted in the highest neutralizing titers against prior SARS-CoV-2 strains. Moderna is working to rapidly test sera from its high dose booster recipients in neutralizing assays to determine if the 100 µg dose provides superior neutralizing protection against Omicron.

Second, Moderna is already studying two multi-valent booster candidates in the clinic that were designed to anticipate mutations such as those that have emerged in the Omicron variant. The first candidate (mRNA-1273.211) includes several mutations present in the Omicron variant that were also present in the Beta variant of concern1. The Company has completed dosing in a potentially pivotal safety and immunogenicity study of mRNA-1273.211 at the 50 µg (N=300) and 100 µg (N=584) dose levels. A second multi-valent candidate (mRNA-1273.213) includes many of the mutations present in the Omicron variant that were also present in the Beta and Delta variants2. The Company has completed dosing at the 100 µg (N=584) dose level and also plans to explore the 50 µg dose level in approximately 584 participants. Moderna will rapidly expand testing of sera from completed and ongoing multi-valent booster studies to determine if these multi-valent candidates are able to provide superior neutralizing protection against Omicron.

Third, Moderna will rapidly advance an Omicron-specific booster candidate (mRNA-1273.529). This candidate is part of the Company’s strategy to advance variant-specific candidates for a subset of variants of significant concern. During 2021 this has already included Beta- and Delta-specific boosters. The Company has repeatedly demonstrated the ability to advance new candidates to clinical testing in 60-90 days.

https://investors.modernatx.com/news-releases/news-release-details/moderna-announces-strategy-address-omicron-b11529-sars-cov-2

Platystemon
Feb 13, 2012

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facialimpediment posted:

So their terrible vaccination rate isn't a matter of supply, it's a matter of demand.

There’s also the issue that this variant has been stewing for a long time, greater than one year.

It’s far from certain that it would have been stopped even if every country in southern Africa had had Israel‐level vaccine deployment.

We absolutely should strive to do better, but this one probably still would have come for us.

We need not just vaccines for the global south, but also therapeutic drugs, some of which will be in extremely short supply in the near future, but also the HIV antivirals that we have little excuse for not sharing more widely.

Biden plans to buy ten million courses of Paxlovid. That’s not even a scratch in the problem.

Platystemon fucked around with this message at 06:57 on Nov 27, 2021

Platystemon
Feb 13, 2012

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https://twitter.com/alexmeshkin/status/1464604739291783174

There is no realistic possibility that this is anything other than the first case of Omicron to be found in the United States.

Platystemon
Feb 13, 2012

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Should’ve gotten its GED like Alex. :colbert:

Platystemon
Feb 13, 2012

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shame on an IGA posted:

:hmmyes: surely 300 linear feet of cargo boxes is the insurmountable obstacle that will stop people who already walked from El Salvador

They misunderstood the “three hundred foot” wall in Game of Thrones.

Platystemon
Feb 13, 2012

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Terrifying Effigies posted:

The Trumps weren't the first to go for unsettling Christmas photos at the White House though.



This is mostly a product of bad lighting and bad photography, but I feel that that tree would be creepy enough in any context.

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Platystemon
Feb 13, 2012

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BIG HEADLINE posted:

She's just so used to hearing the etymological root passionately used on another word.

They’re like “isle” and “island” in that they feel like they should share a root, but they do not.

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