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skooma512)
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Nodelphi posted:The FDA has been gutted and compromised now so there really aren’t many guardrails left. That's true, but the study you linked to is Japanese, and GLP-1 agonists have been approved by pretty much every global regulatory body for at least diabetes, if not weight loss. Diabetes and obesity also have relatively high all-cause mortality risks, so the issue is many of these unpleasant, undesirable side effects may still be "worth" the trade off within a population. on the flip side, GLP-1 agonists have been shown to halt the progression of early stage parkinsons. very interesting drug!
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Apr 20, 2024 15:16
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Nodelphi posted:Speaking of number going down. I mean of Ozempic helps you reach a healthy weight and if you are able to make lifestyle adjustments to diet and exercise after reaching your target weight BMI of 25 or less wouldn’t that be better overall? The problem of course is no one actually making any lifestyle changes when they wean off the drug
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Apr 20, 2024 15:16
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DaysBefore posted:Yeah but computer touchers are losing weight so it must be good My real fear is people will learn the wrong lesson and become more sedentary while taking the medication which will further increase risk of a blood clot.
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Apr 20, 2024 15:16
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Also Vioxx was a wonderful anti inflammatory and the hysteria at the time made it sound like you would get a heart attack if you took it, very sad
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Apr 20, 2024 15:18
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Nodelphi posted:My real fear is people will learn the wrong lesson and become more sedentary while taking the medication which will further increase risk of a blood clot. What if we just cut off everyone’s legs who are on that drug? No legs, means no leg clots can form, they have an excuse for why they can’t exercise, and they lose some extra weight. It’s wins all around.
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Apr 20, 2024 15:18
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Nodelphi posted:My real fear is people will learn the wrong lesson and become more sedentary while taking the medication which will further increase risk of a blood clot. ding ding, I agree most are able to lose weight due to the shear massive reduction in calories and then choose not to exercise at all because well I’m losing weight so EZ
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Apr 20, 2024 15:19
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Scarabrae posted:The problem of course is no one actually making any lifestyle changes when they wean off the drug well yeah capitalism is still the underlying mode of production
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Apr 20, 2024 15:19
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I would hate for a incredibly useful drug to be pulled because of a bunch of bad actors, it’s like not letting anyone chew gum in class
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Apr 20, 2024 15:20
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Scarabrae posted:Also Vioxx was a wonderful anti inflammatory and the hysteria at the time made it sound like you would get a heart attack if you took it, very sad Oh agreed, the media blew up the risks disproportionately at the time. You're absolutely right that the end result stunted the use and development of the drug when the intention was just to further investigate potential problems with the drug.
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Apr 20, 2024 15:21
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combining lifestyle changes and actual exercise/eating well with the drug would be the actual way to do it but no-body will and you're going to get tons of problems down the road prob
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Apr 20, 2024 15:23
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HallelujahLee posted:combining lifestyle changes and actual exercise/eating well with the drug would be the actual way to do it but no-body will and you're going to get tons of problems down the road prob In a country with proper healthcare and public option for insurance I would like to see people have to check in with a nutritionist to start building those skills when its time to go off the medicine but alas
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Apr 20, 2024 15:25
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webcams for christ posted:That's true, but the study you linked to is Japanese, and GLP-1 agonists have been approved by pretty much every global regulatory body for at least diabetes, if not weight loss. Diabetes and obesity also have relatively high all-cause mortality risks, so the issue is many of these unpleasant, undesirable side effects may still be "worth" the trade off within a population. Parkinson's is a topic near and dear to my heart, the problem is there seem to be so many drugs which have at least some effect on mitigating an aspect of the disease. I think the problem lies in the root cause of parkinsonisms are poorly understood and likely multi factorial.
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Apr 20, 2024 15:26
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Scarabrae posted:In a country with proper healthcare and public option for insurance I would like to see people have to check in with a nutritionist to start building those skills when its time to go off the medicine but alas capitalism.txt
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Apr 20, 2024 15:27
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Wraith of J.O.I. posted:some good news for a change The TN government is going to punish VW so much for this it's going to end up with the plant closing. The governor is frothing at the mouth with union hate.
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Apr 20, 2024 15:34
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DaysBefore posted:Yeah but computer touchers are losing weight so it must be good Now they can cram in double the amount of computer toucher. 
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Apr 20, 2024 15:39
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Pittsburgh Fentanyl Cloud posted:My job is all google workspace and it's a loving nightmare I have fought tooth and nail to migrate us off Google Workspace and my efforts have finally succeeded. We'll be dropping Google in August. Google is good for one thing and that's their shared docs ability and collaboration on spreadsheets. Most users are still gonna end up with the browser version of apps though lol PE backed and they won't spend the money for E3 licenses for everyone
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Apr 20, 2024 15:41
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Scarabrae posted:I mean of Ozempic helps you reach a healthy weight and if you are able to make lifestyle adjustments to diet and exercise after reaching your target weight BMI of 25 or less wouldn’t that be better overall? I saw a friend recently who's an MD in New Orleans and said he's seeing people think they can double down on terrible eating habits because ozempic will take care of it and they're actually gaining weight on a month-over-month basis.
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Apr 20, 2024 15:57
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quote:Possible side effects include nausea, diarrhea, vomiting, constipation, abdominal pain, headache, fatigue, indigestion/heartburn, dizziness, abdominal distension, belching, hypoglycemia (low blood glucose) in people with type 2 diabetes, flatulence, gastroenteritis, and gastroesophageal reflux disease (GERD).[15] It can also cause pancreatitis, gastroparesis, and bowel obstruction.[35]
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Apr 20, 2024 16:00
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DaysBefore posted:Yeah but computer touchers are losing weight so it must be good fat computer touchers are all that remains of america's middle class. we must make them svelte and sexy
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Apr 20, 2024 16:09
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DaysBefore posted:Yeah but computer touchers are losing weight so it must be good Computer touchers work 2 hour days and spend the remainder of their time riding $10,000 bicycles and discussing whats better, kubetnetes or docker. They're already 150 lbs.
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Apr 20, 2024 16:09
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love recommending Personal Responsibility to alleviate Structural Problems in the economics thread anyway how about this for a hot take: electric cars : vehicle emissions :: glp-1 agonists : obesity prevalence
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Apr 20, 2024 16:11
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Salt Fish posted:Computer touchers work 2 hour days and spend the remainder of their time riding $10,000 bicycles and discussing whats better, kubetnetes or docker. They're already 150 lbs.  where do you people get this from?i mean you guys are very clearly just confusing Tech Support with stock standard CTOs or something 
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Apr 20, 2024 16:33
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True Computer Touchers can buy land and Teslas
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Apr 20, 2024 16:42
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The term "computer toucher" has taken on significance far beyond its literal definition I remember a GBS thread where people were posting one of those overpriced cereal bar places as an example of a tech company and got mad when I said it wasn't
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Apr 20, 2024 16:48
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It’s GBS
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Apr 20, 2024 16:57
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docker sucks. kubetneses for the win.
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Apr 20, 2024 16:58
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Scarabrae posted:In a country with proper healthcare and public option for insurance I would like to see people have to check in with a nutritionist to start building those skills when its time to go off the medicine but alas The massive failure rate of of long-term weight loss means that a drug that acts as an appetite suppressant will probably never work as something that you can eventually wean people off of, at least not if there aren't some magical properties that allow it to keep working after you stop taking it. You either keep people on the drug forever or you treat it as an emergency intervention to bring someone's weight down, but I'm honestly not sure that you can "learn better habits" or whatever dumb bullshit when you're literally removing the urge to do the thing. There are clearly structural and environmental reasons for why successful long-term weight loss is so horrifically uncommon and I don't know how you ever fix it without properly identifying and resolving those causes first.
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Apr 20, 2024 16:59
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It’s cars
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Apr 20, 2024 17:07
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Paradoxish posted:The massive failure rate of of long-term weight loss means that a drug that acts as an appetite suppressant will probably never work as something that you can eventually wean people off of, at least not if there aren't some magical properties that allow it to keep working after you stop taking it. You either keep people on the drug forever or you treat it as an emergency intervention to bring someone's weight down, but I'm honestly not sure that you can "learn better habits" or whatever dumb bullshit when you're literally removing the urge to do the thing. the cause is capitalist food companies using science to make food super addictive, see samoa for the endgame of it
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Apr 20, 2024 17:08
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lol @ everyone itt hand wringing that fat people might lose weight without suffering enough
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Apr 20, 2024 17:28
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It’s the poop. I have no doubt that we’ll eventually find out that at least half of weight differences can be explained by GI functionality differences.
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Apr 20, 2024 17:30
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spiritual bypass posted:lol @ everyone itt hand wringing that fat people might lose weight without suffering enough There's also a lot of people mad that the weight loss drug that works costs $1,000/mo
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Apr 20, 2024 17:31
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Yeah, my bigger issue is that there is going to be absolutely no cultural shift away from "lol you're fat because you're dumb and lazy" even as the correlation between obesity and poverty approaches 1.
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Apr 20, 2024 17:35
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Salt Fish posted:Computer touchers work 2 hour days and spend the remainder of their time riding $10,000 bicycles and discussing whats better, kubetnetes or docker. They're already 150 lbs. this person is actually pretty right. They're describing silicon valley prestige tech but they are right. There is pressure to be healthy and it can easily affect your professional career to be too overweight. There are people who buck the trend of course, and obviously the IT dudes are gonna be fat for whatever reason. But when I worked in the valley it was very rare to work with anyone more than, like "kinda pudgy" because people really do care in that environment. It's full of sociopathic career pushers. So glad to leave silicon valley, gently caress that place. That being said sometimes you would meet a high level director who was fat and you would be like, drat, this dude's power reading is off the charts if he can roll like that. Power move. Taima has issued a correction as of 17:38 on Apr 20, 2024 |
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Apr 20, 2024 17:36
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spiritual bypass posted:lol @ everyone itt hand wringing that fat people might lose weight without suffering enough Ozempic has turned into a weird culture war thing. People have turned valid criticisms into these weird hoots and hollers from the sidelines where they are happy there are potential side effects or critical of anyone who would even consider it. I can see why basically every celebrity is lying about taking it.
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Apr 20, 2024 17:37
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we need to go back to when the standard of beauty was a deathly pale 200 pound woman covered in 50 pounds of clothing
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Apr 20, 2024 17:42
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still is for me tbqh
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Apr 20, 2024 17:43
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mistermojo posted:we need to go back to when the standard of beauty was a deathly pale 200 pound woman covered in 50 pounds of clothing 
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Apr 20, 2024 17:46
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Rectal Death Alert posted:Ozempic has turned into a weird culture war thing. People have turned valid criticisms into these weird hoots and hollers from the sidelines where they are happy there are potential side effects or critical of anyone who would even consider it. Well I mean sure, if the internet is your gauge on it. opinions and values differ across social classes and geographically in real life because it's a really, really complex topic that touches on so many lovely parts of our society, from its absurd cost, to its untested long-term ramifications, and yeah, people genuinely not wanting to see anyone else shine. What really amazes me is how much ozempic et al is kind of a proxy battle for many of the ills of society right now, in one neat package. You can tell a lot about someone by understanding their position on GLP agonists
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Apr 20, 2024 17:52
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mistermojo posted:we need to go back to when the standard of beauty was a deathly pale 200 pound woman covered in 50 pounds of clothing why not update it to 1600lb of power armor?
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Apr 20, 2024 17:53
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