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Volmarias
Dec 31, 2002

EMAIL... THE INTERNET... SEARCH ENGINES...

knox_harrington posted:

yup for sure, or surface area, or lean mass.

we were working on pediatric dosing for a cell therapy I work on and one proposal was to base it off estimated blood volume. cell therapy Pk is very different from small molecule Pk of course.

Simply exsanguinate the child, measure the amount of blood, and then resanguinate them.

mediaphage posted:

anyway seems like yet another an indictment of society that everyone’s in enough pain all the time to only buy extra strength versions

"My pain is important, I want the strongest thing you've got!"

Less "everyone is in pain" and more "everyone is more important than everyone"

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fart simpson
Jul 2, 2005

DEATH TO AMERICA
:xickos:

mediaphage posted:

generally i get way better care from nurses than i ever do doctors but like with any job it’s hit and miss. anyway with ibuprofen try to take it with food or a big glass of water to make it easier on your stomach. also do not take it regularly with pepto bismol.

i can’t remember if i’ve brought it up before but i’ve noticed a trend in the last few years where almost all the ibuprofen and acetaminophen in the pharmacies are now extra strength only. i actually have to hunt for the “regular strength” pills so that i have more latitude with dosing

anyway seems like yet another an indictment of society that everyone’s in enough pain all the time to only buy extra strength versions

in china they only sell ibuprofen in powered form or in blister packs of only 6 pills

Achmed Jones
Oct 16, 2004



"more important" doesn't make any sense, both are available and have nothing to do with "importance." you're doing the weird cspam thing.

but note that they're the same prize, and so taking one 500mg pill goes through a bottle half as fast as if you normally take two 200mg pills. if you want one 200mg this doesn't really help, but for even doses it saves money. and even for the non budget conscious, "more = better value" is pretty common (and again, isn't some weirdo indictment of the person buying it)

fart simpson
Jul 2, 2005

DEATH TO AMERICA
:xickos:

Achmed Jones posted:

"more important" doesn't make any sense, both are available and have nothing to do with "importance." you're doing the weird cspam thing.

but note that they're the same prize, and so taking one 500mg pill goes through a bottle half as fast as if you normally take two 200mg pills. if you want one 200mg this doesn't really help, but for even doses it saves money. and even for the non budget conscious, "more = better value" is pretty common (and again, isn't some weirdo indictment of the person buying it)

i don’t think i did any of that!

Shaggar
Apr 26, 2006
a doc once told me ibuprofen dosage is more about controlling usage over time rather than a single dosage. the guideline he gave me was 100mg per hour.

like the idea is if you do 2x200mg standard pills thats 400mg or 4 hours before you should take more and ensuring minimal long term dosing is more important than any single dose.

like if you take 4x200mg pills at once for acute pain and then you dont take anything for another month thats probably not a problem, but if you're taking like 4 a day every day for weeks thats a problem

altho to be clear all dosing guidelines are guesses based on minimal effective dosing and on top of that its possible that for some people guideline doses are completely ineffective.

as always consult your primary care physician before listening to anything posted online

mystes
May 31, 2006

fart simpson posted:

i don’t think i did any of that!
someone else said "more important" so I'm not sure he's responding to you

mediaphage
Mar 22, 2007

Excuse me, pardon me, sheer perfection coming through

mystes posted:

someone else said "more important" so I'm not sure he's responding to you

acting like a fart post is in good faith is always a mistake

mystes
May 31, 2006

oh he was doing the weird fart simpson thing

fart simpson
Jul 2, 2005

DEATH TO AMERICA
:xickos:

mystes posted:

someone else said "more important" so I'm not sure he's responding to you

if he wasnt replying to the post above, why didnt he quote it? checkmate

mystes
May 31, 2006

fart simpson posted:

if he wasnt replying to the post above, why didnt he quote it? checkmate
He wasn't replying to the post above (your post); that's exactly why he didn't quote it.

post hole digger
Mar 21, 2011

fart simpson posted:

in china they only sell ibuprofen in powered form or in blister packs of only 6 pills

whats it powered by :mmmhmm:

mystes
May 31, 2006

if that's what they sell in china do they sell other forms in plastic or paper packaging?

mystes
May 31, 2006

I'm fart simpson

Truman Peyote
Oct 11, 2006



mystes posted:

I'm fart simpson

mystes
May 31, 2006

lol

Captain Foo
May 11, 2004

we vibin'
we slidin'
we breathin'
we dyin'

echinopsis posted:

hmm I would be wary of generalising and some drugs are even “ideal body weight” it’s not like you get to take more drugs just coz you’re a wee bit chunky lol

ok FINE i will defer to an expert

fart simpson
Jul 2, 2005

DEATH TO AMERICA
:xickos:

fart simpson
Jul 2, 2005

DEATH TO AMERICA
:xickos:

post hole digger posted:

whats it powered by :mmmhmm:

ibuprofen

EIDE Van Hagar
Dec 8, 2000

Beep Boop

fart simpson posted:

in china they only sell ibuprofen in powered form or in blister packs of only 6 pills

powered? like with a motor?

fart simpson
Jul 2, 2005

DEATH TO AMERICA
:xickos:

EIDE Van Hagar posted:

powered? like with a motor?

with chemicals

echinopsis
Apr 13, 2004

by Fluffdaddy
powered by mitochondria

The Fool
Oct 16, 2003


DELETE CASCADE posted:

, because what the gently caress do nurses know

me observing my mil, a covid-denier and anti-vaxxer: gently caress all

me observing my wife, in a nursing program and just finished an anatomy course: way the gently caress more than me

knox_harrington
Feb 18, 2011

Running no point.

Shaggar posted:

a doc once told me ibuprofen dosage is more about controlling usage over time rather than a single dosage. the guideline he gave me was 100mg per hour.

like the idea is if you do 2x200mg standard pills thats 400mg or 4 hours before you should take more and ensuring minimal long term dosing is more important than any single dose.

like if you take 4x200mg pills at once for acute pain and then you dont take anything for another month thats probably not a problem, but if you're taking like 4 a day every day for weeks thats a problem

altho to be clear all dosing guidelines are guesses based on minimal effective dosing and on top of that its possible that for some people guideline doses are completely ineffective.

as always consult your primary care physician before listening to anything posted online

with your example about taking a big dose being fine, thinking in terms of chronic exposure is absolutely not true if you apply it to other drugs and if you do it with paracetamol/acetaminophen you can easily gently caress yourself up as the therapeutic window is small. Once you have a dose that saturates the main hepatic metabolic pathway, the remaining drug is converted into a very toxic metabolite. That dose can be as low as 4g/day in susceptible people e.g. alcoholics.

3D Megadoodoo
Nov 25, 2010

fart simpson posted:

ibuprofen in powered form

MAI IBUPROFEN IS FULL BOWER HA HA HA. IT IS CARBITCH.

Shaggar
Apr 26, 2006

knox_harrington posted:

with your example about taking a big dose being fine, thinking in terms of chronic exposure is absolutely not true if you apply it to other drugs and if you do it with paracetamol/acetaminophen you can easily gently caress yourself up as the therapeutic window is small. Once you have a dose that saturates the main hepatic metabolic pathway, the remaining drug is converted into a very toxic metabolite. That dose can be as low as 4g/day in susceptible people e.g. alcoholics.

yeah thats why i was talking specifically about ibuprofen.

Cold on a Cob
Feb 6, 2006

i've seen so much, i'm going blind
and i'm brain dead virtually

College Slice
getting over shingles but my back is hurting in a way that is very reminiscent of when i had kidney stones

if i get kidney stones again immediately after having shingles i'm gonna be pissed

Kenny Logins
Jan 11, 2011

EVERY MORNING I WAKE UP AND OPEN PALM SLAM A WHITE WHALE INTO THE PEQUOD. IT'S HELL'S HEART AND RIGHT THEN AND THERE I STRIKE AT THEE ALONGSIDE WITH THE MAIN CHARACTER, ISHMAEL.

Cold on a Cob posted:

if i get kidney stones again immediately after having shingles i'm gonna be pissed
you won't be the only thing that gets pissed

Volmarias
Dec 31, 2002

EMAIL... THE INTERNET... SEARCH ENGINES...

Kenny Logins posted:

you won't be the only thing that gets pissed

That's if you're lucky though.

:cry:

3D Megadoodoo
Nov 25, 2010

"Uh-huh so in the spots you indicated hurt the most, you have this thing called LIMAPUSSI, which might be inflamed."
"Oh OK. I was already wondering if the big G could affect the ankle."
"I was just about to say, you might have GOUT IN YOUR LIMAPUSSI."

(Slimebag in English.)

3D Megadoodoo
Nov 25, 2010

Lol of course (According to gogle), Anglos call a LIMAPUSSI IN FLAMES "bursitis". Good going, nerd.s.

Mr. Nice!
Oct 13, 2005

bone shaking.
soul baking.
this weekend i was at karaoke. i did the song freak on a leash by korn. right after the first grunting interlude there's a loud GO and then the music gets heavy before some more grunting interspersed with words. i threw off my hat and glass and started headbanging hard right after yelling go.

my neck hurts so bad today i couldn't sleep last night. :lol:

3D Megadoodoo
Nov 25, 2010

Mr. Nice! posted:

this weekend i was at karaoke. i did the song freak on a leash by korn. right after the first grunting interlude there's a loud GO and then the music gets heavy before some more grunting interspersed with words. i threw off my hat and glass and started headbanging hard right after yelling go.

my neck hurts so bad today i couldn't sleep last night. :lol:

is that the uuA A A A song?

Mr. Nice!
Oct 13, 2005

bone shaking.
soul baking.

3D Megadoodoo posted:

is that the uuA A A A song?

goes kindof like this:

https://voca.ro/1ivjEEg9Qrlx

Beeftweeter
Jun 28, 2005

OFFICIAL #1 GNOME FAN

lmao

Mr. Nice!
Oct 13, 2005

bone shaking.
soul baking.
anyways, yeah, I did that and headbanged too hard and now my neck hurts when i turn my head in any way. gotta love getting old.

3D Megadoodoo
Nov 25, 2010

got four recipes today. or "prescriptions" as some people call them for some loving reason.

gotta squeeze value out of that 20-minute appointment.

mystes
May 31, 2006

sounds like a recipe for success

3D Megadoodoo
Nov 25, 2010

mystes posted:

sounds like a recipe for success

Gotta say, they worked. I'm not in huge pain anymore, just a!

well-read undead
Dec 13, 2022

that new click in my knee that started last week: arthritis!

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3D Megadoodoo
Nov 25, 2010

well-read undead posted:

that new click in my knee that started last week: arthritis!

Isn't gout a type of arthritis? Could be gout. Probably gout, IMHO.

E: it is lol. But sorry to hear you have it whatever it is.

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