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The FDA has approved the first ever gene-editing treatment. Summary: - This is just a gene editing process for curing sickle cell disease. It does not necessarily mean that widespread gene editing treatment will be approved or that non-medical gene editing will be available soon. - The treatment allows people to edit their genes and modify their own stem cells to essentially become their own bone marrow donor without major surgery. Previously, the only way to cure sickle cell was to go through an incredibly painful bone marrow donation process that had a high chance of failure and was difficult for some patients to find a matching donor. The process does involve chemotherapy, though. - The therapy is currently incredibly expensive. It is expected to cost between $1 million and $2 million (not counting potential insurance or manufacturer discounts) per patient. - Roughly 65% of people who undergo the treatment are permanently cured. They have studied patients for two years after treatment and found no long-term side effects, but they can't say for sure that there may not be side effects that take more than to years and are awaiting data. Everyone involved in the clinical trials will be followed for an additional 13 years (15 total) to track and confirm if there are any long-term side effects. https://twitter.com/Phil_Lewis_/status/1733165402471924014 quote:The Food and Drug Administration on Friday approved a powerful treatment for sickle cell disease, a devastating illness that affects more than 100,000 Americans, the majority of whom are Black. Leon Trotsky 2012 fucked around with this message at 18:10 on Dec 8, 2023 |
# ? Dec 8, 2023 18:06 |
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# ? May 26, 2024 09:15 |
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zoux posted:College Station...say why's it called that could be, but the thing is, for some people, many people, perhaps even most people, those dollars at the grocery store are life or death and not hypotheticals. Economists with five degrees insisting with graph after graph that everything is fine means jack poo poo when your individual perception is you need loving bread to feed your children because they will die if they don't get food, and the bread costs 2.5x as much as it did a year ago dumbass political opinions will happen, sure, but no one is going to forget when buying potatoes at walmart tripled for no reason Edgar Allen Ho fucked around with this message at 18:26 on Dec 8, 2023 |
# ? Dec 8, 2023 18:16 |
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Edgar Allen Ho posted:could be, but the thing is, for some people, many people, perhaps even most people, those dollars at the grocery store are life or death and not hypotheticals. Economists with five degrees insisting with graph after graph that everything is fine means jack poo poo when your individual perception is you need loving bread to feed your children because they will die if they don't get food. This is like the turbo opposite version of the "look at this graph, you dumb pleebs!" argument. "Most people" in the U.S. did not decide the economy was bad in October 2023 because they were legitimately worried their children would starve to death due to lack of bread. That's bonkers.
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# ? Dec 8, 2023 18:22 |
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CRISPR editing for sickle cell, didn't see that one coming so soon. Wild stuff. With it being bone marrow editing will the genetic modifications be passed on to any children? Personal gene editing to cure maladies, like the muscular dystrophy that I lost someone to, are super duper cool and I hope the treatments start happening but even that can start getting in to some pretty tangled moral territory. Genetic modifications that get passed on to future generations get their really fast.
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# ? Dec 8, 2023 18:28 |
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bird food bathtub posted:CRISPR editing for sickle cell, didn't see that one coming so soon. Wild stuff. With it being bone marrow editing will the genetic modifications be passed on to any children? Personal gene editing to cure maladies, like the muscular dystrophy that I lost someone to, are super duper cool and I hope the treatments start happening but even that can start getting in to some pretty tangled moral territory. Genetic modifications that get passed on to future generations get their really fast. CRISPR does not edit your entire genetic code and you can't pass it on to the next generation unless you specifically edit your egg/sperm or edit the fertilized egg/embryo in utero. quote:These changes are isolated to only certain tissues and are not passed from one generation to the next. However, changes made to genes in egg or sperm cells or to the genes of an embryo could be passed to future generations. https://medlineplus.gov/genetics/un...%20generations.
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# ? Dec 8, 2023 18:30 |
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bird food bathtub posted:CRISPR editing for sickle cell, didn't see that one coming so soon. Wild stuff. With it being bone marrow editing will the genetic modifications be passed on to any children? Personal gene editing to cure maladies, like the muscular dystrophy that I lost someone to, are super duper cool and I hope the treatments start happening but even that can start getting in to some pretty tangled moral territory. Genetic modifications that get passed on to future generations get their really fast. Unless you're impregnating someone with your bone marrow, no. This is an important first step on a slam dunk case that will eventually see us getting to the point we can address a lot of issues in unborn children but there's big conversations along the way (I want my kid to not have sickle cell and also be blonde and blue eyed).
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# ? Dec 8, 2023 18:31 |
Morrow posted:Unless you're impregnating someone with your bone marrow, no. This is an important first step on a slam dunk case that will eventually see us getting to the point we can address a lot of issues in unborn children but there's big conversations along the way (I want my kid to not have sickle cell and also be blonde and blue eyed). If you think about it, it would be wrong to deny my child gills, such that he may conquer the seas
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# ? Dec 8, 2023 18:33 |
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bird food bathtub posted:CRISPR editing for sickle cell, didn't see that one coming so soon. Wild stuff. With it being bone marrow editing will the genetic modifications be passed on to any children? Personal gene editing to cure maladies, like the muscular dystrophy that I lost someone to, are super duper cool and I hope the treatments start happening but even that can start getting in to some pretty tangled moral territory. Genetic modifications that get passed on to future generations get their really fast. No, you would need to edit the cells in sperm/egg cells My dad has been working in this field for a long time to cure immune system diseases and its amazing to see where the field is now compared to 20 years ago. They can do stuff like find and fix a single incorrect base pair out of your entire genome that is preventing your immune systems cells from maturing Morrow posted:Unless you're impregnating someone with your bone marrow, no. This is an important first step on a slam dunk case that will eventually see us getting to the point we can address a lot of issues in unborn children but there's big conversations along the way (I want my kid to not have sickle cell and also be blonde and blue eyed). A lot of that is already happening with IVF where they can check the genome before implantation to make sure it didn't inheriet diseases (and make sure its a boy/girl or what have you). The
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# ? Dec 8, 2023 18:34 |
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https://twitter.com/JenGriffinFNC/status/1733114689356288352 Hard to determine who got captured harder by whom, the US right wing or the Russian right wing. I see a lot of stuff about how Genocide Joe is shipping WMDs to Israel, but the does the death of the border/UKR/ISR aid deal means they haven't gotten anything they didn't have on 10/6? Or have we released or otherwise supplied them with additional materiel through other means?
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# ? Dec 8, 2023 18:36 |
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Morrow posted:Unless you're impregnating someone with your bone marrow, no. This is an important first step on a slam dunk case that will eventually see us getting to the point we can address a lot of issues in unborn children but there's big conversations along the way (I want my kid to not have sickle cell and also be blonde and blue eyed). There are 100% going to be people who campaign to ban things like curing deafness or down syndrome. You already have people who are against getting their deaf kids cochlear implants because it eliminates deaf culture or they themselves are deaf and are worried that it will take away their ability to fully connect with their kids. I can understand the emotional aspect to it, and unfortunately I have a feeling that the emotional aspect will probably win out when it comes to crafting laws around it, but I don't think banning a world where nobody is deaf or forcing your kids to be deaf when you could have prevented it is a good thing. They have already tried (and been partially successful) to ban IVF or abortion procedures that aim to prevent down syndrome or inheriting genetic diseases. Leon Trotsky 2012 fucked around with this message at 18:41 on Dec 8, 2023 |
# ? Dec 8, 2023 18:36 |
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If you buy things on sale, fresh ingredients aren't that much higher than their pre-COVID levels, at least in my experience in the NY metro area. Maybe it's worse in food deserts where there's only one supermarket within 30 miles that can jack up prices without any competition while blaming "inflation." The great egg panic of 2023 was due to bird flu or something, the prices eventually dropped back down to near "normal" levels after a few months. It's the name brand junk food and frozen pizza and soda and other things that nobody actually needs to survive that are twice as expensive as they were 4 years ago.
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# ? Dec 8, 2023 18:43 |
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People who are struggling to afford essentials, or are even slightly worried about struggling to afford essentials cut back on spending elsewhere. They certainly don't buy loads of gadgets and other random junk. And yet, this year's Black Friday broke records for the amount of random poo poo bought on Black Friday, and this year's Cyber Monday also broke records for the amount of unessential poo poo bought on Cyber Monday. Clearly a lot of people are not afraid of spending on frivolous stuff.
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# ? Dec 8, 2023 18:48 |
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At Ingles, the largest grocery chain in my area by an overwhelming amount, green bell peppers are $2 at regular pricing. They were on sale yesterday 2 for $3. I get most of my produce from Trader Joes where all peppers are generally under $1.
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# ? Dec 8, 2023 18:50 |
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Quixzlizx posted:If you buy things on sale, fresh ingredients aren't that much higher than their pre-COVID levels, at least in my experience in the NY metro area. Maybe it's worse in food deserts where there's only one supermarket within 30 miles that can jack up prices without any competition while blaming "inflation." The great egg panic of 2023 was due to bird flu or something, the prices eventually dropped back down to near "normal" levels after a few months. People really like their name brand junk food and pizzas, though. Their spending indicates that they would prefer to pay higher prices for them than switch to something else, so it is going to annoy them even if they technically could change the brand/product or make their own to get more value. Also, anything with added sugar (which is more than half of things in a U.S. grocery store) or processed wheat/potatoes genuinely is a lot more expensive right now because of shortages. Potato chips, frozen pizzas, cereal, crackers, and other things like that are incredibly popular and people would rather pay the higher prices than swap their diet entirely for those items, so it is going to make people mad because they won't all act like entirely rational economic actors. Yes, they could dramatically improve their grocery store purchase value by optimizing their purchases and changing their habits, but nobody likes doing that and many people just won't. So the solution is technically there, but it's not really a practical one for making people less angry because people will pay the prices and be angry or switch to something else and be angry they had to switch.
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# ? Dec 8, 2023 18:54 |
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golden bubble posted:People who are struggling to afford essentials, or are even slightly worried about struggling to afford essentials cut back on spending elsewhere. They certainly don't buy loads of gadgets and other random junk. And yet, this year's Black Friday broke records for the amount of random poo poo bought on Black Friday, and this year's Cyber Monday also broke records for the amount of unessential poo poo bought on Cyber Monday. Clearly a lot of people are not afraid of spending on frivolous stuff. They are spending to cope with their economic precarity, which makes them more precarious, which makes them spend more....it's a viscous cycle. It's been very disheartening to see so many people just forget that anecdotes aren't data because they don't like the data. Kagrenak posted:Again with this? Why do people keep posting these things without addressing the part which is actually confusing: if people are unable to feed their children properly because bread is so expensive, why are they rating their own financial situation as good? Especially when the lowest socioeconomic groups have seen the most real wage growth. But I know that's just what the "facts" and "data" say.
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# ? Dec 8, 2023 18:54 |
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Edgar Allen Ho posted:could be, but the thing is, for some people, many people, perhaps even most people, those dollars at the grocery store are life or death and not hypotheticals. Economists with five degrees insisting with graph after graph that everything is fine means jack poo poo when your individual perception is you need loving bread to feed your children because they will die if they don't get food, and the bread costs 2.5x as much as it did a year ago Again with this? Why do people keep posting these things without addressing the part which is actually confusing: if people are unable to feed their children properly because bread is so expensive, why are they rating their own financial situation as good?
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# ? Dec 8, 2023 18:55 |
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zoux posted:Hard to determine who got captured harder by whom, the US right wing or the Russian right wing. They didn’t need to be captured. (But they certainly were trying in both directions). They just had to recognize they were the same and decide to cooperate.
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# ? Dec 8, 2023 18:55 |
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Leon Trotsky 2012 posted:
Man, I remember being a little kid sometime in the early 90s and stopping at a rail crossing, and just how blazing fast the Amtrak seemed when it zoomed past. I think they discontinued that line sometime in Clinton's admin. I see they're planning on reinstituting the Mobile to New Orleans line in that map, which is where I would have seen that train. I'm not a train weirdo or anything but seeing that dotted line made me a little emotional. Like we're clawing back better things from this austerity poo poo. Drop in the bucket in the long run. Probably not happening fast enough to make me abandon my plans to leave the country.
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# ? Dec 8, 2023 19:02 |
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zoux posted:They are spending to cope with their economic precarity, which makes them more precarious, which makes them spend more....it's a viscous cycle. It’s really really important for folks to understand these things are feedback cycles or loops. Lack of time -> bad food and life choices choices to save time-> need for more hours to pay for more expensive bad food -> health issues resulting from bad food and time stress-> exhaustion and fatigue-> lack of time A lot of people think it’s a single choice and matter of will. It’s very much not, most of things in our lives determinative of success or failure are similar loops.
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# ? Dec 8, 2023 19:09 |
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Leon Trotsky 2012 posted:People really like their name brand junk food and pizzas, though. Their spending indicates that they would prefer to pay higher prices for them than switch to something else, so it is going to annoy them even if they technically could change the brand/product or make their own to get more value. I was responding to the poster who was saying that kids are starving because their parents are spending too much on
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# ? Dec 8, 2023 19:10 |
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Bar Ran Dun posted:It’s really really important for folks to understand these things are feedback cycles or loops. Sorry I was making fun of news outlets who are ignoring the data to come up with insane new ideas about consumer spending
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# ? Dec 8, 2023 19:15 |
The Glumslinger posted:There is already a Metrolink rail line from Union Station (main hub of the LA's transit system) to Rancho Cucamonga, but it would be nice to get that upgraded. But I'm sure LA would rather spend that money on building new subway lines LA public transit in general, and the Metrolink in particular, needs a huge update. CityNerd just did an analysis of high speed rail vs. flying vs. driving for people living throughout Los Angeles, and if you don't live right next to the station, flying (including time spent going to and waiting at the airport) is way faster solely because of the time it takes to cross LA by public transit. I live pretty close to the Redondo Beach Cheesecake Factory that he uses as a starting point, and I confirmed it would take me over 3 hours to cross LA and get to the Rancho Cucamonga station by public transit (primarily via MetroLink), which is a pathetic amount of time for it to take to cross the second-most-populous city in the US by public transit. Edit: Google maps was being very bad at suggesting routes. Updated the time above. VikingofRock fucked around with this message at 20:06 on Dec 8, 2023 |
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# ? Dec 8, 2023 19:41 |
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zoux posted:Sorry I was making fun of news outlets who are ignoring the data to come up with insane new ideas about consumer spending Something I watched my dad do growing up was to splurge on a big item he couldn’t afford intermittently. This was normally computer related (but occasionally was a guitar or a banjo). My parents didn’t have a lot of money. I’ve gotten bonuses larger than either’s yearly income. We were my room was the top half of a large trailer closet (sister had the bottom half) if you dropped the gallon of milk that meant no milk for two weeks poor. Being that kind of poor, that leads to my parents denying themselves sometimes for years at a time. Every now and then all that pent up not having, the mental effort required breaks and one buys something large and stupid financially. It’s a part of the experience of being quite poor. I think the doomflation stuff is the idea that the pandemic made middle class folks experience that.
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# ? Dec 8, 2023 20:19 |
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https://twitter.com/_phillipsmorgan/status/1733183491326509370 Time to gently caress off forever Nancy quote:But less than 18 months since that heartwarming proposal, DailyMail.com can exclusively reveal that the couple have broken up and are now in the middle of a messy legal fight over multi-million-dollar homes they bought together. quote:While dating Bryant, Mace often openly discussed her sex life in the office, including in front of male junior staffers, according to three sources who recalled such comments in graphic detail to DailyMail.com. So she is as obnoxious as she seems on TV. quote:
This is actually a huge problem in the GOP caucus, half the membership is just there for the memes zoux fucked around with this message at 20:21 on Dec 8, 2023 |
# ? Dec 8, 2023 20:19 |
Bar Ran Dun posted:Something I watched my dad do growing up was to splurge on a big item he couldn’t afford intermittently. This was normally computer related (but occasionally was a guitar or a banjo). My parents didn’t have a lot of money. I’ve gotten bonuses larger than either’s yearly income. Sure, maybe, but statistically speaking you think everyone is doing that at once?
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# ? Dec 8, 2023 20:25 |
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zoux posted:Senate GOP now hoping for "hit by a bus" to get them out of a Trump nom https://www.shreveporttimes.com/sto...or/70776844007/ quote:"I'm not his doctor, but I will say his doctor put out a statement listing the tests the leader has gone through and there was no evidence or any terrible thing that had happened," Cassidy said Wednesday in a response to a question from the USA Today Network. "So at this point I say that Mitch can still be leader of the Republican caucus." How about you stay in your lane, gastroenterology? zoux posted:https://twitter.com/_phillipsmorgan/status/1733183491326509370 Reminder FizFashizzle fucked around with this message at 20:41 on Dec 8, 2023 |
# ? Dec 8, 2023 20:32 |
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Hieronymous Alloy posted:Sure, maybe, but statistically speaking you think everyone is doing that at once? Yes, some people are screwed in the American system. No, they are not particularly more screwed than they were four years ago. No, not everybody who is complaining about the economy right now is screwed, or worse off than they were before the pandemic, or even struggling at all. And, yes, the media has a huge impact on what people think about the economy, because outside of their personal finances people are unlikely know anything about economics or the economy aside what they are told by the media. The Financial Times did that survey, previously discussed, that showed people are egregiously misinformed - not only do they not know the facts, a supermajority is more likely to believe incorrect things than correct things. Leaving aside the negative slant of coverage in places like the NYT, half of the media will argue that the economy is bad no matter what if there is a Democratic president, and their viewers/readers generally do not question their assertions. Why do people find it so hard to believe that the widespread dissatisfaction is caused by that misinformation and not material conditions, especially when people report their material conditions as "pretty okay, I guess" at about the same rate they have the last 10 years? Why can't we accept the obvious answer, which is that people are being told that the economy is bad, and so they believe it? No other explanation given has really been able to demonstrate meaningful difference from the economic problems we had pre-pandemic or the the difference between sentiment in the US versus the rest of the west. (Of the arguments that have been made, I find interest rates and algorithmic pricing to be the most compelling.) That said, there were serious economic problems in 2022 (although people rated them as "spring 2009" bad, which was ridiculous), and I think most of what we are seeing right now is just a hangover in public sentiment from those problems. It takes people a little while after an economic improvement to "feel" it; the media is slowing down that process but they can't completely halt it. Sentiment is improving, albeit slowly, because conditions have improved. Misunderstood fucked around with this message at 20:50 on Dec 8, 2023 |
# ? Dec 8, 2023 20:47 |
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Hieronymous Alloy posted:Sure, maybe, but statistically speaking you think everyone is doing that at once? Every one went through a specific event at about the same time for roughly the same amount of time. But different parts of society experienced the pandemic very very differently, so I think it’s reasonable that some parts are doing it all at roughly the same time and other parts aren’t doing it at all. If one isn’t in one of the demographics that things really sucked for it wouldn’t make any sense looking at if from the outside.
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# ? Dec 8, 2023 20:49 |
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People just understand inflation really, really, really badly. As many times as I've heard the phrase "too much money chasing too few goods" over the last couple of years, people don't understand the theoretical basis all that well. I think a lot of people think inflation works like... "we're having trouble selling this stuff, so we have to mark it up to make up for the losses." People think that things that are correlated with a good economy, like high gas prices, are correlated with a bad economy. They can watch gas plummet to $1.50 in December 2008 or May 2020 and somehow they still don't get that gas prices aren't "economy is this bad:" signs. That's the kind of thing that makes Americans more likely than not to agree with the statement "unemployment is currently at a 50-year high." They just have no loving clue what causes inflation.
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# ? Dec 8, 2023 20:52 |
Misunderstood posted:
Because, generally speaking, you can't fool all the people all the time. People may not be expert in economics or law or politics but they are expert in how they feel personally and generally if people tell you they're feeling a particular way you should believe them because they probably aren't wrong.
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# ? Dec 8, 2023 20:57 |
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Hieronymous Alloy posted:Because, generally speaking, you can't fool all the people all the time. People may not be expert in economics or law or politics but they are expert in how they feel personally and generally if people tell you they're feeling a particular way you should believe them because they probably aren't wrong.
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# ? Dec 8, 2023 21:03 |
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Hieronymous Alloy posted:Because, generally speaking, you can't fool all the people all the time. People may not be expert in economics or law or politics but they are expert in how they feel personally and generally if people tell you they're feeling a particular way you should believe them because they probably aren't wrong. So why don't you believe the majority of people who say they are doing fine? The reason is we've demonstrated that Americans have a very poor understanding of the economy (and lots of stuff, people tend to think stuff like "25% of the population is gay"). I trust a layperson's judgement on their own financial stability, I do not trust them to evaluate macroeconomic trends. We wouldn't give this kind of deference to climate change deniers ignoring graphs of skyrocketing ocean temperatures and all the reams of data we have showing anthropogenic climate change is real and saying "but it's cold where I am", so I don't know why suddenly these people are experts on national financial trends. e: I shouldn't say "it's cold where I am" this is more "I saw on the news that it's snowing in colorado, so even though I'm boiling hot I think that global warming is fake" e2: speaking of disturbing polling results zoux fucked around with this message at 21:21 on Dec 8, 2023 |
# ? Dec 8, 2023 21:06 |
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zoux posted:https://twitter.com/_phillipsmorgan/status/1733183491326509370 If Nancy Mace resigns, is that it for the GOP majority?
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# ? Dec 8, 2023 21:58 |
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just dawning on me that it seems like that, in the event that both Trump and Biden die of old-man-itis, that the 2024 election has a decent chance of being Harris vs Haley (if I'm remembering the news of who the behind the scenes folks in the republican party are starting to coalesce towards correctly)
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# ? Dec 8, 2023 22:00 |
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Edgar Allen Ho posted:the bread costs 2.5x as much as it did a year ago Weird. The bread where I am costs roughly the same as it did a year ago.
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# ? Dec 8, 2023 22:02 |
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Ither posted:If Nancy Mace resigns, is that it for the GOP majority? Why would she resign? Boebert didn't resign after getting caught on camera giving someone an old fashioned. But yes that would end their majority as things now stand.
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# ? Dec 8, 2023 22:02 |
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zoux posted:So why don't you believe the majority of people who say they are doing fine? This shouldn't be a surprise; one of 2 governing parties in the US is committed to making voters as stupid as possible. To the point of giving the military difficulties finding new officers because average education standards have fallen so low. The GOP is fine having the economy, military and their own personal safety be compromised if they can convince more people to join red team because they don't know any better. There will unfortunately be strengthening of holocaust misinformation as a side effect of the Israeli government making themselves this year's villain. Some young people will understand the nuance, but others definitely will not.
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# ? Dec 8, 2023 22:08 |
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Orthanc6 posted:There will unfortunately be strengthening of holocaust misinformation as a side effect of the Israeli government making themselves this year's villain. Some young people will understand the nuance, but others definitely will not. Yeah but that's a really really bad thing. 30 percent of under-29s just asking questions about if the Holocaust happens is how another one happens.
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# ? Dec 8, 2023 22:10 |
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I don't think the average person knows how much a bag of potatoes cost in April 2021. I don't think the average person experiencing severe food insecurity knows either. Not a value judgement, I just don't think remembering how much potatoes cost two years ago is important unless you're some kind of economist.
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# ? Dec 8, 2023 22:11 |
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Digamma-F-Wau posted:just dawning on me that it seems like that, in the event that both Trump and Biden die of old-man-itis, that the 2024 election has a decent chance of being Harris vs Haley (if I'm remembering the news of who the behind the scenes folks in the republican party are starting to coalesce towards correctly) predicto posted:Weird. The bread where I am costs roughly the same as it did a year ago.
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# ? Dec 8, 2023 22:11 |