(Thread IKs:
PoundSand)
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Mathew Perry died, no foul play and no drugs. Found unresponsive in his jacuzzi, maybe a heart attack? He was only 54 (USER WAS PUT ON PROBATION FOR THIS POST)
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# ? Oct 29, 2023 02:15 |
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# ? May 25, 2024 14:35 |
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Glumwheels posted:Mathew Perry died, no drugs. guy was a loving mess so I dunno about that part
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# ? Oct 29, 2023 02:17 |
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Glumwheels posted:Mathew Perry died, no foul play and no drugs. Found unresponsive in his jacuzzi, maybe a heart attack? Vaxxed? (He had a history of drugs, almost died of opioids)
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# ? Oct 29, 2023 02:17 |
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Glumwheels posted:Mathew Perry died, no foul play and no drugs. Found unresponsive in his jacuzzi, maybe a heart attack? he was 97 in opioid years though
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# ? Oct 29, 2023 02:22 |
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According to my Aranet my house has swung from nearly 1300 to basically perfect outdoor air 550 then back up to like 1300 at times... without opening windows or anything, just over the span of a couple days. No loving clue what's going on with that.
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# ? Oct 29, 2023 02:29 |
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Rescue Toaster posted:According to my Aranet my house has swung from nearly 1300 to basically perfect outdoor air 550 then back up to like 1300 at times... without opening windows or anything, just over the span of a couple days. No loving clue what's going on with that. central air? most houses are quite drafty and central air will create negative or positive pressure depending
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# ? Oct 29, 2023 02:35 |
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WrasslorMonkey posted:Vaxxed? yea im on team "he might not have taken them last night, but matthew perry has loved drugs for a very, very long time" it's not covid!!
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# ? Oct 29, 2023 02:39 |
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Rescue Toaster posted:According to my Aranet my house has swung from nearly 1300 to basically perfect outdoor air 550 then back up to like 1300 at times... without opening windows or anything, just over the span of a couple days. No loving clue what's going on with that. Does it usually happen around the same time? Certain types of cooking can really gently caress your air quality
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# ? Oct 29, 2023 02:41 |
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please don't be weird about mathew perry's death
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# ? Oct 29, 2023 02:42 |
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speng31b posted:please don't be weird about mathew perry's death Yeah, cum to the Trump thread for that.
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# ? Oct 29, 2023 02:47 |
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Glumwheels posted:Mathew Perry died, no foul play and no drugs. Found unresponsive in his jacuzzi, maybe a heart attack? the thread is down to like one rule!
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# ? Oct 29, 2023 02:53 |
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Here’s a heavy one. Resurgence of SARS-CoV-2 Delta after Omicron variant superinfection in an immunocompromised pediatric patient quote:The patient was a school-aged child previously diagnosed with a neuroinflammatory condition initially treated with the IFN-γ blocking antibody emapalumab-Iszg and ongoing therapy with steroids and monthly etoposide. The patient had a history of varicella encephalitis and remained on suppressive valacyclovir therapy. In early January 2022, the child developed upper respiratory tract infection symptoms and was diagnosed with COVID-19 at an outside healthcare facility (symptom day 0). quote:Results of WGS indicate the patient was initially infected with the SARS-CoV-2 Delta variant before developing a SARS-CoV-2 Omicron variant superinfection, which became predominant. Shortly thereafter, viral loads decreased below the level of detection before resurgence of the original Delta variant with no residual trace of Omicron. After 54 days of persistent infection, the patient tested negative for SARS-CoV-2 but ultimately succumbed to a COVID-19-related death. Despite protracted treatment with remdesivir, no antiviral resistance mutations emerged. quote:All amplicons from days 4, 13, and 31 were consistent with a Delta variant infection, while nearly all amplicons from day 18 were consistent with an Omicron variant infection with the exception of a single Delta amplicon. These data suggest that the Omicron superinfection started sometime after day 13 with both variants present at day 18 prior to clearance of the Omicron superinfection by day 31. This strongly implies that the child was infected with Omicron while in the hospital, to which he was admitted on day four. I have no words. Let’s move on to conclusions. quote:Despite the relative stasis in recent months, the sustained presence of Delta lineages after June 2022 underlines its continued circulation and divergence. Furthermore, our analysis of the pairwise p-distances confirms the observation from ML phylogeny (Fig. 4E). During the peak of Delta prevalence, we observed minimal genetic divergence among the samples. However, the samples collected after June 2022 exhibit a marked increase in genetic diversity, as demonstrated by the significantly higher within group pairwise p-distances, as well as an increase of genetic divergence when comparing the initial and more recent Delta sequences (Fig. 4E). This genetic diversification between the peak and post-June samples substantiates the Delta variant’s continuous evolution, even amidst the rise of Omicron lineages. These results suggest that the SARS-CoV-2 Delta variant continued to cause sporadic infections into 2023 despite the near complete global sweep of the Omicron variant. This may indicate that the Delta lineage has adaptive advantages that enable more persistent infections, perhaps in selected niches or patient populations. quote:Despite the prolonged administration of remdesivir in this patient, no genetic changes undermining the therapeutic potential of remdesivir were detected, including any novel mutations in the nsp12 gene, that could explain either the persistence or resurgence of the Delta lineage virus or the Omicron superinfection. Although some studies reported de novo emergence of remdesivir resistance mutations [37, 38] the occurrences of such mutations in the GISAID repository continue to be consistently low, indicating their limited presence and lack of fitness [39]. The explanation for persistent viral recovery in this patient while on antiviral therapy remains unclear, though persistent or recurrent viral replication with remdesivir despite the absence or resistance mutations have been reported [40] and may result from a variety of factors including reduced immune clearance of virus or potential compromised penetration of remdesivir into the lung [41, 42]. quote:The data suggests that the Delta VOC may populate a unique niche within the host that enables its persistence even in response to subsequent superinfections and therapeutic changes. A better understanding of the anatomical population dynamics that occur during co-infection and superinfection is essential for optimizing treatment course and minimizing the risk of viral recombination. Furthermore, continued surveillance and research are necessary to monitor the dynamics of different variants and their persistence as the pandemic progresses. Evidence of long-term community transmission of the Delta variant after the emergence and predominance of Omicron suggests risks for variant re-emergence as the population gains lineage-specific immunity. Ultimately, understanding these factors will be crucial for effective public health measures, such as monitoring and treatments in susceptible populations, developing targeted therapeutics and vaccines, as well as anticipating future emerging and re-emerging infections. Yeah we’re not going to do all that. It’s been a year since we even had working monoclonal antibodies against SARS‑CoV‑2. Sotrovimab did work at the time this child was hospitalized, but it was never authorized for either hospitalized patients or for patients under twelve years of age.
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# ? Oct 29, 2023 03:23 |
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"apparent drowning" like https://www.youtube.com/watch?v=ZGJ9wuk_Yyw speng31b posted:please don't be weird about mathew perry's death did anyone ask for a hall monitor? make yourself scarce, slim (USER WAS PUT ON PROBATION FOR THIS POST)
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# ? Oct 29, 2023 03:47 |
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Pingui posted:I wonder why that is Pittsburgh Fentanyl Cloud posted:Lol it’s been a while since I saw a concrete deaths number, 1200 deaths a week is as many deaths per year as murders and car crashes combined loving some Americans are dying 1,200+ Americans dying a week? anyways, Tzen has issued a correction as of 04:09 on Oct 29, 2023 |
# ? Oct 29, 2023 03:55 |
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Woodsy Owl posted:Good news, fellow parents of young children! The CDC finally updated their guidance to clarify interchangeability of brands for 6mo+ lol in 2 weeks when I show the pharmacy the CDC info and they'll still refuse to mix and match my kids vaccines
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# ? Oct 29, 2023 04:14 |
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NeonPunk posted:I'm still a believer in the theory that molnupiravir was responsible for the OG Omicron
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# ? Oct 29, 2023 04:35 |
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So, my 5yo has been sick almost every single week, for a couple days each week, since Kindergarten started in early August. I've been passing it off as the typical thing that happens to new kindergarteners when they're exposed to new viruses. But this is just getting extremely excessive. The idea just popped into my head that it could be long COVID? We all had COVID once in May. He's tested negative on a RAT every week. Does that sound like it could be LC? And if so, how would I approach a doctor about that without sounding crazy?
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# ? Oct 29, 2023 07:19 |
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Diamonds On MY Fish posted:So, my 5yo has been sick almost every single week, for a couple days each week, since Kindergarten started in early August. I've been passing it off as the typical thing that happens to new kindergarteners when they're exposed to new viruses. But this is just getting extremely excessive. The idea just popped into my head that it could be long COVID? We all had COVID once in May. He's tested negative on a RAT every week. Does that sound like it could be LC? And if so, how would I approach a doctor about that without sounding crazy? A couple random days each week? That actually sounds a lot more like environmental poisoning than long covid to me. Like mold at the school or something.
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# ? Oct 29, 2023 07:35 |
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# ? Oct 29, 2023 07:41 |
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Got mothed today. Costco ended up having Novavax available soonest, so I went there. No issues at all with insurance weirdness or not having enough Novavax on hand or anything. I got lucky, I guess.
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# ? Oct 29, 2023 07:49 |
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The Oldest Man posted:A couple random days each week? That actually sounds a lot more like environmental poisoning than long covid to me. Like mold at the school or something. It would surprise me if there was mold at the school, they generally keep everything in a pretty good state of repairs. No idea about how I'd even check for that...
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# ? Oct 29, 2023 07:57 |
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speng31b posted:please don't be weird about mathew perry's death who the gently caress are you?
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# ? Oct 29, 2023 08:20 |
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Diamonds On MY Fish posted:So, my 5yo has been sick almost every single week, for a couple days each week, since Kindergarten started in early August. I've been passing it off as the typical thing that happens to new kindergarteners when they're exposed to new viruses. But this is just getting extremely excessive. The idea just popped into my head that it could be long COVID? We all had COVID once in May. He's tested negative on a RAT every week. Does that sound like it could be LC? And if so, how would I approach a doctor about that without sounding crazy? It could just be the new normal as seen in this CDC article, where surveillance testing for an assortment of virusses was 40% positive in the pre-K cohort (indicating they were sick with one or multiple viruses 2 out of 5 days): Pingui posted:At this pace immune debt should be eliminated in no time:
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# ? Oct 29, 2023 10:54 |
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https://twitter.com/wisalallen/status/1718477055497801884?s=46
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# ? Oct 29, 2023 12:21 |
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Platystemon posted:Here’s a heavy one. I mean sadly, 'early January 2022' it was probably impossible to go to a hospital at all without being repeatedly exposed to omicron. And as for mabs, don't worry, AZ will get around to releasing AZD3152 any day now! Well, the study isn't expected to finish until January 2025, and the mab they're using was designed in May 2022 to target early omicron variants, but I'm sure it'll still work just great against whatever the gently caress is going around in 1H 25!
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# ? Oct 29, 2023 15:32 |
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Pingui posted:lmao at this, fingers crossed it was a false positive. well both our PCR was negative. fingers crossed the nurse ‘s quote is right at $100 per if insurance denies it vs the tech telling us 3k guessing I got the rare false positive antigen
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# ? Oct 29, 2023 15:39 |
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I thought this study was very interesting, particularly the nitty-gritty of what exactly the cognitive-linguistic issues are and how they are fairly specific. Naturally this affects employment substantially, which I have also included (it is pretty dire). Sorry about the length, it is a somewhat verbose study, but I am not entirely sure I did it any favors by trying to cut it down even this much. It should be noted that these people are self-selected and are by definition from fairly early in the pandemic. On the other hand some of the people suffering most have selected out, these are mild cases and the cohort is fairly young (just under 50 on average). "Cognitive-linguistic difficulties in adults with Long COVID: A follow-up study" https://www.sciencedirect.com/science/article/pii/S2949903823000325 posted:Abstract
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# ? Oct 29, 2023 16:46 |
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there's basically no chance of there ever being a sterilizing vaccine right? i figure we can accept that now.
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# ? Oct 29, 2023 18:25 |
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JAY ZERO SUM GAME posted:there's basically no chance of there ever being a sterilizing vaccine right? i figure we can accept that now. There’s no reason that it couldn’t happen but we’ve basically eliminated funding research towards it.
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# ? Oct 29, 2023 18:27 |
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Zodium posted:it's time to let me smoke in bars again.
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# ? Oct 29, 2023 18:29 |
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# ? Oct 29, 2023 18:32 |
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Ugh. My wife woke up with congestion, sore throat, and a cough yesterday. Tested yesterday and today, negative so far, no fever, so fingers crossed that we didn't get got. I haven't had any symptoms so far (knock on wood) and I'm masking up, so we'll see how this shakes out I guess. We both got boosted a couple of weeks ago, but my previous booster was back in May and hers was over a year ago, so maybe that's giving me a leg up? We went to see The Armed at a small-ish venue on Tuesday, so that's almost definitely where she picked up whatever this is, despite her Aura. We were the only ones there masked up aside from one security dude, naturally.
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# ? Oct 29, 2023 18:38 |
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JAY ZERO SUM GAME posted:there's basically no chance of there ever being a sterilizing vaccine right? i figure we can accept that now. At this point a sterilizing COVID vaccine would really be a miracle imo. Not impossible, but highly unlikely, and would probably represent a sea change in vaccinations more broadly, as we could probably leverage similar tech to vaccinate against other pathogens that are similarly stubborn like cold and flu viruses.
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# ? Oct 29, 2023 19:50 |
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JAY ZERO SUM GAME posted:there's basically no chance of there ever being a sterilizing vaccine right? i figure we can accept that now. I don't believe we've ever developed a sterilizing vaccine for any coronavirus, in human or animals.
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# ? Oct 29, 2023 19:56 |
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Rescue Toaster posted:I don't believe we've ever developed a sterilizing vaccine for any coronavirus, in human or animals. we’ve never developed a sterilizing vaccine for any disease for which native infection did not confer sterilizing immunity. e.g. if you can only catch it once (measles mumps chicken pox, polio) you can develop a sterilizing vaccine for it, otherwise no.
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# ? Oct 29, 2023 20:18 |
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Yeah it's kind of not how vaccines work, just categorically. They trigger an immune response that provides protection from a pathogen. If the protection provided isn't durable from the disease, there would need to be some kind of mechanism for the vaccine to cause a greater or longer lasting immune response, which seems like a hard sell, especially going from a couple months at best to a lifetime.
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# ? Oct 29, 2023 20:29 |
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https://twitter.com/bnofeed/status/1718670495678128345?s=46 mmhmmm
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# ? Oct 29, 2023 21:34 |
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sterilizing as in "can't transmit for a while", though...
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# ? Oct 29, 2023 21:35 |
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Pingui posted:It increases the mutational space a bit, but seeing what BA.2.86* can cook up on its own, seems more likely to get jumps in immune evasion (to me, a layman) It's obviously hard to say this early on, but it looks like the recombinant referenced keeps the BA.2.86.1/JN spike and adds the Orf8a from HK (eta: HK* is ~20% of sequences from Washington state as of mid October). BA.2.86* is obv. going to be mutating happily on its own but with so much mixing and matching we might get multiple versions with identical net results. In other words... Gunshow Poophole posted:*pounding table* Zantie has issued a correction as of 22:03 on Oct 29, 2023 |
# ? Oct 29, 2023 21:55 |
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# ? May 25, 2024 14:35 |
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maxwellhill posted:sterilizing as in "can't transmit for a while", though... Good point, I would happily accept protection from serious outcomes and cutting back on at least the loving days of asymptomatic transmission for fucks sake.
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# ? Oct 29, 2023 22:12 |