Hellequin posted:

https://twitter.com/RealGayArbys/status/1748869687704690757

Why Am I So Tired posted:

you don't actually have to go to restaurants.

Why Am I So Tired posted:

That article David Berger links to is really good but it has a fatal flaw in that it doesn't seem to recognize that you don't actually have to go to restaurants.

I don't know if that makes it better or worse for sending out to people, considering "no restaurants" seems to be a bridge too far for people.

Pingui posted:

Yeah, it sounded and reads more like him going "chill dude" than him being misogynistic.

Snowglobe of Doom posted:

It's the exact same article I posted yesterday where the infectious diseases prof decided to attend an awards night unmasked and caught covid, lol

Zugzwang posted:

mods?

Hellequin posted:

Yeah, I'm whatever about it, I just think his reaction was very weird and overboard and did not look good. A simple apology would have been fine, instead there was that weird story about his mom and then blocking thousands of people.

Also just as a context for the LCAP group hosting the space he was in, this thread kinda goes into the sort of people involved with it. I've pretty much stopped interacting with any long Covid stuff on any social media platform because the whole space has gotten really weird. I wanted to help out people new to the whole chronic illness thing but I quite literally don't have the energy for this kind of bullshit.

https://twitter.com/mildTin/status/1749203176115626129?t=hx9WqODHz7IuOlJgLvPCIQ&s=19

Steve Yun posted:

https://x.com/fitterhappieraj/status/1749125601724629358?s=46

https://x.com/fitterhappieraj/status/1749127709660242232?s=46

what a roller coaster weekend

Asproigerosis posted:

quote:

Here, we report that infection with and vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces broadly cross-reactive binding antibodies to spikes from a wide range of coronaviruses including members of the sarbecovirus subgenus, other betacoronaviruses including Middle Eastern respiratory syndrome coronavirus, and extending to alpha-, gamma-, and delta-coronavirus spikes. These data show that the coronavirus spike antibody landscape in humans has profoundly been changed and broadened as a result of the SARS-CoV-2 pandemic. While we do not understand the functionality of these cross-reactive antibodies and their impact, there is the possibility that they may lead to enhanced resistance of the population to infection with newly emerging coronaviruses with pandemic potential.

quote:

Fig 3 Percentage of individuals with reactivity above the LoD to different spike proteins for each group shown in Fig. 1. (A) Percentage of pre-pandemic serum samples reactive to different spike proteins (n = 15). (B) Percentage of samples from SARS-CoV-2 convalescent individuals reactive to different spike proteins (n = 15). (C) Percentage of individuals vaccinated 2x with COVID-19 mRNA vaccines reactive to different spikes (n=20) and (D) the same for individuals who got three doses of vaccine (n = 19). (E and F) Percentage of individuals infected with SARS-CoV-2 and then vaccinated twice (n = 20 except for SX2013 where n = 19) or three times (n = 9) who had reactivity to different spike proteins. Subject characteristics can be found in Table S3.

quote:

DISCUSSION

Several of our observations from these experiments are interesting. Even in pre-COVID-19 sera, the prevalence and titers against the spike of β-CoV BCoV are almost as high as against the spike of seasonal β-CoV OC43. This indicates an antigenic relatedness of the BCoV and OC43 spikes. It has been hypothesized that OC43 shares a common ancestor with BCoV and may have split off around 1890 (9). This split would coincide with the “Russian flu” pandemic of 1889/1890, and it has been hypothesized that this pandemic was, indeed, caused by an OC43 ancestor that jumped from cattle into humans (10). The cross-reactivity found may perhaps further support this hypothesis and also explain why zoonotic infections in humans with BCoV are rare even though the virus can infect children (11). In addition, the titers as well as the percentage of positive individuals for the seasonal α-CoV 229E are much higher than for the seasonal α-CoV NL63. These differences may point perhaps to an inherent difference in immunogenicity and antibody durability or represent an artifact of the protein used in the ELISA.

quote:

It is important to note that after mRNA vaccination with the original vaccine containing the ancestral SARS-CoV-2 spike, titers against diverse sarbecovirus spikes are as high as against the Omicron spike. This may suggest, that the protection from severe disease that we observe against Omicron sublineages perhaps also applies to other, diverse sarbecoviruses (e.g., SARS-CoV-1, HKU3-8, SX2013, BM48-31) which may (re)-emerge in the future as human pathogens. While these cross-reactive antibodies may not neutralize more distantly related viruses, they may still afford protection via Fc-mediated effector functions.

quote:

Nevertheless, at this point in time, it remains unclear if these cross-reactive binding antibodies do in fact provide a clinical benefit. Of note, vaccine-enhanced disease has been observed in some animal models for SARS-CoV-1 and Middle Eastern respiratory syndrome coronavirus (MERS CoV) (while in other models protection was found).

quote:

Another interesting aspect is the question of which epitopes these cross-reactive antibodies target. Cross-reactivity within the sarbecoviruses likely targets the receptor binding domain (RBD) but also different epitopes on the S2 subunit. Cross-reactivity to other β-CoV spikes is likely mediated mostly by S2 targeting antibodies since the RBD is probably too divergent. Such antibodies have been isolated with some of them having neutralizing activity although at lower potency (often μg/mL range) than RBD targeting mAbs which can, in some cases, reach the ng/mL range (12, 15–18). Finally, cross-reactivity to α-CoV, δ-CoVs, and γ-CoVs is likely due to more rare antibodies that target the fusion peptide in the S2 domain. These antibodies have also been isolated and they exert neutralizing activity to some extent (19, 20). However, it would be helpful to isolate more mAbs with different reactivity profiles to understand their characteristics better and determine if they indeed can contribute to protection in vivo. Of note, monoclonal antibody therapeutics and prophylactics have been very efficient treatment options for COVID-19, but antigenic changes of SARS-CoV-2 have rendered them irrelevant. Perhaps antibodies that target more conserved epitopes, even if they have lower neutralizing potency, could be a more sustainable solution.

https://www.telegraph.co.uk/news/2024/01/22/early-deaths-from-heart-disease-soar-to-ten-year-high-in-wa/ posted:

Early deaths from heart disease soar to ten-year high in wake of Covid
This was the highest level since 2011, when 83 per 100,000 people died prematurely
(..)
Experts said that since 2020 it is the “first time there has been a clear reversal in the trend for almost 60 years” following a “significant slowdown” in improvements between 2012 and 2019.

More than 39,000 people under 75 died from cardiovascular disease in 2022, which includes heart attacks, strokes, and coronary heart disease. It equates to 107 people dying each day, or almost five people per hour.

Highest number since 2008
It was the highest number of premature deaths from heart disease since 2008 when almost 40,000 people died, and has risen every year since a low of 33,700 in 2014. When adjusted to account for the changing population size and age, the 73 deaths per 100,000 people in 2019 was the lowest rate.
(..)
While the rate of deaths fell by 11 per cent between 2012 and 2019, this was down on the 33 per cent it reduced by in the seven years prior.

Risen 13 per cent since pandemic
It has risen almost 13 per cent since the pandemic, undoing a decade of progress.
(..)

BusError posted:

People who are smart at science reading, what do we make of this study that says wearing eyeglasses is associated with a 15% lower chance of infection?

https://www.sciencedirect.com/science/article/pii/S1201971223007592

15% seems crazy high to me! I think we were all thinking they offered *some* protection, but I would have never guessed it'd be that much.

NeonPunk posted:

I've been saying this

https://twitter.com/xabitron1/status/1749163052941934751

Covidyceps is real

NeonPunk posted:

I've been saying this

https://twitter.com/xabitron1/status/1749163052941934751

Covidyceps is real

Cup Runneth Over posted:

Maybe the changes are good

Dr_0ctag0n posted:

"I need a CAD viewer on my lap top......ASAP. Work on a project and to not have one."
- VP

quote:

Kaplan also confirmed that Alina Habba and Michael Madaio tested negative for Covid-19 in court this morning. They took Covid tests because Habba said she had dinner with her parents three days ago and now they have Covid. Habba said she had a fever and isn't feeling well, though she has not tested positive.

Habba did not appear to be wearing a mask. Trump was sitting next to her in the courtroom.

Rescue Toaster posted:

So one of Trump's trials is delayed by a day because a juror is sick and wants to get a COVID test. There's no alternate jurors though so if they are sick going to be a long delay...

Also, supposedly his lawyer Alina Habba might have it. Although it's much more likely she's just lying to delay the trial past the NH primary tomorrow.

Dr_0ctag0n posted:

"I need a CAD viewer on my lap top......ASAP. Work on a project and to not have one."
- VP

quote:

You Bet Bedpan ………. Alice Is Gone For The Day Here ,
But First Thing In AM Here Charlotte EST Time We Will Up Date
The Specs Taking NTM off & Replacing It With LWB’s ………..
For You & The Teams At LWB

Dr_0ctag0n posted:

"I need a CAD viewer on my lap top......ASAP. Work on a project and to not have one."
- VP

Paradoxish posted:

This is like 90% of the communications I receive from clients. Maybe a little worse now, but wealthy people in positions of power and authority did not really have functioning brains before COVID, either.

When I first started doing consulting work I was so freaked out about sounding professional all the time and meanwhile people who make more money than I'll ever see just send me emails written in something between stream of consciousness and toddler speak.